Methimazole

Tapazole

Tapazole is an FDA-approved medication used for the treatment of hyperthyroidism, which is an overactive thyroid gland. Doctors also prescribe this medication before surgery and radioactive iodine treatment for treating the overactive thyroid gland. Tapazole is available in the market in the form of oral tablets with different strengths. While it is suitable for adults and children to use, the dosage may vary based on the severity of the medical condition and the body weight. Therefore, always talk to a healthcare provider before starting your treatment with Tapazole. Moreover, Tapazole is a prescription medication, so do not share your tablets with other people, even if they share the same condition. Doing so may increase the risk of side effects, causing fatal situations. 

Product Overview

Tapazole, a widely prescribed medication for treating hyperthyroidism (overactive thyroid), contains the active ingredient Methimazole. This component restricts the production of thyroid hormones, effectively controlling the symptoms associated with overactive thyroid. Tapazole is an FDA-approved prescription drug, which ensures its safety and efficacy for patients diagnosed with hyperthyroidism. It is commonly recommended by healthcare professionals for its reliable performance in managing thyroid hormone levels.

Tapazole is available in tablet form, with 5, 10, and 20 mg strengths. The medication should be taken exactly as prescribed by your healthcare provider, typically thrice daily, depending on your condition. It can be taken with or without food. Tapazole is suitable for adults and children over the age of 6 under the supervision of a healthcare provider. Methimazole, the active ingredient, works by blocking the thyroid gland’s ability to produce excessive thyroid hormones, thereby normalizing thyroid function and alleviating symptoms of hyperthyroidism.

Common side effects of Tapazole may include nausea, headache, joint pain, and dizziness. It is crucial to follow your medical provider’s advice to minimize these effects. In case of a missed dose, take it as soon as you remember unless it is almost time for your next dose—do not double up. In the event of an overdose, get medical attention immediately. Patients should inform their healthcare practitioner of any existing health conditions or allergies before starting Tapazole. Tapazole offers a reliable solution for managing hyperthyroidism, ensuring patients can lead healthier lives with controlled thyroid hormone levels.

What Are the Uses of Tapazole?

Tapazone is used for the following purposes:

• Hyperthyroidism Treatment: This medication is used for treating hyperthyroidism, known to be an overactive thyroid gland. It reduces the production of excessive thyroid hormones.
• Preparation for Thyroid Surgery: Before going to thyroid surgery, this medication is prescribed to lower thyroid hormone levels.
• Preparation for Radioactive Iodine Treatment: Tapazole can also be used as a preparation before radioactive iodine treatment for hyperthyroidism.

What Are the Forms & Strengths of Tapazole?

It is available in an oral tablet form with the following strengths:

• 5 mg
• 10 mg, and
• 20 mg

What Are the Recommended Dosage of Tapazole?

The dosage recommendations for Tapazole depend on several factors, including the type/severity of your medical condition and the dose of medication you take. Generally, medical professionals prescribe a starting dose and gradually adjust the drug doses as needed. It is important to note that the dosage recommendations below are only for the average dose. So, if you have been prescribed a different dose, do not change it without consulting your medical practitioner.

Dosage for Hyperthyroidism 

• For Adults: The initial dose is 15 to 60 mg of Tapazole each day, given in three divided doses every eight hours. Then the doctor will prescribe a maintenance dose of 5 to 15 mg each day.
• For Children: Pediatric doses are based on the body weight, so it should be determined by your medical practitioner. The starting dose is 0.4 mg per kg of body weight each day. The doses are divided in three equal parts and given every eight hours. Doctors will then prescribe a maintenance dose of 0.2 mg per kg each day.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Tapazole?

• Read the medication guide or PIL (patient information leaflet) thoroughly to know the correct steps of administration. Doing so will prevent from any serious complications. If you have any questions, you can your doctor.
• Follow the prescribed doses exactly as they are mentioned on the prescription label.
• Do not exceed or subceed the doses without consulting your medical practitioner. This will increase the risk of side effects.
• Take the medication orally, with or without food, thrice a day or as your doctor prescribes.
• Children’s dosages are based on their body weight. Therefore, do not take the medication without consulting a medical professional.
• If you are taking more than one dose in a day, take them at regular intervals. If you need expert opinion on when to take the medication, talk to your doctor.
• Take your medication regularly at the same time to get the most benefit from it.
• Swallow the tablets as a whole with a full glass of water.
• If you are unable to swallow the tablets, talk to a medical professional. They will suggest alternate options, suiting your body needs.
• Avoid breaking, crushing, chewing, or splitting the tablets. Doing so may release the drug at once.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Tapazole Work?

