Human Chorionic Gonadotropin
Pregnyl
Pregnyl is an FDA-approved medication used to address infertility in both men and women. It aids in the normal egg development in women’s ovaries and prompts ovulation while also stimulating testosterone and sperm production in men. Pregnyl contains Human Chorionic Gonadotropin (hCG) as its active ingredient and comes in injectable form, with strengths of 5,000 IU and 10,000 IU vials. It is typically administered via intramuscular injection. Pregnyl dosage and administration are based on individual conditions and healthcare provider guidance. Common side effects of Pregnyl include headaches, fatigue, and injection site reactions. It is crucial to stick to prescribed dosages to get the most out of the medicine. The missed doses should be taken as soon as remembered, and potential overdose needs prompt medical attention. To maintain efficacy, it is essential to follow proper storage guidelines. For personalized guidance, ask your doctor or healthcare provider.
Product Overview
Pregnyl is an FDA-approved medication primarily used to treat infertility in men and women. It contains the active ingredient Human Chorionic Gonadotropin (hCG), which is a hormone that aids the normal development of an egg in a female’s ovary and stimulates the release of the egg during by pregnyl injection and ovulation triggering. In men, it helps to stimulate the production of testosterone and sperm. Pregnyl is often prescribed as part of fertility treatments like in vitro fertilization (IVF) or for certain hormonal conditions.
Pregnyl is available in injectable form with strengths including 5,000 IU (International Units) and 10,000 IU vials. Pregnyl dosage and administration depend on the individual’s condition and the prescribing physician’s instructions. Typically, it is administered via intramuscular injection. Pregnyl should only be taken under the supervision of a healthcare professional.
Pregnyl side effects such as headache, fatigue, and injection site reactions may occur. It is important to follow all medical advice and precautions provided by the healthcare provider. Patients should not miss their scheduled doses and should seek medical advice if a dose is missed or in case of an overdose. Pregnyl injection should be stored away from moisture and heat according to the instructions provided on the label. Patients should be aware of any guidance or warnings provided by their healthcare provider regarding the use of Pregnyl.
What Are the Uses of Pregnyl?
It is used for treating:
- Female infertility.
- Male hypogonadism.
- Assisted reproductive technology (ART).
What Are the Forms & Strengths of Pregnyl?
It comes in the form of an injection (intramuscular). It is available in two strengths:
- Pregnyl 5000 units/vial
- Pregnyl 10000 units/vial
What Is the Recommended Dosage of Pregnyl?
The recommended dosage of Pregnyl can vary based on multiple factors, such as the patient’s age, weight, individual needs, and response to treatment. The dosage mentioned below applies to most patients. However, if your doctor has recommended a different dose than the one listed below, you should use the medication exactly as they have instructed and do not make dosage alterations without first talking to them, as it can be harmful.
For Female Infertility (Ovulation Induction):
- Subcutaneous or intramuscular injection.
- A typical dosage is 5,000 to 10,000 IU (international units) administered once, followed by sexual activity or intrauterine insemination.
- Dosage may differ based on individual response and treatment protocol.
For Male Hypogonadism:
- Intramuscular injection.
- Typically, 500 to 1,000 IU three times a week for a few weeks, followed by maintenance doses.
- Dosage may differ based on individual response and treatment protocol.
For Geriatrics:
- Use with caution in older adults.
- Dosage adjustments may be necessary based on individual health status.
For Specific Populations:
- No specific dosage adjustments for renal impairment.
- Use with caution in patients with adrenal or thyroid disorders.
[Note: These Pregnyl dosage recommendations may differ from individual to individual. Discuss it with your healthcare professional, and they’ll decide your dosage accordingly.]
How to Use Pregnyl?
Before using this medication, you should carefully read and follow the preparation and usage instructions given in the patient information leaflet that came along with your prescription or provided by your healthcare provider or pharmacist, or if available, a medication guide. If you have any queries regarding the medication use or if you have difficulty understanding any part of the leaflet, you should ask your doctor beforehand. For safe and efficient Pregnyl use, you should use it exactly as your doctor has instructed, and you can also refer to the given step-by-step guide for administering the medication:
Step 1. You should thoroughly wash your hands with soap and water before use.
