Eluxadoline

Viberzi

Viberzi is an FDA-approved prescription medication containing the active ingredient Eluxadoline. It targets gut receptors to alleviate symptoms of irritable bowel syndrome with diarrhea (IBS-D) by regulating bowel contractions. It is available in 75 mg and 100 mg tablets. The typically prescribed Viberzi dosage is one tablet twice daily with food for adults. It is not approved for children (under the age of 18). Side effects may include vomiting, nausea, constipation, and stomach discomfort that require medical attention in severe cases. If you have specific medical conditions like bile duct obstruction, pancreatitis, or alcoholism, you should use it with caution. In case of a missed dose, take it promptly unless near the next dose. Seek medical attention if you take an overdose. Store Viberzi at room temperature, away from heat, moisture, and children. Follow your healthcare provider’s guidance for safe and effective use.

Product Overview

Viberzi is an FDA-approved prescription medication containing the active ingredient Eluxadoline. It is primarily designed to treat adults suffering from irritable bowel syndrome with diarrhea (IBS-D). It functions as a mixed opioid receptor agonist and antagonist. It works by targeting the receptors in the gut, thereby reducing bowel contractions and alleviating symptoms associated with IBS-D.

Viberzi is available in tablet form and comes in two strengths: Viberzi 75 mg and Viberzi 100 mg. The typically recommended Viberzi dosage is one tablet taken orally twice daily with food. Viberzi is intended for use by adults only and should not be administered to children or adolescents under the age of 18.

Viberzi side effects may include vomiting, constipation, nausea, and abdominal pain. It is vital to discuss with a healthcare professional if any adverse reactions occur. Additionally, precautions should be taken when using Viberzi, particularly in those with a history of bile duct obstruction, pancreatitis, or alcoholism. If you missed a dose, it is advisable to take it immediately unless it is almost time for the next planned dose. If an overdose is doubted, medical attention should be sought immediately. 

Viberzi should be stored at room temperature, away from moisture and heat. It is necessary to keep it out of reach of children and pets. You should inform your healthcare provider about all medications you are currently taking to prevent any drug interaction. Viberzi is an effective treatment option for adults with IBS-D when used as directed under the guidance of a healthcare professional.

What Are the Uses of Viberzi?

• It treats irritable bowel syndrome with diarrhea (IBS-D) in adults.

[Important warning: Viberzi is not approved for use by anyone younger than 18 years old.]

What Are the Forms & Strengths of Viberzi?

Dosage

Strengths and Forms

It is available in the form of tablets in strengths:

• Viberzi 75 mg tablets
• Viberzi 100 mg tablets

What Are the Recommended Viberzi Doses for Different Patients? 

For Adults with IBS-D:

• The standard recommended dosage is 100 mg taken orally twice daily with food. 

For Children (Under 18 Years):

• It is not recommended for use in children.

For Seniors:

• The recommended dosage is 75 mg or 100 mg twice daily, adjusted based on individual patient needs.

Dosing Modifications

For Pregnant Women:

• A healthcare provider should determine the Viberzi dosage.

For Patients with Hepatic Impairment:

• Mild or Medium Hepatic Impairment (Child-Pugh Class A or B): The usual recommended dosage is 75 mg twice daily.
• Severe Hepatic Impairment (Child-Pugh Class C): Contraindicated due to a significant increase in plasma concentrations.

For Patients with Renal Impairment:

• Mild Renal Impairment: The recommended dosage is 100 mg taken orally twice daily with food. 
• Moderate Renal Impairment: The recommended dosage is 75 mg twice daily.
• Adverse Renal Impairment (eGFR 15 to 30 Ml/min/1.73 M^2) and ESRD Not Yet on Dialysis (eGFR < 15 Ml/min/1.73 M^2): The usual recommended dosage is 75 mg twice daily.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your Viberzi dosage accordingly.]

How to Use Viberzi?

