Nintedanib 

Nintedanib 

Nintedanib is an FDA-approved medication designed to slow the progression of conditions like Idiopathic Pulmonary Fibrosis (IPF) and Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD). Its innovative formula targets pathways involved in fibrosis and inflammation, helping to preserve lung function and improve quality of life. Nintedanib is available in soft gelatin capsules for easy oral administration, which comes in 100 mg and 150 mg strengths, tailored to meet varying therapeutic needs. For optimal results, it’s recommended to take these capsules with food twice daily, as directed by your healthcare provider. For those seeking cost-effective options, you can buy Nintedanib online and enjoy significant savings on your treatment. Services like Polar Bear Meds provide affordable Nintedanib capsules sourced from Canada, ensuring quality and reliability. Plus, first-time buyers can use the Nintedanib coupon code WELCOMEPB10 to receive a 10% discount, making this life-changing medication more accessible. Take control of your lung health today with affordable, effective treatment options.

Product Overview

Managing progressive lung diseases like Idiopathic Pulmonary Fibrosis (IPF) or Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD) can be challenging, but Nintedanib offers a proven solution to slow disease progression. Designed to inhibit pathways involved in fibrosis, inflammation, and angiogenesis, this advanced medication supports lung health and helps preserve the quality of life. Nintedanib is available in 100 mg and 150 mg capsules and is easy to administer with its soft gelatin form, ensuring effective absorption. When you choose to buy Nintedanib online, you can benefit from convenience and significant cost savings without compromising quality. For first-time buyers, using the Nintedanib coupon code WELCOMEPB10 ensures an additional 10% discount, making it even more accessible.

Whether you’re managing mild symptoms or require a more intensive regimen, Nintedanib offers flexible dosing options. The standard adult dosage of 150 mg taken twice daily, approximately 12 hours apart, is effective for most patients. For individuals with mild hepatic impairment, a reduced dose of 100 mg twice daily is recommended. To further reduce gastrointestinal side effects, it’s best to take affordable Nintedanib capsules with food and follow your healthcare provider’s guidance closely. Adjustments may be necessary if side effects like nausea or elevated liver enzymes occur, allowing for a safer and more comfortable treatment experience.

Thanks to online platforms, you can now buy Nintedanib with coupon benefits that significantly reduce out-of-pocket costs. Services like Polar Bear Meds offer genuine, affordable options for U.S. patients by sourcing Nintedanib from Canada. Beyond cost savings, these services ensure reliable delivery, expert support, and adherence to international quality standards, helping you stay focused on improving your lung health.

What Are the Uses of Nintedanib? 

• Idiopathic Pulmonary Fibrosis (IPF)
• Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD)
• Chronic Fibrosing Interstitial Lung Diseases (ILDs) with a Progressive Phenotype
• Non-Small Cell Lung Cancer (NSCLC)

What Are the Forms & Strengths of Nintedanib?

Nintedanib is available as an oral medication designed to be taken by mouth. Its forms and strengths are tailored to meet various therapeutic needs. Below are the details:

• • Form: Soft gelatin capsules for easy oral administration.

• Strengths:

• • 100 mg capsules: Often used for patients requiring a lower dosage or as an initial dose to evaluate tolerance.
  • 150 mg capsules: Standard dosage strength for most adult patients, prescribed based on the severity of the condition being treated.

What Is the Recommended Dosage of Nintedanib?

The recommended dosage of Nintedanib depends on the patient’s condition, liver function, and response to treatment. Below is detailed guidance on standard dosages, adjustments, and key administration practices to ensure optimal results while minimizing side effects.

Standard Dosage

• Adults: The typical dose is 150 mg taken orally twice daily, approximately 12 hours apart, with food. This regimen provides a maximum daily dose of 300 mg.

Dosage Adjustments for Hepatic Impairment

• Mild Hepatic Impairment (Child-Pugh A): A reduced dose of 100 mg twice daily is recommended. Nintedanib is not recommended for patients with moderate or severe hepatic impairment (Child-Pugh B or C).
  Management of Adverse Reactions: In cases of adverse reactions, such as elevated liver enzymes or gastrointestinal issues, consider reducing the dose to 100 mg twice daily or temporarily interrupting treatment until the reaction resolves. Once resolved, therapy may be resumed at the full 150 mg twice daily dosage or at the reduced dosage, with the possibility of increasing to the full dose if tolerated. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Nintedanib?

