Latanoprostene Bunod Ophthalmic Solution

Vyzulta

Vyzults is a topical ophthalmic solution that has been approved by the FDA for treating elevated intraocular pressure in patients with open-angle glaucoma, also known as ocular hypertension. This solution can be used alone or in combination with other eye medications, but its combination use requires you to follow certain guidelines. You need to wait for at least 5 minutes before applying other ophthalmic solutions. However, like every medication, Vyzulta may have certain side effects, which can become intense if you do not follow the dosage recommendations as prescribed by your eye specialist. As with any medication, following the prescribed dosage is crucial to avoid potential side effects. If not used as directed, the side effects may become more severe. Vyzulta is a prescription medication, so it should not be shared with others, even if they have the same condition. If you’re considering treatment, you can buy Vyzulta online, but ensure that you consult with an eye specialist first to confirm that it is the right option for your condition.

Product Overview

Vyzulta (Latanoprostene Bunod ophthalmic solution) 0.024% is a prescription eye drop designed to treat elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. This medication features a dual-action mechanism, combining the effects of latanoprost, a prostaglandin analog, with nitric oxide-donating properties to improve its ability to lower IOP.

FDA-approved and available as an ophthalmic solution, Vyzulta is typically prescribed for once-daily use—one drop in the affected eye(s) in the evening. It works by increasing the outflow of aqueous humor through both the uveoscleral and trabecular meshwork pathways, effectively reducing IOP and helping to prevent optic nerve damage and vision loss. Vyzulta for glaucoma treatment offers an effective solution for managing elevated eye pressure and preventing further damage in adults as directed by a healthcare professional. 

Common side effects of Vyzulta may include eye irritation, redness, and increased pigmentation of the iris. Patients should follow their eye specialist’s advice on usage and report any severe or persistent side effects. Precautions include avoiding contact lenses during application and ensuring the dropper tip does not touch any surfaces to prevent contamination. In case of a missed dose, patients should take it as soon as possible unless it is nearly time for the next dose; do not double up doses. Overdose requires immediate medical attention. Store Vyzulta in a refrigerator before opening, and once opened, it can be stored at controlled room temperature for up to 8 weeks. Always keep it out of reach of children and protect it from light. If you’re looking to start treatment, you can order Vyzulta eye drops online, but make sure to consult with your healthcare provider before purchasing to ensure it is the right treatment for you.

What Are the Uses of Vyzulta?

This medication is used for the following conditions:

• Treats High Intraocular Pressure: Vyzulta helps in lowering high pressure inside the eye.
• Open-Angle Glaucoma: It manages intraocular pressure in patients with open-angle glaucoma.
• Ocular Hypertension: This medication effectively reduces pressure in cases of ocular hypertension.
• Prevents Optic Nerve Damage: Lowering eye pressure helps prevent damage to the optic nerve.
• Reduces Risk of Vision Loss: It helps in preventing vision loss associated with high intraocular pressure.

What is the Form & Strength of Vyzulta?

Vyzulta comes in an ophthalmic solution with a strength of 0.024%.

What Are the Recommended Dosage of Vyzulta?

The dosage recommendations for Vyzulta depend on several factors, including the type and severity of your medical condition and the form of medication you take. Generally, medical professionals prescribe a starting dose and gradually adjust the drug doses as needed. It is important to note that the dosage recommendations below are only for the average dose. So, if you have been prescribed a different dose, do not change it without consulting your medical practitioner.  

Dosage for High Intraocular Pressure

• Instill one drop of Vyzulta ophthalmic solution in the conjunctival sac of the infected eye. Administer the solution once daily, preferably in the evening. 
• Do not use the medication more than once, as doing so reduces the solution’s effectiveness at lowering eye pressure.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Vyzulta?