Tapazole works by reducing the production of thyroid hormones in the thyroid gland. Its active ingredient, Methimazole, restricts the thyroid peroxidase enzyme, which is crucial for synthesizing these hormones. By blocking this enzyme, Tapazole effectively decreases thyroid hormone levels in the body, helping to control the symptoms of hyperthyroidism, such as rapid heart rate, excessive sweating, and weight loss. This allows the thyroid gland to gradually return to normal function, providing relief from the overactive thyroid symptoms. Tapazole is prescribed by healthcare professionals to ensure proper management and monitoring of thyroid hormone levels.

Important Safety Information for Using Tapazole

What Are the Side Effects of Tapazole?

Common Side Effects of Tapazole: This medication may lead to various side effects, which are usually not permanent. These temporary reactions may stay for a few days to weeks. However, if these side effects persist for a long time and get intense over time, visit the nearest clinic and get immediate medical assistance. Common side effects of Tapazole may include:

• Mild skin rash/itching
• Headache
• Hives
• Skin pigmentation
• Neuritis (nerve inflammation)
• Drowsiness
• Dizziness
• Stomach upset
• Edema
• Lymph node diseases
• Nausea
• Vomiting
• Muscle, joint, or nerve pain
• Swelling
• Hair loss
• Change in taste
• Cough
• Unusual sensations like prickling, burning, tingling, tightness, and pulling
• Reduced platelets

Serious Side Effects of Tapazole: Besides common effects, Tapazole may lead to various serious effects, which can be life-threatening to certain patients. If you are noticing any such signs that seem concerning, reach out to a healthcare professional. Serious side effects of Tapazole may include:

• Jaundice
• Dark urine
• Persistent nausea or vomiting
• Change in the amount of urine
• Extreme stomach or abdominal pain
• Agranulocytosis (reduced white blood cell counts)
• Liver toxicity 
• Low thyroid levels. Its symptoms may include:
  • Unusual weakness
  • Fatigue
  • Increased sensitivity to cold
  • Constipation
  • Hair loss
  • Weight gain
  • Depression
• Dry skin
• Sore throat
• Chills
• Unusual bleeding or bruising
• Skin eruptions

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Tapazole?

Tapazole can cause severe side effects in certain patients, or it may not be an ideal treatment option for specific populations due to their medical conditions. So, if you are using this medication, you should remain cautious. Its warnings are as follows:

• Lactose Warning: Tapazole contains lactose monohydrate. Therefore, [atients with hereditary problems like galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency should not take this medication. This may result in severe allergic reactions, which can cause life-threatening situations.
• Anticoagulant Therapy: Co-administration of Tapazole (Methimazole) and warfarin drugs may have certain interactions. Methimazole alters thyroid function, which simultaneously impacts the response of anticoagulant medications. So, patients taking these medications should remain under the supervision of a medical professional. Moreover, if you are starting, discontinuing, or adjusting your Tapazole doses, do it under medical assistance, as this shift can cause two serious concerns such as agranulocytosis and liver toxicity.
• Skin Issues: This medication is not recommended for patients with skin problems like exfoliative dermatitis. Using Tapazole in such conditions may cause serious side effects. Talk to an expert practitioner or dermatologist before making any decision.
• Pregnant Women: Such a group of patients who have untreated Graves’ disease should not take this medication. Doing so may increase the risk of complications like maternal heart failure, neonatal hyperthyroidism, preterm birth, and sudden abortion. Methimazole can cross the placental membrane, affecting the unborn baby. So, doctors usually give a sufficient but not excessive dose of Methimazole during pregnancy. In some cases, anti-thyroid therapy can be stopped a few weeks or months before delivery.

What Are the FDA Boxed Warning for Tapazole?

Boxed warnings, sometimes referred to as black-boxed warnings, are said to be the most stringent guidelines issued by the FDA. These warnings alert doctors and patients about the harmful effects of a particular drug, which can be life-threatening if overlooked. Tapazole has some boxed warnings, so if you are taking this medication, be mindful of the following warnings:  

• Agranulocytosis (Low Blood Cell Count): This condition is among the most serious side effects of Tapazole. Its symptoms may include fever and sore throat. If you are experiencing any of these during your treatment with this medication, talk to your doctor. Moreover, Tapazole may also cause thrombocytopenia, aplastic anemia, and leukopenia. In such situations, discontinue using this medication, and the doctor should monitor the patient’s bone marrow function. 
• Liver Toxicity: Both Methimazole and propylthiouracil can cause severe liver reactions. Although rare, there have been reports of fulminant hepatitis, hepatic necrosis, encephalopathy, and even death. Cholestatic jaundice is also possible. Patients taking these medications should watch for symptoms of liver dysfunction, including jaundice, loss of appetite, itching, or pain in the upper right abdomen. If any of these symptoms occur, they should seek medical assistance and consider stopping this medication.

