Fluticasone Propionate and Salmeterol Xinafoate

Seretide Accuhaler

Seretide Accuhaler is a dry powder inhaler used for treating asthma and chronic obstructive pulmonary disease (COPD). It combines fluticasone propionate, a corticosteroid that reduces inflammation, and salmeterol xinafoate, a long-acting beta2-agonist that relaxes airway muscles, improving breathing. Available in various strengths, it is administered twice daily. The device is designed for direct lung inhalation, requiring careful handling to ensure effective medication delivery and adherence to prescribed dosages. With a valid prescription from your doctor, you may buy Seretide Accuhaler inhaler online from Canada at a cost-effective price.

Product Overview

Seretide Accuhaler is a medical device used primarily to manage and treat symptoms of asthma and chronic obstructive pulmonary disease (COPD). It dispenses a combination of two active ingredients: fluticasone propionate and salmeterol xinafoate. Fluticasone propionate is a potent corticosteroid that decreases airway inflammation, while salmeterol xinafoate is a long-acting beta2-adrenergic receptor agonist that helps relax the muscles around the airways, making breathing easier. 

This dual action helps to prevent the frequency and severity of asthma attacks and improves COPD symptoms. The Accuhaler is available in strengths of 100/50mcg, 250/50mcg, and 500/50mcg, allowing dosage customization based on the severity of the patient’s condition. It’s designed for oral inhalation with two daily doses recommended. The Accuhaler requires specific handling to prepare doses correctly and should be stored properly to maintain effectiveness.

Patients are advised to rinse their mouths after use to prevent infections like oral thrush and to discuss any concerns about side effects or interactions with other medications with their healthcare provider. Regular follow-ups are crucial to adjust the dose as needed and manage the conditions effectively. You may buy Seretide inhaler to manage asthma online from Canada easily with a valid prescription.

What Is a Seretide Accuhaler Used For?

Seretide Accuhaler is used to treat the following medical conditions:

• Asthma
• Chronic Obstructive Pulmonary Disease (COPD)

What Strengths Does Seretide Accuhaler Come In?

Seretide Accuhaler is available in the form of a dry inhalation powder with the following strengths:

• 100/50mcg (fluticasone propionate/salmeterol)
• 250/50mcg (fluticasone propionate/salmeterol)
• 500/50mcg (fluticasone propionate/salmeterol)

What Is the Typical Dosage of Seretide Accuhaler?

The dosage recommendations for Seretide accuhaler depend on several factors, including the type and severity of your medical condition and the form of medication you take. Generally, medical professionals prescribe a starting dose and gradually adjust the drug doses as needed. It is important to note that the dosage recommendations below are only for the average dose. So, if you have been prescribed a different dose, do not change it without consulting your medical practitioner.

Dosage of Seretide for Asthma

• For Adults & Adolescents (12 Years and Older): One inhalation of 50mcg salmeterol & 100mcg fluticasone propionate twice daily. You can also take one inhalation of 50mcg of salmeterol & 250mcg of fluticasone propionate.
• For Children 4 Years of Age and Above: Take one inhalation of 50mcg of salmeterol & 100mcg of fluticasone propionate two times a day.
• For Children Under 4 Years of Age: Medical professionals have not yet determined the safety and effectiveness of the medication. 

Dosage of Seretide for COPD

• For Adults: Take one inhalation of 50mcg salmeterol and 250mcg fluticasone propionate two times a day.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Seretide Accuhaler?