• Read the medication guide thoroughly provided by your pharmacist for complete administration steps. If you have any questions, ask a medical professional.
• Follow the directions as it is mentioned on the prescription label. 
• Do not use the medication in larger or smaller doses unless your doctor prescribes otherwise.
• Administer the drops in the infected eye once daily in the evening. 
• Wash your hands properly with soap and water before and after using the eye drops.
• For the application process, tilt your head and pull your eyelid in a downward direction, making a small space instilling the eye drops. 
• Then, hold the dropper above the eye, not too far, and squeeze out a drop in that small pocket.
• Close your eyes for a few minutes without squinting the eye. 
• Gently push down the inside corner of the eye with your index finger for a minute to keep the liquid in its place and let it absorb.
• If using other eye solutions, wait 5 minutes after using Vyzulta.
• Do not touch the dropper’s tip. Doing so will contaminate the bottle and can infect the eye, leading to serious vision problems.
• Avoid using this medication while wearing contact lenses. Certain preservatives in the medicine can discolor the lenses, especially if they are soft.  
• Once you have used the eye drops, wait for 15 minutes before wearing the lenses back.
• If the liquid’s color seems unusual or it has particles in it, do not use the solution.
• If you have an eye injury, develop an infection, or are planning an eye surgery, consult with a medical professional before using the product.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Vyzulta Work?

Vyzulta (Latanoprostene Bunod) works by utilizing a dual-action mechanism to lower intraocular pressure (IOP) in the eye. It combines the effects of latanoprost, a prostaglandin analog, and a nitric oxide-donating component. Latanoprost increases the outflow of aqueous humor through the uveoscleral pathway, while nitric oxide enhances outflow through the trabecular meshwork. This combined action effectively reduces IOP, helping to prevent damage to the optic nerve & loss of vision in patients with open-angle glaucoma or ocular hypertension.

Important Safety Information for Using Vyzulta

What Are the Side Effects of Vyzulta?

Common Side Effects of Vyzulta: This ophthalmic solution can cause various side effects. These reactions are basically temporary and last from a few days to weeks. However, if they stay for a long period and worsen over time or bother you, reach out to an eye specialist. Common side effects of Vyzulta may include:

• Eye redness or discharge: The medication can cause blood vessels in the eye to dilate, leading to a reddish appearance. Discharge may occur as the eye reacts to the drops, producing extra mucus or tears to flush out any perceived irritants.

• Eye irritation: Some individuals may feel a burning, stinging, or gritty sensation after applying the drops. This is usually temporary and occurs as the eye adjusts to the medication.

• Pain while using the drops: Pain may result from sensitivity to the active ingredients or preservatives in the solution. It can also occur if the eye is already inflamed or irritated prior to using the medication.

• Eyelash changes: Vyzulta can stimulate hair follicles, potentially causing eyelashes to grow longer, darker, or thicker. While this might not be uncomfortable, it is a noticeable change for many users.

• Puffiness on the eyelids: The eyelid tissue may swell due to mild inflammation caused by the medication. This puffiness is often temporary but can be bothersome if severe or persistent.
• Feeling like something is in the eye: This sensation, also known as “foreign body sensation,” may occur as the medication interacts with the eye’s surface. It can be due to minor irritation of the cornea or conjunctiva.

Serious Side Effects of Vyzulta: In addition to the above common reactions, this medication can cause adverse side effects, leading to fatal situations. If you are experiencing any unusual reactions that may seem severe, visit the nearest clinic right away. Serious side effects of Vyzulta may include:

• • Eye problems. Its symptoms may include:

• Vision loss: Damage to the optic nerve or severe pressure changes in the eye may lead to partial or complete loss of vision, which could become permanent if untreated.

• Blurred vision: Caused by increased intraocular pressure or inflammation, making it difficult to see clearly.

• • • Eye pain or swelling: Indicates irritation, infection, or inflammation in the eye, potentially damaging sensitive tissues.

• Seeing halos around lights: A symptom of high intraocular pressure, indicating potential damage to the optic nerve. 