Proper administration of Nintedanib is crucial for managing conditions such as idiopathic pulmonary fibrosis (IPF) and progressive interstitial lung diseases (ILDs). By adhering to recommended dosing and administration guidelines, patients can achieve optimal therapeutic benefits while minimizing side effects. Below are detailed instructions and precautions to ensure safe and effective use.

• The typical dosage is 150 mg taken orally twice daily, approximately 12 hours apart.
• For patients with mild liver impairment (Child-Pugh A), a reduced dose of 100 mg twice daily is recommended. Nintedanib is not recommended for patients with moderate or severe hepatic impairment.
• Take nintedanib with food to enhance absorption and reduce gastrointestinal side effects.
• Swallow the capsules whole with liquid; do not chew, crush, or open them, as this can affect the drug’s effectiveness and may cause a bitter taste.
• If you miss a dose, skip it and take the next dose at the regular scheduled time. Do not take two doses simultaneously to make up for a missed dose. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Nintedanib Work?

Nintedanib works by targeting and inhibiting multiple tyrosine kinases involved in the processes of fibrosis, angiogenesis, and inflammation, which are key contributors to progressive lung diseases. Specifically, it blocks receptors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), which play critical roles in promoting the formation of fibrotic tissue and abnormal blood vessels. By disrupting these pathways, Nintedanib helps slow the progression of diseases like idiopathic pulmonary fibrosis (IPF) and chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype. This inhibition reduces lung scarring, preserves lung function, and mitigates further disease advancement. While not a cure, Nintedanib offers a therapeutic option to manage symptoms and improve the quality of life in patients with these conditions.

Important Safety Information for Using Nintedanib

What Are the Side Effects of Nintedanib?

Common Side Effects of Nintedanib

Nintedanib, while effective in managing progressive lung diseases, can cause side effects in some individuals. These side effects range from mild to moderate and often depend on the patient’s overall health and response to the medication. Below is an overview of the most commonly reported side effects and their detailed explanations.

• Diarrhea: The most frequently reported side effect of Nintedanib. It occurs due to its impact on the digestive system, potentially disrupting normal gut function. Patients experiencing diarrhea should stay hydrated and may require antidiarrheal medication. If symptoms persist or worsen, a healthcare provider may adjust the dosage to manage this side effect.
• Nausea and Vomiting: Nintedanib can irritate the stomach lining, leading to feelings of nausea and occasional vomiting. These symptoms may be alleviated by taking the medication with food or using anti-nausea medication. Persistent nausea should be reported to a doctor, as it may necessitate a dose adjustment or additional treatment.
• Abdominal Pain: It may result from gastrointestinal irritation caused by Nintedanib. This discomfort is typically mild but can affect daily activities if left unmanaged. Taking the medication with food and avoiding heavy or spicy meals can help minimize this side effect. If the pain becomes severe, medical advice should be sought.
• Loss of Appetite: Some patients report a reduced appetite while taking Nintedanib. This may be linked to nausea or changes in the gastrointestinal system. Ensuring small, frequent meals with nutrient-rich foods can help maintain energy levels. A healthcare provider should be consulted if appetite loss leads to significant weight loss or malnutrition.
• Elevated Liver Enzymes: Nintedanib can cause increased liver enzyme levels, indicating potential liver strain. This is often detected through routine blood tests. Monitoring liver function regularly helps identify and address any issues early. If liver enzyme levels rise significantly, the dosage may be adjusted or the medication temporarily discontinued.
• Headache: Some patients experience headaches as a side effect of Nintedanib. These may occur due to dehydration or changes in blood flow associated with the medication. Drinking plenty of fluids and using over-the-counter pain relievers can help manage mild headaches. A healthcare provider should evaluate persistent or severe headaches.
• Fatigue: A common side effect and may result from the body adjusting to the medication or underlying disease progression. Ensuring adequate rest, maintaining a balanced diet, and engaging in light physical activity can help combat fatigue. If fatigue becomes debilitating, it is important to consult a healthcare professional.
• Weight Loss: It can occur due to decreased appetite or gastrointestinal symptoms. To prevent significant weight loss, patients should maintain a balanced diet with calorie-dense foods. If weight loss is rapid or concerning, a doctor may provide nutritional counseling or adjust the treatment plan accordingly.

Serious side effects of Nintedanib

While Nintedanib is an effective medication for managing progressive lung diseases, it can, in rare cases, cause serious side effects that require immediate medical attention. These side effects may impact a patient’s overall health and treatment plan. Below is a detailed explanation of the most serious side effects associated with Nintedanib.

