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What Is Premarin Vaginal Cream (Conjugated Estrogens)?

Premarin Vaginal Cream is a medical cream, not a pill or insert, specifically designed for women. It contains a blend of estrogen hormones, which are important for female health. This cream is applied inside the vagina and is particularly effective in easing moderate to severe discomfort during intercourse, that many women experience after menopause.

What Is This Medication Used to Treat?

What makes Premarin Vaginal Cream unique is its ability to address several menopause-related issues. It helps treat changes in the vaginal area, like dryness, itching, and burning, which are often due to lowered estrogen levels or menopause itself. Additionally, it aids in rebuilding vaginal tissue, making sexual intercourse more comfortable. It’s important to note that this cream is a prescription-only medication, meaning you can only get it through a doctor’s approval. As of now, there isn’t a generic version available.

Premarin Vaginal Cream Dosage, Usage, and Storage


Premarin Vaginal Cream comes in a cream form, with each gram containing 0.625 mg of conjugated estrogens. It’s packaged with a tube and an applicator that helps measure the dose accurately. The specific dosage varies based on your medical needs:

  • For kraurosis vulvae (vaginal and vulvar changes due to menopause) and atrophic vaginitis, start with 0.5 gram daily. The usage is typically in cycles: 21 days on, followed by 7 days off.
  • For painful sexual intercourse, the recommended amount is also 0.5 gram, used twice a week or in the same 21-day cycle.

Remember, these are average doses. Always follow your doctor’s instructions or the label directions.


To use the cream, follow these steps:

  • Wash your hands before and after use.
  • Attach an applicator to the tube and squeeze the tube to fill an applicator to the required dose.
  • Put the applicator in the vagina after the applicator has been detached, and then press the plunger deeply into the vagina.
  • Clean the applicator with mild soap and water. Avoid using hot water.

Read the patient information leaflet that comes with the medicine for detailed instructions. If you miss a dose, take it as soon as you can, but skip it if your next dose is almost due. Don’t double up on doses.


Keep the cream in its container at room temperature, away from heat, moisture, & direct light. Ensure it doesn’t freeze. Store it out of children’s reach and dispose of any unused medicine safely, as advised by your healthcare provider. Avoid using outdated medicine.


  • Using estrogens alone or with progestin can sometimes cause very serious health problems. It’s rare, but it’s important to know.
  • Before starting hormone treatment, have a good discussion with your doctor about the risks and benefits.
  • Don’t use estrogens as a way to prevent heart disease or dementia.
  • Estrogens can increase the risk of cancer in the uterus. If you’re taking progestin as well, it can lower this risk. If you notice any unusual bleeding, tell your doctor right away.
  • In women who have gone through menopause, estrogens (with or without progestin) can raise the risk of breast/ovarian cancer, stroke, dementia, and serious blood clots. When taken with progestin, there’s also an increased risk of heart disease.
  • The risk of side effects depends on how much estrogen you use and how long you use it.
  • It’s best to use the smallest amount that works for you and only for as long as needed.
  • Keep in regular contact with your doctor, like every 3 to 6 months, to check if you still need the medication.
  • If you are using this medication for a long time, you should have complete physical exams, maybe once a year, as your doctor recommends.


Pregnancy: Don’t use this medicine if you’re pregnant, as it can harm your unborn baby. Make sure to use reliable birth control to avoid pregnancy. Note that this medicine might cause certain birth control products like latex condoms, diaphragms, or cervical caps to fail.

Cancer Risks: There’s an increased risk of cancers like endometrial, breast, and uterine cancer. Discuss these risks with your doctor. If you have a uterus, ask if you should also take progestin medicine.

Abnormal Bleeding: If you have unusual vaginal bleeding, contact your doctor immediately.

Dementia Risk: For women aged 65 and above, there’s a heightened risk of dementia.

Blood Clots and Heart Risks: This medicine can increase the chances of blood clots, strokes, or heart attacks, even after you stop using it. This risk is higher if you have high blood pressure, high cholesterol, are overweight, have diabetes, or smoke. 

Seek immediate medical attention if you have symptoms like confusion, trouble speaking, double vision, headaches, or problems moving your arms, legs, or facial muscles.

Premarin Vaginal Cream Side Effects

More common

  • Breast pain
  • Cough or hoarseness
  • Change in vaginal discharge
  • Fever or chills
  • Itching of the vagina or genital area
  • Increased clear or white vaginal discharge
  • Thick, white vaginal discharge with a mild odor or no odor
  • Lower back or side pain
  • Pain during sexual intercourse
  • Painful or difficult urination
  • Pain or feeling of pressure in the pelvis
  • Vaginal bleeding

Less common

  • Feeling faint, dizzy, or lightheaded
  • The feeling of warmth or heat
  • Headache
  • Flushing or redness of the body skin, especially on the face & neck
  • Sweating

What Are the Interactions?

Medicines Usually Not Recommended Together (But Sometimes Necessary):

  • Amifampridine
  • Donepezil
  • Bupropion

Medicines That May Increase Side Effects (But Can Be Beneficial):

  • Etoricoxib
  • Tipranavir
  • Levothyroxine
  • Ginseng
  • Licorice

Other Considerations: 

Be aware that certain medicines can interact with food, alcohol, or tobacco. It’s important to discuss these potential interactions with your healthcare professional.

Frequently Ask Questions

Can I buy Premarin Vaginal Cream over the counter?

No, you can not buy Premarin Vaginal Cream over the counter. Do not take Premarin Vaginal Cream unless your doctor recommends that you do so. You can buy it online from a Canadian Pharmacy from Polar Bear Meds. We offer it at a very reasonable price, just call us at 1-888-779-2193 toll-free.

How quickly does Premarin cream work?

Premarin cream can start working quite fast! Some women might begin to feel better in as little as 4 weeks. However, it’s important to remember that everyone is different, so the time it takes to feel relief can vary. Basically, Premarin cream is used to help with problems like hot flashes, which are a common issue during menopause. In a study, it was found that Premarin was really good at reducing the number and severity of these hot flashes for many women. So, while it might work quickly for some, others might need to wait a little longer to notice the benefits.

What to avoid when taking Premarin?

When taking Premarin, a medication containing estrogens, it’s very important to avoid smoking or using any tobacco products. This is because combining estrogen with tobacco significantly raises the risk of severe health problems like stroke, high blood, blood clots, pressure, and heart attacks. This risk is particularly high for women who are over 35 years old.

How long can a woman stay on Premarin?

The length of time a woman can stay on Premarin, a hormone therapy medication, varies from person to person. Some women might need it for only two or three years, while others might require it for a longer period, like five to seven years or possibly even more. The main aim is to use the smallest dose that effectively manages your symptoms. This means finding a balance where the positive effects of the medication are greater than any potential risks.

Our Guarantee

At, we assure you the most affordable cost to buy Premarin Vaginal Cream 0.625mg/g online. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted products are promptly shipped from Canada directly to your doorstep, ensuring a swift and secure delivery experience. To conveniently access this cream at a substantial premarin vaginal cream price, call us at 1-888-779-2193 toll-free.


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