• • Tunnel vision: Loss of peripheral vision, often due to worsening glaucoma.
• Heart Problems. Its signs are:
  • Rapid or irregular heartbeats: May result from the medication’s effect on the autonomic nervous system, causing palpitations or arrhythmias.
  • Chest fluttering: A sensation of the heart skipping beats, often associated with irregular heart rhythms. 
  • Shortness of breath: Indicates possible cardiovascular strain, limiting oxygen delivery to the body. 
  • Sudden dizziness: A sign of low blood pressure or disrupted blood flow, affecting brain function.
  • Weakness in the leg or arm: Could indicate a transient ischemic attack (TIA) or stroke, requiring immediate medical attention.
• Severe headache: May signify increased cranial pressure or cardiovascular issues affecting blood vessels in the brain.
• Muscle stiffness: These symptoms may be linked to rare adverse drug reactions affecting the nervous system.
• Unsteadiness: Could result from central nervous system side effects, affecting coordination and balance.
• Confusion: Indicates potential drug-related toxicity or insufficient blood supply to the brain.
• Trouble walking: Warning signs of a stroke or other neurological event.
• Excessive sweating: Linked to autonomic nervous system dysfunction or a severe reaction to the medication.
• Tremors: Uncontrolled shaking can result from nervous system irritation or medication side effects.
• Change in eye color (iris) to brown: Vyzulta may cause a gradual increase in melanin production in the iris, permanently darkening the eye’s color. This is a cosmetic change and is typically not harmful but is irreversible.
• Allergic reaction. Its signs are:
  • Rash: Skin irritation caused by hypersensitivity to the medication.
  • Itching/swelling on the face, throat, or tongue: Suggests an allergic response that can progress to life-threatening anaphylaxis.
  • Trouble breathing: A sign of airway constriction or severe allergic reaction, requiring immediate emergency care.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Vyzulta? 

Vyzulta can cause severe side effects in certain patients, or it may not be an ideal treatment option for specific populations due to their medical conditions. So, if you are using Vyzulta eye drops, you should remain cautious as it has several warnings, which are as follows:

• Pigmentation: Vyzulta may cause changes in the color of pigmented tissues. The most commonly reported changes with prostaglandin analogs include increased pigmentation of the iris and the area around the eyes (eyelid). While the pigmentation in the iris is likely to be permanent, changes in the eyelid area and eyelashes are usually reversible after stopping this medication. Patients who develop noticeable changes in iris pigmentation can continue their treatment with Vyzulta, but they should be regularly monitored.
• Eyelash Changes: Vyzulta may gradually alter the eyelashes and small hairs around the treated eye, including increased length, thickness, and number of lashes or hairs. These changes are generally reversible once the treatment is stopped.
• Intraocular Inflammation: This medication should be used cautiously in patients with a history of intraocular inflammation and is generally not recommended for use in such patients, as it may worsen this condition.
• Macular Edema: The use of prostaglandin analogs, like Vyzulta, has shown cases of macular edema, including cystoid macular edema. It should be cautiously used in patients with aphakic and pseudophakic, as well as in patients with known risk factors for macular edema.
• Bacterial Keratitis: Patients using multi-dose containers of topical eye products have reported cases of bacterial keratitis. These containers were accidentally contaminated by patients, often those with existing corneal diseases or a damaged ocular surface.

What Are the FDA Boxed Warning for Vyzulta?

Boxed warnings, sometimes referred to as black-boxed warnings, are said to be the most stringent guidelines issued by the FDA. These warnings alert doctors and patients about the harmful effects of a particular drug, which can be life-threatening if overlooked. Vyzulta does not have any boxed warnings, meaning it is safe to use. However, its safety is based on the precautions you take. Therefore, if you are taking this medication, follow the instructions provided by your eye specialists. If you have any concerns or notice any unusual symptoms, it’s best to consult with an expert.

What Are the Vyzulta Precautions?

When considering treatment with Vyzulta, patients should discuss every risk and benefit with their eye specialist. Here are some of the precautions that you can take before using Vyzulta for elevated intraocular pressure:

• Before considering treatment with Vyzulta, tell your medical practitioner about your allergies or if you are allergic to any of the medication’s ingredients. The product may contain certain inactive components that can cause allergic reactions. 
• If you are thinking of using this medication, inform your doctor about your or your family’s medical history, especially for eye problems like iritis, macular edema, lens extraction, or uveitis.
• Do not drive or use heavy machinery after applying this medication, as it temporarily blurs your vision.
• If you are undergoing surgery or any medical procedure, tell your doctor about the products you take. This includes all prescription drugs, over-the-counter medications, and herbal products. 
• Pregnant women or those who are planning to have a baby should avoid using these eye drops unless they are clearly needed. Discuss every risk and benefit with an eye specialist before using this medication.
• It is not clear whether the drug enters into breast milk. So, if you are a nursing mother, talk to a medical professional before breastfeeding your child.