What Are the Tapazole Precautions?

When considering treatment with Tapazole, patients should discuss every risk and benefit with their medical practitioner. Here are some of the precautions that you can take before using this anti-thyroid drug:

• Before taking Tapazole, tell your healthcare provider about your allergies or if you are allergic to any of the product’s ingredients. The product may contain certain inactive components that can cause severe allergic reactions. 
• When considering treatment with Tapazole, inform your doctor about your or your family’s medical history, especially of any: 
  • Blood disorders
  • Liver problems
  • Pancreatitis
• If you are undergoing any surgery or medical procedure, tell your surgeon or healthcare practitioner about the products you use. This includes all prescription drugs, over-the-counter medications, and herbal products.
• It is important to note that Tapazole is not recommended for use in pregnant women during their first three months. Your practitioner may suggest other anti-thyroid medications during that time. However, if you need Methimazole for emergency treatment, your doctor may prescribe the medicine in the last six months of your pregnancy. Therefore, discuss every risk and benefit with your doctor if you are pregnant or planning to have a baby.
• Methimazole may pass into the breast milk. So, if you are a nursing mother and taking this medication, talk to your doctor, as it may cause adverse effects on the breastfeeding child. 
• While rare, Tapazole may temporarily reduce the white blood cell count, increasing the chances of infection. To reduce the chance of infection:
  • Avoid contact with people having infections. If you think you have an infection, fever, cough, lower back pain, or chills, visit a medical professional. 
  • If you observe unusual bleeding, bruising, or blood in urine or stools, consult with your doctor.
  • Avoid touching your nose or eyes when you have not washed your hands. This may increase the risk of infections. 
  • When using sharp objects like razors or cutters, beware of not cutting yourself. Additionally, avoid sports that involve bruising or injury.
• If you are experiencing symptoms including nausea, vomiting, not feeling hungry, pale stools, dark urine, or stomach pain, talk to a medical practitioner, as these may be signs of liver problems.
• Closely monitor your child’s progress at regular intervals to make sure that the medication is working properly & not causing any adverse effects. Your doctor may order blood & urine tests to check for unwanted results.
• Tapazole may result in very low levels of thyroid hormone in the blood. So, if you are noticing a depressed mood, dry skin, constipation, dry skin, hair loss, husky voice, muscle cramps, weight gain, or sudden tiredness, contact a medical professional.

What Are the Contraindications of Tapazole? 

It is contraindicated in: 

• Patients with hypersensitivity reactions to Tapazole or any of its ingredients.
• Nursing mothers, as the drug can pass into the breast milk.

What If You Missed a Dose of Tapazole?

Generally, it is advisable not to miss any doses of Tapazole, but if someone forgets, they can:

• Take the tablets as soon as possible or whenever you remember.
• If it is almost time for the next dose, you may omit the missed dose and follow your regular dosing schedule as your doctor instructed.
• Remember not to take double doses of your prescribed medication just for the sake of making up for the missed dose. This may cause adverse side effects.
• Use medication apps or set reminders on your phone to avoid skipping any doses.
• Take each dose at the same time every day to get the most benefit out of it.
• If you are still unsure about the missed doses, talk to an expert physician. They will guide you and suggest alternate options.  

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Tapazole?

While patients are educated enough to know the complications of overdose, there are times when they mistakenly take an excessive amount of Tapazole tablets. In such cases, patients are advised not to panic and instead look for unusual signs like:

• Nausea
• Vomiting
• Fever
• Rash
• Joint pain
• Edema (swelling)
• Stomach discomfort

If you are experiencing such overdose symptoms, visit the nearest clinic or get medical assistance immediately by calling 911.  

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Tapazole?

• Store the medication at a room temperature of 15 to 30°C.
• Keep the tablets in a tightly locked container, away from direct sunlight.
• Store the medicine somewhere safe, away from the reach and sight of children.
• Place safety locks on the container to avoid poisoning the children and pets. There are many products in the market that are not child-resistant.
• Do not flush the medication down the toilet.
• Avoid keeping the medicines in moist or damp areas, like the bathroom or near the sink.
• Do not keep the product under extreme heat.
• Avoid refrigerating the medication.
• Do not use a medication if its expiration date has passed. The expiration date is the last day of the month mentioned on the back of the prescription label or carton.
• You should dispose of the medications in such a way that children and animals cannot consume them, as it may cause accidental overdose and death if someone else consumes them.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.
• Ask a medical professional or pharmacist how to dispose of the medication properly without damaging the environment.
• Read the product’s label for detailed storage information.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Tapazole?

