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Relpax is an FDA-approved medicine to treat migraines with the active ingredient Eletriptan Hydrobromide, which belongs to triptans. It relieves the symptoms of migraine by narrowing brain blood vessels. A dose of 20 or 40 mg is recommended orally at migraine onset, with a maximum daily dose of 80 mg. It can be taken with or without food but cannot be used for other headaches or as a prophylaxis. Before taking it, you should inform your healthcare provider about all your heart, kidney, or liver medical conditions. Seek medical help if you experience chest pain, irregular heartbeat, or stroke signs after the use of Relpax.

Product Overview

Relpax is an FDA-approved medication containing the active ingredient eletriptan hydrobromide. It belongs to a class of drugs known as triptans and is primarily used to treat migraines with or without aura in adults. It is indicated for the acute treatment of migraine headaches and works by narrowing blood vessels in the brain, thereby relieving migraine symptoms such as headache pain, nausea, sensitivity to light, and sensitivity to sound. It does not prevent future migraines or reduce the frequency of attacks.

The recommended dosage is typically a single dose of Relpax 20 mg or Relpax 40 mg taken orally at the onset of a migraine headache. Suppose the headache returns after the starting relief; a second Relpax dose may be taken after at least 2 hours, with a maximum daily dose of 80 mg. It can be taken with or without food but should not be used prophylactically or to treat other types of headaches. 

Before taking Relpax, it’s essential to inform your healthcare provider about any medical conditions you have, like heart disease, high blood pressure, liver, or kidney problems. It may cause dizziness or drowsiness, so it’s important to avoid driving or operating machinery with it. If you experience chest pain, tightness in the chest, rapid or irregular heartbeat, difficulty breathing, or signs of a stroke after taking Relpax, seek medical attention immediately.

Uses of Relpax 

Relpax is used to:

  • Treat migraines with or without aura in adults (An aura is a sensation you may experience when a migraine begins, such as flashes of light or tingling sensations).
  • Provides relief from migraine symptoms such as headache pain, nausea, sensitivity to light, and sensitivity to sound.

How to Use Relpax?


Forms and Strengths 

Relpax is available as a tablet that is swallowed. There are two strengths available: 

  • Relpax 20 mg tablets
  • Relpax 40 mg tablets

Recommended Adult Dose for Migraine

Take 20 mg or 40 mg orally daily as an initial dose. If migraine symptoms recur, a second dose may be administered at least 2 hours after the first. The maximum dose per day is 80 mg. You need to keep these points in mind:

  • It should only be used after a precise migraine diagnosis has been established. 
  • It should not be used for basilar or hemiplegic migraines since these patients have a higher chance of stroke.
  • Three or more migraine attacks in 30 days have not been proven to be safe.

[Note: Always follow the recommended dosage and administration instructions provided by your healthcare provider or pharmacist when taking Relpax migraine]. 

How to Take It?

It would help if you took Relpax precisely as directed by your doctor. Ensure that you follow all directions on your prescription label and read all medication guides and instruction sheets. Your doctor may change your dose from time to time. As soon as you notice migraine symptoms, take Relpax 40 mg. If your headache does not completely go away after taking a tablet or it goes away and comes back, take a second tablet 2 hours later. You should take at most 80 mg of Relpax in 24 hours. 

[Note: You should contact your doctor if your migraine symptoms have not improved before taking any more Relpax tablets].

How Does Relpax Work?

Relpax works by stimulating receptors in the nervous system that respond to serotonin, a natural chemical. A migraine headache occurs when the blood vessels widen over time, causing too much blood to enter the brain and when certain sensory chemicals are released into the nervous system. A serotonin receptor-activated drug such as eletriptan constricts the blood vessels in the nervous system and prevents sensory chemicals from being released into the body. As a result, migraine pain is relieved.

Important Safety Information

Side Effects

Over time, your body may become accustomed to the following Relpax side effects. If you continue to experience these symptoms or if they worsen, tell your healthcare provider right away.