To use the Seretide Accuhaler effectively for managing asthma or chronic obstructive pulmonary disease (COPD), follow these instructions:

• Follow the dosage recommendations exactly as they are mentioned on your prescription label. 
• Seretide accuhaler is only for inhalation purposes. The medication should be inhaled directly into the lungs. 
• Before using the accuhaler, you need to prepare the device. Hold the Accuhaler in one hand.
• Use the thumb of the other hand to slide the thumb grip until you hear a click. This action opens a small hole in the mouthpiece and readies a dose.
• Now, exhale completely and avoid breathing out into the accuhaler.
• Put the mouthpiece to your lips, making sure your lips form a tight seal around it.
• Inhale deeply and try to take the medication in one inhalation.
• Ensure you are inhaling the medication directly into your lungs.
• Once you are done, remove the accuhaler and hold your breath for 10 seconds. This step ensures that the medication settles into your lungs properly.
• Now, release the breath slowly. 
• Slide the thumb grip back to the original position to close the device.
• This action resets the accuhaler for the next dose and protects the mouthpiece.
• Rinse your mouth with water & spit it out. This aids in minimizing the risk of developing a fungal infection in your mouth.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Seretide Accuhaler Work?

The Seretide Accuhaler works by combining two active ingredients: fluticasone propionate and salmeterol xinafoate. Fluticasone propionate is a potent corticosteroid that lowers inflammation in the airways, while salmeterol xinafoate is a long-acting beta2-agonist that eases the tensed muscles around the airways. Together, these ingredients help to open up the airways, making it easier to breathe. This dual-action approach helps prevent and control symptoms of asthma & chronic obstructive pulmonary disease (COPD), such as wheezing and shortness of breath. The Seretide Accuhaler delivers a consistent dose of medication, ensuring effective management of these conditions.

What Are the Important Safety Information for Using Seretide?

What Are the Side Effects of Seretide Accuhaler?

Common Seretide Accuhaler Side Effects: Seretide Accuhaler, like all medications, can cause side effects. While many of these effects are temporary and might last only a few days to weeks, it’s important to consult your healthcare provider if they persist or become severe. Here are some common side effects you may experience with Seretide Accuhaler:

• Sinus inflammation: Swelling or irritation inside your nose.
• Stomach discomfort: Pain or an upset stomach.
• Upper respiratory tract infection: Infections in the airways, often indicated by a cold or flu-like symptoms.
• Cough: Frequent coughing which is not related to a cold.
• Voice change: Your voice may sound hoarse or raspy.
• Headache: Persistent or severe headaches.
• Aggressive behavior: Unusual irritability or aggression.
• Mouth dryness: A dry, sometimes sticky feeling in the mouth.
• Nasopharyngitis: Inflammation of the nose and throat, typically resulting in a sore throat or runny nose.
• Fungal infection of the oropharynx: A yeast infection in the throat, often causing pain and difficulty swallowing.
• Anxiety: Feelings of nervousness or unease.
• Arthralgia: Joint pain.
• Back pain: Pain located in the back.
• Blurred vision: Temporary loss of sharpness of vision.
• Bronchitis: Inflammation of the bronchi in the lungs, often leading to coughing.
• Contact dermatitis: Skin rash or irritation where the drug may have come into contact with the skin.
• Contusion: Bruises.
• Cutaneous reactions: Various skin reactions, such as rashes.
• Dizziness: A sensation of spinning or losing one’s balance.
• Facial edema: Swelling in the face.
• Hoarseness: Roughness in the voice, often temporary.
• Hyperactivity in children: Increased activity levels that are more than what is normal for the child.
• Hypersensitivity reactions: Allergic reactions which can range from skin rashes to more severe reactions.
• Sleep disturbances: Trouble falling or staying asleep.
• Throat irritation: Soreness or discomfort in the throat.
• Tremor: Involuntary shaking or trembling.

