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Sentinel

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Product Details

Description

Sentinel is a prescription medication for dogs designed to provide comprehensive parasite control. It combines milbemycin oxime, which targets heartworm larvae and intestinal worms, with lufenuron, which prevents flea egg development. This dual-action treatment prevents heartworm disease, treats intestinal parasites, and helps manage flea populations by stopping the hatching of flea eggs. Unlike other flea treatments, Sentinel does not kill adult fleas; instead, it interrupts their lifecycle, making it ideal for ongoing prevention. Always consult a veterinarian before use, especially for puppies or pregnant dogs. Order Sentinel online today from trusted Canadian pharmacies and enjoy reliable, affordable delivery straight to your home.

Generic NameMilbemycin oxime & Lufenuron
Brand NameSentinel
FormsTablets
Strengths Available23mg/460mg/228mg
Packaging
Requires PrescriptionPrescription only (Rx)
Ships to USAYes
Uses and Benefits

Sentinel tablets for dogs are used for the following purposes:

  • It helps protect against heartworms, roundworms, hookworms, and whipworms.
  • It also helps control the population of fleas by preventing flea eggs from hatching.

Benefits of Sentinel

  • It targets heartworm larvae before they can mature and cause damage.
  • It removes and controls certain worms, helping to keep your dog’s digestive system parasite-free.
  • Most dogs handle Sentinel well, with minimal risk of side effects when used as directed.
Dosage

Sentinel is recommended for use in dogs and puppies aged four weeks and older, and weighing 2 lbs or more. Administer Sentinel once a month with food. Follow the instructions given by your veterinarian.

Dosage of Sentinel for Parasite Prevention

  • Weighing 2 to 10 lbs- 2.3 mg milbemycin oxime / 46 mg lufenuron
  • Weighing 11 to 25 lbs- 5.75 mg milbemycin oxime / 115 mg lufenuron
  • Weighing 26 to 50 lbs- 11.5 mg milbemycin oxime / 230 mg lufenuron
  • Weighing 51 to 100 lbs- 23 mg milbemycin oxime / 460 mg lufenuron

Weighing Over 100 lbs- Use two tablets (based on vet guidance)

Usage Guide

Follow all directions provided by your veterinarian & follow the usage instructions outlined in the medication guide.

  • You can use Sentinel flavor tabs with Capstar tablets for effective flea control. Capstar kills adult fleas while Sentinel prevents eggs from hatching. For ongoing protection, especially in a high-risk environment, using both is recommended.
  • Sentinel tablets are flavored and usually acceptable to dogs, but they can be hidden in food if needed. Ensure your dog consumes the entire dose at once.
  • Food is essential for the absorption of the medication.
  • Administer Sentinel once a month, ideally on the same date. Begin treatment before flea and mosquito season begins and continue throughout the season, or year-round if infestations persist.
How It Works

Milbemycin oxime, an active ingredient in Sentinel, is a macrocyclic anthelmintic that works by interfering with the neurotransmission of invertebrates. It eliminates tissue-stage heartworm larvae and adult hookworms, roundworms, and whipworms when administered orally. On the other hand, another active ingredient, lufenuron, is an insect development inhibitor that stops flea reproduction by disrupting chitin formation, preventing flea eggs from hatching. While it doesn’t kill adult fleas, it breaks the flea cycle when ingested by fleas feeding on treated dogs.

Side Effects

Common Sentinel side effects may include:

  • Vomiting
  • Diarrhea
  • Decreased appetite
  • Fatigue (lethargy)
  • Pruritus (itching)
  • Red skin or rash

Serious side effects (rare):

  • Dilated pupils
  • Excessive drooling
  • Lack of energy or weakness
  • Seizures or coma
  • Stumbling or collapse

Note: Call your veterinarian if your dog experiences any severe symptoms or unusual changes.

Warnings

Below are some warnings to consider when using Sentinel with your dog.

