Tazret Forte Cream

Tazarotene Cream is a highly effective topical treatment designed for the management of acne and plaque psoriasis. This dermatological cream, available in both 0.05% and 0.1% strengths, comes in cream and gel formulations to suit various skin types and preferences. For acne, Tazarotene Cream works by slowing down skin cell production, preventing pore clogging, and reducing the formation of blackheads and whiteheads. It should be applied once daily in the evening to clean dry skin. In treating plaque psoriasis, the cream mitigates rapid skin cell turnover and reduces inflammation, easing the symptoms associated with scaly skin plaques. The product is also notable for its skin-sensitizing properties due to its retinoid content, necessitating the use of broad-spectrum sunscreen & protective clothing to guard against increased sun sensitivity. Patients should consult with healthcare providers to tailor the treatment to their specific conditions. Tazarotene Cream is not recommended during pregnancy and should be used with caution in conjunction with other skin treatments due to potential interactions.

Tazarotene Cream is a versatile topical treatment designed to effectively manage and alleviate symptoms of skin conditions such as acne and plaque psoriasis. This retinoid-based medication comes in various forms and strengths to cater to different needs & preferences, including creams and gels with concentrations of 0.05% and 0.1%. For acne management, Tazarotene Cream offers a robust approach by lowering the rate of skin cell production, thus preventing the clogging of pores and minimizing the formation of blackheads and whiteheads. It is available as Tazorac Cream or Gel, recommended for adults and children over 12, and Fabior Foam or Arazlo Lotion, suitable for different age groups, each to be applied once daily in the evening.

When treating plaque psoriasis, Tazarotene Cream helps slow down the overproduction of skin cells and lowers inflammation, thereby smoothing the scaly plaques characteristic of psoriasis. The treatment should be applied to no more than 20% of the body surface area once daily in the evening, starting with a 0.05% formulation. The key to achieving the best results with Tazarotene Cream is the correct application. The skin should be cleansed and dried prior to application. A pea-sized amount suffices for the entire face or affected areas, avoiding sensitive parts like the eyes and mouth. Moreover, because Tazarotene Cream can increase skin sensitivity to sunlight, wearing protective clothing and applying a broad-spectrum sunscreen of at least SPF 30 is advisable.

Tazarotene Cream may interact with other topical treatments or certain antibiotics, increasing skin sensitivity or the risk of severe sunburn. It is not recommended during pregnancy or breastfeeding due to potential hazards, for those looking for alternatives, other topical retinoids, antibiotics, coal tar products, and oral treatments are available. Each option has specific uses based on the severity and nature of the skin condition. Always consult with a healthcare specialist to determine the best treatment approach for your condition.

• Acne
• Plaque psoriasis

What Are the Forms & Strengths of Tazarotene Cream?

Tazarotene Cream is available in different forms and strengths and is designed to address various skin conditions effectively. Here are the commonly available forms and strengths:

• Cream Formulation:
• • 0.05% Cream: Typically used for the treatment of acne and mild to moderate plaque psoriasis.
  • 0.1% Cream: This higher concentration is also used for acne and psoriasis, offering a stronger treatment option for more persistent or severe cases.
• Gel Formulation:
  • 0.05% Gel: Used for similar indications as the cream, suitable for those who prefer a gel base that might absorb faster or feel less greasy.
  • 0.1% Gel: Provides a potent treatment in a gel form for effective management of acne and plaque psoriasis.

What Are the Recommended Dosage of Tazarotene Cream?

Acne Treatment

• Tazorac Cream or Gel: For adults and children over 12 years old, start by washing your face. Once dry, apply a thin layer of 0.1% Tazorac cream or gel to the affected area(s) once daily in the evening.
• Fabior Foam: For adults and children 12 years or older, clean the affected areas with a gentle cleanser and allow them to dry completely. Then, lightly massage a thin layer of the foam into the skin until it is fully absorbed, once daily in the evening.
• Arazlo Lotion: Suitable for adults and children 9 years or older. Apply a thin layer of Arazlo lotion on the affected area(s) once daily.

