Buy Xarelto Online from the Certified Canadian Pharmacy
Xarelto
Xarelto, also known as Rivaroxaban, is an FDA-approved drug, prescribed for treating blood clots and related health issues. It’s part of a group of medicines known as DOACs, or direct oral anticoagulants, which are a type of medicine that helps prevent blood clots. DOACs are different from older blood-thinning drugs because they target fewer parts of the blood clotting process. Xarelto is available in two forms that you can take by mouth: a tablet and a liquid suspension, which is a type of liquid blend. It comes in three different doses, and the right dose for you will depend on the specific health condition being treated. Adhere to the instructions of your healthcare provider regarding its side effects, warnings, and precautions to use your medication effectively and safely.
Product Overview
Xarelto, a factor Xa inhibitor, plays a crucial role in managing conditions related to blood clots and stroke prevention. For adults experiencing atrial fibrillation not due to heart valve defects, Xarelto significantly reduces the risk of stroke and blood clots. It is also essential in treating deep vein thrombosis (DVT) and pulmonary embolism (PE), as well as preventing these conditions from happening again in individuals at continued risk. Additionally, Xarelto is effective in preventing blood clots in patients following hip or knee replacement surgery and in hospitalized adults at risk of clotting due to immobility and other factors.
The medication is available in various strengths for tablets (2.5 mg, 10 mg, 15 mg, and 20 mg) and as a 1 mg/ml oral suspension, accommodating different patient needs and conditions. Dosage recommendations are specific to each condition, ranging from 10 mg once daily for post-surgical prevention to 20 mg daily for atrial fibrillation and after initial treatment of blood clots. For children, including newborns up to 17 years old, Xarelto is indicated for treating blood clots and preventing them from forming again, with dosages adjusted according to body weight and specific conditions. Despite its benefits, users must be aware of potential side effects and the risk of serious bleeding, underscoring the importance of medical guidance and regular monitoring while on Xarelto.
Xarelto can make you bleed more easily than you normally would. This could mean getting nosebleeds or seeing bruises on your body. If you notice these or any other unusual signs, you should tell your doctor right away. Do not use Xarelto if you have serious issues with your kidneys or liver, if you are already bleeding, or if you are on medication that affects blood clotting. It’s also important not to breastfeed while taking Xarelto. Unlike some other blood thinners, you don’t need regular blood tests (PT-INR) to check your clotting levels while on this medication.
Uses of Xarelto
Xarelto is a medicine prescribed for:
- Reducing the chance of stroke and blood clots in adults with a condition called atrial fibrillation, which is not related to a heart valve issue. In atrial fibrillation, a part of the heart does not beat correctly, leading to blood clots that can cause a stroke or travel to other body parts.
- Treating blood clots in the legs (known as deep vein thrombosis, or DVT) or in the lungs (called pulmonary embolism, or PE).
- Lowering the risk of blood clots forming again in adults who are still at risk for DVT or PE after having been treated for blood clots for at least six months.
- Helping to prevent blood clots in the legs and lungs in adults who have recently undergone hip or knee replacement surgery.
- Assisting in preventing blood clots in certain adults who are hospitalized for a severe illness and after they leave the hospital. This is for those who are at risk of blood clots due to being less mobile (able to move around) and other clot risks and who do not have a high risk of bleeding.
Xarelto, when taken with a low dose of Aspirin, is used to:
- Lower the chance of severe heart issues, heart attacks, and strokes in adults who have coronary artery disease (a situation where the blood supply in the heart is reduced or blocked).
- Decrease the risk of a sudden reduction in major amputation, serious heart issues, blood flow to the legs, or strokes in adults with peripheral artery disease (a situation where the blood flow to the legs is reduced). This also includes adults who have recently undergone a procedure to enhance blood flow to their legs.
Xarelto is for children from newborns up to 17 years old. It is used to:
- Treat or lower the chance of blood clots forming again in children. This is after they have already been treated with medicine given by injection or through an IV for at least five days.