What Are the Contraindications of Vyzulta? 

There are no contraindications of Vyzulta.

What If You Missed a Dose of Vyzulta?

Generally, it is advisable not to miss any doses of your Vyzulta application, but if someone forgets to use their eye drops, they can:

• Instill the eye drops as soon as possible or whenever you remember.
• If it is almost time for the next application, skip the missed dose and follow your regular dosing schedule as your ophthalmologist instructed.
• Remember not to take double doses of your prescribed eye drops just for the sake of making up for the missed dose. This may cause adverse side effects.
• Use medication apps or set reminders on your phone to avoid skipping any doses.
• Take each dose at the same time every day to get the most benefit out of it.
• If you are still unsure about the missed doses, talk to an ophthalmologist. They will guide you and suggest alternate options.  

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Vyzulta?

While patients are educated enough to know the complications of overdose, there are times when they mistakenly put in excessive amounts of Vyzulta eye drops. In such cases, patients are advised not to panic, be calm, and rinse their eyes immediately with regular tap water. However, if someone has swallowed Vyzulta and is experiencing adverse symptoms like fainting, seizure, and difficulty breathing, visit the nearest clinic or get medical assistance immediately by calling 911.  

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Vyzulta?

• Store the unopened bottle of Vyzulta in the refrigerator at a temperature of 2°C to 8°C. 
• Once you have opened the bottle, store it at 2° to 25°C maximum for eight weeks.
• Avoid refrigerating the bottle.
• Keep it away from moisture and light.
• Do not store the medication under direct sunlight.
• Do not flush the medication down the toilet.
• Avoid keeping the bottle in damp or moist areas like the bathroom or near the sink.
• Discard the product eight weeks after opening the bottle.
• Keep the medication somewhere safe and away from the reach and sight of children.
• Place safety locks in the product’s container to prevent your children or pets from consuming it. Many medications on the market are not child-resistant.
• Do not use a medication if its expiration date has passed. The expiration date is the last day of the month mentioned on the back of the prescription label or carton.
• You should dispose of the medications in such a way that children and animals cannot consume them, as it may cause accidental overdose and death if someone else consumes them.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.
• Ask a medical professional or a pharmacist how to properly dispose of the product without damaging the environment.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Vyzulta?

Drug interactions occur when one or more medications are taken simultaneously. These interactions can either raise the risk of developing side effects in certain patients or affect the functioning of one of the drugs. Either way, it results in adverse reactions. Therefore, patients need to be aware of the drugs that may interact with their Vyzulta medication. Below are some of the drugs that can interact with Vyzulta:

• Bimatoprost ophthalmic: Using Bimatoprost and Vyzulta together may reduce their effectiveness in lowering intraocular pressure. These medications belong to the same class of prostaglandin analogs, and combining them can lead to receptor saturation, minimizing the therapeutic effect.
• Bimatoprost topical: Applying bimatoprost topically for eyelash growth (e.g., Latisse) while using Vyzulta may decrease the intraocular pressure-lowering effects of both drugs. The interaction occurs due to competitive binding to prostaglandin receptors, diminishing their action in controlling eye pressure
• Latanoprost ophthalmic: Combining latanoprost (another prostaglandin analog) with Vyzulta may cause paradoxical increases in intraocular pressure rather than lowering it. This could result from receptor desensitization or changes in aqueous humor dynamics due to overlapping mechanisms.
• Omidenepag isopropyl ophthalmic: Using both drugs simultaneously might lead to unpredictable effects on eye pressure control, increasing the risk of adverse reactions such as eye irritation or inflammation. Omidenepag targets similar pathways to Vyzulta, creating a risk of pharmacodynamic overlap.
• Tafluprost ophthalmic: Combining tafluprost with Vyzulta may reduce the pressure-lowering effects of either drug and increase side effects like eye redness or discomfort. These drugs may compete for the same prostaglandin receptors, reducing their individual efficacy.
• Travoprost ophthalmic: Using Travoprost and Vyzulta together can lead to diminished intraocular pressure control and heightened side effects, such as changes in iris pigmentation or eyelash growth. Both are prostaglandin analogs and may interfere with each other’s receptor activity.
• Unoprostone ophthalmic: Co-administration with Vyzulta might result in less effective eye pressure reduction and irritation or discomfort in the eyes. Although Unoprostone is a prostaglandin analog, it acts differently, potentially creating inconsistent pressure-lowering results when combined with Vyzulta.

