Orlistat

Orlistat is used along with a low-calorie diet and regular physical exercise to help with weight management in patients who are overweight/obese. It is indicated for use in adult patients with a body mass index or BMI of 30 or greater/those with a BMI of 27, and obesity-related conditions like hypertension or diabetes, and children above 12. It is available in the form of capsules with 60mg & 120mg strengths to be taken orally by mouth with a meal or within one hour afterward. It functions by blocking the enzymes responsible for breaking down dietary fats, preventing their absorption into the body. For safe and efficient use of the medication you are using, you can buy Orlistat low cost from trusted pharmacies.

Orlistat contains Orlistat, an active lipase inhibitor used to manage obesity by reducing fat absorption in the digestive system. It functions by blocking the enzymes responsible for breaking down dietary fats, preventing their absorption into the body. This mechanism helps lower calorie intake and supports weight management when combined with a reduced-calorie diet.

This medication is available in 60 mg and 120 mg strengths. It should be taken with a meal containing fat or within an hour afterward. Swallow the capsule whole with water. Orlistat is suitable for adults with a BMI of 30 or more/with a BMI of 27 and obesity-related conditions like hypertension or diabetes. It is not intended for children under 12. By reducing fat absorption, Orlistat helps in gradual weight management and maintaining a healthier body composition.

Common side effects include oily stools, increased bowel movements, flatulence, and abdominal discomfort. To minimize these effects, follow a low-fat diet. Avoid use if pregnant, breastfeeding, or if you have chronic malabsorption syndrome or cholestasis. If a dose is missed, skip it and take the next as scheduled. Do not double the dose. In case of overdose, seek medical attention. Store at room temperature, away from moisture. Regular exercise and a balanced diet enhance its effectiveness. Consult with a licensed medical practitioner for personalized guidance before starting Orlistat.

It is used to:

• Manage obesity and reduce the risk of regaining weight that has already been lost

What Are the Forms & Strengths of Orlistat?

It is available in the form of oral capsules with the following strengths:

• 60mg
• 120mg

What Is the Recommended Dosage of Orlistat?

The dosage for Orlistat varies from individual to individual and is based on multiple factors, such as the patient's age, condition, and tolerance. It also depends on the form, strength, and duration of the medicine. The dosage mentioned here is generalized, and if your doctor has instructed you to use Orlistat at a different dose, you should not alter your dosage without talking to them first. For a safe and efficient use of the medicine, you should take it exactly as prescribed.

For the Treatment of Obesity

• Adults and teenagers: 120mg thrice each day with meals containing fat.
• Children less than 12 years: The usage and dosage will be determined by a medical practitioner.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they'll customize your dosage accordingly.]

• Before using Orlistat for the first time and each time you get a refill, you should refer to the patient information leaflet (PIL) and the medication guide, if provided by your pharmacist or healthcare provider. If you have any questions or concerns regarding the medicine use or if you have trouble understanding any part of the leaflet, you should ask your doctor.
• If you are using the over-the-counter Orlistat product to self-treat, you should carefully read and understand the directions on the product.
• You should take Orlistat exactly as directed and do not take more or less of it, in larger quantities, or more often than prescribed, as it can cause unwanted side effects.
• Orlistat prevents the absorption of certain fats that you consume. You should take it with fluids during the meal or up to one hour after eating. If you occasionally miss a meal or eat food that contains no fat, you should omit the Orlistat dose.
• Because Orlistat can reduce the amount of some vitamins that your body absorbs from meals, you will be required to take a multivitamin supplement once daily. Take the vitamin supplement at least two hours before or after taking this medicine. You may also need to take your multivitamin supplement at bedtime.
• While taking Orlistat, your diet should not contain more than 30% of calories as fat. Having more fat in your meals will increase the risk of unwanted side effects associated with this medicine.
• While being treated with Orlistat, you should follow a nutritionally balanced diet, and your daily intake of fat, carbohydrates & protein should be distributed over three main meals.
• Special care may be required if you have been using this medicine in pediatric patients. While this medicine is prescribed for children as young as 12 years of age for certain conditions, precautions should be taken.
• Using Orlistat for children under 18 years of age without a prescription is not advisable.
• Carefully follow your doctor’s or dietician’s instructions regarding a reduced-calorie diet plan and regular exercise. You should discuss this with your doctor before starting any exercise plan.
• If you are also using cyclosporine, you should take it at least three hours before or after taking this medicine. If you are using levothyroxine, you should take it four hours before or after taking Orlistat.
• If your doctor has recommended you use a multivitamin supplement that contains vitamins A, E, D & K with beta carotene, you should take it at least two hours before or after taking this medicine. Orlistat restricts your body from absorbing some of the vitamins from your meal.
• It may take around two weeks to notice some weight loss after you start using Orlistat. Let your doctor or healthcare provider know if your condition does not get better or if it worsens.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They'll adjust it as needed over time.]

