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What Is Viberzi (Eluxadoline)?

Viberzi is a prescription medication that contains the active ingredient Eluxadoline. It is primarily used for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults. IBS-D is a gastrointestinal disorder characterized by abdominal pain and frequent episodes of diarrhea.

How Does Viberzi Work?

Eluxadoline works as a mixed opioid receptor modulator. It has both agonist and antagonist effects on opioid receptors in the gastrointestinal tract. By targeting specific receptors, it helps to reduce bowel contractions and alleviate abdominal pain, leading to better control of bowel habits in individuals with IBS-D. It is important to note that Eluxadoline is not classified as a traditional opioid but interacts with opioid receptors in the gut.

Viberzi Dosage and Storage Instructions


Viberzi (Eluxadoline) is available in different strengths. Common strengths include Viberzi 75 mg and Viberzi 100 mg tablets. The typical starting dose is often 100 mg twice daily with food. Healthcare providers may adjust the dosage based on the patient’s response to treatment and tolerability. Some individuals may start at a lower dose of 75 mg twice daily.

How to Store?

Store Viberzi at room temperature, away from excessive heat and moisture. Keep the medication in its original packaging to protect it from light. Ensure that the medication is stored in a child-resistant container and kept out of reach of children. Do not store Viberzi in the bathroom, as the humidity in this environment may affect its stability.

Important Precautions While Taking Viberzi 

  • Viberzi may cause spasms of the sphincter of Oddi, leading to severe abdominal pain. It is not recommended for use in patients with a history of biliary duct obstruction or liver impairment.
  • Limit or avoid alcohol consumption while taking Viberzi 100mg tablets. Alcohol use may increase the risk of pancreatitis.
  • Consult your healthcare provider before using Viberzi during pregnancy or breastfeeding. The potential risks and benefits should be carefully considered.
  • Viberzi may cause constipation. Monitor bowel habits, and if constipation becomes severe or persists, consult your healthcare provider.

Warnings to Consider

Viberzi has been associated with an increased risk of pancreatitis, particularly in individuals without a gallbladder. Inform your healthcare provider immediately if you experience persistent abdominal pain, especially in the upper abdomen.

Viberzi Side Effects

It may cause a number of side effects. Common side effects of Viberzi (Eluxadoline):

  1. Nausea and constipation
  2. Abdominal pain
  3. Pancreatitis
  4. Sphincter of Oddi Spasm
  5. Allergic reactions
  6. Hepatic events
  7. Bowel obstruction
  8. Alcohol interaction
  9. Sedation and dizziness:

[Note: It’s crucial to report any Viberzi side effects to your healthcare provider promptly. This list may not include all possible side effects, and individual reactions can vary. Always follow your healthcare provider’s guidance and attend regular check-ups during Viberzi 100mg treatment].

What Things Interact with Viberzi?

Medicines that Interact with Viberzi (Eluxadoline):

  1. Opioids medications
  2. Medications Affecting Gastrointestinal Motility
  3. Alcohol
  4. Medications metabolized by CYP3A4 Enzymes
  5. Bile acid sequestrants
  6. Strong CYP3A4 inhibitors
  7. Immunosuppressive medications
  8. Gallbladder disorders medications

This is not an exhaustive list, and interactions can vary based on individual health conditions. Always inform your healthcare provider about all medications.

Frequently Asked Questions

Can I take Viberzi 100mg tablets for occasional diarrhea?

Viberzi 100mg tablets are specifically designed for irritable bowel syndrome with diarrhea (IBS-D) and are not intended for occasional diarrhea. It’s crucial to use this medication only as prescribed by your healthcare provider. If you experience occasional diarrhea, consult your doctor for advice on the most appropriate treatment options tailored to your specific situation.

What should I do if I experience severe abdominal pain on Viberzi?

If you experience severe abdominal pain while on Viberzi, stop taking it and contact your healthcare provider immediately. Severe abdominal pain could be a sign of a serious side effect like pancreatitis. Your doctor will assess the situation, provide guidance, and adjust your treatment plan as needed for your safety and well-being.

Can I stop taking Viberzi if my symptoms improve?

No, do not stop taking Viberzi without consulting your healthcare provider, even if your symptoms improve. It’s important to complete the prescribed treatment course. Abruptly stopping the medication may lead to a recurrence of symptoms. Your doctor will guide you on the appropriate duration of treatment and any necessary adjustments based on your individual response to the medication.

Is constipation a common side effect of Viberzi?

Yes, constipation is a potential Viberzi side effect. If you experience persistent or severe constipation, inform your healthcare provider. They can assess your symptoms and may adjust the dosage or recommend additional measures to manage this side effect. Always communicate any concerns or changes in your condition to ensure the most effective and comfortable use of the medication.

Our Guarantee

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