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Premarin Vaginal Cream

Premarin Vaginal Cream is a female sex hormone which is used as a part of hormone replacement therapy. It helps in treating the deficiency of estrogen. In some cases, it is also used to treat prostate and breast cancer along with other anticancer drugs. Before starting to take this medication, it is essential to tell your doctor if you have recently taken or are currently taking other medicines to treat the same condition. Your doctor will help you decide the dosage, frequency, and duration of the medication. They may also suggest you undergo some tests to determine the effectiveness and potential side effects of the drug. 

Product Overview

Premarin Vaginal Cream is a type of estrogen hormone that is used in hormone replacement therapy. It is used to treat symptoms associated with a lack of estrogen, such as hot flashes and vaginal dryness. It is sometimes prescribed to treat breast cancer and prostate cancer, in addition to other anticancer medicines. You should take it at the same time every day. Your doctor will determine the appropriate dose and duration based on your symptoms. If you miss a dose, take it as soon as you remember. Do not skip any doses and complete the entire course of treatment. 

Do not stop taking this medication suddenly without consulting your doctor, as it may affect its effectiveness. The cream may cause some common side effects, such as breast pain, headaches, abdominal cramps or bloating, irregular vaginal bleeding or spotting, and vomiting. However, there are some warning signs and symptoms that should be taken seriously and require immediate medical attention, such as breast lumps, dizziness, faintness, unusual vaginal bleeding, severe headaches, shortness of breath, chest pain, and pains in your legs.

Before taking this medicine, it is essential to tell your doctor if you are taking or have recently taken any other drugs for the same disease or other diseases. Before you initiate this HRT, you must consult the doctor if you have a history of a blood clot in your legs or your lungs or if you have ever had unusual vaginal bleeding. If you are pregnant or breastfeeding, you should tell your doctor before taking this medicine. Your doctor may suggest some diagnostic or laboratory tests to know the effects and side effects of this medicine on your body.

Uses of Premarin Vaginal Cream

Premarin Vaginal Cream is used for:

  • Female hormone replacement therapy
  • Treatment of atrophic vaginitis
  • Treatment of kraurosis vulvae
  • Treatment of Moderate to Severe Dyspareunia

How to Use Premarin Vaginal Cream?


Premarin Vaginal Cream is a medical cream that comes inside a tube that contains 30 grams of the medication. Each gram contains:

  • 0.625 mg conjugated estrogens

Recommended Dosage for Premarin Vaginal Cream

Recommended Dosage for Treatment of Kraurosis Vulvae and Atrophic Vaginitis

Premarin Vaginal Cream should be administered intravaginally daily for three weeks and then off for 7 days. The recommended initial dosage for treatment should be 0.5 g. Adjustments to dosage should be based on the body’s response to medication. 

Recommended Dosage for Treatment of Moderate to Severe Dyspareunia

Premarin Vaginal Cream should be administered intravaginally twice weekly or in a cyclic regimen. Adjustments to dosage should be based on the body’s response to medication.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • You should use estrogen for the shortest duration at the lowest effective dose to reduce the risk of unwanted side effects. 
  • You should regularly talk to your doctor to decide the duration of the treatment and adjust the dosage of the medication. 
  • Vaginal cream should be administered intravaginally as directed by your doctor. 
  • You are required to clean and dry the affected area and apply a blueberry-sized dose (0.5 grams) with an applicator deep into your vagina or to the affected area.
  • Wash your hands properly after applying the cream. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Premarin Vaginal Cream Work?

Premarin Vaginal Cream contains a combination of estrogen hormones, which are used in hormone replacement therapy to treat symptoms of menopause. It works by maintaining the levels of estrogen in menstrual women. It prevents the walls of the vagina from becoming dry and thin and helps in rebuilding vaginal tissue, and makes painful sex after menopause more comfortable. 

Important Safety Information

Side Effects

Common side effects of Premarin Vaginal Cream may include: 

  • Burning sensation and abnormal bleeding vagina
  • Pelvic pain
  • Irritation
  • Breast pain
  • Vaginal spotting and itching
  • Leg cramps
  • Depression
  • Stomach pain

Serious side effects of Premarin Vaginal Cream may include: 

  • Dementia
  • Heart attack
  • Blood clots 
  • Cancer of the breast, womb, or ovary 
  • Stroke 
  • High blood pressure 
  • High blood sugar
  • Severe allergic reaction 
  • Enlargement of fibroids 

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


  • Do not use the cream if you’ve had breast or uterine cancer, unusual vaginal bleeding, blood clots, stroke or heart failure, liver problems, or hypersensitivity to Premarin Vaginal Cream or any of its inactive ingredients.
  • You should not use estrogen or Premarin to prevent dementia or cardiovascular disease.
  • Estrogens may increase the risk of developing endometrial cancer. You should take progestin to decrease the chances of cancer of the uterus. 
  • In postmenstrual women, estrogen increases the chances of developing cancer of different organs, dementia, and serious blood clots. When taken along with progestin, it may lead to heart failure. 
  • If you are using Premarin for the long term, you should have regular full-body checkups as suggested by your doctor. 