Orlistat functions by inhibiting the working of lipase, an enzyme made in the pancreas that breaks down fats in the diet. When lipase is blocked, about 30% of the fat consumed in a meal is not absorbed & is instead eliminated through bowel movements. This reduction in fat absorption can help reduce caloric intake and contribute to weight loss. Orlistat is usually used in conjunction with a reduced-calorie diet and regular physical activity for maximum effectiveness. You should adhere to a well-balanced diet while taking Orlistat to avoid potential gastrointestinal side effects.

Common side effects of Orlistat: Similar to other medicines, Orlistat can cause certain side effects for some people who use it. These symptoms are usually temporary and usually resolve independently without the need for medical intervention. However, if they persist or become worrisome, you should let your doctor or healthcare provider know. Report any new or worsening symptoms to your doctor. Some of the common side effects of Orlistat include:

• Increased Number of Bowel Movements: This medicine reduces fat absorption in the body, leading to more fat in the stool. This unabsorbed fat can cause the body to expel waste more frequently, causing an increased number of bowel movements. To manage this side effect, you should stick to a low-fat diet. Following a low-fat diet can reduce the frequency of bowel movements.
• Oily or Fatty Stools: The presence of unabsorbed fat in the stool can make it appear oily or fatty, often with a greasy consistency. This occurs because the undigested fat is excreted directly. Consuming meals with lower fat content can help reduce the oiliness of stools.
• Oily Spotting in Undergarments: Orlistat can lead to unabsorbed fat, which can sometimes leak from the anus, causing oily spotting on undergarments. This is more likely to occur in patients who have a high dietary fat intake. Maintaining a diet where fat constitutes no more than 30% of total caloric intake can help prevent this issue.
• Orange or Brown Colored Oil in Stool: The excretion of undigested fat can result in stools that have an orange or brown oily appearance. This discoloration is due to the fat mixing with bile pigments. Reducing dietary fat intake can minimize this effect.
• Gas with Oily Discharge: Intestinal bacteria can ferment unabsorbed fat to produce gas accompanied by an oily discharge. This can be uncomfortable and embarrassing. Eating a low-fat diet and avoiding foods known to cause gas can help manage this side effect.
• Loose Stools or Urgent Need to Defecate: The presence of unabsorbed fat in the intestines can lead to loose stools and an urgent need to defecate. This happens because the fat retains water in the stool, increasing its liquidity. Gradually introducing dietary changes and spreading fat intake evenly across meals can help control these symptoms.
• Inability to Control Bowel Movements: In certain cases, some Orlistat users can experience fecal incontinence or an inability to control bowel movements, which is often due to the laxative effect of unabsorbed fats. To manage this condition, it is recommended to strictly limit fat intake and monitor how different foods affect the body.
• Stomach Pain, Nausea, and Rectal Pain: Gastrointestinal discomfort, including stomach pain, nausea, and rectal pain, can occur as the digestive system adjusts to the medication and increases fat excretion. These symptoms are often temporary and can be alleviated by consuming a balanced, low-fat diet and ensuring adequate hydration.

Serious side effects of Orlistat: Orlistat can cause rare but severe side effects in some using it, which require immediate medical assistance and can become life-threatening if left untreated. You should seek prompt medical intervention if you experience any of the side effects given below.

