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Silodosin is a medication primarily used to treat symptoms of benign prostatic hyperplasia (BPH) in adult men. It works by relaxing the smooth muscles in the prostate and bladder, improving urinary flow, and reducing symptoms like difficulty in urination. Silodosin is typically taken as an 8 mg oral capsule once daily with a meal. It can interact with various medications, including antibiotics, antifungals, and blood pressure drugs, so it’s essential to inform your healthcare provider about all medications you are taking. Common side effects include dizziness, diarrhea, and nasal congestion. Special precautions are necessary for seniors, those with kidney or liver disease, and individuals planning to undergo cataract surgery. Regular monitoring by a doctor is advised to manage any potential side effects and ensure the medication’s effectiveness.

Product Overview

Silodosin is a medication used to manage symptoms of benign prostatic hyperplasia (BPH) in adult men. It belongs to the class of drugs known as alpha-1 blockers, which relax the smooth muscles in the prostate and bladder, thereby improving urinary flow and alleviating symptoms such as difficulty in urination. The typical dosage is an 8 mg oral capsule taken once daily with a meal. For individuals with moderate kidney disease, a lower dose of 4 mg may be recommended, while those with severe kidney or liver disease should avoid using silodosin.

Silodosin can interact with various medications, including antibiotics like clarithromycin and erythromycin, antifungals such as ketoconazole and itraconazole, HIV medications, and certain blood pressure drugs. These interactions can increase the risk of side effects or reduce the drug’s effectiveness. Therefore, it’s crucial to inform your healthcare provider about all medications, vitamins, and herbs you are taking. Common side effects include dizziness, diarrhea, nasal congestion, and retrograde ejaculation. More serious side effects can occur, such as a significant drop in blood pressure, liver problems, and severe allergic reactions. 

Special precautions are necessary for seniors, individuals with kidney or liver disease, and those planning cataract surgery due to the risk of intraoperative floppy iris syndrome (IFIS). To ensure the best results, take silodosin at the same time each day and with a meal to reduce side effects. If you miss a dose, take it as soon as you remember unless it’s close to the next dose. Do not double up on doses. Regular medical check-ups are essential to monitor progress and manage any potential side effects. For cost savings, consider purchasing silodosin from Canadian pharmacies, which may offer lower prices and discounts.

What Are the Uses of Silodosin?

It is used to treat adult men with:

  • The symptoms of BPH (benign prostatic hyperplasia).

What Are the Forms & Strengths of Silodosin?

It comes in the oral capsule form and is available in these 2 strengths: 

  • Silodosin 4 mg capsule
  • Silodosin 8 mg capsule

What Are the Recommended Dosage of Silodosin?

Dosage for Benign Prostatic Hyperplasia (BPH)
  • Adult Dosage (ages 18–64 years): The usual dose is 8 mg, taken once daily with a meal.
  • Child Dosage (ages 0–17 years): The safety and effectiveness of silodosin in children under 18 years old have not been established.
  • Senior Dosage (ages 65 years and older):
    • As people age, their organs, like the liver and kidneys, may not function as efficiently. This can cause the body to process the drug more slowly, leading to an increased risk of side effects.
    • Depending on how well your liver and kidneys are working, your doctor may adjust your dosage or decide that this drug is not suitable for you.
Special Dosage Considerations
  • For People with Kidney Disease:
    • Severe Kidney Disease: Silodosin is not recommended.
    • Moderate Kidney Disease: The recommended dose is 4 mg, taken once daily with a meal.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Silodosin? 

  • Dosage and Administration: Your dose, form, and frequency of taking silodosin will depend on the following:
    • The condition being treated
    • Your age
    • The severity of your condition
    • Your response to the first dose
    • Other medical conditions you have
  • Continuity:
    • If you stop taking silodosin or miss doses, your BPH symptoms may worsen.
    • If you miss taking this medication for several days, consult your doctor before starting it again.
  • With Food:
    • Silodosin should be taken with a meal to reduce the risk of side effects.
    • Taking it on an empty stomach may increase the chance of a sudden drop in blood pressure when standing up.
  • Consistency: Take silodosin at the same time every day to help minimize side effects.
  • For Those with Swallowing Difficulties:
    • If you have trouble swallowing capsules, you can carefully open the capsule and sprinkle the powder on a tablespoon of applesauce.
    • Swallow the applesauce immediately, without chewing, and follow with an 8-ounce glass of cool water to ensure you’ve swallowed all the powder.
    • Ensure the applesauce is not hot and is soft enough to be swallowed without chewing.
    • Do not store any leftover powder/applesauce mixture for future use.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Silodosin Work?