• Liver Problems: Call your doctor immediately if you notice yellowing of your skin or the whites of your eyes (jaundice), dark or tea-colored urine, pain in the upper right side of your abdomen, unusual bruising or bleeding, fatigue, or loss of appetite. Your doctor will monitor your liver function with blood tests before and during your treatment.
• Diarrhea, Nausea, and Vomiting: Stay hydrated and consult your doctor if you experience diarrhea, nausea, or vomiting, especially if these symptoms persist or worsen. Your doctor may recommend medications to manage these side effects. Inform your doctor if you’re taking laxatives, stool softeners, or other supplements that might worsen diarrhea.
• Heart Attack: Seek medical help immediately if you experience chest pain or pressure, pain radiating to your arms, back, neck, or jaw, or shortness of breath, as these may be signs of a heart attack.
• Stroke: Contact your doctor immediately if you experience numbness or weakness on one side of your body, difficulty speaking, severe headache, or dizziness, as these could indicate a stroke.
• Bleeding Problems: Nintedanib may increase your risk of bleeding. Notify your doctor of unusual bleeding, bruising, or wounds that don’t heal. Also, inform them if you take blood thinners, including aspirin or prescription anticoagulants.
• Gastrointestinal Perforation: This medication can increase the risk of tears in the stomach or intestinal wall. Seek immediate care if you experience severe abdominal pain or swelling.
• Protein in Urine (Proteinuria): Nintedanib may cause proteinuria. Tell your doctor if you notice foamy urine, swelling in your hands, arms, legs, or feet, or sudden weight gain.

What Are the Nintedanib Precautions?

Following specific precautions is essential to ensure safe and effective therapy when using Nintedanib to treat progressive lung diseases. These precautions help minimize potential risks and side effects while maximizing the medication’s benefits. Below is a comprehensive list of precautions to keep in mind during treatment. Always consult your healthcare provider for personalized advice.

• Liver Function Monitoring: Before starting treatment, assess liver enzymes monthly for the first three months and periodically thereafter, as Nintedanib can cause liver enzyme elevations.
• Bleeding Risk: If you have a known risk of bleeding, use caution, as Nintedanib may increase this risk. Also, inform your healthcare provider about any anticoagulant medications you’re taking.
• Gastrointestinal Perforation: Patients with a history of gastrointestinal disorders or recent abdominal surgeries should be aware of the potential risk of gastrointestinal perforation. If you experience severe abdominal pain, fever, or vomiting, seek immediate medical attention.
• Pregnancy and Contraception: Nintedanib can cause fetal harm. Women of reproductive potential should use effective contraception during treatment and for at least three months after the last dose. If pregnancy occurs, discontinue the medication and consult your doctor immediately.
• Cardiovascular Health: Monitor for signs of cardiovascular complications, such as chest pain or shortness of breath, especially in patients with pre-existing heart conditions. Report any concerning symptoms to your healthcare provider promptly.
• Dehydration and Diarrhea Management: Nintedanib may cause diarrhea, leading to dehydration. Maintain adequate hydration and consider antidiarrheal medications if necessary. Consult your healthcare provider if diarrhea persists or becomes severe.
• Kidney Function: Regularly monitor kidney function during treatment, especially in patients with pre-existing kidney conditions. Report any signs of kidney impairment, such as swelling or decreased urine output, to your healthcare provider.

What Are the Contraindications of Nintedanib?

Nintedanib is contraindicated in the following situations:

• Hypersensitivity: Patients with known hypersensitivity to nintedanib, peanuts, or soy should not use this medication.
• Pregnancy: Nintedanib can cause fetal harm and is contraindicated during pregnancy.
• Severe Hepatic Impairment: The safety and efficacy of nintedanib have not been investigated in patients with moderate to severe hepatic impairment (Child-Pugh B and C); therefore, its use is not recommended in these populations.
• Pediatric Population: Nintedanib has not been studied in patients below 18 years of age and is contraindicated in this population.

What If You Miss a Dose of Nintedanib?

If you miss a dose of Nintedanib, do not double your next dose to make up for the missed one. Instead, take the next dose at your regularly scheduled time. Doubling doses can increase the risk of side effects and may not enhance the medication’s effectiveness. If you frequently miss doses, consult your healthcare expert to discuss strategies for improving your adherence to the treatment schedule. 