Step 2. Make sure the injection site is cleaned with an alcohol swab before injecting. Leave the skin to air dry for at least a minute.
Step 3. Wipe the rubber stopper with a cotton swab soaked in alcohol after removing the hard, plastic cap. Check the product for any visual change in appearance. Do not use it if it seems to be discolored, cloudy, or has particles in it. Discard it and ask your pharmacist to provide you with a new one.
Step 4. Use a sterile syringe and needle to pull 1ml of air into the syringe, then inject this air into the vial with the liquid. Draw all the liquid into the syringe. Next, carefully inject the liquid into the vial with the powder. Gently swirl the vial, and avoid shaking it. Finally, draw up the prescribed dose of Pregnyl. You should have 1 ml in the syringe now.
Step 5. As directed by your healthcare professional, inject the medication into the muscle just below the navel area. However, your healthcare provider or nurse can suggest you inject the medication at an alternative site. Pinch your skin & insert the needle at a 90° angle to the surface of the skin. Gently remove the needle from your skin. Avoid rubbing the injection site.
Step 6. After injection, dispose of the needle and syringe properly in a sharps container.
Step 7. Wash your hands again after administering the injection.
The medication is not meant for daily use, and the dosage of Human Chorionic Gonadotropin for male patients is usually thrice a week, and for females, it is one dose after finishing your menotropin treatment. To get the most out of your prescription medication, you should keep consistency in dosage and take it around the same time on days when you need to receive the medication. Your doctor may recommend you undergo certain tests to determine the duration of the treatment and if it is working as well as it should. Pregnyl can affect the results of certain medical tests, so tell your doctor and lab technician that you are using this medication.
[Note: Your doctor will decide the right amount and procedure of Pregnyl injection for you based on your condition, following guidelines and studies on the drug. They’ll adjust your Pregnyl dosage as needed over time.]
How Does Pregnyl Work?
Pregnyl contains Human Chorionic Gonadotropin (hCG), a hormone that imitates the action of luteinizing hormone (LH) in the body. In women, LH surge triggers ovulation, the release of the egg from the ovary. Pregnyl stimulates this process, aiding in egg maturation and release, which is crucial for fertility treatments such as in vitro fertilization (IVF). In men, Pregnyl stimulates the Leydig cells in the testes, promoting the production of testosterone, essential for sperm production. By mimicking LH, Pregnyl helps regulate reproductive functions in both men and women, addressing infertility and related conditions.
Important Safety Information for Using Pregnyl
What Are the Side Effects of Pregnyl?
Common side effects of Pregnyl: Similar to other medications, Pregnyl can cause certain side effects in some users. These side effects are usually mild and disappear within a couple of days or weeks as your body adjusts to the medication without medical assistance. If you have any concerns regarding the potential risks linked with the use of this medication, you should talk to your doctor before using this medication. Common side effects of Pregnyl are as follows:
- Headache: This is a common side effect associated with the use of Pregnyl, which can occur due to hormonal changes or the body’s response to the medication.
- Fatigue: This can occur during the initial days of starting treatment with this medication and may disappear on its own as your body adjusts to the medication. Unusual tiredness can also occur due to the effects of pregnyl on hormone levels.
- Restlessness: Hormonal fluctuations caused by this medication can cause feelings of restlessness and irritability.
- Injection spot reactions such as redness/swelling/pain: Like other injectable medications, this medication can also cause injection site reactions. To prevent this, you should not rub the spot after administering the dose.
Tell your doctor if any of these symptoms persist or worsen. There may be some other side effects of this medication that are not listed here. You should report any new or worsening symptoms to your doctor.
Mild side effects of Pregnyl: This medication can cause certain mild side effects in some people using it. These side effects do not usually require medical attention. Mild side effects of Pregnyl include:
- Nausea: Due to its hormonal effects on the gastrointestinal system, some users can experience nausea while using Pregnyl. This effect is more similar to the nausea some women experience during early pregnancy due to similar hormonal changes.
