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Xeljanz is a prescription medication containing tofacitinib, a medicine that helps control overactive immune responses. It belongs to a class of drugs known as Janus kinase (JAK) inhibitors. The medication is used to treat autoimmune and inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and ankylosing spondylitis. Xeljanz is available in 5 mg and 10 mg strengths at Polar Bear Meds in Canada. A valid prescription is required.
| Product Name | Xeljanz |
|---|---|
| Active Ingredient | Tofacitinib |
| Drug Class | Janus kinase (JAK) inhibitors |
| Available Forms | Oral Tablets |
| Strengths Available | 5 mg and 10 mg |
| Routes of Administration | Taken by mouth |
| Xeljanz Uses | Treats: Rheumatoid arthritis Psoriatic arthritis Ulcerative colitis Active ankylosing spondylitis |
| Xeljanz Storage | Store in a cool, dry place (below 30°C) |
| Pregnancy and Breastfeeding | Consult a doctor |
| Legal Status | Rx only |
| FDA Black Box Warning | Serious infections, major adverse cardiovascular events (heart attack and stroke), cancer, blood clots, and death. |
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Xeljanz is typically prescribed for patients who have had an inadequate response or intolerance to one or more TNF blockers, depending on the condition:
Xeljanz is also approved to treat polyarticular juvenile idiopathic arthritis in children 2 years or older who have had an intolerance to one or more TNF blockers.
Taking Xeljanz tablets along with other medicines that suppress the immune system can increase the risk of serious side effects. Inform your healthcare provider or pharmacist about all the medications you take.
Xeljanz (tofacitinib) inhibits Janus kinases (JAKs) in immune cells. In autoimmune diseases such as ulcerative colitis and rheumatoid arthritis, inflammatory proteins (cytokines) activate the JAK-STAT signaling pathway, which, in turn, activates pathways that increase inflammation. Xeljanz primarily blocks JAK1 and JAK3, thereby reducing this signaling pathway and decreasing the production of inflammatory mediators. By blocking these signals, Xeljanz helps calm the immune system and reduce inflammation.
Like all prescription medicines, Xeljanz may cause side effects, ranging from mild to serious:
FDA Boxed Warning: Xeljanz tablets have an increased risk of:
Important safety information: Always tell your doctor the exact dose you are taking. Do not stop taking Xeljanz without medical advice, as symptoms may worsen.
Keep the following Xeljanz precautions in mind before you consider taking it for the treatment of autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, and others.
Xeljanz should not be used in patients with severe active infections. Treatment should be avoided in patients with significantly low hemoglobin, lymphocytes, or neutrophil counts. Use Xeljanz (tofacitinib) with caution in patients with:
You must be under medical supervision before taking Xeljanz tablets. Xeljanz should only be used in children when specifically prescribed by a specialist. Please consult your doctor for the potential risks.
The dosage schedule for Xeljanz oral tablets is as follows:
An Xeljanz overdose may increase the risk of serious side effects. Seek immediate medical help if you have taken too much Xeljanz. Contact the Poison Control Center or a nearby hospital if symptoms are severe.
If you missed a dose of Xeljanz, take it as soon as possible. However, if it is time for your next scheduled dose, take the next scheduled dose at the regular time. Skip the missed dose and do not make up for it.
Inform your healthcare professional about all the medications that you are taking (prescription-based or over-the-counter) for arthritis or any other condition. The medicines that may interact with Xeljanz are:
Here, the Xeljanz interaction list is incomplete. Other medicines may interact with Xeljanz (tofacitinib). Consult your doctor before starting the medication.
Here are some common Xeljanz alternatives for treating autoimmune diseases such as rheumatoid arthritis and psoriatic arthritis.
Consult your healthcare professional before switching to any of the above Xeljanz alternatives.
Xeljanz (tofacitinib) can be costly when purchased from local U.S. pharmacies, especially for patients who require long-term treatment for arthritis. At Polar Bear Meds, we help you access your prescribed medications at more affordable prices by sourcing them through fully licensed Canadian and international pharmacy partners.
When you choose to buy Xeljanz online from Polar Bear Meds, you may benefit from significantly lower pricing compared to many U.S. retail pharmacies — often saving a substantial percentage on your medication costs while maintaining standard pharmacy dispensing practices.
Here’s why patients trust Polar Bear Meds for their Xeljanz prescription:
At Polar Bear Meds, your safety and satisfaction come first. Every order is processed through licensed pharmacy partners to ensure you receive authentic Xeljanz medicine as prescribed by your healthcare professional. If you are seeking a trusted, affordable way to buy Xeljanz online, Polar Bear Meds offers a secure and cost-effective solution tailored to your needs.
The information provided about Xeljanz is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. Xeljanz (tofacitinib) is a prescription-based medicine and should be used only under the supervision of a healthcare professional. Always consult your doctor before changing or stopping your Xeljanz dosage.
Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.
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