Serious Side Effects of Seretide Accuhaler: Seretide Accuhaler, while beneficial for managing asthma and COPD, can also lead to some serious side effects that might be life-threatening. If you notice any unusual or concerning symptoms, it’s crucial to seek medical attention immediately. Here are some of the serious side effects that could occur with Seretide Accuhaler:

• Adrenal suppression: This condition involves the adrenal gland not producing enough steroid hormones, which can affect your body’s response to stress.
• Aggression: Increased feelings of anger that are unusual for the person’s normal behavior.
• Angioedema: Severe swelling beneath the skin, particularly of the eyes, lips, and face, which can lead to breathing difficulties.
• Atrial fibrillation: An irregular and often rapid heart rate that can increase the risk of strokes, heart failure, and other heart-related complications.
• Behavioral disturbances (children): Changes in behavior in children, including increased irritability or mood swings.
• Cardiac arrhythmias: Irregular heartbeats that can feel like a fluttering or racing heart and can be serious.
• Cushing’s syndrome: A condition caused by high levels of cortisol that can result in weight gain, particularly around the midsection and upper back, facial puffiness, and bruising.
• Decrease in bone mineral density: Thinning of the bones, which can increase the risk of fractures.
• Depression: Feelings of severe despondency and dejection.
• Glaucoma: An increase in eye pressure which can lead to vision loss.
• Growth retardation (children): Slower than normal growth in children.
• Hyperglycaemia: High blood sugar levels, which can be a concern for people with diabetes.
• Hypokalaemia: Lower than normal levels of potassium in the blood, which can affect muscle function and heart rhythm.
• Paradoxical bronchospasm: Instead of opening the airways, the medication causes them to tighten, making breathing more difficult.
• Pneumonia: Infection that inflames the air sacs in one or both lungs, which can cause cough with phlegm or pus.
• Tachycardia: An abnormally fast heart rate that can lead to heart complications.
• Visual disturbances: Changes in vision, including blurred vision or blind spots.
• Heavy bleeding: Unusually severe bleeding, which can include bleeding gums, nosebleeds, or heavier menstrual bleeding.
• Chest pain: Pain or discomfort in the chest that might indicate heart-related issues.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Using Seretide Accuhaler?

Seretide accuhaler can cause severe side effects in certain patients, or it may not be an ideal treatment option for specific populations due to their medical conditions. So, if you are using this medication, you should remain cautious. Its warnings are as follows:

• Asthma Patients: Patients with exacerbated and unstable asthma symptoms should not use this accuhaler as Seretide is not for sudden asthma attacks. Always have a fast-acting inhaler (like salbutamol) for quick relief.
• Pneumonia: Studies have reported increased cases of pneumonia in patients with COPD using Seretide. Therefore, COPD patients should be aware of the possible development of pneumonia. Doctors should watch for signs of pneumonia in these patients, as pneumonia and COPD flare-ups can look similar. 
• Corticosteroids: Seretide contains inhaled corticosteroids, and such corticosteroids increase the chances of experiencing systemic side effects in patients, which are less likely to happen with oral corticosteroids. The possible side effects may include Cushing’s syndrome, growth retardation, decreased bone density, behavioral changes, adrenal suppression, cataracts, and glaucoma. Patients switching from oral steroids to inhaled fluticasone propionate need special care and regular monitoring of adrenal function. Therefore, patients are advised to consult a medical practitioner before starting treatment with Seretide accuhaler.
• Cardiovascular Diseases: Using sympathomimetic drugs like Seretide can sometimes lead to increased systolic blood pressure and heart rate, particularly at higher doses. In rare cases, Seretide may cause irregular heartbeats such as extrasystoles, atrial fibrillation, and supraventricular tachycardia. Therefore, it is important to use Seretide cautiously in patients with existing heart conditions.
• Lower Serum Potassium: Sympathomimetic drugs can temporarily decrease serum potassium levels. Therefore, Seretide should be administered carefully to patients who are prone to low potassium levels.
• Diabetes Mellitus: While rare, patients have reported increased blood sugar levels while using Seretide. This should be taken into account when prescribing Seretide to patients with a history of diabetes mellitus.

What Are the FDA Black Boxed Warning for Seretide Accuhaler?