You can take Viberzi effectively by following these instructions:

• You should take Viberzi tablets orally with food.
• Swallow the tablet whole with water; do not split, crush, or munch it.
• The typically recommended dosage is one tablet twice daily.
• Take Viberzi at evenly spaced intervals, approximately 12 hours apart.
• Make sure you adhere to your healthcare professional’s Viberzi dosage instructions.
• Only take the recommended dose if directed by your doctor.

[Note: Your healthcare professional will determine the right amount of Viberzi for you based on your condition, following guidelines and studies on the drug. They may adjust it as required over time.]

How Does Viberzi Work?

Viberzi works as a mixed opioid receptor modulator. It has both agonist and antagonist effects on opioid receptors in the gastrointestinal tract. Targeting specific receptors helps to reduce bowel contractions and alleviate abdominal pain, leading to better control of bowel habits in individuals with IBS-D. It is important to note that Eluxadoline is not classified as a traditional opioid but interacts with opioid receptors in the gut.

Important Safety Information

What Are the Side Effects of Viberzi?

Common side effects of Viberzi: When you consider eluxadoline buy online, you should know the several common side effects associated with this. Here are some of them:

• • Dizziness: This is a common side effect of Viberzi, which may cause a sensation of lightheadedness or a feeling of spinning. It’s often temporary but can affect daily activities. If dizziness persists, it’s recommended to consult a healthcare provider.

• Gas: Flatulence, or excessive gas, is another frequent side effect. This can cause bloating, discomfort, and the frequent need to pass gas. While usually mild, it can be bothersome, and dietary adjustments may help alleviate symptoms.

• Constipation: This involves infrequent or difficult bowel movements and is a common side effect of Viberzi. Patients may experience hard stools, straining, or a feeling of incomplete evacuation. Increasing fluid intake and dietary fiber may help manage this side effect.

• Nausea: This is the sensation of an upset stomach or the urge to vomit when you use Viberzi. It can occur alone or with other digestive symptoms. Nausea often subsides as the body adjusts to the medication, but if it persists, medical advice should be sought.

• Runny or Stuffy Nose: Viberzi may cause symptoms resembling a cold, such as a runny or stuffy nose. This side effect is usually mild and can be managed with over-the-counter medications if needed.

• Abdominal Pain or Discomfort: This issue can range from mild cramping to more intense pain. This side effect may be related to the way Viberzi affects the digestive system. If the pain is severe or persistent, it’s important to contact a healthcare provider.

• Vomiting: Vomiting is a less common but notable side effect of Viberzi that may accompany nausea. Persistent vomiting can lead to dehydration and should be addressed by a healthcare provider.

Mild Side Effects of Viberzi: Although the issues listed below are mild, they need the doctor’s attention. This includes:

• • Mild Dizziness: Dizziness can also be a mild side effect, potentially causing slight unsteadiness. While typically not severe, if it continues, reducing the dosage or adjusting the timing of the Viberzi may be necessary under a doctor’s guidance.

• Fatigue: Fatigue, or a general feeling of tiredness, is another mild side effect of Viberzi. It may make it harder to perform daily tasks, but it often improves as the body adjusts to the medication.

• • Gas or Bloating: Mild gas or bloating may occur as a side effect. This can cause discomfort and a feeling of fullness in the abdomen. Simple dietary changes, such as avoiding certain foods, may help reduce these symptoms.
  • Indigestion: Also known as dyspepsia, it includes symptoms like discomfort in the upper abdomen, burping, and a burning sensation. This mild side effect can often be managed with antacids or by eating smaller, more frequent meals.

• Dry Mouth: Dry mouth, or xerostomia, is a mild side effect that can lead to a parched feeling in the mouth, difficulty swallowing, and an increased need to drink water. Chewing sugar-free gum or sucking on sugar-free candies can help stimulate saliva production.