- Prevent blood clots in children aged two years and older who have heart disease they were born with following a heart surgery known as the Fontan procedure.
Xarelto has not been researched and is not advised for use in infants younger than six months if they:
- Were born before reaching 37 weeks of pregnancy (before the gestation period),
- Have been eating by mouth for less than ten days or
- Their body weight is less than 5.7 pounds (2.6 kg).
How to Use Xarelto?
Dosage
Xarelto comes in two forms:
- Tablets
- Oral Suspension
Xarelto is available in four strengths as tablets and in one strength as a suspension:
- Xarelto 2.5 mg tablet
- Xarelto 10 mg tablet
- Xarelto 15 mg tablet
- Xarelto 20 mg tablet
- Xarelto 1 mg/ml suspension
The prescribed dosage strength of Xarelto tablets will depend upon the specific condition targeted for prevention or treatment.
[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
Recommended Dosage For Different Treatments
Stroke Prevention in Atrial Fibrillation
Normal and Mildly Impaired Kidney Function
- 20 mg Once daily
Impaired Kidney Function
- 15 mg Once Daily (Use With Caution)
Pulmonary Embolism and Deep Vein Thrombosis in Adults (≥18 years)
Day 1 to 21
- 15 mg Twice Daily (day/night)
From day 22
- 20 mg Once daily
After Month 6
- 10 mg Once Daily
- 20 mg Once Daily, only If there is a high risk of VTE recurrence:
- Complicated comorbidities
- Recurrent PE or DVT on extended prevention while on Xarelto 10 mg once daily
Venous Thromboembolism in Children (0–17 years)
Children Weighing 30 kg to 50 kg
- 15 mg Once Daily
Children Weighing 50 Kg or Even More
- 20 mg Once daily
Prevention of Atherothrombotic Events
Patients with Coronary Artery Disease and Peripheral Artery Disease (30 kg or more)
Dual Pathway Inhibition
- 2.5 mg Twice Daily (day/night) with a low dose of Aspirin
Prevention of VTE in Adults Undergoing Elective Hip or Knee Surgery
10 mg Once Daily
Take the first dose 6-10 hours after surgery, but only after confirming that bleeding has stopped (hemostasis)
Secondary Prevention After Acute Coronary Syndromes
- 2.5 mg Twice Daily (day/night) with Antiplatelet Therapy
The starting dose should be taken only after the Acute Coronary Syndromes (ACS) event stabilization.
[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
How to Take It?
- The reason you need Xarelto and the dose your doctor recommends will guide how you should take the medication.
- Typically, you will take Xarelto once or twice a day. Children may take it once, twice, or three times daily.
- For many conditions that need a once-daily dose of Xarelto, you can choose any time of the day to take your dose. However, it’s important to take it at the same time every day to maintain steady levels of the medication in your body.
- If you are taking Xarelto for atrial fibrillation (AFib), you must take your once-daily dose with your evening meal.
- For conditions that require Xarelto to be taken twice daily, you should take one dose in the morning and another in the evening, spacing them about 12 hours apart. Aim to take your doses at consistent times each day.
- Children who need to take Xarelto three times a day should space each dose 8 hours apart.
Taking Xarelto with Food
- If you are taking 2.5 mg or 10 mg of Xarelto tablets, you can take them either with food or on an empty stomach. However, if your Xarelto tablets are 15 mg or 20 mg, you must take them with food.
- For children who are taking Xarelto because of venous thromboembolism (VTE), they need to take their medicine with food. But children who are taking Xarelto after having the Fontan surgery can take their medicine with or without food, depending on what their doctor advises. If you’re unsure about how to take Xarelto, ask your doctor for guidance.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
How Does Xarelto Work?