Boxed warnings, also called black-boxed warnings, are among the most stringent guidelines issued by the FDA. These warnings alert doctors and patients about the harmful effects of a particular drug, which can be life-threatening if overlooked. Seretide does not have any boxed warnings, meaning it is safe to use. However, its safety is based on the precautions you take. Therefore, if you are taking this drug, follow the instructions provided by your medical practitioner. If you have any concerns or notice any unusual symptoms, it’s best to consult with an expert.

What Are the Precautions for Seretide?

When considering treatment with Seretide accuhaler, patients should discuss every risk and benefit with their medical practitioner. Here are some of the precautions that you can take before using Seretide accuhaler to treat asthma and COPD:

• Before using this product/medication, patients should tell their healthcare provider if they have allergies or are allergic to any of the medication’s ingredients. The product may contain certain inactive components that can cause severe allergic reactions.
• When considering treatment with Seretide accuhaler, tell your physician about your or your family’s medical history, especially of:
  • Adrenal sufficiency
  • Cardiac arrhythmias
  • Diabetes mellitus
  • Electrolyte imbalance
  • Long QT syndrome
  • Hypertension
  • Hyperthyroidism
  • Hypokalaemia
  • Lactose intolerance
  • Severe cardiovascular disorder
  • Thyrotoxicosis
• If you are undergoing surgery or any medical procedure, inform your medical expert or surgeon about the products you are using. This includes all prescription drugs, over-the-counter medications, and herbal products.
• If you are using your medication more often, it means your asthma is getting worse. Do not overlook this situation; talk to a medical professional.
• If Seretide accuhaler is not controlling your asthma, consult a doctor. You might need an alternate treatment. 
• Seretide can cause serious asthma problems. If your condition does not improve or worsens over time, talk to your medical expert. 
• Seretide accuhaler may make you wheeze more right away. If this happens on a regular basis, use a fast-acting inhaler and discontinue Seretide. 
• When your asthma symptoms get under control, discuss them with your practitioner. They might gradually reduce your Seretide dose.
• If you have an electrolyte imbalance, correct your electrolyte disorder before starting your treatment with Seretide accuhaler.
• If you have asthma or COPD, avoid stopping the medication abruptly without consulting a medical professional. Doing so may increase the risk of side effects or exacerbate the condition, causing life-threatening situations.  
• Patients with active or quiescent pulmonary tuberculosis must use this medication cautiously or under medical supervision. 
• If you are pregnant or planning to have a baby, avoid using Seretide accuhaler unless it is clearly needed. While there is limited data, the medication used in this product may harm the unborn baby. Consult a medical professional and discuss every risk and benefit associated with it.
• It is not clear whether this medication is safe during breastfeeding. If you are a nursing mother, talk to your medical expert about the safety of this product for your breastfeeding child.

What Are the Contraindications for Seretide Accuhaler? 

Seretide accuhaler is contraindicated in:

• Patients with hypersensitivity reactions to salmeterol xinafoate, fluticasone propionate, or any of the ingredients used in the medication’s formulation. You can check the product’s label or ask a pharmacist for detailed ingredient information.
• Patients with severe milk-protein allergy.
• Children under 4 years of age.
• Patients with QT syndrome

What If You Miss a Dose of Seretide Accuhaler?

Patients are usually advised not to miss their doses of any medication, and when it comes to controlling symptoms of asthma and COPD, taking medication on time becomes more important. However, if somehow you forget to use Seretide accuhaler:

• Take the missed dose as soon as possible unless your doctor advises otherwise.
• Call your doctor for specific instructions on what to do next.
• Remember not to take double doses. 
• If it is almost time for the next dose, you may omit the missed dose and continue your regular dosing schedule.
• If you feel chest tightness before taking your dose, use a reliever puffer. You may get relief from it within minutes.
• Use medication apps or set phone reminders to avoid missing doses.
• Take your medication at the same time every day to get the most benefit from it.
• Make sure to get your prescription refilled before you run out of medicine. This will ensure that you do not miss any doses.
• If you have any questions or concerns about it, ask your medical practitioner. They will suggest alternate options that suit your body’s needs.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Use Too Much Seretide?