Boxed Warning

Premarin Vaginal Cream has a boxed warning for cardiovascular disorders, endometrial cancer, breast cancer and dementia. 


  • Do not use Premarin Vaginal Cream if you are pregnant, planning to get pregnant, or breastfeeding a baby. 
  • You should not take Premarin Vaginal Cream if you are over 35 of age, if you smoke, or have a medical history of heart disease or blood clots.
  • It is not recommended to engage in sexual activity immediately after using Premarin Cream, as your partner’s skin may absorb some of the medication.

Premarin Vaginal Cream Contraindications

  • Undiagnosed abnormal vaginal bleeding.
  • History of breast cancer.
  • Estrogen-dependent neoplasia.
  • Active or a history of conditions like deep vein thrombosis, pulmonary embolism.
  • Active arterial thromboembolic disease
  • Known or suspected pregnancy

Missed Dose

  • If you happen to miss a dose of Premarin Vaginal Cream, apply it as soon as you remember. 
  • However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. 
  • Do not take a double dose of the same medication to compensate for the missed dose. 

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]


If a woman takes estrogen more than required, it may cause vomiting, breast tenderness, nausea, abdominal cramps, fatigue, and abnormal bleeding. Treatment of overdose involves discontinuation of therapy with premarin, and the patient is to be kept under observation till the symptoms of overdose are under control.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]


  • You may store the medicine in a tightly closed container at room temperature, away from direct sunlight, excess heat, or moisture. 
  • Do not freeze the medication and keep it away from the sight and reach of children. 
  • Do not keep expired medicine or medicine you no longer need. Safely discard it. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Premarin Vaginal Cream Interactions

  • Atorvastatin 
  • Levothyroxine
  • Metformin
  • Prednisone
  • Synthroid (levothyroxine)
  • St. John’s Wort
  • Grapefruit juice

[Note: This isn’t a complete list, and there could be other drugs that interact with Premarin Vaginal Cream. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Premarin Vaginal Cream Alternatives

  • Estradiol (estradiol)
  • Estrace (estradiol)
  • Prempro (medroxyprogesterone)
  • Vagifem (estradiol)
  • Progynova (climara)
  • Premphase (estradiol)
  • Menostar (estradiol)
  • Divigel (estradiol)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Can I buy Premarin Vaginal Cream over the counter?

No, you can not buy Premarin Vaginal Cream over the counter. Do not take Premarin Vaginal Cream unless your doctor recommends that you do so. You can buy it online from a Canadian Pharmacy, Polar Bear Meds. We offer it at a very reasonable price; call us at 1-888-779-2193 toll-free.

How quickly does Premarin cream work?

Premarin cream can start working quite fast! Some women might begin to feel better in as little as 4 weeks. However, it’s important to remember that everyone is different, so the time it takes to feel relief can vary. Basically, Premarin cream is used to help with problems like hot flashes, which are a common issue during menopause. In a study, it was found that Premarin was really good at reducing the number and severity of these hot flashes for many women. So, while it might work quickly for some, others might need to wait a little longer to notice the benefits.

What to avoid when taking Premarin?

When taking Premarin, a medication containing estrogens, it’s essential to avoid smoking or using any tobacco products. This is because combining estrogen with tobacco significantly raises the risk of severe health problems like stroke, high blood, blood clots, pressure, and heart attacks. This risk is exceptionally high for women who are over 35 years old.

How long can a woman stay on Premarin?

The length of time a woman can stay on Premarin, a hormone therapy medication, varies from person to person. Some women might need it for only two or three years, while others might require it for a more extended period, like five to seven years or even more. The main aim is to use the smallest dose that effectively manages your symptoms. This means finding a balance where the positive effects of the medication are more significant than any potential risks.

Our Guarantee

At, we assure you the most affordable price to buy Premarin Vaginal Cream from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently access Premarin Vaginal Cream at a substantial cost, call us at 1-888-779-2193 toll-free.


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