Drug interactions occur when one or more medications are taken simultaneously. These interactions can either raise the risk of developing side effects in certain patients or affect the functioning of one of the drugs. Either way, it results in adverse reactions. Therefore, patients need to be aware of the drugs that may interact with their Tapazole medication. Below are some of the drugs that can interact with Tapazole:

• Aminophylline
• Anisindione
• Brentuximab
• Bedaquiline
• Clofarabine
• Clozapine
• Daclizumab
• Deferiprone
• Efavirenz
• Fluphenazine
• Isoniazid
• Ketoconazole
• Labetalol
• Leflunomide
• Levoketoconazole
• Lomitapide
• Metoprolol
• Mipomersen
• Naltrexone
• Oxtriphylline
• Pegaspargase
• Pexidartinib
• Prednisolone
• Propranolol
• Remdesivir
• Rifampin
• Teriflunomide
• Theophylline
• Valoctocogene roxaparvovec
• Warfarin

What Are the Other Tapazole Interactions?

Besides drugs, the presence of some medical problems may also affect the functioning of Tapazole. If you have the below conditions, you may experience Tapazole interactions:

• Blood or bone marrow problems
• Leukopenia (low white blood cells) 
• Agranulocytosis
• Aplastic anemia 
• Breathing problems 
• Kidney disease
• Liver problems
• Lung diseases
• Thrombocytopenia (low platelets in the blood)
• Hypoprothrombinemia (a blood disorder)
• Blood dyscrasias

[Note: This isn’t a complete list, and there could be other drugs that interact with Tapazole. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Tapazole Alternatives?

People usually take alternative drugs for many reasons. In some cases, the prescribed medication may not be an ideal option for them due to their medical conditions. On the other hand, they may not achieve the results they are aiming for. Therefore, you should talk to a medical professional before you start a particular treatment or if you want to change your medication. They may help you decide which medication is best suited for you. Some of the alternatives to Tapazole are as follows:

• Propylthiouracil
• Potassium iodide
• ThyroShield
• Sodium iodide-i-131
• Hicon
• I3odine Max
• Propranolol
• Nadolol
• Metoprolol

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Tapazole Cost & Coupons

It is important to note that Tapazole’s cost is not the same everywhere. The actual price of these tablets depends on several factors, including your insurance plan, location, and the pharmacies you use. Tapazole, with its anti-thyroid qualities, can be expensive for certain patients. Here, insurance coverage plays a significant role. You can buy your medication at affordable rates with an insurance coverage plan. However, not all drugs/medications are covered under the insurance plan. If you are residing in America and searching for affordable pharmacies to manage your medication’s cost, reach out to Polar Bear Meds. Here, you can buy Tapazole online from Canada or the USA at discounted rates. Moreover, first-time buyers can use the Tapazole coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

Can thyroid be cured permanently with Tapazole?

Tapazole is effective in managing hyperthyroidism but does not cure it permanently. While it controls thyroid hormone levels and alleviates symptoms, some patients may achieve long-term remission, others might require ongoing therapy or alternative treatments like radioactive iodine or surgery. Regular follow-up with your medical provider is essential for monitoring and managing your thyroid condition to ensure the best possible outcome and adjust treatment as needed.

Does Tapazole make my blood thinner?

Tapazole does not have a blood-thinning effect. It specifically targets thyroid hormone production in the thyroid gland to manage hyperthyroidism. If you are taking blood-thinning medications or have any concerns about blood clotting, it’s important to discuss these with your healthcare provider. They can offer personalized advice & ensure that Tapazole is safe to use alongside any other medications you may be taking to avoid any adverse interactions.

Does Tapazole cause weight gain?

Tapazole itself does not directly cause weight gain. However, by normalizing thyroid hormone levels it can lead to changes in weight. Patients with hyperthyroidism often lose weight due to an overactive metabolism, and Tapazole can stabilize this. As thyroid function is controlled, some may regain lost weight or experience weight stabilization. Maintaining a healthy diet & exercise routine is crucial, and any significant weight changes should be discussed with your healthcare provider for appropriate guidance.

Can I take Tapazole at night?

Yes, Tapazole can be taken at night. The timing of your dose should be consistent each day and as prescribed by your healthcare provider. Whether taken in the morning or at night, maintaining a regular schedule ensures effective management of your thyroid hormone levels. Always follow your healthcare provider’s instructions on how to take Tapazole for optimal results and to ensure the medication’s effectiveness in managing your condition.

Does Tapazole increase cholesterol levels?

Tapazole does not directly increase cholesterol levels. However, as it manages hyperthyroidism by normalizing thyroid hormone levels, changes in cholesterol levels may occur. Hyperthyroidism often causes lower cholesterol levels due to an increased metabolism. Once thyroid levels are stabilized with Tapazole, cholesterol levels might return to normal. Regular monitoring of your cholesterol and thyroid levels by your healthcare provider will help manage any changes effectively and maintain overall health.

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