Overdosing any medication is not a solution. While patients are educated enough to know the complications of excessive dosing, there are times when they accidentally take too much of the prescribed medication. In such situations, patients can experience unusual symptoms, including:

• Significant muscle tremor
• Headache
• Increased blood pressure
• Rapid heartbeat
• Increased rate of breathing
• High blood sugar

If you are experiencing such overdose symptoms, visit the nearest clinic or get medical assistance immediately by calling 911.  

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How Do You Store Seretide Accuhaler?

To keep Seretide Accuhaler for asthma management effective and safe, it’s important to store it properly. Here are some simple guidelines for storing this accuhaler:

• Store your Seretide accuhaler below 30°C.
• Keep the product in its original container/packaging.
• Store it somewhere safe, away from the reach and sight of children and pets.
• Protect the product from direct heat and sunlight.
• Avoid refrigerating the product because if your accuhaler becomes extremely cold, it may not work properly. So, keep it away from frost.
• Do not flush the medication down the toilet.
• Avoid keeping it in damp or moist places like the bathroom or near the sink.
• Do not store it in the car or on window sills.
• Do not use a medication if its expiration date has passed.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Does Seretide Interact With?

Seretide Accuhaler, which contains fluticasone propionate and salmeterol xinafoate, can interact with various medications, potentially affecting its effectiveness or increasing the risk of side effects. Here’s how Seretide interacts with different types of drugs:

• Blood pressure-lowering medications such as Propranolol and Atenolol, as well as diuretics (commonly known as water pills), can interact with Seretide. These medications might enhance the cardiovascular effects of Seretide, potentially leading to changes in heart rhythm or blood pressure.
• Anti-bacterial medications like Itraconazole, Ketoconazole, and Erythromycin can increase the levels of fluticasone and salmeterol in the body. This can lead to an increased risk of systemic corticosteroid side effects such as decreased immune response, increased chance of infections, and potential endocrine problems.
• Anti-viral medicines such as Ritonavir and Cobicistat-containing products significantly increase the concentration of Seretide’s active components in the blood, which can enhance the risk of cardiovascular effects such as irregular heartbeats or palpitations.
• Other Drugs that can interact with Seretide include:
  • Levacetylmethadol and Sotalol: These can affect the heart’s rhythm, potentially exacerbating any heart-related side effects of Seretide.
  • Atomoxetine: This might increase the risk of cardiovascular side effects when used with Seretide.
  • Domperidone and Methacholine: Can increase the risk of heart issues.
  • Astemizole, Acetazolamide, Vandetanib, Sulpiride: These drugs can interact with Seretide to alter heart rhythm or effectiveness of either medication.
  • Sevoflurane and Propofol: Used in anesthesia, these might increase cardiovascular risks when undergoing surgery if taking Seretide.
  • Quinidine: Another medication affecting heart rhythm, which might interact with Seretide.

What Are the Other Interactions of Seretide Accuhaler?

Besides medications, Seretide Accuhaler can also interact with certain foods, drinks, herbs, or dietary supplements, potentially affecting the medication’s effectiveness or increasing the likelihood of side effects. Here’s an overview of these interactions:

• Caffeine: Consuming large amounts of caffeine, found in coffee, tea, and some sodas, can increase the side effects of salmeterol in Seretide, such as nervousness, tremor, and palpitations.
• Grapefruit Juice: This drink can increase the level of fluticasone in your body by affecting how it is broken down in the liver, potentially leading to more side effects.
• Licorice: Eating a lot of licorice can potentially interfere with the hormone balance in your body. This can affect how fluticasone works and increase the risk of side effects.
• Non-Prescription Herbal Supplements: Some herbs, like St. John’s wort and echinacea, can affect the immune system and might change how effective Seretide is in managing your asthma or COPD.
• Omega-3 Fatty Acids: Found in fish oil and some nut oils, omega-3 fatty acids can affect blood clotting and may interact with the effects of salmeterol on the cardiovascular system.
• High-Fat Meals: Eating meals high in fat just before taking Seretide can slightly alter how quickly the medication is absorbed and processed by your body, which might impact its effectiveness.