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Nintedanib?

Taking too much nintedanib can lead to an increased risk of severe side effects, including significant gastrointestinal issues such as severe diarrhea, nausea, and vomiting, which can result in dehydration and electrolyte imbalances. Additionally, an overdose may exacerbate liver dysfunction, causing elevated liver enzyme levels and symptoms such as jaundice, abdominal pain, and fatigue. In rare cases, overdose can heighten the risk of bleeding, kidney impairment, or cardiovascular complications. If an overdose is suspected, immediate medical attention is crucial. Treatment typically involves supportive care, including managing symptoms and monitoring vital functions, as there is no specific antidote for nintedanib overdose. Always adhere to prescribed dosages and consult your healthcare provider if you have concerns.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store Nintedanib?

Proper storage of nintedanib is essential to maintaining its effectiveness and ensuring safety. Storing the medication in the right conditions helps preserve its stability and prevent accidental misuse. Below are detailed instructions on how to store nintedanib to ensure its continued safety and effectiveness.

• Keep the medication at room temperature, between 20°C to 25°C. Temporary excursions are allowed between 15°C to 30°C.
• Store nintedanib in its original packaging to protect it from moisture and light. Do not transfer the capsules to other containers.
• Ensure the packaging is tightly closed and stored in a dry place, away from high humidity or water exposure.
• Do not freeze or expose the medication to excessive heat, which can degrade its effectiveness.
• Store nintedanib in a secure location, out of reach of children and pets, to prevent accidental ingestion.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Nintedanib?

Nintedanib, a medication used to treat certain lung conditions, can interact with various drugs, potentially altering its effectiveness or increasing the risk of side effects. Notable interactions include:

• Ketoconazole: A potent inhibitor of P-glycoprotein (P-gp) and CYP3A4 enzymes, ketoconazole can increase nintedanib levels in the bloodstream. This elevation may enhance therapeutic effects but also raise the likelihood of adverse reactions. Close monitoring is recommended when these medications are used together.
• Rifampicin: A strong inducer of P-gp and CYP3A4, rifampicin can decrease nintedanib concentrations by approximately 50%. This reduction may diminish nintedanib’s efficacy, necessitating careful consideration before co-administration. Alternative treatments should be evaluated to avoid reduced therapeutic outcomes.
• Anticoagulants (e.g., Warfarin): Nintedanib may increase the risk of bleeding, especially when taken with anticoagulants. Patients should be monitored for signs of bleeding; dose adjustments may be necessary to mitigate this risk.
• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Concurrent use of NSAIDs with nintedanib can elevate the risk of gastrointestinal bleeding. Patients should be advised to use caution and promptly report any signs of gastrointestinal distress.
• St. John’s Wort: This herbal supplement is a known inducer of P-gp and CYP3A4, potentially lowering nintedanib levels and reducing effectiveness. Patients are advised to avoid St. John’s Wort during nintedanib therapy.

What Are the Other Nintedanib Interactions?

In addition to interactions with medications, nintedanib may interact with certain foods, beverages, herbs, and supplements. These interactions can impact the medication’s effectiveness or increase the risk of side effects. Below are some notable interactions to consider.

• Supplements: Share a list of all supplements, herbs, and vitamins with your doctor or pharmacist before starting Ofev to avoid potential interactions.
• St. John’s Wort: Avoid using this herbal supplement with Ofev, as it speeds up the activity of CYP3A4 and P-gp proteins, reducing Ofev’s effectiveness. Ask your doctor about alternative options if you take St. John’s Wort.

• Vitamins: No specific interactions are reported, but consult your doctor before taking any vitamin products with Ofev.
• Food: Grapefruit and grapefruit juice can slow Ofev’s breakdown, increasing its level in the body and the risk of side effects. Avoid consuming these products while on Ofev.
• Digestive Side Effects: To manage nausea, vomiting, or diarrhea, avoid rich, greasy, spicy, or high-fiber foods, dairy products, alcohol, and caffeinated drinks like coffee.

