Tolcapone

Tasmar 

Tasmar is an essential medication for managing Parkinson’s disease, mainly when used alongside carbidopa/levodopa. It functions by inhibiting the catechol-O-methyltransferase (COMT) enzyme, thereby enhancing the availability of dopamine in the brain and helping to alleviate symptoms like tremors and stiffness. This mechanism is especially beneficial for managing levodopa’s ‘wearing-off’ effect. This drug is available in 100 mg & 200 mg tablets. It requires careful management due to potential side effects, including severe liver damage and neurological issues. Regular liver function tests are mandatory for monitoring, and with a prescription from your doctor, you can order Tolcapone Tasmar online from Canada easily.

Product Overview

Tasmar (tolcapone) is a crucial medication for managing Parkinson’s disease, particularly effective as an adjunct treatment to carbidopa/levodopa. It enhances the availability of dopamine in the brain by inhibiting the catechol-O-methyltransferase (COMT) enzyme, which metabolizes levodopa. This mechanism helps reduce symptoms like tremors, stiffness, and slow movement. It is particularly beneficial in managing the ‘wearing-off’ effect, where the benefits of levodopa decrease before the next dose.

Tasmar is available in oral tablet form with strengths of 100 and 200 mg. It is typically administered thrice daily with adjustments needed based on patient response and side effects. Patients must adhere strictly to their prescribed regimen and undergo regular liver function tests due to the risks of liver toxicity. Despite its effectiveness, Tasmar can cause side effects ranging from mild—such as nausea and dizziness—to severe, including liver damage and hallucinations.

Tasmar for Parkinson’s disease management is contraindicated in patients dealing with liver disease or severe psychiatric conditions. Interactions with other medications like antidepressants, antipsychotics, and certain antibiotics are also concerns that require careful management. WIth a valid prescription you may buy Tasmar online from Canada easily. Check-in with your doctor regularly for medical oversight, it is essential to balance benefits against potential risks.

What Is Tasmar Used For?

• Tasmar is used to treat Parkinson’s disease (PD).

What Strengths Do Tasmar Come In?

This medication usually comes in tablet form and is available in the following strengths:

• Tasmar 100 mg tablet
• Tasmar 200 mg tablet

What Is the Typical Dosage of Tasmar?

The typical dosage for Tasmar, which is used primarily for the treatment of symptoms in Parkinson’s disease, varies depending on factors such as the specific condition being treated and its severity. Here’s how the dosage typically works:

• Starting Dosage: Doctors usually prescribe an initial dose based on your current health status and other medications you might be taking.
• Adjustments: Over time, your doctor might adjust the dosage of Tasmar based on how well the medication is working for you and how you respond to the treatment.

It’s important to remember that the dosage information provided here is a general guideline. You should strictly follow the dosage your doctor has prescribed for you.

Dosage of Tasmar for Parkinson’s Disease

• Initial Dosage
  • Adults: The initial recommended dose of Tasmar is 100 mg three times a day. This dosage is used as a starting point to assess tolerance and effectiveness in improving symptoms of Parkinson’s disease.
• Maintenance Dosage
  • If the initial dose is well-tolerated and effective, it usually remains at 100 mg thrice daily.
  • However, the dosage of Tasmar for Parkinson’s disease management can be adjusted depending on the patient’s response and any side effects. Some patients may require a lower dose if they experience adverse effects.
• Dosage Adjustments
  • Liver Function: Tasmar should not be used in patients with liver disease or significantly impaired liver function due to the risk of liver injury.
  • Elderly Patients: Generally, the starting dose does not change for elderly patients, but they may be more sensitive to the effects of Tasmar, necessitating careful monitoring and possibly requiring dosage adjustments based on tolerance and medical response.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your medical expert, and they’ll customize your dosage accordingly.]

How Do You Use Tasmar?

Always follow the specific instructions provided by your healthcare provider for using Xifaxan effectively. If you have any questions or concerns about taking this medication, do not hesitate to contact your doctor or pharmacist.