Understanding these interactions can help you manage your health better while using Seretide Accuhaler. It’s important to discuss your diet and any supplements you take with your healthcare provider to ensure your treatment is as effective as possible.

[Note: This isn’t a complete list, and there could be other drugs that interact with Seretide Accuhaler. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Alternatives to Seretide Accuhaler?

People usually take alternative drugs for many reasons. In some cases, the prescribed medication may not be an ideal option for them due to their medical conditions. On the other hand, they may not achieve the results they are aiming for. Therefore, you should talk to a medical professional before you start a particular treatment or if you want to change your medication. They may help you decide which medication is best suited for you. Some of the alternatives of Seretide accuhaler (fluticasone propionate and salmeterol xinafoate) are as follows:

• Breztri Aerosphere
• Spiriva
• Albuterol
• Advair Diskus
• Symbicort
• Combivent
• Dulera
• AirDuo RespiClick
• Wixela Inhub
• Breo Ellipta
• Trelegy Ellipta
• Asmanex HFA
• Qvar RediHaler 
• Flovent HFA

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Seretide Accuhaler Coupons & Cost

Managing asthma or COPD is essential but can be costly with medications like Seretide Accuhaler. To reduce this financial burden, consider buying Seretide Accuhaler online from Canada through Polar Bear Meds. We offer this medication at prices much lower than those typically found in the U.S., making it more accessible for those who need it. Utilize the Seretide Accuhaler coupon code “WELCOMEPB10” to get an extra 10% off your first purchase from us. Additionally, our referral program can help you save up to $200 on your medication expenses, further lowering the cost of maintaining your respiratory health.

Frequently Asked Questions

What happens if you don’t rinse your mouth after using Seretide?

When you use your Seretide inhaler, a small amount of the steroid medication can stick to the inside of your mouth and throat. If not rinsed out, this residue can lead to a type of fungal infection called oral thrush. To prevent this, it’s important to rinse your mouth with water and spit it out after each use of your inhaler.

Do you need to shake Seretide?

For medications like Seretide that come in an Accuhaler form, shaking is not required. To use, simply open the cover, hold the inhaler horizontally, and slide the lever until it clicks. This prepares the dose for you to inhale.

Can you drink water right after using an inhaler?

Yes, it’s actually recommended to drink water right after using an inhaler. After inhaling your dose, rinse your mouth with water, gargle, and spit it out to avoid any potential side effects like oral thrush. Make sure not to swallow the rinse water.

When is the best time to take Seretide?

To manage your symptoms effectively, use Seretide twice a day at about the same times each day. Consistent use helps maintain symptom control throughout both day and night, enhancing the medication’s effectiveness.

How long does it take for Seretide to start working?

Seretide begins to improve breathing quickly and, when used daily, it helps prevent asthma attacks and manage symptoms like wheezing or night-time coughing. You should start to notice improvements within a few days of regular use.

Is Seretide the same as Advair?

Yes, Seretide and Advair are essentially the same medication but marketed under different names in different regions. In the U.S. and Canada, it’s known as Advair, while in many other countries it is sold as Seretide. Both contain a combination of medicines used to prevent asthma attacks and control symptoms.

How many puffs of Seretide is safe?

For children, the typical dosage is two inhalations of 25 micrograms of salmeterol and 50 micrograms of fluticasone propionate twice daily. The highest approved dose for children using Seretide is 100 micrograms of fluticasone propionate twice daily. Currently, there are no guidelines for children under 4 years old regarding the use of Seretide.

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