Rosuvastatin Calcium

Rosuvastatin is an FDA-approved medication for high cholesterol, widely known by its brand name ‘Crestor”. It contains Rosuvastatin Calcium, a statin that reduces liver-produced cholesterol. It is obtainable in strengths of 5 mg, 10 mg, 20 mg, or 40 mg oral tablets, and your healthcare provider determines the dosage based on your cholesterol levels. It is typically taken daily with or without food. It is suitable for adults and children above 10 years of age and requires particular caution if you have certain conditions like liver or kidney issues. Common side effects include muscle pain, fatigue, stomach discomfort, nausea, and headache. Missed doses should be taken promptly, and in case of overdose, seek immediate medical attention. Store at room temperature, following healthcare provider guidance for safe usage.

Rosuvastatin is a medication approved by the FDA for treating high cholesterol levels. It contains Rosuvastatin Calcium, which belongs to a class of drugs known as statins, which work by decreasing the cholesterol level produced by the liver. Rosuvastatin is available under the brand name “Crestor” and is widely prescribed to lower LDL (bad) cholesterol and triglycerides levels while also increasing HDL (good) cholesterol levels.

Rosuvastatin is available in oral tablet form and contains strengths of 5 mg, 10 mg, 20 mg, or 40 mg of Rosuvastatin Calcium. The strength prescribed depends on individual cholesterol levels and the treatment’s severity. It is usually taken orally, with or without food, once daily. A healthcare professional may adjust the Rosuvastatin dose range based on the patient’s response to treatment and lipid profile.

It is suitable for adults and children above 10 with high cholesterol levels. However, it may not be ideal for individuals with certain medical conditions like Liver, kidney, or thyroid problems. Common side effects of Rosuvastatin may include muscle pain, extreme fatigue, stomach pain, nausea, and headache. It is essential to promptly report any severe or lasting side effects to a healthcare provider.

If a dose of Rosuvastatin is missed, it should be taken as soon as remembered unless it is almost time for the next dose. In case of an overdose, medical attention should be sought immediately. Rosuvastatin should be stored at room temperature, away from moisture and heat. You should follow your healthcare provider’s guidance and warnings regarding using Rosuvastatin to ensure safe and effective treatment.

Rosuvastatin is used for the treatment of:

• High “bad” cholesterol
• High triglyceride levels

Strengths and Forms

It is available as oral tablets in the following strengths:

• Rosuvastatin 5 mg
• Rosuvastatin 10 mg
• Rosuvastatin 20 mg
• Rosuvastatin 40 mg

Recommended Dosage for Rosuvastatin

For Adults with Hyperlipidemia:

• The initial dose is 10 mg to 20 mg orally once a day.
• The maintenance dose is 5 mg to 40 mg orally once a day.
• The maximum dose is 40 mg (Rosuvastatin high dose is reserved for those who have yet to achieve their LDL-C goal with a 20 mg dose).

For Adults with Hyperlipoproteinemia Type III (Elevated beta-VLDL + IDL):

• The initial dose is 10 mg to 20 mg orally once a day.
• The maintenance dose is 5 mg to 40 mg orally once a day.
• The maximum dose is 40 mg (Rosuvastatin high dose is reserved for those who have yet to achieve their LDL-C goal with a 20 mg dose).

For Adults with Hypertriglyceridemia:

• The initial dose is 10 mg to 20 mg orally once a day.
• The maintenance dose is 5 mg to 40 mg orally once a day.
• The maximum dose is 40 mg (Rosuvastatin high dose is reserved for those who have yet to achieve their LDL-C goal with a 20 mg dose).

For Children with Heterozygous Familial Hypercholesterolemia:

• The recommended dose is 5-10 mg daily for children 8-10 years old.
• The recommended dose is 5-20 mg for children of 10-17 years.

For Children with Homozygous Familial Hypercholesterolemia:

• The recommended dose is 20 mg daily.