Serious side effects of Viberzi may include: Viberzi is used to treat the symptoms of irritable bowel syndrome and can cause some of the listed serious side effects:

• • Severe Constipation or Bowel Obstruction: Severe constipation is characterized by infrequent and difficult bowel movements, often resulting in hard and dry stools. This condition can be uncomfortable and, if left untreated, may progress to a more serious state known as bowel obstruction. This occurs when there is a physical blockage in the intestines, preventing the normal movement of digestive contents. Viberzi can increase the risk of this, and symptoms may include serious bloating, abdominal pain, and an inability to pass gas or stool, sometimes accompanied by vomiting. Bowel obstruction is a medical emergency that requires immediate intervention to prevent complications like infection or tissue death.
  • Sphincter of Oddi Spasm: This is an important muscle that regulates the flow of bile and pancreatic juices into the small intestine. A spasm in this muscle due to the overuse of Viberzi can cause a painful blockage, leading to a condition known as Sphincter of Oddi dysfunction. Patients may experience sudden and intense pain in the upper abdomen, often radiating to the back or shoulder. This pain can be accompanied by nausea, vomiting, and jaundice, indicating a buildup of bile. This condition can lead to severe complications such as bile duct obstruction or pancreatitis if not treated promptly, necessitating urgent medical care.

• Severe Cramping: Severe abdominal pain or cramping while on Viberzi can be a sign of an underlying serious condition, such as pancreatitis, bowel obstruction, or another gastrointestinal disorder. The pain may present as sharp, stabbing, or cramping sensations and can occur anywhere in the abdomen. It may also be associated with other symptoms like nausea, vomiting, and changes in bowel habits. Such pain should not be ignored, as it could indicate a life-threatening condition requiring an immediate medical evaluation to determine the cause and appropriate treatment.

• • Severe or Persistent Diarrhea: Diarrhea, especially when severe or persistent, can lead to significant health issues, including dehydration and electrolyte imbalances. This condition involves frequent, loose, or watery stools and may cause additional symptoms like abdominal cramping and fatigue. Persistent diarrhea due to Viberzi can weaken the body and lead to further complications, such as malnutrition or severe dehydration, which may require hospitalization. If diarrhea continues for an extended period or becomes severe, medical attention is necessary to manage the symptoms and prevent further health risks.
  • Liver Problems: Viberzi may cause liver problems, a serious side effect that can manifest as jaundice, characterized by the yellowing of the eyes or skin. Other symptoms include dark urine, persistent nausea or vomiting, and upper right abdominal pain. These symptoms suggest liver injury, a condition that can progress to liver failure if not addressed. Liver damage is a life-threatening issue that requires prompt medical intervention. Regular monitoring of liver function during treatment with Viberzi is crucial to detect any early signs of liver problems and take appropriate action.

• Pancreatitis: This is a severe inflammation of the pancreas, an organ essential for digestion and blood sugar regulation. Viberzi has been associated with an increased risk of developing pancreatitis, which presents as a severe, sharp pain in the upper abdomen, often radiating to the back. This pain is typically accompanied by nausea, vomiting, and sometimes fever. Pancreatitis can lead to serious complications, including infection, organ failure, and, in severe cases, death. Immediate medical attention is necessary if symptoms of pancreatitis appear, as early treatment is crucial for preventing long-term damage.

• Serious Allergic Reaction: A serious allergic reaction to Viberzi can be caused in various ways, from skin reactions to more severe respiratory issues. Symptoms might include redness, itching, swelling (especially of the face, lips, or throat), severe dizziness, and difficulty breathing. These signs could indicate anaphylaxis, a life-threatening allergic reaction that requires immediate medical intervention. Anaphylaxis can lead to shock, loss of consciousness, and even death if not treated promptly with emergency care, such as epinephrine injection and supportive measures.
• Severe Gastrointestinal Disorder: These disorders, including conditions like ischemic colitis or inflammatory bowel disease, may occur as a side effect of Viberzi. These disorders present with severe abdominal pain, persistent nausea or vomiting, and sometimes bloody stools. Such symptoms indicate significant inflammation or damage to the gastrointestinal tract, which can lead to serious complications like perforation, severe bleeding, or infection. These conditions require urgent medical evaluation and intervention to prevent life-threatening outcomes, emphasizing the importance of monitoring any severe gastrointestinal symptoms during Viberzi treatment.

[Note: Remember, this list may not cover all possible Viberzi side effects. Always consult with your healthcare giver for medical advice about side effects.]

