Trelegy Ellipta

Trelegy Ellipta is a prescription inhaler used for the long-term management of chronic obstructive pulmonary disease (COPD) and asthma in adults. It contains 3 active medications: fluticasone furoate, umeclidinium, and vilanterol. By combining these three therapies in a single inhaler, this medication helps control symptoms like shortness of breath, wheezing, and chronic cough when used regularly. It is designed for daily maintenance therapy and should not be used as a rescue inhaler for unexpected breathing problems.

Below is a quick overview of important facts for patients and caregivers:

Trelegy Ellipta is prescribed for the maintenance treatment of certain chronic respiratory conditions in adults. It is used for:

• Chronic obstructive pulmonary disease (COPD): This medication is used for long-term maintenance treatment of COPD, a chronic lung disease that includes:
  • Chronic bronchitis
  • Emphysema

It helps improve breathing and reduce COPD flare-ups when used regularly. It is also used to reduce exacerbations in patients with COPD.

• Asthma (Adults): This medication is also indicated for the maintenance treatment of asthma in adults aged 18 years and older whose symptoms require long-term inhaled therapy.

Limitations of use:

• This inhalation powder is not used to relieve acute bronchospasm.
• It should not be used as a rescue inhaler for sudden breathing problems.

Trelegy Ellipta improves breathing through three complementary mechanisms.

• Reduces airway inflammation: Fluticasone furoate is a corticosteroid that helps reduce airway inflammation, thereby reducing swelling and irritation associated with COPD and asthma.
• Relaxes airway muscles: Umeclidinium in this medication blocks muscarinic receptors on airway smooth muscle, helping the airways open and making breathing easier.
• Opens the airways (bronchodilation): Vilanterol stimulates beta2 receptors in the lungs, causing the airway muscles to relax and allowing more air to move through the lungs.

By combining three different medications in a single inhaler, Trelegy Ellipta helps improve lung function and supports long-term control of COPD and asthma symptoms.

Always follow your healthcare provider’s instructions. General guidelines include:

• Inhale 1 puff once daily at the same time each day.
• Do not take more than one inhalation within 24 hours.
• Only use this medication after your healthcare provider has shown you the proper inhaler technique.
• If a dose is missed, take it as soon as you remember, but do not take two doses at the same time.
• This medication does not relieve sudden breathing problems. Use a rescue inhaler if needed.

The recommended dosage of Trelegy Ellipta depends on the condition being treated and the patient’s response to therapy. It is taken once daily by oral inhalation.

Important dosage information:

• COPD dosing: The 100 mcg / 62.5 mcg / 25 mcg strength is typically used for COPD maintenance treatment.
• Asthma dosing: Depending on symptom control, your healthcare provider may prescribe either the 100 mcg / 62.5 mcg / 25 mcg or 200 mcg / 62.5 mcg / 25 mcg strength.
• Maximum asthma dose: One inhalation of 200 mcg / 62.5 mcg / 25 mcg once daily.
• Rinse your mouth with water and spit it out after inhalation to help reduce the risk of oral thrush.

Taking more than the recommended dose may cause serious side effects. Symptoms may vary depending on the amount used and whether other medicines were involved. Symptoms of overdose may include:

• Rapid or irregular heartbeat
• Chest pain or palpitations
• Headache or dizziness
• Nervousness or tremors
• Muscle cramps
• Dry mouth
• Nausea
• Fatigue or weakness
• Changes in blood pressure

High doses of umeclidinium may cause anticholinergic effects, while excessive exposure to vilanterol may lead to beta-adrenergic stimulation, such as tachycardia or arrhythmias. If an overdose is suspected, seek immediate emergency medical help or contact a poison control center. Treatment typically involves supportive medical care and monitoring in a healthcare setting.

Like most medications, Trelegy Ellipta may cause side effects in some patients. Many side effects are mild and may improve as the body adjusts, but some reactions require medical attention.

Common Side Effects

Commonly reported Trelegy Ellipta side effects are listed below:

• Upper respiratory tract infection
• Bronchitis
• Headache
• Back pain
• Joint pain
• Runny nose or sore throat
• Sinus inflammation
• Cough
• Hoarseness
• Taste changes
• Nausea, vomiting, or diarrhea
• Constipation
• Mouth or throat irritation

Serious Side Effects

Seek immediate medical attention if you experience any of the following:

• Pneumonia, especially in people with COPD
• Serious allergic reactions, including swelling, rash, or breathing difficulty
• Heart-related effects, such as increased blood pressure or irregular heartbeat
• Nervous system effects, including tremors or nervousness
• Eye problems, such as cataracts, glaucoma, or blurred vision
• Urinary retention, including difficulty or pain when urinating
• Oral or throat fungal infection (thrush)
• Sudden breathing problems after inhalation
• Reduced adrenal gland function
• Bone thinning (osteoporosis)
• Changes in blood sugar or potassium levels

This is not a complete list of side effects. Contact your healthcare provider for medical advice about adverse reactions. You may report side effects to the FDA at 1-800-FDA-1088 or visit MedWatch.

