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Eluxadoline

Viberzi

Viberzi is an FDA-approved prescription medication containing the active ingredient Eluxadoline. It targets gut receptors to alleviate symptoms of irritable bowel syndrome with diarrhea (IBS-D) by regulating bowel contractions. It is available in 75 mg and 100 mg tablets. The typically prescribed Viberzi dosage is one tablet twice daily with food for adults. It is not approved for children (under the age of 18). Side effects may include vomiting, nausea, constipation, and stomach discomfort that require medical attention in severe cases. If you have specific medical conditions like bile duct obstruction, pancreatitis, or alcoholism, you should use it with caution. In case of a missed dose, take it promptly unless near the next dose. Seek medical attention if you take an overdose. Store Viberzi at room temperature, away from heat, moisture, and children. Follow your healthcare provider’s guidance for safe and effective use.

Product Overview

Viberzi is an FDA-approved prescription medication containing the active ingredient Eluxadoline. It is primarily designed to treat adults suffering from irritable bowel syndrome with diarrhea (IBS-D). It functions as a mixed opioid receptor agonist and antagonist. It works by targeting the receptors in the gut, thereby reducing bowel contractions and alleviating symptoms associated with IBS-D.

Viberzi is available in tablet form and comes in two strengths: Viberzi 75 mg and Viberzi 100 mg. The typically recommended Viberzi dosage is one tablet taken orally twice daily with food. Viberzi is intended for use by adults only and should not be administered to children or adolescents under the age of 18.

Viberzi side effects may include vomiting, constipation, nausea, and abdominal pain. It is vital to discuss with a healthcare professional if any adverse reactions occur. Additionally, precautions should be taken when using Viberzi, particularly in those with a history of bile duct obstruction, pancreatitis, or alcoholism. If you missed a dose, it is advisable to take it immediately unless it is almost time for the next planned dose. If an overdose is doubted, medical attention should be sought immediately. 

Viberzi should be stored at room temperature, away from moisture and heat. It is necessary to keep it out of reach of children and pets. You should inform your healthcare provider about all medications you are currently taking to prevent any drug interaction. Viberzi is an effective treatment option for adults with IBS-D when used as directed under the guidance of a healthcare professional.

Uses of Viberzi

  • It treats irritable bowel syndrome with diarrhea (IBS-D) in adults.

[Important warning: Viberzi is not approved for use by anyone younger than 18 years old.]

How to Use Viberzi?

Dosage

Strengths and Forms

It is available in the form of tablets in strengths:

  • Viberzi 75 mg tablets
  • Viberzi 100 mg tablets

Recommended Dosage for Viberzi

For Adults with IBS-D:

  • The standard recommended dosage is 100 mg taken orally twice daily with food. 

For Children (Under 18 Years):

  • It is not recommended for use in children.

For Seniors:

  • The recommended dosage is 75 mg or 100 mg twice daily, adjusted based on individual patient needs.

Dosing Modifications

For Pregnant Women:

  • A healthcare provider should determine the Viberzi dosage.

For Patients with Hepatic Impairment:

  • Mild or Medium Hepatic Impairment (Child-Pugh Class A or B): The usual recommended dosage is 75 mg twice daily.
  • Severe Hepatic Impairment (Child-Pugh Class C): Contraindicated due to a significant increase in plasma concentrations.

For Patients with Renal Impairment:

  • Mild Renal Impairment: The recommended dosage is 100 mg taken orally twice daily with food. 
  • Moderate Renal Impairment: The recommended dosage is 75 mg twice daily.
  • Adverse Renal Impairment (eGFR 15 to 30 Ml/min/1.73 M^2) and ESRD Not Yet on Dialysis (eGFR < 15 Ml/min/1.73 M^2): The usual recommended dosage is 75 mg twice daily.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your Viberzi dosage accordingly.]

How to Take It?

  • You should take Viberzi tablets orally with food.
  • Swallow the tablet whole with water; do not split, crush, or munch it.
  • The typically recommended dosage is one tablet twice daily.
  • Take Viberzi at evenly spaced intervals, approximately 12 hours apart.
  • Make sure you adhere to your healthcare professional’s Viberzi dosage instructions.
  • Only take the recommended dose if directed by your doctor.

[Note: Your healthcare professional will determine the right amount of Viberzi for you based on your condition, following guidelines and studies on the drug. They may adjust it as required over time.]