What Are the Viberzi Warnings?

Are you thinking about Eluxadoline buy online? Well, this medication is really effective in treating symptoms of IBS-D (Irritable Bowel Syndrome with Diarrhea). However, this medication comes with several warnings that include: 

Pancreatitis Risk: Viberzi has been associated with cases of pancreatitis, an adverse inflammation of the pancreas. Symptoms may include stomach pain that may lead to the back, nausea, vomiting, and fever. If you experience these symptoms, seek medical attention promptly.

Spasm of the Sphincter of Oddi: Viberzi can cause spasms of the sphincter of Oddi, a muscular valve that regulates the flow of digestive juices into the small intestine. This can lead to abdominal pain, which may be severe. If you develop intense abdominal pain, especially in the upper right quadrant, along with nausea and vomiting, discontinue Viberzi and seek immediate medical attention.

Constipation Risk: Viberzi may cause constipation, which can cause problems such as fecal impaction or bowel obstruction, particularly in patients with a history of gastrointestinal obstruction. Monitor your bowel movements and inform your healthcare provider if you experience severe constipation or are unable to have a bowel movement for several days.

Severe Allergic Reactions: Some people may undergo severe allergic reactions to Viberzi, characterized by symptoms such as redness, burning, inflammation of the face, lips, or throat, difficulty breathing, or dizziness. If you notice any of the symptoms, seek immediate medical help.

Hepatic Impairment: Viberzi should be used with caution in patients with liver impairment or a history of liver disease, as it may exacerbate existing liver conditions. Monitoring of hepatic function may be essential during treatment.

Interactions with Alcohol: Consumption of alcohol while taking Viberzi may increase the risk of pancreatitis and other adverse reactions. It is recommended to avoid alcohol while taking Viberzi.

Adverse Reactions in Pediatric Patients: The safety and effectiveness of Viberzi in pediatric patients have not been established. It is not recommended for use in individuals under the age of 18.

Pregnancy and Breastfeeding: The safety of Viberzi during pregnancy and breastfeeding has not been studied. Let your healthcare professional know if you are pregnant or breastfeeding before taking Viberzi.

What Are the Viberzi Precautions?

When you buy Viberzi online from Canada, you should know the various precautions while taking this medication. Some of them are listed below:

• You should monitor for signs of pancreatitis, such as severe stomach pain, constipation, vomiting, nausea, and fever.
• Be alert for symptoms of sphincter of Oddi spasm, including intense upper right quadrant abdominal pain, nausea, and vomiting.
• Watch for constipation, especially if you have a history of gastrointestinal issues, and inform your doctor if it is severe.
• Be aware of the potential for severe allergic reactions and seek immediate medical attention if you experience rash, itching, swelling, difficulty breathing, or dizziness.
• Exercise caution if you have liver impairment or a history of liver disease, and discuss monitoring with your healthcare provider.
• Avoid alcohol consumption while taking Viberzi to reduce the risk of adverse reactions.
• Do not use Viberzi if you are under 18 years old, pregnant, planning to become pregnant, or breastfeeding unless advised otherwise by your doctor.

What Are Viberzi Contraindications?

This medication is contraindicated in certain situations where its use could be harmful. Here are the main contraindications for Viberzi:

• A person without a gallbladder.
• A person with biliary duct obstruction or sphincter of Oddi dysfunction.
• A person with structural diseases of the pancreas.
• A person with a history of pancreatitis.
• A person who drinks 3 or more alcoholic beverages daily or who is an alcoholic, alcohol abuse, or addiction patient.

What Happens If You Miss a Dose of Viberzi?

If you forget to take a dose of Viberzi tablets, take it immediately when you recall. But if it’s nearly time for your next planned dose, skip the missed one and continue with your regular dosing plan. Avoid taking two doses concurrently to compensate for the missed one.

[Note: If you have missed a dose of Viberzi and are still deciding when to take the next dose, directly consult your healthcare professional.]

What Happens If You Take Too Much Viberzi?