Plaque Psoriasis Treatment

• Tazorac Cream or Gel: Start with the 0.05% formulation and upgrade to 0.1% as your tolerance develops. Apply a thin layer of the cream of gel to the affected areas once daily in the evening, taking care not to treat more than 20% of your body surface area.

[Note: Remember, these recommendations may differ from person to person. Discuss it with your medical expert, and they’ll prescribe your dosage accordingly.]

Using Tazarotene Cream correctly is essential for achieving optimum results while minimizing potential side effects. Here’s how to use Tazarotene Cream:

• Consult Your Doctor: Before starting Tazarotene Cream, consult with your healthcare provider to confirm that it’s appropriate for your condition and to understand any precautions you need to follow.
• Read the Patient Information Leaflet: This will be provided by your pharmacist before you begin using Tazarotene Cream and each time you get a refill of this medication. If you have any questions regarding the same, ask your doctor or pharmacist.
• Cleanse the Skin: Wash the treatment area with a mild cleanser and pat dry. Ensure your skin is properly dry before applying the cream.
• Apply a Small Amount: Use a pea-sized amount for the entire face or as directed by your doctor.
• Avoid Sensitive Areas: Be careful to avoid getting the cream in the eyes, mouth, nostrils, or mucous membranes. If contact occurs, rinse thoroughly with water.
• Wash Your Hands: After applying Tazarotene Cream, wash your hands immediately unless the hands are in the treated area.
• Use Sunscreen and Wear Protective Clothing: Tazarotene Cream can make your skin more sensitive to sunlight. Apply a broad-spectrum chemical or mineral sunscreen with an SPF of a minimum of 50 and wear protective clothing when outdoors.
• Avoid Certain Products: Do not use products that may irritate, such as harsh soaps, shampoos, skin cleansers, hair coloring or permanent chemicals, hair removers or hot waxes, or products with alcohol, spices, astringents, or lime.
• Be Patient with Results: It may take several weeks to see improvement in your condition. Use the medication as directed and inform your medical expert if your condition does not improve or if it worsens.

[Note: Your healthcare specialist will decide the appropriate amount for you as per your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Tazarotene Cream topical cream is used in the treatment of acne and plaque psoriasis, belonging to a group of medications known as retinoids. This class of drugs functions similarly, with a specific mechanism of action that defines how they impact the body.

• Mechanism of Action for Acne Treatment

Acne develops when there is an accumulation of dead skin cells, and sebum (oil) accumulates, blocking pores. Bacteria that thrive on sebum produce waste that triggers inflammation, leading to the formation of blackheads, whiteheads, and inflamed skin lesions. In severe cases, painful nodules and cysts may form deep within the skin.

Tazarotene Cream addresses acne by reducing the rate at which skin cells are produced, preventing the clogging of pores. This action helps to clear existing blockages and prevents the formation of new blackheads and whiteheads. Additionally, Tazarotene Cream reduces skin inflammation, helping to alleviate the symptoms of acne.

• Mechanism of Action for Plaque Psoriasis Treatment

In plaque psoriasis, the immune system erroneously targets skin cells, accelerating their growth. This rapid turnover results in the buildup of scaly plaques on the skin’s surface, accompanied by inflammation.

Tazarotene Cream works by decelerating the production of skin cells, effectively reducing the formation of psoriatic plaques. It also diminishes inflammation, providing relief from the symptomatic swelling associated with psoriasis.