While taking this medication, the following warnings and precautions should be considered:

• LABA safety warning: Long-acting beta2-agonists (LABAs) used alone to treat asthma may increase the risk of asthma-related death. It contains both an inhaled corticosteroid and a LABA, which helps reduce this risk when used as directed.
• Eye problems: Long-term use may increase the risk of glaucoma, cataracts, or increased eye pressure.
• Immune system effects: It may weaken the immune system and increase susceptibility to infections.
• Urinary retention: Patients with bladder obstruction or prostate enlargement may experience difficulty urinating.
• Paradoxical bronchospasm: In rare cases, inhaled medications may cause sudden worsening of breathing immediately after use.
• Cardiovascular effects: This medication may increase heart rate, raise blood pressure, or cause irregular heartbeat in some patients.
• Not for sudden breathing problems: It should not be used as a rescue inhaler for sudden asthma attacks or breathing emergencies.
• Bone density reduction: Long-term use of inhaled corticosteroids may reduce bone mineral density and increase the risk of osteoporosis.
• Pneumonia risk in COPD patients: People with COPD using inhaled corticosteroids may have an increased risk of developing pneumonia.
• Oral fungal infections (thrush): Inhaled corticosteroids such as fluticasone may cause oral or throat fungal infections. After each use, rinse your mouth to minimize this risk.
• Do not exceed the recommended dose: Using higher doses or combining with other long-acting beta-agonist (LABA) medications may increase the risk of serious cardiovascular effects.
• Use with caution in patients with cardiovascular disease, diabetes, thyroid disorders, seizures, or electrolyte imbalances.

Pregnancy and Breastfeeding

There is limited information on the use of this medication during pregnancy and breastfeeding. Animal studies did not show significant harm to the fetus at high exposure levels, but the risk in humans is not fully known. Pregnant women with asthma should be carefully monitored, and the medicine should be used only if the potential benefit outweighs the possible risk. It is also unknown whether the components pass into human breast milk, so the benefits of treatment should be weighed against potential risks to the infant.

Trelegy Ellipta may interact with certain medications and increase the risk of serious side effects. Important drug interactions include:

• Strong CYP3A4 inhibitors: Medicines such as ketoconazole and other strong CYP3A4 inhibitors may increase fluticasone furoate and vilanterol levels in the body.
• Other anticholinergic medications: Using Trelegy Ellipta with other anticholinergic drugs may enhance the risk of anticholinergic side effects.
• Non-potassium-sparing diuretics: Loop or thiazide diuretics may increase the risk of electrolyte imbalance when combined with beta-agonists.
• QT-prolonging drugs: Medicines that prolong the QT interval may increase the risk of heart rhythm disturbances when used with this medication.
• Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants: These medications may enhance the cardiovascular effects of beta2-agonists like vilanterol.
• Beta-blockers: These may reduce the bronchodilator effects of vilanterol and may trigger bronchospasm in patients with asthma or COPD.

Patients should inform their healthcare provider about all supplements, over-the-counter drugs, and prescription medications they use before starting Trelegy Ellipta inhalers.

Other inhalers may be considered depending on a patient’s condition and response to treatment.

Brand availability may vary depending on location and pharmacy supply. A healthcare provider will determine the most appropriate option based on the patient’s symptoms and treatment response.

Prescription respiratory medications may be costly at many U.S. retail pharmacies. Ordering Trelegy Ellipta online from Polar Bear Meds may help reduce overall costs while maintaining safety, quality, and reliability.

• Competitive pricing compared to many U.S. retail pharmacies.
• Medications sourced from licensed and reputable Canadian pharmacies.
• Properly dispensed prescription products under regulatory standards.
• Transparent pricing with no hidden fees.
• U.S. customers can order with a valid prescription.
• Simple online ordering with easy prescription upload.
• Discreet packaging with order tracking for added security.
• Shipping across the United States typically takes 3-5 business days via Xpress Post.
• Shipping timelines may vary depending on processing requirements and location.
• Dedicated customer support team to assist with prescriptions, orders, and delivery questions.
• Customers may also use the coupon code WELCOMEPB10: 10% off your first order.

All Trelegy Ellipta orders require a valid prescription. Medications are dispensed by licensed pharmacies that comply with applicable pharmacy regulations and safety standards.

• https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/209482s018lbl.pdf
• https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b5a81d5a-4648-4c7a-951d-33c014a63c7e
• https://www.drugs.com/medical-answers/alternatives-trelegy-ellipta-3552952/