Overdosing on Viberzi can lead to serious complications such as:

• Severe constipation
• Nausea and vomiting
• Abdominal pain or cramping
• Dizziness or lightheadedness
• Difficulty breathing
• Changes in heart rate or rhythm
• Confusion or disorientation
• Loss of consciousness

[Note: If you consumed more than the recommended Viberzi dosage, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How Do You Store Viberzi? 

There are major considerations in storing this medication. Here are the guidelines you need to follow: 

• Store Viberzi at room temperature, away from excessive heat and moisture. 
• Keep the Viberzi tablets in their original box to protect them from light. 
• Ensure that the medication is kept in a child-resistant container and kept out of reach of children. 
• Do not store Viberzi in the bathroom, as the humidity in this environment may affect its stability.

[Note: Discuss with your healthcare professional about the proper disposal of any unused Viberzi tablets and any questions you may have regarding their storage.]

What Are the Viberzi Interactions?

Viberzi (eluxadoline) can interact with a variety of drugs and diseases, which may affect how it works or increase the risk of serious side effects. Here are some key interactions to be aware of:

Drug Interactions:

• Amitriptyline
• Cyclobenzaprine
• Cymbalta (duloxetine)
• Lomotil (atropine/diphenoxylate)
• Lyrica (pregabalin)
• Prednisone
• Trazodone
• Zyrtec (cetirizine)
• Amlodipine
• Atorvastatin
• Buspirone
• Dicyclomine
• Famotidine
• Gabapentin
• Ibuprofen
• Levothyroxine
• Lisinopril
• Meloxicam
• Metformin
• Omeprazole
• Tramadol
• Vitamin B12 (cyanocobalamin)
• Vitamin D3 (cholecalciferol)

Disease Interactions:

• Constipation
• Pancreatitis
• Hepatic Impairment

Viberzi and Alcohol:

During treatment with Viberzi, avoid excessive alcohol use. Drinking more than 3 alcoholic beverages daily while taking Viberzi may increase the risk of pancreatitis, which is inflammation of the pancreas. If you have any concerns, consult your doctor.

[Note: This isn’t a complete list, and there could be other drugs that interact with Viberzi. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are Viberzi Alternatives?

Whether you buy Viberzi online or consider its alternatives, you need to prioritize your health first. So, here are some options based on different treatment approaches:

• Lotronex (alosetron)
• Imodium (loperamide)
• Xifaxanta (rifaximin)
• Welchol (colesevelam)
• Elavil (amitriptyline hydrochloride)
• Flexeril (cyclobenzaprine)
• Cymbalta (duloxetine)
• Lomotil (atropine and diphenoxylate)
• Lyrica (pregabalin)
• Prednisone (prednisone)

[Note: Your doctor will choose the best Viberzi alternative for you. Only use these alternative medications after consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

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Frequently Asked Questions

How long does it take for Viberzi to work?

Viberzi typically starts to show its effects within a few days to a week after starting treatment. However, individual responses may vary. It’s essential to follow your doctor’s instructions and continue taking Viberzi consistently for the prescribed duration to achieve the best results.

Can I take Viberzi with other medications?

Viberzi may interact with certain medications. Avoid combining it with Lotronex (alosetron), anticholinergic medicines, and opioid pain medicines. Always discuss with your healthcare professional for a complete list of potential interactions.

Can pregnant women take Viberzi?

Viberzi can be used during pregnancy, but only if the advantages outweigh the possible risks to the unborn baby. While animal studies have not shown teratogenicity, there is no controlled data on human pregnancy. Consult your healthcare provider for personalized advice.

What if I experience severe abdominal pain on Viberzi?

If you experience severe abdominal pain while on Viberzi, stop taking it and contact your healthcare provider immediately. Intense stomach pain can be a symptom of a profound side effect like pancreatitis. Do not ignore severe pain or delay seeking help.

Can I stop taking Viberzi if my symptoms improve?

No, you shouldn’t stop taking Viberzi without consulting your healthcare provider. It is essential to complete the prescribed treatment course. Stopping the medication unexpectedly may result in the recurrence of symptoms.

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