- Breast tenderness: This medication can lead to changes in the breast tissue, making them feel sore, tender, or swollen. This happens because Pregnyl stimulates breast tissue growth and fluid retention, similar to what occurs during the menstrual cycle or pregnancy.
- Mood swings: Hormonal changes due to this medication can significantly affect mood and emotional stability. Fluctuating hormone levels can cause mood swings, characterized by periods of irritability, anxiety, or sadness. These emotional changes can be abrupt and similar to premenstrual syndrome or other hormonal shifts.
Severe side effects of Pregnyl: In rare cases, Pregnyl can cause serious side effects in some people belonging to certain groups. These severe side effects need immediate medical attention and can become life-threatening if not properly treated. You should seek prompt medical attention if you experience any of the side effects mentioned below. You can call your doctor or 911. Severe side effects of Pregnyl include:
- Severe allergic reactions: Its symptoms may include redness, itching, inflammation of your lips, face, tongue, or throat, severe dizziness, or trouble breathing. You should seek prompt medical attention if you experience any of the given symptoms.
- Ovarian hyperstimulation syndrome: This condition can occur in women undergoing fertility treatment before or after treatment. Rarely, severe OHSS can cause fluid buildup in the stomach, chest & heart. Seek prompt medical assistance if you have severe or swelling in the lower abdomen, severe vomiting/nausea, sudden or rapid weight gain, or reduced urination.
- Fluid build-up around the stomach or lungs: Its symptoms may include rapid weight gain, stomach pain, bloating, shortness of breath, pain when breathing, rapid heart rate, and a cough with foamy mucus.
- Signs of a blood clot: This medication can cause deep vein thrombosis and pulmonary embolism. Its symptoms may include chest pain, sudden numbness or weakness on one side of the body, problems with vision, or pain or swelling in one leg.
- Early puberty in boys: Precocious puberty can occur in males while using Pregnyl. Its symptoms may include enlarged testicles and penis, facial hair, and a deepened voice.
- Serious vision problems: Its symptoms may include sudden vision loss, blurred vision, eye pain or swelling, or seeing halos. You should not drive a car or engage in any hazardous activity if you experience temporary blurred vision or other changes.
- Severe heart symptoms: Its symptoms may include fast, irregular, or pounding heartbeat, shortness of breath, sudden dizziness, or passing out.
[Note: Remember, this list may not cover all possible Pregnyl side effects. Always consult with your healthcare giver for medical advice about side effects.]
Are There Any Warnings for Pregnyl?
There are certain warnings that you should consider while using Pregnyl. The key warnings include:
- Ovarian Hyperstimulation Syndrome (OHSS): Pregnyl may cause OHSS, a state defined by enlarged ovaries and fluid build-up in the abdominal cavity. Symptoms include abdominal pain, bloating, nausea, vomiting, and difficulty breathing. Severe cases of OHSS can be life-threatening.
- Multiple Pregnancies: Pregnyl treatment may increase the likelihood of multiple pregnancies (e.g., twins, triplets). Multiple pregnancies carry increased risks for both the mother and the babies.
- Thromboembolic Events: Pregnyl may increase the risk of thromboembolic events (e.g., blood clots), particularly in patients with a history of thromboembolic disorders.
- Hypersensitivity Reactions: Some people may experience hypersensitivity reactions (e.g., rash, itching, swelling) to Pregnyl. Patients with a known hypersensitivity to chorionic gonadotropin or any of the other ingredients in Pregnyl should not use this medication.
- Precocious Puberty: Pregnyl should not be used in children with precocious puberty (early onset of puberty) unless directed by a healthcare professional.
- Prostate Cancer: Pregnyl should be used with caution in patients with prostate cancer, as it may stimulate the growth of hormone-sensitive tumors.
- Polycystic Ovary Syndrome (PCOS): Patients with PCOS may be at increased risk of OHSS when treated with Pregnyl. Close monitoring is recommended in these patients.