• Allergic Reactions: Hypersensitivity reactions to Orlistat or any of its components are rare but can occur. These reactions can occur when your immune system mistakenly identifies the medicine as a harmful substance, triggering symptoms such as skin rash, itching, swelling, hives & respiratory difficulties. If you experience any signs and symptoms of an allergic reaction to this medicine, you should discontinue using the medicine and seek medical assistance. To prevent such reactions, you should tell your doctor or healthcare provider about any known allergies before using Orlistat.
• Bloody or Black Tarry Stools: The presence of bloody or black tarry stools while being treated with Orlistat may indicate gastrointestinal bleeding. While this is not a common side effect associated with the use of this medicine, it can occur, possibly due to rectal bleeding. If you notice such symptoms, contact your healthcare provider promptly for evaluation. To reduce the risk of this side effect, you should follow the recommended dosage and avoid high-fat meals, as excessive fat intake can increase gastrointestinal side effects.
• Kidney Stones: Orlistat may, in rare cases, lead to kidney-related issues. The medication can cause increased levels of oxalate in the urine, potentially resulting in kidney stones. Its symptoms include blood in the urine, lower back or side pain, and discomfort during urination. To prevent this, maintain adequate hydration to help flush oxalate from the kidneys and discuss any history of kidney stones with your doctor before starting Orlistat.
• Liver Injury: Although rare, severe liver injury has been reported in some individuals taking Orlistat. The exact mechanism behind why this happens is not well understood, but it may involve an adverse reaction affecting liver function. Symptoms to watch for include dark urine, jaundice, light-colored stools, nausea, loss of appetite, fatigue, and pain in the upper right abdomen. If any of these symptoms occur, you should discontinue use and seek immediate medical attention. Regular monitoring of liver function may be advisable for those on prolonged Orlistat therapy.
• Trouble While Urinating or Change in the Amount of Urine: Difficulty urinating or changes in urine volume may signal kidney issues, potentially related to increased oxalate levels from Orlistat use. If you have any of these symptoms, consult with your healthcare provider for assessment. Ensuring proper hydration and discussing any pre-existing kidney conditions with your doctor can help mitigate this risk.
• Uncontrolled, Urgent Bowel Movements: Orlistat works by blocking fat absorption, leading to its excretion through the feces. This can result in gastrointestinal side effects such as oily spotting, flatulence with discharge, and urgent or uncontrolled bowel movements, especially after meals high in fat. To manage these effects, adhere to a low-fat meal (with less than 30% of daily calories from fat) and distribute fat intake evenly across meals. Over time, these side effects often diminish as your body adjusts to the medication and dietary modifications.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

• You should use Orlistat with a reduced-calorie healthy diet that contains less than 30% of the calories from fat. Divide your daily intake of fat, carbohydrates & protein equally among your three main meals. Adhere to a well-balanced, reduced-calorie, low-fat, nutritious diet. Before starting to take Orlistat, try starting this diet. Following a low-fat, healthy diet can help reduce the potential side effects of Orlistat.
• Orlistat can decrease the absorption of certain vitamins. After consulting with a healthcare professional, you should take a daily multivitamin that has normal amounts of vitamins D, E, K, beta-carotene, or vitamin A. Take the multivitamin once daily at bedtime unless instructed otherwise by your doctor or healthcare professional. Discuss the foods you consume and the vitamins you take with your healthcare provider.
• Do not use Orlistat if you have ever had an organ transplant, as it interferes with certain medicines used to prevent transplant rejection.
• Women should inform their healthcare professional if they plan to become pregnant or suspect they may be pregnant. Losing weight while being pregnant is not advised and may cause harm to the unborn child. Discuss with your healthcare professional for more information.
• Avoid breastfeeding while using Orlistat, as it can cause harm to the nursing baby. Consult your doctor or healthcare practitioner before breastfeeding while using Orlistat.

• Before using Orlistat, tell your doctor or healthcare provider if you have or have ever had an allergic reaction to Orlistat or any of the ingredients listed in the product. This medicine also contains certain active or inactive ingredients, which can cause hypersensitivity reactions or other issues in the people using it. If you are not aware of all the ingredients your medicine contains, you should discuss this with your healthcare provider or pharmacist.
• Before using this product, tell your doctor if you are allergic to any medicine, dyes, preservatives, or animals.
• Inform your physician if you are using any medicine that suppresses the immune system, such as cyclosporine. If you are using cyclosporine, you should take it at least three hours after Orlistat. If you are using levothyroxine, you should take it at least four hours after this medicine. If you are using fat-soluble vitamins and beta-carotene, you should take them two hours after this medicine.
• Let your doctor or healthcare professional know if you have ever had an organ transplant or if you have cholestasis or malabsorption syndrome. If you have any of the mentioned conditions, your doctor is most likely to recommend you to use an alternative treatment option.
• Inform your healthcare practitioner if you have a history of eating disorders, including anorexia nervosa or bulimia, or pancreatitis, diabetes, kidney stones, gallbladder, or thyroid disease.
• You should adhere to the diet program your dietician or doctor has recommended to you. You should divide the amount of your fat, protein, and carbohydrate intake evenly over three main meals. If you use Orlistat with a high diet in fat, or with one meal high in fat, you may have an increased chance of side effects from the medication.
• While being treated with Orlistat, do not consume food items that have more than 30% fat. Carefully read the label on everything you buy. When eating meat, poultry, or fish, stick to 2-3 ounces (55-85 grams) per serving—about the size of a deck of cards. Choose lean cuts of meat & remove the skin from poultry. Fill most of your plate with grains, fruits, and vegetables. Swap whole milk for nonfat or 1% milk, and choose reduced- or low-fat dairy products. Cook with less fat by using vegetable oil spray instead of butter or heavy oils. Many salad dressings, baked goods, and processed or fast foods are high in fat. Opt for low-fat or nonfat versions, or eat smaller portions. When eating out, ask how dishes are prepared and request minimal added fat.
• Orlistat decreases the absorption of fat-soluble vitamins (A, D, E, and K) and beta-carotene. To prevent deficiencies, take a daily multivitamin that includes these nutrients. Check the label to ensure it contains all the necessary vitamins. Take the multivitamin once a day, either two hours before or after taking Orlistat, or at bedtime. If you have any questions about taking a multivitamin with Orlistat, consult your doctor or pharmacist.