• Tasmar is typically taken three times daily, with evenly spaced doses. It should be taken at the exact times each day to maintain an even level of the medication in the body.
• Tasmar can be taken with or without a meal. However, taking it with food may help reduce nausea, a common side effect.
• Tasmar for Parkinson’s disease management is used in combination with levodopa and carbidopa. It is essential to continue taking all Parkinson’s disease medications as prescribed by your doctor.
• The entire tablet should be swallowed with a glass of water. The tablet must not be crushed, chewed, or split.
• Routine follow-up visits with your healthcare specialist are essential. They will check your response to the medication, adjust doses if necessary, and check for any side effects.
• Liver function tests must be performed regularly as Tasmar can increase liver enzymes and potentially cause liver damage.
• Be aware of potential side effects such as diarrhea, nausea, and vivid dreams or hallucinations. If you experience significant side effects, contact your healthcare provider for advice.
• Serious side effects, for instance symptoms of liver problems (e.g., yellowing of the skin or eyes, dark urine, abdominal pain), require immediate medical attention.
• Consistent medication adherence is crucial for managing symptoms of Parkinson’s disease effectively. Do not stop taking Tasmar or change the dose without consulting your healthcare provider.
• Avoid driving or operating machinery or vehicles if you experience dizziness or drowsiness from the medication.
• Limit alcohol consumption in all ways possible, as it can heighten the chances of liver damage.

[Note: Your medical expert will decide the appropriate dosage amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Tasmar Work?

Tasmar treats Parkinson’s disease. Parkinson’s disease causes symptoms like shaking, stiffness, and slow movement because there isn’t enough dopamine, a vital chemical, in the brain. Levodopa helps by increasing dopamine levels, but a lot of it gets broken down before it can reach the brain. This breakdown is done by an enzyme called catechol-O-methyltransferase (COMT). Tasmar works by blocking this enzyme, which means more levodopa can get into the brain and turn into dopamine. This helps reduce Parkinson’s symptoms and manages the issue where the effects of levodopa wear off before it’s time for the next dose. Although Tasmar does not cure Parkinson’s disease, it plays a crucial role in controlling its symptoms and improving the quality of life for those affected.

What Are the Important Safety Information for Using Tasmar?

What Are the Side Effects of Tolcapone (Tasmar)?

Common Tasmar Side Effects: While taking Tasmar, you might experience some side effects that are generally common and temporary, lasting from a few days to a couple of weeks. If these side effects do not go away, become bothersome, or intensify, it’s important to consult your doctor or pharmacist to ensure your safety. Here are some common side effects associated with Tasmar:

• Dyskinesia: This is when you might notice involuntary, uncontrollable movements.
• Nausea: Feeling like you are going to vomit.
• Sleep Disturbances: Trouble falling asleep, staying asleep, or experiencing disrupted sleep.
• Diarrhea: Frequent loose or watery bowel movements.
• Excessive Dreaming: Having more dreams than usual, which can be vivid or disturbing.
• Confusion: Feeling unusually perplexed or unable to think clearly.
• Hallucinations: Seeing, hearing, or feeling things that are not really there.
• Orthostatic Hypotension: A sudden drop in blood pressure when you stand up, which might make you feel dizzy or lightheaded.
• Vomiting: Throwing up.
• Loss of Appetite: Not feeling hungry or interested in eating.
• Muscle Cramps: Painful tightening of the muscles, often suddenly.
• Increased Sweating: Sweating more than usual without a clear reason.
• Abdominal Pain: Pain or discomfort in the stomach area.
• Fatigue or Weakness: Feeling more tired or weaker than usual, even after rest.
• Headache: Pain or discomfort in the head.
• Dizziness: Feeling unsteady, as if the room is spinning around you.
• Urine Discoloration: Changes in the color of your urine, which is usually harmless but noticeable.