Tazarotene Cream can cause side effects, typically temporary, ranging from a few days to several weeks. If these side effects persist beyond this time frame, become bothersome, or intensify, it is crucial to seek advice from a certified medical specialist. Common side effects associated with Tazarotene Cream include:

• Skin irritation
• Redness
• Dryness
• Peeling
• Burning or stinging sensation
• Itching
• Skin warmth

Serious side effects: While serious side effects of Tazarotene Cream are rare, it’s important to be aware of them. Here are some potentially serious side effects that may require immediate medical attention:

• Severe skin reactions:
  • Severe burning, stinging, or redness
  • Severe swelling or blistering
  • Crusting or oozing of the skin
• Signs of an allergic reaction:
  • Rash
  • Itching or hives
  • Swollen face, lips, tongue, or throat
  • Difficulty breathing
• Eye problems:
  • Eye irritation
  • Conjunctivitis
  • Eyelid swelling
• Severe dryness or cracking of the skin
• Signs of vitamin A toxicity (rare, but possible with excessive use):
  • Severe headache
  • Blurred vision
  • Dizziness
  • Nausea or vomiting
• Skin infections:
  • Increased redness, warmth, or swelling
  • Pus or drainage from the treated area
• Changes in skin color that persist after stopping treatment

[Note: Remember, this list does not cover all possible side effects. Always consult with your healthcare expert for medical advice about side effects.]

• Increased Sun Sensitivity: Tazarotene Cream enhances skin sensitivity to sunlight, increasing the likelihood of sunburn. Always wear protective clothing & apply sunscreen with a minimum SPF of 30. Avoid direct sun exposure, especially the afternoon sun, as much as you can, and steer clear of tanning beds during treatment.
• Skin Irritation: Tazarotene Cream may cause skin irritation, including peeling, dryness, and itching. Protect your skin from cold or windy weather, and do not use products that can potentially dry out the skin, such as those containing alcohol. If irritation persists, consult your healthcare expert for possible adjustments to your treatment.
• Potential Harm to Unborn Baby: Tazarotene Cream is not safe for use during pregnancy as it could harm the unborn baby. Ensure a negative pregnancy test two weeks prior to starting the medication and use effective contraception throughout treatment to prevent pregnancy.
• Flammability (Specific to Fabior Foam): The Fabior foam version of Tazarotene Cream is flammable. Keep it away from open flames, and do not smoke during or immediately after application to avoid the risk of fire.

When using Tazarotene Cream topical cream, it’s important to take certain precautions to ensure you get safe and effective treatment. Here are key considerations to keep in mind:

• Sun Sensitivity: Tazarotene Cream increases the skin’s sensitivity to sunlight, which can increase the chances of sunburn. Use a broad-spectrum chemical or mineral sunscreen with SPF 30 or more & wear protective clothing when outdoors. Avoid tanning beds and prolonged sun exposure.
• Pregnancy and Breastfeeding: Tazarotene Cream is categorized as FDA pregnancy category X, meaning it is not to be used during pregnancy due to potentially high risks to the unborn baby. Women of childbearing age should practice using effective birth control while using this medication. It’s also recommended to consult a healthcare provider about use while breastfeeding, as it’s unclear if Tazarotene Cream passes into breast milk.
• Skin Irritation: Tazarotene Cream may cause skin irritation, redness, peeling, or dryness, especially during the first few weeks of use. If irritation becomes severe, consult a healthcare provider. They may recommend adjusting the application frequency or using a moisturizer.
• Avoid Eyes, Mouth, and Nose: Be careful to avoid applying Tazarotene Cream near the eyes, inside the nose, mouth, or on other mucous membranes, as it can cause severe irritation.
• Allergic Reactions: If you observe the occurrence of allergic reactions like hives, difficulty breathing, or swollen face, tongue, lips, or throat, seek immediate medical attention.
• Wash Hands: After applying Tazarotene Cream, wash your hands thoroughly unless the treatment area includes the hands.
• Application Instructions: Apply Tazarotene Cream as directed by your healthcare provider, typically once daily in the evening, to the affected areas only.
• Combining Skincare Products: Avoid using other skin products on the treated area within one hour before or after using Tazarotene Cream unless directed by your doctor. Certain cosmetics, lotions, or other topical medications may increase irritation.
• Pre-existing Skin Conditions: If you have eczema or other skin conditions, discuss with your medical professional how this medication may affect your medical condition, how your medical condition may affect the dosing & effectiveness of this medication, and whether any special monitoring is needed.
• Discontinue if Worsening: If your skin condition worsens with the use of Tazarotene Cream, stop using it and inform your healthcare provider.