Orlistat should not be used if you have the following conditions:

• Individuals with malabsorption syndrome should not use Orlistat.
• Patients who have a hypersensitivity to Orlistat or any other active or inactive ingredients present in Orlistat should avoid using it.
• People with reduced gallbladder function, such as after a cholecystectomy, should avoid this medication.
• It should not be used by individuals who are pregnant or breastfeeding
• Individuals with anorexia and bulimia (eating disorders) should not use Orlistat.

• To see the full benefits of Orlistat, you should stay consistent in dosage, and take it around the same time every day.
• If you have missed a dose of Orlistat, you should take it within one hour following the meal, which contains fat.
• However, you should omit the missed dose if it is almost time to take your next scheduled dose and take only that dose.
• You should not take double or extra doses of the same medicine to compensate for the missed dose.
• If you occasionally skip a meal or consume a meal without fat, you should skip that dose of Orlistat.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Taking too much Orlistat can cause uncomfortable side effects such as oily stools, abdominal pain, diarrhea, and frequent bowel movements since it blocks fat absorption. In rare cases, allergic reactions like hives, itching, and breathing difficulties may occur. If you or someone else has taken Orlistat more than the recommended dose, you should seek immediate medical assistance by calling a healthcare professional or 911. You can also go to the nearest medical care centre.

[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

• You should keep Orlistat in a cool, dry, and dark place, in its original container, away from direct exposure to sunlight, moisture & heat.
• Keep this medication in a secure place, tightly closed, away from the sight and reach of children and pets to avoid accidental consumption.
• Do not keep medicines that have passed their expiration date or are no longer needed. Discard them safely in such a way that does not let children, animals, and others consume them.
• You should not throw unwanted or unused medicines in the household garbage bin, pour them into the drain, or flush them down the toilet unless instructed to do so by a licensed healthcare professional.
• For more information on how to dispose of outdated or unwanted medicines, talk to your pharmacist or healthcare provider.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Certain medicines may interact with Orlistat and cause unwanted side effects or reduce its effectiveness. To prevent or manage such interactions, it is important to tell your doctor or healthcare provider about all medicines you are currently using or plan to use alongside Orlistat. These include all prescriptions, over-the-counter drugs, herbs, or vitamin and mineral supplements. This information is essential to help your doctor identify and prevent potential drug interactions. If a significant drug interaction is found, they may make dosage alterations in one or both drugs or suggest you use a different treatment option altogether. Some of the drugs that may interact with Orlistat are as follows:

• Ambien
• Benadryl
• Cobicistat
• Cyclosporine
• Dabigatran Etexilate
• Dalteparin
• Danaparoid
• Darunavir
• Desirudin
• Diazepam
• Didanosine
• Edoxaban
• Efavirenz
• Elvitegravir
• Emtricitabine
• Lamictal
• Ozempic
• Synthroid
• Topamax
• Vitamin B12
• Vitamin B6
• Vitamin C
• Vitamin D3
• Wegovy
• Wellbutrin

What Are the Other Orlistat Interactions?

Apart from medicines, certain herbs, vitamin or mineral supplements, food items, and beverages may interact with Orlistat and affect how it works. If you are concerned about any such interactions, discuss them with your doctor. If any potential interaction is found, they may recommend you to make certain dietary or lifestyle changes. The presence of certain medical conditions may affect the use of Orlistat. Before using this medicine, make sure to tell your doctor about your complete medical history, especially if you have the following conditions:

• Diabetes
• Eating disorders such as anorexia nervosa/bulimia
• Gallbladder issues
• Hyperthyroidism
• HIV infection
• Hyperoxaluria
• Kidney failure
• Kidney stones
• Liver disease
• Malabsorption syndrome

[Note: This isn't a complete list, and there could be other drugs that interact with Orlistat. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

If Orlistat is not suitable for you to use, there are several alternatives available on the market that can help with weight management. If you plan to switch your current prescription or start a new one, you should not use it without consulting with your doctor first. Based on your condition, needs, age, and other factors, they will help you determine the medicine that is most suitable for you to use. These mainly include:

• Xenical (orlistat)
• Alli (orlistat)
• Qsymia (phentermine and topimarate)
• Contrave (naltrexone and bupropion)
• Saxenda (liraglutide)
• Wegovy (semaglutide)
• Zepbound (tirzepatide)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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