How Does Viberzi Work?

Viberzi works as a mixed opioid receptor modulator. It has both agonist and antagonist effects on opioid receptors in the gastrointestinal tract. Targeting specific receptors helps to reduce bowel contractions and alleviate abdominal pain, leading to better control of bowel habits in individuals with IBS-D. It is important to note that Eluxadoline is not classified as a traditional opioid but interacts with opioid receptors in the gut.

Important Safety Information

Side Effects

Common side effects of Viberzi may include:

  • Dizziness
  • Gas
  • Constipation
  • Nausea
  • Runny or stuffy nose
  • Abdominal pain or discomfort
  • Vomiting

Mild side effects of Viberzi may include:

  • Headache
  • Dizziness
  • Fatigue
  • Gas or bloating
  • Indigestion
  • Dry mouth

Serious side effects of Viberzi may include:

  • Severe constipation or bowel obstruction
  • Sphincter of Oddi spasm (contraction of the muscle that controls bile flow)
  • Severe abdominal pain or cramping
  • Severe or persistent diarrhea
  • Liver problems (dark urine, persistent nausea or vomiting, yellowing of the eyes or skin)
  • Pancreatitis (severe abdominal pain, nausea, vomiting)
  • Serious allergic reaction (redness, itching, swelling, severe dizziness, trouble breathing)
  • Severe gastrointestinal disorder (severe abdominal pain, persistent nausea or vomiting, bloody stools)

[Note: Remember, this list may not cover all possible Viberzi side effects. Always consult with your healthcare giver for medical advice about side effects.]

Warnings

Pancreatitis Risk: Viberzi has been associated with cases of pancreatitis, an adverse inflammation of the pancreas. Symptoms may include stomach pain that may lead to the back, nausea, vomiting, and fever. If you experience these symptoms, seek medical attention promptly.

Spasm of the Sphincter of Oddi: Viberzi can cause spasms of the sphincter of Oddi, a muscular valve that regulates the flow of digestive juices into the small intestine. This can lead to abdominal pain, which may be severe. If you develop intense abdominal pain, especially in the upper right quadrant, along with nausea and vomiting, discontinue Viberzi and seek immediate medical attention.

Constipation Risk: Viberzi may cause constipation, which can cause problems such as fecal impaction or bowel obstruction, particularly in patients with a history of gastrointestinal obstruction. Monitor your bowel movements and inform your healthcare provider if you experience severe constipation or are unable to have a bowel movement for several days.

Severe Allergic Reactions: Some people may undergo severe allergic reactions to Viberzi, characterized by symptoms such as redness, burning, inflammation of the face, lips, or throat, difficulty breathing, or dizziness. If you notice any of the symptoms, seek immediate medical help.

Hepatic Impairment: Viberzi should be used with caution in patients with liver impairment or a history of liver disease, as it may exacerbate existing liver conditions. Monitoring of hepatic function may be essential during treatment.

Interactions with Alcohol: Consumption of alcohol while taking Viberzi may increase the risk of pancreatitis and other adverse reactions. It is recommended to avoid alcohol while taking Viberzi.

Adverse Reactions in Pediatric Patients: The safety and effectiveness of Viberzi in pediatric patients have not been established. It is not recommended for use in individuals under the age of 18.

Pregnancy and Breastfeeding: The safety of Viberzi during pregnancy and breastfeeding has not been studied. Let your healthcare professional know if you are pregnant or breastfeeding before taking Viberzi.

Precautions

  • You should monitor for signs of pancreatitis, such as severe stomach pain, constipation, vomiting, nausea, and fever.
  • Be alert for symptoms of sphincter of Oddi spasm, including intense upper right quadrant abdominal pain, nausea, and vomiting.
  • Watch for constipation, especially if you have a history of gastrointestinal issues, and inform your doctor if it is severe.
  • Be aware of the potential for severe allergic reactions and seek immediate medical attention if you experience rash, itching, swelling, difficulty breathing, or dizziness.
  • Exercise caution if you have liver impairment or a history of liver disease, and discuss monitoring with your healthcare provider.
  • Avoid alcohol consumption while taking Viberzi to reduce the risk of adverse reactions.
  • Do not use Viberzi if you are under 18 years old, pregnant, planning to become pregnant, or breastfeeding unless advised otherwise by your doctor.