Common Side Effects

  • Nausea
  • Dizziness
  • Sleepiness
  • Body weakness
  • A feeling of Pins and needles in the arms or legs

Mild Side Effects

  • Dry mouth
  • Acid or sour stomach
  • Belching
  • Headache
  • Flushing or warmth
  • Stomach pain, cramps, or pressure
  • Heartburn
  • Throat tightness or difficulty swallowing
  • Chest tightness, pain, or pressure

Adverse/Serious Side Effects

  • Heart Attack: chest pain, breathing difficulty, arm or leg pain, cold sweat, dizziness
  • Stroke: sudden weakness in your body, facial hollowing, severe headaches, vision changes, lack of consciousness
  • Serotonin Syndrome: fast heartbeat, extremely low or high blood pressure, fever, confusion, mood, delusions
  • Severe Allergic Reactions: breathing difficulties, swelling in lips, tongue, face, and throat, and rashes on the skin.
  • Extremely High Blood Pressure: severe headaches, trouble breathing, nosebleeds, heartache, vision changes, lightheadedness.

[Note: If you experience any of the severe Relpax side effects mentioned, seek immediate medical attention. It’s essential to report any persistent or worsening symptoms to your healthcare provider promptly].


Heart Attack and Angina

A few hours after taking Relpax 40 mg, some people suffered heart attacks that led to death. Heart attacks and chest pain can strike without warning, even in people without a history of heart disease. When you start Relpax, your doctor will check your heart to make sure it’s healthy if you’re at high risk for heart disease. 

Your doctor may have you take your first dose in their office so they can monitor your heart immediately, depending on your medical history. You might also be monitored periodically while taking eletriptan. Get medical help if you experience chest pain, breathing trouble, dizziness, arm pain, or a cold sweat. If you have heart problems, don’t take eletriptan.

Arrhythmias (Irregular Heart Rhythm)

There is a risk of life-threatening heart rhythm changes caused by Relpax, sometimes within a few hours of taking the medication. You should not take Relpax if you have conditions that cause irregular heartbeats. Immediately contact your healthcare provider if your heart races while you are taking Relpax.

Stroke and Brain Hemorrhage

Relpax can cause life-threatening strokes or brain hemorrhage (bleeding in the brain) in some people. A stroke can cause sudden weakness on one side of your body, facial drooping, headaches, difficulty breathing, or changes in speech or vision. Symptoms such as these can be similar to migraines. Tell your provider right away if you notice any signs of a stroke while taking Relpax. If you’ve had a stroke, don’t take Relpax.

Blood Vessel Issues

Blood vessels in your body can spasm when you take Relpax, preventing certain body parts from getting enough blood. The result can be stomach pain or bloody diarrhea. You can also develop Raynaud’s syndrome from cold temperatures or emotional stress. Occasionally, blood vessel spasms can cause partial or complete vision loss. If you experience any of these symptoms, contact your healthcare provider. You should not take Relpax if you have blood vessel disease or ischemic bowel disease, which affects your blood supply to your body.

Serotonin Syndrome

There is a possibility that serotonin syndrome is caused by Eletriptan, which happens when your body produces too much of a chemical called serotonin. Taking other medications that increase serotonin levels in your body increases the risk. Examples of such medicines are sertraline, fluoxetine, duloxetine, and amitriptyline. There can be changes in thought, mood, and movement, as well as hallucinations in people with serotonin syndrome. Consult your doctor if you notice these symptoms while taking Relpax.

High Blood Pressure

Relpax can lead to life-threatening organ damage due to extremely high blood pressure. The symptoms include headaches, breathing issues, nosebleeds, chest pain, dizziness, and vision changes. It can happen even to people without a history of high blood pressure. While taking Relpax migraine, you should monitor your blood pressure regularly. Relpax should not be taken if your blood pressure is uncontrolled.


  1. Inform your doctor about any allergies, as this medication may contain inactive ingredients that could trigger allergic reactions.
  2. Disclose your medical history, especially if you have blood circulation problems, certain types of headaches, heart issues, liver disease, seizures, or a history of stroke.
  3. Be aware of conditions that can increase your risk of heart problems, such as high blood pressure, high cholesterol, diabetes, family history of heart disease, being overweight, smoking, postmenopausal status, or being over 40 years old.
  4. Use caution when consuming alcohol or marijuana, as they can enhance the dizziness or drowsiness caused by this medication.
  5. Avoid activities requiring alertness, such as driving or operating machinery, until you know how this medication affects you.
  6. Inform your healthcare provider about your medications before surgery or dental procedures.