It works by targeting and inhibiting a specific protein in the blood called Factor Xa (10a), which plays a crucial role in the clotting process. Normally, Factor Xa helps convert another protein, prothrombin, into thrombin. Thrombin is key for the series of steps that lead to the formation of blood clots. By blocking Factor Xa, Xarelto effectively reduces the risk of clots forming or growing larger. This medication is part of a group of drugs called Factor Xa inhibitors, named after their target in the clotting process. An interesting fact is that the name ‘Xarelto’ starts with ‘Xa’ (pronounced as 10a), which can help you remember its function as a Factor Xa inhibitor.
Important Safety Information
Side Effects
Common side effects of Xarelto include:
- Muscle spasms
- Belly pain
- Fatigue (low energy)
- Difficulty sleeping
- Back pain
The most common side effects reported in children were:
- Cough
- Vomiting
- Bleeding
- Gastroenteritis (inflamed stomach and intestines)
Mild side effects of Xarelto include:
- Belly pain
- Muscle spasms
- Dizziness
- Trouble sleeping
- Itchiness
- Fatigue (low energy)
- Back pain
- Mild allergic reaction
Serious side effects of Xarelto include:
- Bleeding, which may be serious or even life-threatening
- Changes in mood, such as anxiety or depression
- Risk of hematoma formation around the brain or spinal cord following specific spinal injection procedures
- Risk of blood clots after stopping Xarelto treatment too early
- Severe allergic reaction
[Note: Serious side effects of Xarelto are rare, but if they occur, seek medical attention right away.]
Warnings
Xarelto has received the highest level of warnings from the FDA, known as Black Box Warnings, regarding blood clots and bleeding. These warnings are very serious and should be carefully considered. These warnings include:
- Stopping Xarelto Too Soon: If you stop taking Xarelto before your doctor says it’s okay, you could get blood clots. Always talk to your doctor before stopping the medication. If your doctor agrees it’s time to stop Xarelto, they might suggest a different treatment to prevent blood clots.
- Risk of Blood Clots Near Brain or Spine: If you need an injection in your back or near your spinal cord for certain medical procedures, taking Xarelto can increase the chance of getting blood clots near your brain or spine. These clots can cause very serious problems, like paralysis.
If you’re taking Xarelto and need a spinal or epidural injection, your doctor will watch closely for any signs of blood clots in your brain or spine. Inform your healthcare provider immediately if you feel any tingling, pain, numbness, weakness in your back, feet, or legs or have trouble with bladder or bowel control.
Precautions
Allergic Reactions: Before taking Rivaroxaban, it’s important to let your doctor or pharmacist know if you’re allergic to it. This medication may have other ingredients that could cause allergic reactions or other issues. Your pharmacist can give you more information about this.
Considering Health History: When discussing your health history with your doctor or pharmacist, mention if you have had any of the following:
- Cancer
- Liver problems
- Kidney problems
- Issues with bleeding, such as bleeding in your stomach or brain
- Stroke
- Artificial heart valves
- Recent serious injury or surgery
- Blood disorders like anemia, hemophilia, or low platelet counts
- History of falling often or getting injured
- Eye problems (specifically retinopathy)
- A clotting disorder called antiphospholipid syndrome
- Genetic enzyme deficiencies like galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption
Surgeries Related Considerations: If you’re going to have surgery or any procedure that involves your teeth or spine (like spinal puncture or anesthesia), you must tell your healthcare provider that you’re taking Rivaroxaban. You might need to stop taking it before the procedure, so ask for specific advice on this.
Risk of Bleeding in Stomach: Rivaroxaban can increase the risk of stomach bleeding. Drinking alcohol daily while on this medication can make this risk higher, so it’s best to limit alcohol consumption. Ask your healthcare provider how much alcohol is safe for you.
Risk of Bleeding: This medication also increases the risk of bleeding. To reduce the risk of cuts, bruises, or injuries:
- Be careful with sharp objects, including razors and nail cutters.
- Avoid contact sports.