Dosing Adjustments

Patient with Severe Renal Dysfunction:

• The initial dose is 5 mg daily
• The maximum dose is 10 mg daily

For Asian Patients:

• The initial dose is 5 mg daily.
• If Asian patients are not adequately controlled at doses up to 20 mg/day, Rosuvastatin high dose should be considered.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your Rosuvastatin dose range accordingly.]

• It would help if you took the tablets exactly as prescribed by your doctor.
• Take one tablet per day by mouth. Completely swallow the tablet.
• The tablets can be taken anytime, with or without food.
• The dose of this medication should only be changed or stopped with your doctor’s approval.
• Your doctor may test you for cholesterol levels before and during Rosuvastatin treatment. Depending on your needs, your doctor may change your dose.
• You may need to start a cholesterol-lowering diet before you begin taking Rosuvastatin. Take this medication while following this diet.
• You should wait at least two hours after taking Rosuvastatin tablets before taking an aluminum or magnesium hydroxide antacid.

[Note: Your doctor will decide your Rosuvastatin dose range for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Rosuvastatin works by stopping the enzyme HMG-CoA reductase, which plays a vital role in cholesterol production in the liver. By blocking this enzyme, Rosuvastatin reduces the liver’s ability to produce cholesterol, leading to lower LDL (bad) cholesterol levels in the bloodstream. Additionally, it can modestly increase levels of HDL (good) cholesterol. By lowering LDL cholesterol levels, Rosuvastatin helps reduce the chances of cardiovascular issues like heart attacks and strokes in individuals with high cholesterol levels.

Common side effects of Rosuvastatin may include:

• Muscle pain or weakness (myalgia)
• Headache
• Abdominal pain or discomfort
• Nausea
• Constipation
• Dizziness
• Fatigue
• Insomnia
• Nasopharyngitis (inflammation of the nose and throat)
• Increased blood sugar levels (hyperglycemia)

Mild side effects of Rosuvastatin may include:

• Headache
• Nausea
• Abdominal discomfort
• Dizziness
• Constipation
• Fatigue
• Insomnia
• Minor gastrointestinal disturbances

Serious side effects of Rosuvastatin may include:

• Rhabdomyolysis
• Liver problems
• Allergic reactions (redness, irritation, swelling of the face, lips, tongue, or throat, and difficulty breathing)

[Note: This list may not cover all possible side effects of Rosuvastatin. Always consult with your healthcare giver for medical advice about side effects.]

• Severe Muscle Problems Caution: This medication can cause severe muscle issues, including myopathy characterized by muscle pain, tenderness, or weakness. In extreme cases, myopathy can progress to rhabdomyolysis, leading to kidney damage or even death. If you have muscle pain or tiredness, especially accompanied by fatigue or fever, promptly inform your doctor. Your doctor may opt to discontinue your treatment with this medication if necessary. Notify your doctor immediately if muscle problems persist after stopping the drug.
• Liver Function Caution: Rosuvastatin can elevate liver enzyme levels, indicating possible liver damage. Regular monitoring of hepatic function may be necessary during treatment.
• Allergic Reactions: This medication can trigger a severe allergic reaction, marked by symptoms such as rash, hives, facial swelling, or difficulty breathing. Seek immediate medical attention immediately. Do not retake this medication if you’ve experienced an allergic reaction to it previously, as doing so could be life-threatening.
• Alcohol Interaction Caution: Consumption of alcohol may increase the risk of liver problems associated with Rosuvastatin. Inform your doctor if you consume more than two alcoholic beverages per day or have a history of liver issues.

Warnings for Specific Health Conditions

• Individuals with Liver or Kidney Problems: Consult your doctor as you may be at a higher risk of severe muscle problems.
• Individuals of Asian Descent: Due to potential increased levels of Rosuvastatin in the bloodstream, your doctor may initiate treatment with a lower dosage.
• Pregnant or Breastfeeding: Discuss the risks and advantages with your doctor. Rosuvastatin may pose risks during pregnancy and breastfeeding, necessitating careful consideration of treatment options.
• Seniors: Close monitoring for side effects is crucial due to potential changes in drug metabolism in older adults.
• Children: Rosuvastatin should be used cautiously in pediatric populations, following specific age-related guidelines and under medical supervision.