Silodosin is part of a class of medications known as alpha-1 blockers. These drugs function in a similar way and are often used to treat comparable conditions. Alpha-1 receptors, located in the prostate and bladder, control the contraction of the smooth muscles in these areas. Silodosin works by blocking these alpha-1 receptors, which leads to the relaxation of the smooth muscles in the prostate and bladder. This relaxation helps to reduce the symptoms of benign prostatic hyperplasia (BPH), such as difficulty in urinating and improves overall urinary flow. By easing muscle tension, silodosin effectively enhances the ability to urinate and alleviates discomfort associated with BPH.

Important Safety Information for Using Silodosin

What Are the Side Effects of Silodosin?

Silodosin oral capsules generally do not cause drowsiness, but they can lead to other side effects. Mild side effects may go away within a few days to a couple of weeks. If these side effects persist or become severe, consult your doctor or pharmacist. Common side effects of silodosin include:

  • Common cold
  • Retrograde ejaculation
  • Headache
  • Stuffy nose
  • Orthostatic hypotension
  • Dizziness
  • Diarrhea

Call your doctor immediately if you experience any serious side effects. If you believe your symptoms are life-threatening or you are having a medical emergency, call 911 right away. Serious side effects of Silodosin may include:

  • Sudden drop in blood pressure. Signs may include:
    • Feeling lightheaded
    • Dizziness
    • Fainting
  • Liver problems. Signs may include:
    • Pale stool color
    • Vomiting
    • Dark urine
    • Loss of appetite
    • Nausea
    • Stomach pain and swelling
    • Yellowing of your skin or the whites of your eyes
    • Bruising easily
    • Unusual or unexplained tiredness
  • Allergic reaction. Signs may include:
    • Hives
    • Problems with breathing or swallowing
    • Blisters on your skin or in your mouth, nose, or eyes
    • Very rapid heartbeat
    • Itching
    • Skin rash
    • Swelling of your face, lips, tongue, or throat
    • Fainting or feeling dizzy
    • Peeling skin
  • Priapism (erection that lasts longer than four hours)

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Silodosin?

This drug comes with several warnings. Here are they:

  • Breastfeeding Warning: This medication is not intended for use in women and is used to treat BPH in men. It is unknown if silodosin passes into breast milk.
  • Fainting and Dizziness Warning: Silodosin may cause low blood pressure, especially when you stand up after sitting or lying down. This can lead to dizziness and fainting. Because of this, avoid driving, using machinery, or performing any tasks that could be dangerous until you know how this medication affects you.
  • Pregnancy Warning: Silodosin is used to treat benign prostatic hyperplasia (BPH) in men and is not intended for use in women. It is categorized as a pregnancy category B drug, meaning animal studies have not shown risk to the fetus, but there are insufficient studies in pregnant women to determine if there is a risk to the fetus.
  • Senior Patients: Seniors aged 65 years and older may be at increased risk of developing low blood pressure when standing up (orthostatic hypotension) while using silodosin. Extra caution is advised for elderly patients due to this increased risk.
  • For Children: The safety and effectiveness of silodosin in children under 18 years old have not been established.
  • Cataract Surgery Warning: Silodosin may affect your pupils during cataract surgery, potentially causing a complication known as intraoperative floppy iris syndrome (IFIS). Inform your eye surgeon if you are taking or have recently taken silodosin.
  • For People with Kidney Disease: Silodosin is partly excreted through the kidneys. If your kidneys are not functioning properly, more of the drug may remain in your body, increasing the risk of side effects. Silodosin is not recommended for those with severe kidney disease. If you have moderate kidney disease, your doctor may prescribe a lower dosage.
  • For People with Liver Disease: Silodosin is processed by the liver. If your liver function is impaired, more of the drug may stay in your body, raising the risk of side effects. Silodosin is not recommended for people with severe liver disease, as its effects have not been studied in this population.
  • For People with Low Blood Pressure (Hypotension): Silodosin may cause low blood pressure when you stand up, leading to dizziness or even further drops in blood pressure. Avoid driving, using machinery, or performing dangerous tasks until you know how silodosin affects you.
  • Allergy Warning: Silodosin can cause severe allergic reactions. Symptoms may include trouble breathing, swelling of the throat or tongue, hives, itching, or rash. If you experience these symptoms, call 911 or go to the nearest emergency room immediately. Do not take silodosin again if you have had an allergic reaction to it, as it could be fatal.

What Are the Silodosin Precautions?