- Injection Site Reactions: Pain, redness, or swelling at the injection site may occur with Pregnyl administration.
- Pregnancy and Breastfeeding: Pregnyl is not indicated for use during pregnancy. It is unknown whether Pregnyl is excreted in human milk, so caution is advised when administering Pregnyl to breastfeeding mothers.
What Are the Pregnyl Precautions?
As with any medication, Pregnyl also has some important precautions that you should be aware of when using it. You should discuss the precautions with your doctor or healthcare provider before using it to ensure a safe and efficient use of the medication. It includes:
- Medical History: You should inform your healthcare provider about your complete medical history, especially if you have a history of hormone-related disorders, thromboembolic disorders, or ovarian cysts.
- Monitoring: Close monitoring is essential during treatment with Pregnyl, particularly in patients undergoing fertility treatments or those who have ovarian hyperstimulation syndrome (OHSS). Monitoring may involve regular ultrasound examinations and hormone level assessments.
- Ectopic Pregnancy: Patients should be informed about the increased risk of ectopic pregnancy following treatment with Pregnyl. They should be advised to seek medical help if they encounter symptoms such as abdominal pain or vaginal bleeding.
- Multiple Pregnancies: Patients should be counseled about the increased risk of multiple pregnancies (e.g., twins, triplets) associated with Pregnyl treatment. Multiple pregnancies carry higher risks for both the mother and the babies.
- Injection Technique: Healthcare providers should ensure proper injection techniques to diminish the risk of injection site reactions and infections.
- Pediatric Use: Pregnyl is not recommended for use in pediatric patients unless specifically directed by a healthcare professional.
What Are the Contraindications of Pregnyl?
Pregnyl is contraindicated for use in patients:
- If you’ve had allergic reactions to human gonadotropins or any of the excipients.
- In women with primary gonadal failure.
- In the presence of uncontrolled thyroid, adrenal, or pituitary disorder.
What If You Miss a Dose of Pregnyl?
To get the most from your medication, it is crucial to keep consistency in dosage, and if you have missed a dose of Pregnyl, follow the instructions below.
- If you miss a dose of Pregnyl, contact your healthcare provider for advice.
- Avoid self-adjusting your dosage without consulting your healthcare provider first.
- You can use your smartphone to set a reminder to help you remember to take the medication at the scheduled time.
[Note: If you have missed a dose of Pregnyl injection and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]
What Happens If You Take Too Much of Pregnyl?
You should not take Pregnyl more than recommended, in large doses, or more often, as it can cause an overdose. Overdosing on Pregnyl can lead to various adverse effects. Symptoms of an overdose may include:
- Severe pelvic pain
- Swelling of the hands or legs
- Shortness of breath
- Nausea
[Note: If you consumed more than the recommended dose of Pregnyl HCG, get medical help right away or call the Poison Help line at 1-800-222-1222.]
How to Store Pregnyl?
Following proper storage guidelines is important to ensure the potency and accuracy of the medication. Usually, it is kept at room temperature in a dark and dry place, away from direct exposure to moisture and sunlight.
- You should store Pregnyl HCG according to your healthcare provider’s instructions.
- Typically, it can be kept at room temperature (20°C to 25°C).
- Keep Pregnyl away from light, moisture, and heat sources.
- Do not freeze Pregnyl.
- Keep it out of reach of children and pets.
- Do not use Pregnyl if it has expired or if the packaging is damaged. Discard it safely. Avoid flushing the medicine down the toilet, pouring it into the drain, and throwing it into the household garbage bin.
- You should dispose of unwanted and expired medications in such a way that prevents animals, children, and others from accidentally consuming them.
- Used needles, syringes & prefilled pens should be eliminated in an FDA-approved sharps disposal container. If you do not have a sharps container, you can ask your pharmacist or may use a hard plastic container with a tightly fitting lid.
[Note: Discuss the proper storage and disposal of Pregnyl injections with your healthcare professional.]
What Medications Interact with Pregnyl?