• Take Rosuvastatin precisely as prescribed by your healthcare provider.
• Tell your healthcare professional about any existing medical conditions, including liver or kidney problems, allergies, or a history of muscle problems.
• Report any unusual muscle pain, weakness, or tenderness to your doctor promptly. They may adjust your Rosuvastatin dose range.
• Do not eat grapes or drink the juice when taking Rosuvastatin.
• Limit alcohol intake and discuss your alcohol consumption with your doctor.
• If you are of Asian descent, be aware of potential increased levels of Rosuvastatin in your bloodstream, and follow your doctor’s recommendations closely.
• If you become pregnant while taking Rosuvastatin, contact your doctor immediately.
• Do not breastfeed while taking Rosuvastatin without consulting your doctor.
• Keep all appointments for lab tests to monitor your liver function and overall health.
• Let your healthcare provider know about all medications you are taking, as they may interact with Rosuvastatin.

• Known hypersensitivity to Rosuvastatin Calcium.
• During pregnancy or breastfeeding.
• Acute liver failure or decompensated cirrhosis.
• Creatine Kinase levels are more than 10 times the upper limit of normal.
• History of myopathy (muscle disease).
• Elevated liver function tests (LFTs).
• Hypothyroidism.
• History of alcohol abuse.

Take the skipped dose when you remember if it’s far from the next planned dose. If it’s time for your following dose, ignore the skipped one and continue your standard dosing timetable. Do not take a dual dose to compensate for the missed one.

[Note: If you missed a dose of Rosuvastatin and are unsure of the next one, immediately consult your doctor or pharmacist.]

It is not recommended to take more than the prescribed dose of Rosuvastatin. Symptoms of overdose may include severe muscle pain, weakness, or tenderness, as well as liver problems. Do not attempt to treat an overdose without medical guidance.

[Note: If you consumed more than the recommended dose of Rosuvastatin, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

• Store Rosuvastatin tablets at room temperature between 20°C to 25°C (68°F to 77°F).
• Keep the medication in its original box with the lid tightly closed.
• Protect from moisture and light.
• Keep Rosuvastatin out of reach of children and pets.
• Do not store Rosuvastatin in the bathroom or kitchen, as it has high moisture levels.
• Do not use Rosuvastatin past its expiration date, and discard any unused medication properly according to local regulations or guidelines.

[Note: Discuss with your healthcare provider the correct disposal of any Rosuvastatin and any questions you may have regarding its storage.]

It is known that 222 drugs interact with Rosuvastatin. Some of these drugs are:

• Niacin
• Fibrates, such as Gemfibrozil and Fenofibrate
• Cyclosporine
• Antifungal medications, such as Itraconazole and Ketoconazole
• Antibiotics, such as Clarithromycin and Erythromycin
• HIV protease inhibitors, such as Ritonavir and Atazanavir
• Warfarin
• Colchicine
• Grapefruit juice
• Heart medications, such as Amiodarone and Verapamil
• Calcium channel blockers (Diltiazem and Amlodipine
• Rifampin
• Digoxin
• Contraceptives containing ethinyl estradiol and norethindrone
• Ezetimibe
• Daptomycin
• Lomitapide
• Mifepristone

[Note: This isn’t a complete list, and there could be other drugs that interact with Rosuvastatin. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

• Lipitor (atorvastatin)
• Zocor (simvastatin)
• Pravachol (pravastatin sodium)
• Mevacor (lovastatin)
• Altoprev (lovastatin)
• Lescol (fluvastatin)
• Livalo (pitavastatin)

[Note: You should only take these alternative medications, Rosuvastatin, after consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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