It’s important to have regular visits with your doctor to monitor your progress and check for any adverse effects from the medication. Take the precautions mentioned below:

  • Silodosin may cause dizziness, lightheadedness, or fainting, especially when standing up from a seated or lying position. To manage these symptoms, rise slowly to a sitting position before standing. If you feel dizzy, lie down to prevent fainting, then sit for a few moments before standing.
  • This medication may impair your alertness. Avoid driving or engaging in activities that require full concentration until you know how silodosin affects you.
  • Because benign prostatic hyperplasia (BPH) can present symptoms similar to prostate cancer, and the two conditions can coexist, your doctor may screen for prostate cancer before starting treatment with silodosin.
  • Inform your ophthalmologist that you are using or have used silodosin if you are planning to undergo cataract surgery or any other eye procedures. Silodosin may cause Intraoperative Floppy Iris Syndrome (IFIS), a complication during eye surgery.

What If You Missed a Dose of Silodosin?

If you happen to miss a dose of silodosin, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose (just a few hours away), it’s best to skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to catch up, as this can increase the risk of experiencing dangerous side effects.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Silodosin?

Taking too much silodosin can lead to low blood pressure, particularly noticeable when standing up from a sitting or lying position. Symptoms of an overdose might include:

  • Fainting
  • Feeling dizzy or lightheaded
  • Weakness
  • Confusion
  • Blurry vision

If you suspect an overdose of silodosin, it’s important to act quickly. Contact your doctor or contact the American Association of Poison Control Centers at 1-800-222-1222 or use their online tool for guidance. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Silodosin?

  • Store silodosin at a temperature between 59°F and 86°F (15°C and 30°C).
  • Keep this medication away from light.
  • Do not store silodosin in moist or damp areas, such as bathrooms.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Silodosin?

Silodosin, commonly used to treat symptoms of an enlarged prostate, can interact with various medications, vitamins, or herbs, potentially altering how it works. These interactions can either be harmful or inhibit the drug’s effectiveness. To minimize the risk of interactions, it’s crucial to manage your medications carefully under the guidance of a healthcare professional. Below are the drugs that can interact with silodosin:

  • Antibiotics: Certain antibiotics can also raise silodosin levels, which may increase the likelihood of experiencing side effects. If you are prescribed Clarithromycin or Erythromycin while taking silodosin, it’s crucial to discuss the potential interactions with your healthcare provider. They may need to adjust your medication regimen or monitor you more closely to manage these interactions effectively.
  • Calcium Channel Blockers: When taken with silodosin, calcium channel blockers can increase the levels of silodosin in your body. This interaction could lead to enhanced side effects. Examples of calcium channel blockers include:
    • Diltiazem
    • Verapamil
  • Cyclosporine and Silodosin Interaction: Taking cyclosporine, an immune-suppressing drug, along with silodosin, can lead to increased levels of silodosin in your body. This interaction may heighten the risk of experiencing side effects associated with silodosin. Due to these potential complications, it is generally not recommended to take these two medications together. If you are currently using cyclosporine and require treatment with silodosin, consult your healthcare provider. They can offer guidance on safe medication practices or suggest alternative treatments to avoid adverse interactions.
  • HIV Medications and Silodosin Interaction: HIV medications, particularly those from the protease inhibitor class, can interact with silodosin, leading to increased levels of silodosin in your body. This increase might enhance the likelihood of side effects from silodosin. Some examples of protease inhibitors that should be used cautiously with silodosin include:
    • Darunavir
    • Atazanavir
    • Indinavir
    • Fosamprenavir
    • Saquinavir
    • Nelfinavir
  • Antifungal and Silodosin Interaction: Taking certain antifungal medications with silodosin can significantly increase the levels of silodosin in your body, potentially leading to an increased risk of side effects. Specifically, the following antifungals should not be taken with silodosin:
    • Ketoconazole
    • Itraconazole
  • Other BPH Medications and Silodosin: Combining silodosin with other drugs used to treat benign prostatic hyperplasia (BPH) can lead to an excessive drop in blood pressure. This interaction also raises the risk of orthostatic hypotension, where blood pressure suddenly decreases when standing up from a seated or lying position, potentially causing dizziness or fainting. Here are some BPH medications that should be used with caution if you are also taking silodosin:
    • Doxazosin
    • Alfuzosin
    • Tamsulosin
    • Terazosin
    • Prazosin
  • Erectile Dysfunction Drugs and Silodosin: Taking silodosin in combination with erectile dysfunction medications can lead to dangerously low blood pressure. These drugs can also increase the risk of orthostatic hypotension—a sudden drop in blood pressure when you stand up after sitting or lying down. This condition may result in symptoms such as dizziness or fainting. Some common erectile dysfunction medications that should be used cautiously with silodosin include:
    • Sildenafil
    • Avanafil
    • Vardenafil
    • Tadalafil
  • Blood Pressure Drugs and Silodosin: When taken with silodosin, certain blood pressure medications can cause a significant drop in blood pressure. This combination may also heighten the risk of orthostatic hypotension, a condition where blood pressure falls suddenly upon standing, leading to symptoms like dizziness or fainting. If you are being treated with any of the following blood pressure medications, it is crucial to consult your doctor before combining them with silodosin:
    • Carvedilol
    • Metoprolol
    • Clonidine
    • Atenolol
    • Losartan
    • Valsartan
    • Lisinopril
    • Amlodipine