- Use an electric razor for shaving.
- Use a soft toothbrush.
Other Important Precautions
- If you fall or hurt yourself, especially if you hit your head, call your doctor immediately. They may need to check you for injuries.
- Older adults might be more prone to the side effects of this drug, particularly bleeding.
- If you are pregnant, use this medication only if it’s necessary. Talk to your doctor about the potential risks and benefits.
Missed Dose
It’s really important not to skip any dose of Xarelto because missing doses can raise your chances of getting blood clots. The FDA has given Xarelto a special warning about this risk because it’s very serious. If you ever forget to take your Xarelto, what you should do next depends on how much you normally take. Here are some tips for what to do if you miss a dose based on your regular dosage:
- If your normal dose is 2.5 milligrams (mg) taken two times a day, don’t worry about the dose you missed. Just take your next dose when it’s supposed to be taken. It’s important not to take extra to make up for the missed dose.
- If you usually take 15 mg of Xarelto two times a day and you forget a dose, take it as soon as you remember. Then, go back to taking your next dose at the regular time. If you forget your morning dose and only remember at your evening dose time, it’s okay to take two 15 mg tablets (30 mg in total) for your evening dose. Just make sure you don’t take more than 30 mg in a day.
- If your normal dose is 10 mg, 15 mg, or 20 mg of Xarelto once a day, take your missed dose as soon as you remember. After that, take your next dose at the regular time. Remember, don’t take two doses in one day to make up for the dose you missed the day before.
- For children taking Xarelto:
- If your child is on a once-daily schedule and misses their dose, they should take it as soon as they remember, but only if it’s still the same day. Do not give them two doses in one day to catch up.
- If your child takes Xarelto twice a day and forgets the morning dose, they should take it as soon as you remember. It’s okay to give them both the missed morning dose and the regular evening dose at the same time in the evening. But, if they miss the evening dose, only give it to them that same evening. Refrain from doubling the morning dosage the next day to compensate for the missed evening dose.
- If your child is supposed to take Xarelto three times a day and misses a dose, simply skip it and continue with the normal schedule. Do not give extra doses to make up for the missed one.
[Note: Consider using a medication reminder to help remember to give Xarelto on time. This could be setting an alarm or using a reminder app on your phone.]
Overdose
Seek emergency medical attention or call the Poison Help line immediately. An overdose may cause excessive bleeding. Symptoms of excessive bleeding can include:
- Bloody or black stool
- Bruising more easily than usual
- Bloody urine
- Coughing up blood
- Vomiting blood or a substance that looks like coffee grounds
- Frequent nosebleeds
[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]
Storage
- Store at room temperature.
- Keep out of the reach of children.
- Keep it away from freezing temperatures.
[Note: Ask your doctor any query you may have regarding storage and disposing of this medication.]
Xarelto Interactions Guide
When you’re taking Xarelto, it’s crucial to be aware of how it might interact with other substances, including alcohol, medications, and even certain foods or supplements. Understanding these interactions can help you use Xarelto safely and effectively.
Alcohol and Xarelto
While there’s no direct interaction known between Xarelto and alcohol, it’s important to remember that alcohol can thin your blood. Combining it with Xarelto could increase your risk of bleeding. If you enjoy alcoholic beverages, discussing your intake with your doctor is wise to ensure it’s safe.
Interactions with Other Medications
Before starting Xarelto, share a complete list of your medications with your healthcare provider. This list should include prescription drugs, over-the-counter medications, and any supplements or herbs you’re taking. This helps prevent potential interactions that could affect how well Xarelto works or increase side effects.
Some key interactions include:
- Nsaids and Other Pain Relievers (Like Aspirin and Ibuprofen): These can increase bleeding risks when taken with Xarelto. Your doctor might recommend safer alternatives for pain relief.
- Other Anticoagulants (Like Warfarin or Heparin): Taking these with Xarelto could significantly increase bleeding risks. Usually, doctors will recommend one or the other, not both.