• Pregnancy: Tazarotene Cream is contraindicated in pregnant women or those planning to conceive due to the potential risk of congenital disabilities.
• Breastfeeding: It’s not recommended for use while breastfeeding due to potential risks to the infant.
• Hypersensitivity: Individuals with known hypersensitivity to Tazarotene Cream or any components of the cream should not use it.
• Eczema: It’s generally contraindicated for people with eczema as it can exacerbate the condition.
• Sunburn or excessive sun exposure: Should not be used on sunburned skin or if excessive sun exposure is expected.
• Open wounds or damaged skin: Not to be applied on cuts, abrasions, or eczematous skin.
• Concurrent use with certain medications: May interact with other topical medications, particularly those that cause skin irritation.
• Children under 12 years old: Generally not recommended for use in young children, though this can vary depending on the specific product & condition being treated.
• Certain skin conditions: May not be suitable for individuals with certain skin disorders or infections.

If you miss a dose of Tazarotene Cream, apply it as soon as you remember. However, if it’s almost time for your next scheduled dose, leave the missed application of this cream and continue with your routine application schedule. Do not apply more than needed of this cream to make up for a missed dose to avoid potential overdose or increased side effects. Consistency is key for effectiveness, so try to use the cream at the same time each day to maintain a routine.

[Note: If you have missed a dose of this medication and are unsure regarding the next dose, immediately consult your doctor or pharmacist.]

Using too much Tazarotene Cream can lead to increased side effects, such as severe skin irritation, redness, peeling, or discomfort. If you accidentally apply more Tazarotene Cream than recommended, you might experience these heightened reactions. If this occurs, or if you experience any severe symptoms from overuse, it’s important to wash the affected area with mild soap and water and contact your healthcare provider. They can guide you on how to treat the irritation and adjust your usage to prevent further issues. In cases of severe reactions, medical intervention might be necessary.

[Note: If you have taken more than the recommended dose of the Tazarotene Cream, get medical help right away or call the Poison Help line at 1-800-222-1222.]

Storing Tazarotene Cream properly is essential to maintain its effectiveness and safety. Here are the recommended storage guidelines for Tazarotene Cream:

• Temperature: Store the cream at an average room temperature of anywhere between 68°F to 77°F (20°C to 25°C). Avoid storing the cream in areas where the temperature could fluctuate significantly, such as near radiators, windows, or in a car during hot weather.
• Avoid Light: Keep the cream in its original packaging to keep it safe from light, as exposure can degrade the active ingredients over time.
• Keep It Dry: Store the cream in a dry place. Avoid areas where it might be exposed to moisture, such as in a bathroom cabinet, which can be humid.
• Cap Tightly: Ensure the cap is tightly closed after each use to prevent the cream from drying out and to maintain its potency.
• Keep Out of Reach: As with all medications, keep Tazarotene Cream out of reach of children & pets to prevent accidental ingestion or misuse.
• Do Not Freeze: Avoid freezing the cream, as extreme cold can alter its chemical structure and effectiveness.
• Check Expiration: Regularly check the expiration date on the cream. Do not use it past the expiry date, as it may not be effective or could be unsafe.

[Note: Discuss with your healthcare expert about the proper disposal of any unused medication and any questions you may have regarding its storage.]