Serious Tasmar Side Effects: Tasmar can cause serious side effects that may need immediate medical attention. If you experience any of the following severe reactions while taking Tasmar, contact your doctor right away. In cases where the side effects seem life-threatening, or if you think you’re having a medical emergency, call your local emergency number or 911 immediately. Here are the serious side effects associated with Tasmar:

• Severe Liver Injury or Failure: This is a very serious condition where your liver stops working properly, which can be life-threatening and might require a liver transplant.
• Neuroleptic Malignant Syndrome (NMS): This rare but critical condition is marked by a high fever, stiff muscles, and confusion. It can cause severe health issues and needs urgent medical care.
• Rhabdomyolysis: This is when muscle tissue breaks down rapidly, releasing substances into the blood that can lead to kidney damage.
• Severe Orthostatic Hypotension: A significant and sudden drop in blood pressure when you stand up, which can make you feel dizzy or faint.
• Hallucinations or Psychotic-like Behavior: Some people, especially the elderly or those with a history of psychiatric issues, may experience seeing or hearing things that aren’t there, or they might display behaviors that are out of character or extreme.
• Severe Dyskinesia: This involves uncontrollable and often severe movements that can disrupt daily activities.
• Impulse Control Disorders: Some people may start showing compulsive behaviors, such as gambling, excessive shopping, or increased sexual urges.
• Significant Changes in Heart Rhythm: This can include QT prolongation, a specific measure on an ECG that can indicate abnormal heart rhythms, which may be dangerous.
• Severe Diarrhea: Persistent and severe diarrhea can lead to a loss of too much body water and salts, which is dangerous and needs to be treated.
• Hyperpyrexia and Confusion: This is a sudden, extremely high fever combined with confusion, often occurring if the medication is stopped suddenly.

[Note: Remember, this list does not cover all Tasmar side effects. Always consult with your healthcare expert for medical supervision about side effects.]

Are There Any Warnings for Using Tasmar? 

Tasmar for Parkinson’s disease management can cause significant health risks, especially for individuals with certain pre-existing conditions. Discuss these risks with your doctor or pharmacist and consider alternative treatments if you’re concerned.

• Serious Liver Damage: Tasmar may lead to severe, potentially life-threatening liver damage. It should be avoided by individuals with existing liver issues or a history of liver damage due to tolcapone. Regular liver tests will be conducted to monitor your liver health. Symptoms such as yellowing of the skin or eyes, pale stools, fatigue, and loss of appetite are urgent and should be reported immediately. If you see no improvement within 3 weeks of starting the medication, your doctor may discontinue its use.
• Sleepiness and Sudden Sleep Episodes: Tolcapone can unexpectedly cause deep sleep or sleepiness during daily activities. Avoid driving or doing tasks that require mental alertness until you understand how tolcapone affects you. Report any instances of sudden sleep onset or excessive daytime sleepiness to your healthcare provider.
• Low Blood Pressure and Fainting: Tolcapone may cause a sudden drop in blood pressure levels when standing, leading to falls or fainting. Inform your doctor if you experience such symptoms. To minimize risks, rise slowly from sitting or lying positions and stabilize yourself.
• Hallucinations and Behavioral Changes: Increases in dopamine levels from tolcapone can lead to hallucinations, delusions, confusion, aggression, and altered perception. These effects may appear soon after starting the medication or after a dosage increase. Contact your doctor if these symptoms occur; a dose adjustment may be necessary.
• Impulse Control Problems: Some patients experience diminished impulse control under the influence of Parkinson’s disease medications like tolcapone, presenting as uncontrollable urges to gamble, overeat, spend money, or increase sexual urges. If these behaviors disrupt your life, discuss with your doctor for possible dose adjustments or discontinuation of the medication.
• Muscle Damage (Rhabdomyolysis): Tolcapone has been linked to severe muscle damage that can escalate to kidney damage. Symptoms like muscle pain, tenderness, cramping, or dark-colored urine require immediate medical attention, as these may indicate rhabdomyolysis.

What Is the FDA Black Box Warning for Tasmar?

Tasmar is a medication used in the treatment of Parkinson’s disease. It has a significant FDA-boxed warning due to its potential for serious side effects. Here are the critical points of the FDA boxed warning for Tasmar:

• Risk of severe liver injury:

• • • Tasmar can cause severe, sometimes fatal, liver injury.
    • Cases of acute liver failure causing death or liver transplant have been reported.

• Liver monitoring:

• • • Liver function tests must be performed before beginning the treatment and regularly during therapy.
    • Treatment should be discontinued if liver enzyme levels become elevated or signs and symptoms of liver dysfunction develop.