Viberzi Contraindications

  • A person without a gallbladder.
  • A person with biliary duct obstruction or sphincter of Oddi dysfunction.
  • A person with structural diseases of the pancreas.
  • A person with a history of pancreatitis.
  • A person who drinks 3 or more alcoholic beverages daily or who is an alcoholic, alcohol abuse, or addiction patient.

Missed Dose

If you forget to take a dose of Viberzi tablets, take it immediately when you recall. But if it’s nearly time for your next planned dose, skip the missed one and continue with your regular dosing plan. Avoid taking two doses concurrently to compensate for the missed one.

[Note: If you have missed a dose of Viberzi and are still deciding when to take the next dose, directly consult your healthcare professional.]

Overdose

Overdosing on Viberzi can lead to serious complications such as:

  • Severe constipation
  • Nausea and vomiting
  • Abdominal pain or cramping
  • Dizziness or lightheadedness
  • Difficulty breathing
  • Changes in heart rate or rhythm
  • Confusion or disorientation
  • Loss of consciousness

[Note: If you consumed more than the recommended Viberzi dosage, get medical help right away or call the Poison Help line at 1-800-222-1222.]

Storage

  • Store Viberzi at room temperature, away from excessive heat and moisture. 
  • Keep the Viberzi tablets in their original box to protect them from light. 
  • Ensure that the medication is kept in a child-resistant container and kept out of reach of children. 
  • Do not store Viberzi in the bathroom, as the humidity in this environment may affect its stability.

[Note: Discuss with your healthcare professional about the proper disposal of any unused Viberzi tablets and any questions you may have regarding their storage.]

Viberzi Interactions

Drug Interactions:

  • Amitriptyline
  • Cyclobenzaprine
  • Cymbalta (duloxetine)
  • Lomotil (atropine/diphenoxylate)
  • Lyrica (pregabalin)
  • Prednisone
  • Trazodone
  • Zyrtec (cetirizine)
  • Amlodipine
  • Atorvastatin
  • Buspirone
  • Dicyclomine
  • Famotidine
  • Gabapentin
  • Ibuprofen
  • Levothyroxine
  • Lisinopril
  • Meloxicam
  • Metformin
  • Omeprazole
  • Tramadol
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)

Disease Interactions:

  • Constipation
  • Pancreatitis
  • Hepatic Impairment

Viberzi and Alcohol:

During treatment with Viberzi, avoid excessive alcohol use. Drinking more than 3 alcoholic beverages daily while taking Viberzi may increase the risk of pancreatitis, which is inflammation of the pancreas. If you have any concerns, consult your doctor.

[Note: This isn’t a complete list, and there could be other drugs that interact with Viberzi. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Viberzi Alternatives

  • Lotronex (alosetron)
  • Imodium (loperamide)
  • Xifaxanta (rifaximin)
  • Welchol (colesevelam)
  • Elavil (amitriptyline hydrochloride)
  • Flexeril (cyclobenzaprine)
  • Cymbalta (duloxetine)
  • Lomotil (atropine and diphenoxylate)
  • Lyrica (pregabalin)
  • Prednisone (prednisone)

[Note: Your doctor will choose the best Viberzi alternative for you. Only use these alternative medications after consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

How long does it take for Viberzi to work?

Viberzi typically starts to show its effects within a few days to a week after starting treatment. However, individual responses may vary. It’s essential to follow your doctor’s instructions and continue taking Viberzi consistently for the prescribed duration to achieve the best results.

Can I take Viberzi with other medications?

Viberzi may interact with certain medications. Avoid combining it with Lotronex (alosetron), anticholinergic medicines, and opioid pain medicines. Always discuss with your healthcare professional for a complete list of potential interactions.

Can pregnant women take Viberzi?

Viberzi can be used during pregnancy, but only if the advantages outweigh the possible risks to the unborn baby. While animal studies have not shown teratogenicity, there is no controlled data on human pregnancy. Consult your healthcare provider for personalized advice.

What if I experience severe abdominal pain on Viberzi?

If you experience severe abdominal pain while on Viberzi, stop taking it and contact your healthcare provider immediately. Intense stomach pain can be a symptom of a profound side effect like pancreatitis. Do not ignore severe pain or delay seeking help.

Can I stop taking Viberzi if my symptoms improve?

No, you shouldn’t stop taking Viberzi without consulting your healthcare provider. It is essential to complete the prescribed treatment course. Stopping the medication unexpectedly may result in the recurrence of symptoms.

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