Relpax Contraindications

You should not use Relpax if you have:

  • Ischemic heart disease (e.g., angina pectoris, history of myocardial infarction)
  • Cerebrovascular syndromes (including strokes of any type and transient ischemic attacks)
  • Peripheral vascular disease (including ischemic bowel disease)
  • Uncontrolled hypertension
  • Hemiplegic or basilar migraine

Missed Dose

You take Relpax only if you suffer from migraines. Relpax does not prevent migraines, so you don’t need to take it daily. After 2 hours, you can take another dose of Relpax if you still have migraines.

[Note: If you have any questions or concerns about dosing or missed doses, consult your healthcare provider for guidance tailored to your needs].


Overdosing on Relpax can cause serious side effects. There is no need to take more than 80 mg of Relpax in a 24-hour period. The symptoms of an overdose can include:

  • Dizziness
  • Increased blood pressure
  • Increased risk of heart attack or stroke

[Note: Call your doctor if you think you have overdosed on Relpax. You can also contact the Poison Control Centers at 800-222-1222. If your symptoms are severe, call 911].


Relpax 40 mg tablets should be stored at room temperature (between 68°F and 77°F/20°C and 25°C). Sometimes, you can keep the medication between 15°C and 30°C for short periods if necessary. Do not store Relpax in areas where it might get damp, such as bathrooms.

You should dispose of leftover Relpax medication safely if you no longer need it. This prevents other people, including children and pets, from accidentally taking the drug. Additionally, it prevents the drug from harming the environment.

[Note: You can consult with your healthcare professional for proper storage and disposal methods of Relpax tablets].

Relpax Interactions

Relpax (Eletriptan Hydrobromide) can interact with various medicines:

  1. Serotonergic medications (selective serotonin reuptake inhibitors – SSRIs, serotonin-norepinephrine reuptake inhibitors – SNRIs)
  2. CYP3A4 enzyme inhibitors (ketoconazole, clarithromycin)
  3. Ergotamine-containing Medications
  4. Monoamine oxidase (MAO) inhibitors
  5. Propranolol or other beta-blockers
  6. Other Triptans (sumatriptan, zolmitriptan)

[Note: Inform your healthcare provider about all medications you are currently taking to avoid potential drug interactions with Relpax].

Relpax Alternatives

  • Maxalt (rizatriptan)
  • Imitrex (sumatriptan)
  • Zomig (zolmitriptan)
  • Frova (frovatriptan)
  • Axert (almotriptan)
  • Amerge (naratriptan)
  • Treximet (sumatriptan/naproxen)
  • Cambia (diclofenac potassium)

[Note: It’s essential to consult with a healthcare professional before switching to another medication, as they can provide recommendations based on your medical history and needs].

Frequently Asked Questions

How long does Relpax take to work?

Relpax typically starts working within 30 minutes to 2 hours after taking it. It’s usually fastest when taken on an empty stomach. However, it may take longer to work if taken with food. You must follow your doctor’s instructions and not take more than the recommended dose. A higher dose may result in severe side effects.

Can I take Relpax and Ibuprofen together?

Both Relpax and ibuprofen work differently to relieve pain. Relpax is a migraine medicine. It prevents the release of pain-causing chemicals by lowering the amount of blood that gets into the brain. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that relieves general pain by blocking swelling pathways. Taking Relpax along with ibuprofen is not known to pose any risks. But talk to your healthcare provider if you plan to do so.

Can I drink alcohol with Relpax?

It is not recommended to consume alcohol while taking Relpax. You can have migraine headaches more often or worsen if you drink alcohol or dehydrate from alcohol use since these can be migraine triggers. A combination of alcohol and eletriptan can also exacerbate the sleepiness or tiredness that the medication can cause, causing accidental injuries.

How often should I take Relpax?

It is up to your doctor to tell you how much Relpax to take and how frequently. If you feel symptoms of migraine, take one Relpax tablet by swallowing it. You can take a second dose of Relpax if you do not feel better within two hours after taking your first dose. Never take more than 80 mg of Relpax in a 24-hour period.

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