[Note: This isn’t a complete list, and there could be other drugs that interact with Vyzulta. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Vyzulta Alternatives?

People usually take alternative drugs for many reasons. In some cases, the prescribed medication may not be an ideal option for them due to their medical conditions. On the other hand, they may not achieve the results they are aiming for. Therefore, you should talk to a medical professional before you start a particular treatment or if you want to change your medication. They may help you decide which medication is best suited for you. Some of the alternatives of Vyzulta are as follows:

• Combigan (brimonidine/timolol)
• Zioptan (tafluprost)
• Omidenepag isopropyl ophthalmic
• Omlonti
• Bimatoprost
• Travatan Z
• Travoprost (Bak Free)
• Xalatan
• Durysta
• Betoptic
• Betoptic S
• Carteolol 
• Timolol
• Levobunolol
• Metipranolol
• Dorzolamide (Trusopt)
• Brinzolamide (Azopt)
• Acetazolamide (Diamox)
• Methazolamide
• Brimonidine (Alphagan-P)
• Apraclonidine
• Cosopt

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Vyzulta Cost & Coupons

It is important to note that the cost of Vyzulta is not the same everywhere. The actual price of these tablets depends on several factors, including your insurance plan, location, and the pharmacies you use. Vyzulta, with its effective therapeutic qualities, can be expensive for certain patients. Here, insurance coverage plays a significant role. You can buy your medication at affordable rates with an insurance coverage plan. However, not all drugs/medications are covered under the insurance plan. If you are residing in America and searching for affordable pharmacies to manage your medication’s cost, reach out to Polar Bear Meds. Here you can buy Vyzulta online from Canada in the USA at discounted rates. Moreover, first-time buyers can use the Vyzulta coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

How effectively does Vyzulta (latanoprostene bunod) lower eye pressure?

In clinical studies, Vyzulta demonstrated significant effectiveness in reducing intraocular pressure. When used once daily for up to a year, it was shown to lower eye pressure by approximately 7 mmHg to 9 mmHg compared to baseline levels. If you are using Vyzulta, it’s important to follow up regularly with your optometrist or ophthalmologist to monitor how well the medication is lowering your eye pressure and to ensure it is effectively managing your condition.

Can Vyzulta eye drops make you sleepy?

Vyzulta eye drops are not known to cause drowsiness or make you sleepy. Its primary effects are localized to the eyes, focusing on reducing intraocular pressure. If you experience unusual side effects, such as drowsiness or fatigue, consult your healthcare provider for further evaluation and advice on whether an alternative treatment is needed.

Which is better, Vyzulta or Xalatan?

Both Vyzulta and Xalatan are effective in reducing intraocular pressure in people with open-angle glaucoma/ocular hypertension. Vyzulta has a dual-action mechanism that may provide additional benefits. The choice between the two depends on individual patient needs and responses. Therefore, it’s best to consult with your eye care doctor to choose the most suitable option for your specific condition.

When is the best time to use Vyzulta?

The best time to use Vyzulta is in the evening. Administering one drop in the affected eye(s) at this time helps maximize its effectiveness in reducing intraocular pressure. Follow your healthcare provider’s instructions and maintain a consistent routine for optimal results, ensuring that you do not skip doses to achieve the best outcome.

Do Vyzulta eye drops cause dry eyes?

Dry eyes are not commonly reported as a side effect of Vyzulta. However, some patients may experience eye irritation or discomfort. If you notice persistent dryness, irritation, or other symptoms, contact your healthcare provider to discuss potential solutions or alternative treatments to ensure your comfort and the continued effectiveness of the medication.

Our Guarantee

At PolarBearMeds.com, we assure you the most affordable price to buy Vyzulta online from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently buy Vyzulta online to treat elevated intraocular pressure at a substantial cost, call us at 1-888-779-2193 toll-free.