Tazarotene Cream topical cream may interact with various substances, increasing the risk of skin irritation or severe sunburn. Here’s how different treatments and medications might interact with Tazarotene Cream:

• Topical Treatments: Combining Tazarotene Cream with other treatments for acne or psoriasis, such as benzoyl peroxide, calcipotriene (Dovonex, Sorilux), coal tar products (Psoriatar, Scytera, Cutar, Eucutasol), or salicylic acid, can lead to increased skin dryness or irritation.
• Certain Antibiotics: Some antibiotics heighten sun sensitivity, which may enhance the risk of severe sunburn when used with Tazarotene Cream. These include:
  • Ciprofloxacin (Cipro)
  • Doxycycline (Vibramycin, Monodox, Acticlate)
  • Minocycline (Solodyn, Minolira, Ximino)
  • Sulfamethoxazole
• Thiazide Diuretics: These drugs, often used in blood pressure medications like hydrochlorothiazide, can increase skin sensitivity to sunlight, heightening the risk of severe sunburn when used with Tazarotene Cream.
• Phenothiazines: Used for treating nausea, vomiting, and certain mental health conditions such as schizophrenia, drugs like prochlorperazine (Procomp) and promethazine (Promethegan) also increase sun sensitivity, raising the potential for severe sunburn.

What Are the Other Tazarotene Cream Interactions?

• Herbs and Supplements: While no specific herbs or supplements are known to interact with Tazarotene Cream, it’s crucial to discuss any you’re taking with your doctor or pharmacist to avoid potential interactions.
• Foods: There are no known food interactions with Tazarotene Cream topical cream, but always consult your doctor with any dietary concerns.

[Note: This is not a complete list, and there could be other drugs that interact with Tazarotene Cream. Make sure to tell your doctor regarding any prescription, over-the-counter medicines & herbal products you’re taking.]

Topical Retinoids:

• Differin (adapalene)
• Epiduo, Epiduo Forte (adapalene/benzoyl peroxide)
• Fabior, Arazlo, Tazorac (Tazarotene Cream)
• Avita, Renova, Retin-A, Altreno, Atralin (tretinoin)

Topical Antibiotics:

• Evoclin, Cleocin T, Clina-derm, Clindagel (clindamycin)
• Acanya, Benzaclin, Duac, Onexton (clindamycin/benzoyl peroxide)
• Veltin, Ziana (clindamycin/tretinoin)
• Erygel, Erythra-derm (erythromycin)
• Benzamycin (erythromycin/benzoyl peroxide)

Topical Dapsone:

• Aczone (dapsone)

Oral Antibiotics:

• Vibramycin, Monodox, Acticlate (doxycycline)
• Solodyn, Minolira, Ximino (minocycline)
• Achromycin V (tetracycline)

Birth Control Pills:

• Beyaz, Safyral, Tydemy (ethinyl estradiol/drospirenone/levomefolate calcium)
• Yaz, Kyra, Nikki (ethinyl estradiol/drospirenone)
• Estarylla, Mili, Mono-Linyah (ethinyl estradiol/norgestimate)

Oral Retinoids:

• Absorica, Amnesteem, Claravis (isotretinoin)

Alternatives for Plaque Psoriasis

Other Forms of Tazarotene Cream:

• Fabior, Arazlo, Tazorac (Tazarotene Cream)

Coal Tar Products:

• Psoriasin, Cutar, Eucutasol (coal tar)

Topical Corticosteroids:

• Diprolene, Sernivo (betamethasone dipropionate)
• Olux, Cormax, Embeline, Clobex (clobetasol)
• Synalar (fluocinolone)
• Lexette, Bryhali, Ultravate (halobetasol)
• Duobrii (halobetasol/Tazarotene Cream)

Topical Vitamin D Analogues:

• Vectical (calcitriol)
• Dovonex, Sorilux (calcipotriene)
• Enstilar, Wynzora, Taclonex (calcipotriene/betamethasone)

Oral Treatments:

• Acitretin (acitretin)
• Otezla (apremilast)
• Neoral (cyclosporine)
• Trexall (methotrexate)

Biologic Treatments:

• Cimzia (certolizumab)
• Enbrel (etanercept)
• Humira (adalimumab)
• Cosentyx (secukinumab)
• Stelara (ustekinumab)
• Taltz (ixekizumab)

[Note: Your doctor will choose the best alternative for you. Don’t use any of these medications mentioned above without consulting your healthcare expert. Taking them without medical supervision may cause serious side effects.]

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