• Smoking: Smoking lowers Ofev levels in the body, reducing its effectiveness and increasing risks of heart attack or stroke. Quitting smoking is highly recommended.
• Heart Disease: Ofev can rarely cause blood clots, potentially leading to a heart attack or stroke. Discuss your risk with your doctor if you have heart disease.
• Blood Clotting Problems: Ofev may increase the risk of bleeding. Notify your doctor if you have existing clotting issues or are on blood thinners.
• Liver Problems: Mild liver issues may require a lower dosage of Ofev. However, the drug is not recommended for moderate or severe liver problems.
• Kidney Problems: Ofev may cause or worsen proteinuria (protein in urine). Consult your doctor if you have existing kidney conditions.
• Diverticular Disease: A history of diverticulitis or similar conditions may increase the risk of gastrointestinal perforation with Ofev.
• Recent Abdominal Surgery: GI perforation risk is heightened if you’ve had recent abdominal surgery.

• Pregnancy: Ofev is not safe during pregnancy due to the risk of birth defects or pregnancy loss. Use effective contraception during treatment and for at least 3 months after stopping Ofev.
• Breastfeeding: It’s unclear if Ofev passes into breast milk, but it may pose risks to a breastfeeding child. Avoid breastfeeding while taking Ofev.

• Vaccines: No known interactions with vaccines, but consult your doctor to ensure you’re up to date.
• Lab Tests: Ofev is not known to interact with lab tests. Discuss any concerns with your doctor.

[Note: This isn’t a complete list, and there could be other drugs that interact with Nintedanib. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Nintedanib Alternatives?

For those unable to tolerate nintedanib or who require a different treatment approach, several alternatives exist to help manage conditions like idiopathic pulmonary fibrosis or other progressive lung diseases. These options, ranging from antifibrotic therapies to lung transplantation, are outlined below, listing the brand names first and their generic counterparts in parentheses.

• Esbriet (pirfenidone)
• Imuran (azathioprine)
• CellCept (mycophenolate mofetil)
• Cytoxan (cyclophosphamide)
• Trexall, Otrexup, Rasuvo (methotrexate)
• Rituxan (rituximab)
• Prograf, Advagraf (tacrolimus)
• Prednisone, Medrol (corticosteroids)
• Tracleer (bosentan)
• Revatio, Viagra (sildenafil)
• Varies (antifibrotic therapies)
• Supplemental oxygen devices (oxygen therapy)
• Pulmonary rehabilitation programs (rehabilitation therapies)
• Surgical lung transplantation (lung transplantation)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Nintedanib Cost & Coupons

Managing the cost of Nintedanib can be a challenge for many individuals, especially since health insurance in the U.S. often doesn’t cover this medication, leaving patients to face out-of-pocket expenses exceeding $1,000 per month. If you’re looking for ways to make this treatment more affordable, Polar Bear Meds offers a reliable option to buy Nintedanib online from Canada, ensuring significant savings. Their service provides access to affordable Nintedanib capsules without compromising quality or authenticity. To make your first purchase even more cost-effective, use the Nintedanib coupon code WELCOMEPB10 at checkout for a 10% discount. This is an excellent way to alleviate the financial burden of necessary medications. Explore this convenient and affordable alternative today, and enjoy peace of mind, knowing that managing your health doesn’t have to come at such a high cost.

Frequently Asked Questions

When will I start noticing the effects of nintedanib?

Nintedanib doesn’t produce immediate effects but works gradually to slow the progression of conditions like idiopathic pulmonary fibrosis (IPF) and other lung diseases. Clinical studies suggest that its impact on lung function decline may become noticeable within 3 to 6 months of consistent use. However, the exact timeframe can vary depending on individual response and disease progression. Regular follow-ups with your healthcare provider are essential to monitor its effectiveness over time.

How long will I need to take Ofev (nintedanib)?

There is no set duration for taking Nintedanib. Your healthcare provider will determine how long you should continue based on how well it manages your condition and whether you experience any significant side effects. Regular check-ins with your provider, including lab tests, will help monitor your progress and ensure your medication is safe and effective.

Is it necessary to take Nnintedanib with food?

Yes, it’s best to take nintedanib with food to ensure proper absorption of the medication. Eat a meal, then swallow the capsules whole with a glass of water for optimal effectiveness.

What can I do to minimize the side effects of Nintedanib?

If side effects persist or become severe, your healthcare provider may recommend adjusting your dose, temporarily pausing treatment, or discontinuing the medication altogether. To help manage symptoms like nausea or vomiting, try taking Nintedanib with food or using an anti-nausea medication as directed by your provider. Always consult your healthcare professional for guidance tailored to your situation.

Our Guarantee

At PolarBearMeds.com, we assure you the most affordable price to buy Nintedanib online from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently buy Nintedanib online at a substantial cost, call us at 1-888-779-2193 toll-free.