• Limited use:

• • • Tasmar should only be used in Parkinson’s disease patients who are experiencing symptom fluctuations and are unable to respond satisfactorily to other therapies.

• Informed consent:

• • • Patients must be informed about the risk of liver injury and the need for routine checkups.
    • They should be made aware of the signs and symptoms of liver disease.

• Discontinuation:

• • • Tasmar should be discontinued if no substantial clinical benefit is observed within 3 weeks of starting the medication.

• Reintroduction:

• • Retrial of Tasmar in patients who have developed liver injury is not recommended.

What Are the Precautions for Using Tasmar?

When you buy Tasmar online from Canada or start your treatment with it, always remember to discuss both the potential risks and benefits of the medication with your doctor. Here are some important steps of precautions to consider:

• Allergies and Pre-existing Conditions: Do not use Tasmar for Parkinson’s disease management if you are allergic to it, have liver disease, have a history of liver problems caused by Tasmar, or have previous muscle damage or fever and confusion caused by any medication.
• MAO Inhibitors: Avoid using Tasmar if you have used any MAO inhibitors within the last 14 days due to the risk of dangerous drug interactions. These include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.
• Liver Failure Risk: Tasmar may lead to liver failure. Before receiving a prescription, you might need to sign a Patient Consent form.
• Health History Requirements: Inform your doctor if you have had liver disease, kidney disease, or low blood pressure to ensure Tasmar is safe for you.
• Increased Cancer Risk: People with Parkinson’s disease may face a higher risk of melanoma. Discuss with your doctor about this risk and the skin symptoms to monitor.
• Pregnancy and Breastfeeding: The effects of Tasmar on an unborn baby are unknown. Inform your doctor if you are pregnant or plan to become pregnant. It’s also unclear whether Tasmar passes into breast milk; inform your medical professional if you are breastfeeding.

What Are the Contraindications for Tolcapone?

Tasmar has several contraindications, but its use is not recommended or should be avoided due to the risk of severe side effects. Here are the critical contraindications for Tasmar:

• Liver Disease: Tasmar is contraindicated in patients with liver disease or elevated liver enzymes. It has been associated with cases of severe hepatotoxicity, including fulminant liver failure leading to death or liver transplant.
• History of Tolcapone-Induced Hepatotoxicity: Patients who have previously experienced hepatotoxicity related to tolcapone should not be re-exposed to the medication.
• MAO Inhibitors: Concomitant use with non-selective monoamine oxidase (MAO) inhibitors is contraindicated because of the risk of hypertensive crisis. However, selective MAO-B inhibitors (used in Parkinson’s disease) are cautiously allowed.
• Hypersensitivity: Tasmar should not be used by patients with a known hypersensitivity to tolcapone or any formulation component, as this could lead to severe allergic reactions.
• Pheochromocytoma: Due to the potential for exacerbating hypertension, Tasmar should be avoided in patients with pheochromocytoma.

What If You Miss a Dose of Tasmar?

• If you miss a dose of Tasmar, take it as soon as you remember unless it is nearly time for your next scheduled dose. In that case, leave the missed dose and continue your regular dosing schedule. 
• Do not take up double doses of Tasmar to compensate for the missed one, which could lead to increased side effects. 
• Maintaining a consistent schedule with your medication is crucial for dealing with the symptoms of Parkinson’s disease effectively, so it’s helpful to use reminders or alarms to avoid missing doses in the future. 
• If you frequently forget doses, discuss this with your healthcare provider to seek additional strategies or adjustments to your treatment plan.

[Note: If you have missed a dose of Tasmar and are not sure about the next dose, immediately consult your doctor or pharmacist.]

What to Do If You Take Too Much Tasmar?

Taking an overdose of Tasmar for Parkinson’s disease management can lead to serious health complications. Symptoms of a Tasmar overdose can include confusion, agitation, hallucinations, severe nausea and vomiting, rapid heart rate, and possibly hypotension (low blood pressure). If you suspect that you or someone else has taken an overdose of Tasmar, it is crucial to seek immediate medical attention.

[Note: If you have consumed this medication more than the prescribed dose, get medical help right away or call the nearest Poison Help line at 1-800-222-1222.]

