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We offer competitive pricing on all our medications. Find a lower price? We'll match it from any verified Canadian online pharmacy! Know More

We offer competitive pricing on all our medications. Find a lower price? We'll match it from any verified Canadian online pharmacy! Know More
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Select the prescribed dosage and quantity, then proceed to checkout.
Sign in or create a new account.
Upload your prescription.
Complete your purchase by processing the payment.
Shipping takes approximately 3-5 business days.
Read what our customers have to say about their shopping experience.
Sentinel is a prescription medication for dogs designed to provide comprehensive parasite control. It combines milbemycin oxime, which targets heartworm larvae and intestinal worms, with lufenuron, which prevents flea egg development. This dual-action treatment prevents heartworm disease, treats intestinal parasites, and helps manage flea populations by stopping the hatching of flea eggs. Unlike other flea treatments, Sentinel does not kill adult fleas; instead, it interrupts their lifecycle, making it ideal for ongoing prevention. Always consult a veterinarian before use, especially for puppies or pregnant dogs. Order Sentinel online today from trusted Canadian pharmacies and enjoy reliable, affordable delivery straight to your home.
| Generic Name | Milbemycin oxime & Lufenuron |
| Brand Name | Sentinel |
| Forms | Tablets |
| Strengths Available | 23mg/460mg/228mg |
| Packaging | – |
| Requires Prescription | Prescription only (Rx) |
| Ships to USA | Yes |
Sentinel tablets for dogs are used for the following purposes:
Sentinel is recommended for use in dogs and puppies aged four weeks and older, and weighing 2 lbs or more. Administer Sentinel once a month with food. Follow the instructions given by your veterinarian.
Dosage of Sentinel for Parasite Prevention
Weighing Over 100 lbs- Use two tablets (based on vet guidance)
Follow all directions provided by your veterinarian & follow the usage instructions outlined in the medication guide.
Milbemycin oxime, an active ingredient in Sentinel, is a macrocyclic anthelmintic that works by interfering with the neurotransmission of invertebrates. It eliminates tissue-stage heartworm larvae and adult hookworms, roundworms, and whipworms when administered orally. On the other hand, another active ingredient, lufenuron, is an insect development inhibitor that stops flea reproduction by disrupting chitin formation, preventing flea eggs from hatching. While it doesn’t kill adult fleas, it breaks the flea cycle when ingested by fleas feeding on treated dogs.
Common Sentinel side effects may include:
Serious side effects (rare):
Note: Call your veterinarian if your dog experiences any severe symptoms or unusual changes.
Below are some warnings to consider when using Sentinel with your dog.
Before using Sentinel for dogs, consider the following precautions.
If you forget to administer the dose of Sentinel and a 30-day interval between dosing is exceeded, give it immediately and return to monthly dosing. If your veterinarian has instructed you to administer Sentinel on a different dosing schedule, contact them for further directions if you forget to give a dose. Do not give a double dose to compensate for a missed one.
A Sentinel overdose can lead to lethargy, loss of appetite, incoordination, salivation, shallow breathing, tremors, and vomiting. If you suspect an overdose, call your veterinarian or emergency veterinary assistance, or call an animal poison control center.
Follow proper storage & handling instructions to ensure the medication you are using is effective. For Sentinel, consider the following:
Sentinel flavor tablets are generally considered safe for use when used as directed; however, potential interactions with Sentinel products should be kept in mind.
Some alternatives to Sentinel include:
At Polar Bear Meds, we’re committed to making prescription medications like Sentinel more accessible and affordable for USA patients. Our prices are significantly lower than typical USA pharmacy retail rates without compromising on safety or quality. Every order is sourced exclusively from licensed and trusted pharmacies and undergoes complete prescription verification to ensure compliance and authenticity. We offer discreet, trackable shipping to all USA states, along with refill support for ongoing treatment. Our friendly customer service team is here to help you.
Get Sentinel delivered straight from Canada to your doorstep in the USA. You can also save more by using the coupon code “WELCOMEPB10” for 10% off on your first order. There are no hidden handling or processing fees, as we believe in complete transparency. Looking to save even more? Join our referral program & get a $20 credit every time you refer a friend or a family member. Your referral will also get a $20 credit, so everyone wins. Additionally, after every 10 verified customers you refer, you'll receive a $100 credit in your account as a thank-you for spreading the word.
AtPolar Bear Meds, your safety is our priority. Every order is dispensed from a fully licensed Canadian pharmacy following strict standards for quality, security, and patient care. To conveniently buy Sentinel from Canada at a substantial cost, call us at1-888-779-2193toll-free.
The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.

We offer competitive pricing on all our medications. We'll match if you find a lower price on an identical product at a verified Canadian online pharmacy!
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