What Are the Other Silodosin Interactions?

  • Alcohol Interaction Warning: Silodosin may cause dizziness, and drinking alcohol can intensify this effect, as well as cause drowsiness. It is advisable to limit your alcohol consumption to reduce the risk of these side effects while on silodosin. Always consult with your healthcare provider for guidance tailored to your specific health needs.
  • Grapefruit Warning: Drinking grapefruit juice while taking silodosin can raise the levels of this medication in your body, potentially leading to more severe side effects. Before consuming grapefruit or its juice, it’s important to discuss with your doctor if these products are safe for you to use alongside silodosin.

[Note: This isn’t a complete list, and there could be other drugs that interact with Silodosin. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Silodosin Alternatives?

There are several alternatives to silodosin available for treating conditions like benign prostatic hyperplasia (BPH). Each medication has its own benefits and may be more suitable depending on individual health factors and how one responds to treatment. Here are some alternatives:

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Silodosin Cost & Coupons

Silodosin is a vital medication for managing symptoms of BPH (benign prostatic hyperplasia), but the retail price can be steep, sometimes surpassing $800 monthly in the USA. To help make Silodosin more affordable, patients can consider purchasing it from Canadian pharmacies, which often offer lower prices. For U.S. residents looking to buy Silodosin online from Canada, Polar Bear Meds is a trustworthy option. They provide competitive pricing, and by using the Silodosin coupon code “WELCOMEPB10” at checkout, customers can receive a 10% discount on their first order. Additionally, for further savings, consider joining our referral program to obtain a free coupon for your next purchase. This approach ensures that Silodosin is more accessible to those in the USA from Canada, helping manage healthcare costs effectively.

Frequently Asked Questions

Does silodosin shrink the prostate?

Silodosin does not shrink the prostate gland. Rather, it functions by relaxing the muscles in the prostate and bladder. This action helps to alleviate symptoms and improve urine flow. By easing muscle tension in these areas, silodosin assists patients in experiencing fewer symptoms related to an enlarged prostate.

Why is silodosin given at night?

Silodosin is often prescribed to be taken at night to minimize the risk of dizziness or fainting, which are possible side effects of the medication. By taking the first dose at bedtime with food, your body can gradually adjust to the effects of silodosin while you are asleep, reducing the likelihood of these side effects occurring during your daily activities. The amount of silodosin you take is tailored to your specific medical condition and how well you respond to the treatment. For the best results, it’s important to take this medication consistently as directed by your doctor.

Can silodosin be taken long-term?

Yes, silodosin can be taken in the long term. It is prescribed for patients with BPH (benign prostatic hyperplasia) to help manage symptoms of an enlarged prostate. As a long-term medication, it is important not to stop taking silodosin suddenly without consulting a doctor. Many patients use it continually to maintain relief from their symptoms.

Can you just stop taking silodosin?

You should not stop taking silodosin without consulting your doctor. It’s important to follow your doctor’s instructions closely, taking the medication exactly as prescribed. Silodosin helps manage symptoms of BPH (benign prostatic hyperplasia) but does not cure the condition. Therefore, even if you feel well, you should continue taking silodosin to maintain symptom control. Stopping the medication abruptly can cause your symptoms to return or worsen. Always talk to your doctor before making any changes to how you take your medication.

Can you take silodosin and Viagra?

Taking silodosin (Rapaflo) together with sildenafil (Viagra) might not be advisable because this combination can cause a significant drop in blood pressure. This can lead to symptoms like dizziness or fainting, particularly when standing up from a sitting or lying position. Always consult your doctor before combining these medications to ensure it is safe based on your overall health and specific medical conditions.

Who should not take silodosin?

Silodosin is not suitable for everyone. It should not be used by women, and its effects during pregnancy or while breastfeeding are not known. Additionally, silodosin is not approved for anyone under the age of 18. It’s important for individuals who do not meet these criteria to avoid taking silodosin and consult a healthcare provider for alternative treatments.

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