How Do You Store Tasmar Tablets?

When you buy Tasmar online from Canada, to properly store it, follow these guidelines:

• Store at room temperature, ideally between 20°C to 25°C.
• Store the medication in a dry place away from direct heat and moisture. Avoid storing it in the bathroom.
• Keep it tightly closed in its original container to protect it from light.
• Ensure that Tasmar is kept out of reach of children & pets to prevent accidental ingestion.
• Regularly check the expiration date on the Tasmar packaging and discard any expired medication properly.

[Note: Discuss with your healthcare expert the proper disposal of unused medicine and any questions you may have regarding its storage.]

What Drugs Interact with Tasmar?

Tasmar can interact with several other medications, which may affect how it works or increase the risk of severe side effects. Managing these interactions by consulting with your healthcare specialist before starting any new medication is essential. Here are some fundamental interactions:

• Dopaminergic Medications: Since Tasmar is used in conjunction with levodopa and carbidopa, adjustments may be needed when combined with other dopaminergic drugs to avoid excessive dopamine effects.
• MAO Inhibitors: Combining Tasmar with monoamine oxidase (MAO) inhibitors (e.g., selegiline, rasagiline) can increase the risk of hypertensive reactions. A careful assessment of the benefits of Tasmar versus the risks is necessary.
• Antidepressants: Some antidepressants, particularly SSRIs (selective serotonin reuptake inhibitors) and tricyclic antidepressants, can interact with Tasmar, potentially leading to serotonin syndrome, a severe condition characterized by confusion, rapid heart rate, and high blood pressure.
• Antipsychotics: Certain antipsychotics may exacerbate the side effects of Tasmar or reduce its efficacy in treating Parkinson’s disease symptoms.
• Antibiotics: Some antibiotics, such as erythromycin, can affect Tasmar’s metabolism, altering its effectiveness and side effect profile.
• Blood Pressure Medications: Tasmar can interact with medications used to treat high blood pressure, potentially requiring dose adjustments to maintain blood pressure control.
• Iron Supplements: Iron can reduce the absorption of Tasmar if taken concurrently. It’s generally recommended to space the administration of Tasmar and iron supplements by a couple of hours.

What Are the Other Interactions to Tasmar?

In addition to the medication interactions previously mentioned, Tasmar (tolcapone) can interact with various substances and conditions that could affect its efficacy and safety. Here are some additional interactions to consider:

• Dietary Interactions

• • • High-Protein Foods: High-protein diets can interfere with how the body absorbs levodopa, a medication often used with Tasmar. This might impact the effectiveness of the treatment, so it may be necessary to monitor and adjust dietary protein intake.
    • Vitamin B6: Large doses of vitamin B6 can decrease levodopa’s efficacy unless combined with carbidopa, commonly co-administered with Tasmar.

• Lifestyle Interactions

• • • Alcohol: Drinking alcohol while taking Tasmar can elevate the risk of liver damage & other medication side effects. It’s generally suggested to limit or avoid alcohol consumption.
    • Smoking: Tobacco use can accelerate the metabolism of some medications, potentially affecting the effectiveness of Tasmar.

• Medical Condition Interactions

• • Liver Disease: Tasmar is contraindicated in patients with liver impairment or liver disease due to the risk of severe hepatotoxicity. Regular liver function tests are recommended for all patients.
  • Neurological Disorders: Patients with certain psychiatric or neurological disorders, including severe psychosis, may experience worsening of their conditions when taking Tasmar.
• Glaucoma: People with glaucoma should use Tasmar cautiously, as it may potentially exacerbate this condition.
• Laboratory Test Interactions: Tasmar can affect liver function tests, so abnormalities in these tests may be influenced by the drug rather than underlying liver disease.

[Note: This is not a complete list, and there could be other drugs that interact with Tasmar. Make sure to tell your medical expert about any prescription, over-the-counter medicines & herbal products you’re taking.]

What Are the Alternatives to Tasmar?