Certain medicines may interact with Pregnyl and reduce its effectiveness or cause unwanted side effects. To avoid this, you should inform your doctor beforehand about all the medications you use, including all prescription medicines, over-the-counter drugs, and herbal or vitamin supplements. Certain medications should not be used together at all times. To prevent unwanted interactions with Pregnyl, your doctor may change your dose of one or both medications or recommend that you use a different medication to treat your condition. Potential interactions with Pregnyl are as follows:
- Gonadorelin
- Ganirelix
- Buserelin
- Leuprolide
- Triptorelin
- Nafarelin
- Histrelin
[Note: This isn’t a complete list, and there could be other drugs that interact with Pregnyl. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
What Are the Other Pregnyl Interactions?
Similar to other medications, certain herbal supplements, food items & beverages may have an interaction with Pregnyl and affect how it works. You should avoid consuming alcohol in large quantities while receiving treatment with this medication, especially in fertility treatments. Apart from such interactions, HCG also has disease interactions and affect how it is tolerated, which include:
- Dependent neoplasm (cancers that are hormonally responsive or hormone-dependent, such as breast cancer, ovarian cancer, prostate cancer, or certain types of uterine cancer.)
- Volume overload (fluid retention/edema, especially during fertility treatment)
What Are the Pregnyl Alternatives?
While Pregnyl is an effective medication, not all patients respond well to it, or they may have contraindications that limit its use. In such cases, patients look for alternative treatments. If you plan to change your existing prescription or start a new one, you should consult your doctor. Based on the condition being treated and individual needs, they will help you determine the medication that works best for your condition. The alternatives include:
- Ovidrel (choriogonadotropin alfa)
- Novarel (chorionic gonadotropin)
- Profasi (human chorionic gonadotropin)
- Chorex (human chorionic gonadotropin)
- Choragon (chorionic gonadotropin alfa)
[Note: Your doctor will choose the best Pregnyl alternative for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
Pregnyl Cost & Coupons
The Pregnyl injection cost can vary significantly depending on factors such as the health insurance coverage, the pharmacy you choose, and geographic location. Many health insurance coverage plans do not cover fertility medications like Pregnyl, which can lead to significant out-of-pocket expenses for those seeking treatment. For patients looking to reduce costs, some people turn to online platforms such as Polar Bear Meds, where they can buy Pregnyl hcg online from Canada at reduced prices. First-time patients can use the coupon code WELCOMEPB10 to receive an additional 10% off on their first purchase.
Frequently Asked Questions
When is Pregnyl used during IVF?
Pregnyl plays a crucial role in specific stages of an IVF cycle. It is used to trigger ovulation by injecting 36 hours before egg retrieval, once the follicles mature, to help the eggs complete their final maturation.
How long does it take to see results with Pregnyl?
Pregnyl typically shows results within 2 to 3 weeks. In women, it aids egg release during assisted reproductive technology (ART) procedures. In men, it boosts testosterone production. While it can cause mild tenderness at the injection site, it is not typically painful. Consult a healthcare professional for proper administration.
How often should I take Pregnyl?
Pregnyl is typically administered as follows:
- Female Infertility: It is usually given as a single injection to trigger egg release during assisted reproductive technology (ART) procedures.
- Male Hypogonadism: The frequency varies but is often administered 2 to 3 times per week to boost testosterone production.
Consult a healthcare professional for individualized guidance on dosage and administration.
What is the best time of day to take Pregnyl?
The best time to administer Pregnyl, which contains Human Chorionic Gonadotropin (HCG), is before ovulation. This trigger shot helps the ovaries release mature eggs during assisted reproductive technology (ART) procedures. It’s typically given once per cycle, either intramuscularly or subcutaneously. For accurate results, consult a healthcare professional and consider taking a pregnancy test at least 2 weeks after the shot.
Can men take Pregnyl for muscle growth or weight loss?
Pregnyl is not recommended for muscle growth or weight loss in men. While it boosts testosterone production, its primary use is for female infertility and male hypogonadism. Consult a healthcare professional for appropriate guidance regarding muscle growth or weight loss strategies.
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