  • Not for Human Use: Sentinel is formulated for dogs only and should not be used by humans. Do not use a veterinary drug, such as Sentinel, for humans. Some of its ingredients may be harmful if ingested or absorbed by humans, especially children or those with sensitivities.
  • Heartworm Testing: Have your dog tested for heartworm infection before starting treatment with Sentinel. Administering it to a dog with an existing infection may cause adverse reactions.
Safety Guide

Before using Sentinel for dogs, consider the following precautions.

  • Medical Supervision Required: Sentinel can only be used by or under the guidance of a licensed veterinarian.
  • Pregnant or Lactating Dogs: The safety and efficacy of this dog flea prevention medication have not been established in pregnant or lactating dogs. Consult your vet before using it.
  • Not for Puppies: This medication is not recommended for use in puppies under four weeks of age and weighing less than 2 lbs.
  • Delayed Flea Control: Sentinel Flavor Tabs stop flea eggs from developing, but adult fleas from existing infestations may continue to emerge for 30-60 days after treatment begins. In cooler areas, this may take longer due to slower flea life cycles.
  • Adult Flea Exposure: If a dog being treated with Sentinel comes into contact with a flea-infested area, it can still pick up adult fleas. While those fleas won’t be able to lay eggs that hatch, you may still need to use another product that kills adult fleas to get rid of them.
Missed Dose

If you forget to administer the dose of Sentinel and a 30-day interval between dosing is exceeded, give it immediately and return to monthly dosing. If your veterinarian has instructed you to administer Sentinel on a different dosing schedule, contact them for further directions if you forget to give a dose. Do not give a double dose to compensate for a missed one.

Overdose

A Sentinel overdose can lead to lethargy, loss of appetite, incoordination, salivation, shallow breathing, tremors, and vomiting. If you suspect an overdose, call your veterinarian or emergency veterinary assistance, or call an animal poison control center.

Storage Guide

Follow proper storage & handling instructions to ensure the medication you are using is effective. For Sentinel, consider the following:

  • Keep Sentinel in a cool and dry place at controlled room temperature, at 59º-77ºF or 15-25ºC.
  • Store the Sentinel flavor tablets in their original packaging until you are ready to use them.
  • Keep this medication in a kitchen cabinet or a medicine drawer out of sight and reach of children & pets to prevent accidental ingestion.
Interactions

Sentinel flavor tablets are generally considered safe for use when used as directed; however, potential interactions with Sentinel products should be kept in mind.

  • Capstar
  • Diethylcarbamazine
  • Other flea and tick treatments
  • Heartworm preventives
  • Common veterinary drugs or supplements
Alternatives

Some alternatives to Sentinel include:

  • Comfortis
  • Nexgard
  • Seresto
  • Trifexis
Cost & Coupons

Why Buy Sentinel from Polar Bear Meds?

At Polar Bear Meds, we’re committed to making prescription medications like Sentinel more accessible and affordable for USA patients. Our prices are significantly lower than typical USA pharmacy retail rates without compromising on safety or quality. Every order is sourced exclusively from licensed and trusted pharmacies and undergoes complete prescription verification to ensure compliance and authenticity. We offer discreet, trackable shipping to all USA states, along with refill support for ongoing treatment. Our friendly customer service team is here to help you.

Cost & Coupons

Get Sentinel delivered straight from Canada to your doorstep in the USA. You can also save more by using the coupon code “WELCOMEPB10” for 10% off on your first order. There are no hidden handling or processing fees, as we believe in complete transparency. Looking to save even more? Join our referral program & get a $20 credit every time you refer a friend or a family member. Your referral will also get a $20 credit, so everyone wins. Additionally, after every 10 verified customers you refer, you'll receive a $100 credit in your account as a thank-you for spreading the word.

FAQ

Guarantee

AtPolar Bear Meds, your safety is our priority. Every order is dispensed from a fully licensed Canadian pharmacy following strict standards for quality, security, and patient care. To conveniently buy Sentinel from Canada at a substantial cost, call us at1-888-779-2193toll-free.

Important Notice

The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.

Dr. Jackson Miller

Medically Reviewed by "Dr. Jackson Miller (M.D)"

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.

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