- Certain Antifungal and Antiviral Medications: These can raise the side effects of Xarelto.
- Specific Antiepileptic Drugs: Some of these can make Xarelto less effective.
Food, Supplements, and Xarelto
Grapefruit and St. John’s wort are known to affect how Xarelto works in your body. Grapefruit might increase bleeding risks, while St. John’s wort can make Xarelto less effective. Always check with your healthcare provider before making any changes to your diet or starting new supplements.
Vaccines and Lab Tests
There’s no known interaction between Xarelto and vaccines or lab tests. However, always inform healthcare professionals about your Xarelto use before receiving vaccines or undergoing lab tests.
[Note: This isn’t a complete list, and there could be other drugs that interact with Xarelto. This includes prescription and vitamins, over-the-counter medicines, and herbal products. Keep in mind that not all possible interactions are mentioned here.]
Xarelto Alternatives
In certain instances, your healthcare provider or physician may advise using an alternative medication to Xarelto, contingent upon the specific condition under treatment. Below are the Alternatives of Xarelto that can help stop or treat blood clots and lower the chances of issues caused by blood clots. These alternatives include:
- Aspirin
- Pradaxa (dabigatran)
- Eliquis (Apixaban)
- Savaysa (Edoxaban)
- Jantoven or Coumadin (Warfarin)
- Lovenox (Enoxaparin)
- Fragmin (Dalteparin)
- Arixtra (Fondaparinux)
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
Quick Tips
- Is There a Cheaper Alternative for Eliquis?
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Frequently Asked Questions
What foods can not be eaten with blood thinners?
If you’re taking blood thinners like Xarelto, you need to be careful with foods that have a lot of vitamin K because they can make your medicine less effective. Try not to eat too much of the following:
- Broccoli
- Cauliflower
- Brussels sprouts
- Asparagus
- Green onions
- Parsley
- Kale
- Spinach
Also, it’s best not to have too much green tea, alcohol, and cranberry juice.
How long does Xarelto stay in your system?
When you take Xarelto, about half of it remains in your body for about 5 to 9 hours. A small amount can stay for 1 to 2 days. Over time, the drug’s presence in your body reduces until you take your next dose. If you are over 75 years old, Xarelto might stay in your body a bit longer than usual.
Is 20mg of Xarelto a lot?
Xarelto 20 mg tablet is a standard amount for adults with a type of heart rhythm problem called atrial fibrillation (Afib), which isn’t due to a heart valve issue. People usually take this dose once every evening with their meals to help prevent strokes and blood clots.
Why is it better to take Xarelto at night?
Taking Xarelto (Rivaroxaban) at night can be more effective because it keeps the medicine in your system longer. This timing works well with your body’s natural processes, especially because our bodies are less effective at breaking down blood clots in the morning. By taking it at night, the medication’s action is better aligned with when your body needs it the most, potentially making the treatment both safer and more effective.
Does Xarelto make you tired or sleepy?
Yes, Xarelto might make you feel tired or sleepy. If you start feeling this way, contacting your healthcare provider as soon as possible is important. Feeling tired could be a warning of a more serious problem. Your doctor can help you determine the best way to deal with it.
How long before surgery should Xarelto be stopped?
If you’re taking Xarelto (Rivaroxaban) and you have any surgery coming up, you’ll need to stop taking it before your procedure. Here’s when to stop it based on the type of surgery and your kidney health:
- For surgeries that don’t usually cause a lot of bleeding, stop Xarelto at least 24 hours before if your kidneys are working well. If the surgery might cause a lot of bleeding, stop it 48 to 72 hours before.
- If your kidneys are not working as well as they should (but still working okay), and the surgery is not likely to cause a lot of bleeding, stop Xarelto 48 hours before. If the surgery could cause a lot of bleeding, also stop it 48 to 72 hours before.
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