Here are the alternatives to Tasmar for Parkinson’s disease management:

• Other COMT inhibitors:

• • • Comtan (entacapone)
    • Ongentys (opicapone)

• MAO-B inhibitors:

• • • Eldepryl (selegiline)
    • Zelapar (selegiline)
    • Azilect (rasagiline)
    • Xadago (safinamide)

• Dopamine agonists:

• • • Mirapex (pramipexole)
    • Requip (ropinirole)
    • Neupro (rotigotine)
    • Apokyn (apomorphine)

• Levodopa/carbidopa combinations:

• • • Sinemet (immediate-release)
    • Sinemet CR (controlled-release)
    • Rytary (extended-release)
    • Duopa (intestinal gel)

• Amantadine for Parkinson’s disease:

• • • Symmetrel (amantadine)
    • Gocovri (amantadine)

• Anticholinergics:

• • • Trihexyphenidyl 
    • Benztropine 

• Adenosine A2A antagonist:

• • Nourianz (istradefylline)

[Note: Your doctor will prescribe a suitable medication alternative for you. Avoid using any of the above-mentioned Tasmar alternatives without medical supervision. Taking them by yourself may cause serious side effects.]

Tasmar Coupons & Cost

Tasmar for Parkinson’s disease management, which is used in combination with carbidopa/levodopa, is high in retail costs. U.S. residents may find it more affordable to buy Tasmar online from Canadian pharmacies online. Polar Bear Meds is a trusted source known for its competitive medication pricing. By using the Tasmar coupon code “WELCOMEPB10” at checkout, customers can get up to 10% discount on their first order. Additionally, joining our referral program can provide further savings, offering a free coupon for future purchases.

Frequently Asked Questions

Which is better, Entacapone or Tolcapone?

Entacapone and tolcapone are both medications used to enhance the effects of levodopa in treating Parkinson’s disease by inhibiting an enzyme called catechol-O-methyltransferase (COMT). However, entacapone is generally considered safer than tolcapone because it does not have the same risk of causing liver toxicity. This makes entacapone a preferred choice for many doctors and patients as an addition to levodopa/carbidopa therapy in managing Parkinson’s symptoms.

Can tolcapone cross the blood-brain barrier?

Yes, tolcapone can cross the blood-brain barrier, which means it can reach the brain from the bloodstream. This ability is significant because it can directly affect brain function, which is crucial in treating Parkinson’s disease. Tolcapone is taken three times a day and is quickly absorbed into the body, although food can slow down this absorption. Although it can enter the brain, most of the drug remains in the bloodstream because it binds strongly to proteins. The body metabolizes almost all of the administered dose of tolcapone, with 60% of its byproducts eliminated through the urine.

What is the drug class of tolcapone?

Tolcapone belongs to a class of medications known as COMT inhibitors. These drugs work by slowing the breakdown of levodopa, a key treatment for Parkinson’s disease. By inhibiting the enzyme COMT, tolcapone extends the duration of levodopa’s effect, helping to better manage and control the symptoms of Parkinson’s disease.

How does Tasmar differ from carbidopa/levodopa?

Sinemet (carbidopa/levodopa) is a primary treatment for Parkinson’s disease and can be used as a standalone therapy. Tasmar, for Parkinson’s disease management, is used in conjunction with Sinemet when Sinemet alone is insufficient. Both carbidopa and tolcapone enhance the effectiveness of levodopa by slowing its breakdown, thereby increasing dopamine levels and alleviating symptoms of Parkinson’s disease.

When should I expect to feel the effects of Tasmar?

The timing can differ among individuals, but typically, you should notice an improvement within three weeks of starting Tasmar. If you do not observe any benefits by then, discussing this with your healthcare provider is essential, as tolcapone might not be the most suitable medication for you.

Is Tasmar safe to use during pregnancy?

Clinical studies have not conclusively determined the safety of Tasmar during pregnancy. If you are pregnant or planning to conceive, it is crucial to discuss the use of tolcapone and all your Parkinson’s disease medications with your healthcare provider to ensure safety.

Is it safe to consume alcohol while taking Tasmar?

It is suggested to avoid alcohol consumption while on Tasmar therapy. Both alcohol and tolcapone can increase the risk of serious liver issues, as well as exacerbate symptoms such as confusion, drowsiness, and dizziness.

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