Prednisone

Prednisone, with its generic name Prednisone, is approved by the FDA to help with various health issues like asthma, allergies, arthritis, inflammatory bowel diseases, adrenal problems, and blood or bone marrow disorders. It works by reducing inflammation, calming down an immune system that’s too active, or replacing cortisol, a hormone the body usually makes. Cortisol is essential for how the body reacts to stress, sickness, and injuries. Available in different strengths, Prednisone belongs to a group of medicines known as steroids. This is a prescribed medication, so if you want to buy Prednisone online from a Canadian Pharmacy, you need a doctor’s prescription.

Prednisone, also referred to by its generic denomination prednisolone, is an FDA-approved pharmaceutical agent utilized in the management of diverse medical conditions, including asthma, arthritis, allergies, and inflammatory bowel diseases. Classified within the pharmacotherapeutic group of steroids, its mode of action involves attenuating inflammation, modulation of an excessively responsive immune system, or substitution for cortisol, a pivotal hormone integral to the stress response.

The medication is available in diverse formulations and potencies, including tablets, concentrate, and oral suspension, with dosage adjustments contingent upon the specific medical condition, subject to modification by the attending physician. Administration of Prednisone necessitates strict adherence to prescribed guidelines, involving ingestion with water, conformity to recommended dosages, consumption with food, and generally scheduled for morning intake if administered once daily.

Prednisone is associated with potential side effects, ranging from mild manifestations like weight gain to more severe complications such as hypertension and Cushing’s syndrome. Caution is warranted in specific medical conditions, and vigilance is crucial during pregnancy and lactation. Possible interactions with concurrent medications exist, prompting consideration of alternatives such as dexamethasone or methotrexate under the supervision of a healthcare professional.

It is used to treat a wide range of medical conditions, such as:

• Adrenal problems
• Blood or bone marrow problems
• Arthritis
• Asthma
• Severe allergies
• Eye or vision problems
• Stomach or bowel problems
• Endocrine problems
• Lupus
• Kidney problems
• Skin conditions
• Inflammation (swelling)
• Flare-ups of multiple sclerosis
• Ulcerative colitis

It comes in 3 different forms & the following strengths:

Tablets

• 1mg
• 2.5mg
• 5mg
• 10mg
• 20mg
• 50mg

Concentrate

• 5mg/5ml

Oral suspension

• 5mg/5ml

Delayed-release tablet

• 1mg
• 2mg
• 5mg

Recommended Dosage for Different Patients

For oral dosage form:

The dose depends on the medical condition

• Adults— Start with 5 to 60 milligrams per day. Your doctor might change it if necessary.
• Children— The dose amount depends on their weight and should be decided by the doctor. Usually, it’s 0.14 to 2 milligrams per kilogram of body weight each day, split into 3 or 4 doses. The doctor may change the dose as needed.

[Note: Remember these recommendations may vary depending on person to person. Consult your healthcare provider or doctor, and they’ll customize your dosage accordingly.]

• Take this medication with a glass of water.
• Follow the directions on the prescription label.
• Take this medication with food.
• If you’re taking it once a day, take it in the morning.
• Don’t take more medication than prescribed.
• Don’t suddenly stop taking it to avoid severe reactions.
• Your care team will guide you on the right dosage.
• If your care team advises stopping, the dose may be gradually lowered to prevent side effects.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Prednisolone goes into the cells, creates inflammation, and stops the body’s response, causing swelling. It lessens the signs of certain conditions, but it doesn’t cure them. It also works as cortisol, a natural hormone that helps your body handle stress, illness, and injury. Prednisone can step in and do the job when your body doesn’t make enough cortisol, keeping things in check during tough times.

Mild side effects of Prednisone include:

• Weight gain
• Hair loss
• Mild allergic reaction
• Nausea
• Salt and water retention (buildup)
• Increased appetite

Serious side effects of Prednisone include

• High blood pressure
• Mood & behavior changes, such as psychosis, insomnia, or depression
• High blood sugar
• Osteoporosis
• Increased risk of infection
• Cushing’s syndrome
• Eye problems, such as cataracts and glaucoma
• Adrenal insufficiency
• Severe allergic reaction

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

• Don’t take prednisone if you have a fungal infection needing oral antifungals. It’s usually okay with topical antifungals, but always tell your doctor about your medicines before starting prednisone.
• Prednisone can make your immune system weaker, so stay away from sick people. Don’t get a “live” vaccine while using prednisone.
• Call your doctor if you have trouble breathing, severe upper stomach pain, bloody stools, intense sadness, personality changes, vision problems, or eye pain.
• Don’t stop using prednisone suddenly. Follow your doctor’s instructions on gradually reducing your dose.

Don’t use Prednisone if you have:

• Liver disease
• Any illness that causes diarrhea
• Kidney disease
• Diabetes
• Heart disease
• Low levels of potassium in your blood;
• A thyroid disorder
• A history of malaria;
• Tuberculosis
• Osteoporosis
• Glaucoma
• Cataracts
• Stomach ulcers
• Ulcerative colitis
• Myasthenia gravis
• Depression or mental illness

Other Important Precautions

Pregnancy: If you’re pregnant or planning to be, taking Prednisone during the first trimester could lead to low birth weight or birth defects. Inform your doctor about your pregnancy or plans and use effective birth control.

Breastfeeding: Prednisone can get into breast milk and harm a nursing baby, so let your doctor know if you’re breastfeeding.

Children: In children, steroids may affect growth. If you’re concerned about your child not growing generally while using this medicine, talk to your doctor.

If you forget to take Prednisone, take it as soon as you remember. But if your next dose is coming up soon, just skip the missed one and take the next dose at your usual time. Don’t take extra Prednisone to make up for the missed one, as it can cause more side effects. To avoid missing doses, use a reminder like an alarm, timer, or a phone app.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Using too much prednisone is not likely to cause life-threatening problems. However, if you take high doses of steroids for a long time, you might experience issues like thinning skin, changes in body fat, easy bruising, difficulty getting or keeping an erection, more acne or facial hair, problems with your periods, or a decreased interest in sex. In such conditions, you can call your doctor immediately.

[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

• Keep Prednisone away from children’s reach.
• Store Prednisone at room temperature (15-30°C or 59-86°F).
• Shield it from light and moisture.
• Keep the medication container tightly closed.
• Dispose of any unused medication after the expiration date.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Don’t mix this medicine with:

• Metyrapone
• Mifepristone

This medicine can also cause issues if taken with:

• Amphotericin B
• Isoniazid
• Warfarin
• Ephedrine
• Cholestyramine
• Diuretics
• Toxoids
• Aspirin and similar pain relievers
• Vaccines
• Aminoglutethimide
• NSAIDs, which are medications for pain and inflammation, like ibuprofen or naproxen
• Barbiturates
• Female hormones, including estrogens and birth control pills
• Drugs that affect cholinesterase
• Ketoconazole
• Digoxin
• Rifampin
• Cyclosporine
• Phenytoin
• Certain diabetes medications, such as glipizide or glyburide

[Note: This isn’t a complete list, and there could be other drugs that interact with Prednisone. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

• Decadron (dexamethasone)
• Trexall (methotrexate)
• Xatmep (methotrexate)
• Jylamvo (mycophenolate)
• Otrexup (mycophenolate)
• Rasuvo (mycophenolate)
• Purinethol (mercaptopurine)
• Imuran (azathioprine)
• Arava (leflunomide)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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