Zaditen

Zaditen is an FDA-approved antihistamine medication used to treat hypersensitivity conditions such as allergic rhinitis, allergic conjunctivitis, asthma prophylaxis, and chronic urticaria. It contains the active ingredient Ketotifen Hydrogen Fumarate, which functions by blocking the release of histamine and other substances that cause allergic reactions. This helps to reduce inflammation and prevent asthma symptoms. Zaditen is available in various forms and strengths, including oral tablets (1 mg), slow-release tablets (2 mg), eye drops (0.25 mg/ml), and syrup (5 ml). The medication dosage is based on age, medical condition, and response to treatment. You should consult a licensed healthcare practitioner for safe and efficient use of the medication.

Zaditen contains the active ingredient Ketotifen Hydrogen Fumarate, an antihistamine used to treat allergic conditions such as allergic rhinitis, allergic conjunctivitis, asthma prophylaxis, and chronic urticaria. Ketotifen functions by blocking the release of histamine and other substances that cause allergic reactions, helping to reduce inflammation and prevent asthma symptoms.

Zaditen is available in various forms and strengths, including oral tablets (1 mg), slow-release tablets (2 mg), eye drops (0.25 mg/ml), and syrup (5 ml). The dosage varies based on age, medical condition, and response to treatment. For example, adults and children over three years may take 1 mg twice daily for asthma, while eye drops are typically used twice daily for allergic conjunctivitis. It’s important to follow your doctor’s instructions and the guidelines provided in the medication leaflet.

Common side effects of Zaditen may include drowsiness, dry mouth, and dizziness. Precautions should be taken if you have a history of seizures, liver disease, or other health conditions. If a dose is missed, take it as soon as possible, but skip it if it’s almost time for the next dose. Avoid taking double doses. Store Zaditen in its original container, away from heat and moisture, and out of reach of children. Consult an expert medical giver for any concerns or guidance on using Zaditen.

It is used to treat:

• Allergic rhinitis
• Allergic conjunctivitis
• Asthma prophylaxis
• Chronic urticaria

What Are the Forms & Strengths of Zaditen?

It comes in the following forms and strengths:

Form: Oral tablets 

Strength: 1 mg

Form: Slow-release tablets 

Strength: 2 mg 

Form: Eye drops 

Strength: 0.25 mg/ml

Form: Syrup

Strength: 5 ml

What Are the Recommended Dosage of Zaditen?

The medication dosage varies from patient to patient and is based on age, medical condition, and response to treatment. In pediatric patients, it is also based on weight. You should follow the directions given by your doctor very closely and read and follow the instructions for use given in the patient information leaflet that came along with the prescription medication.

The amount of medication you take depends on the strength and form of the drug. It also depends on the number of doses you take each day, the gap between each dose, and the duration of the medication course.

For Asthma

Tablet and Syrup Form

• Adults and children above three years of age: The typical recommended dose is 1 mg twice daily, once in the morning & once in the evening.
• Infants and children aged six months to three years: The dose for this age group is based on body weight and should be determined by a licensed healthcare professional. The usual recommended dose is 0.25 ml of syrup per kg of body weight twice daily, once in the morning and once in the evening.

For Allergic Conjunctivitis

Eye Drops

• Adults: You should use one drop of the ophthalmic solution into the conjunctival sac twice daily.
• Children over three years old: Use one drop into the conjunctival sac twice daily.
• Children less than three years of age: The safety & efficacy of this medication have not been established in patients belonging to this age group. You should consult your doctor before using this medication.

For Chronic Urticaria

Tablets 

• You should take one 2 mg tablet in the evening or two 1 mg tablets twice daily, once in the morning and once in the evening, with food.
• Your doctor may increase your dosage as required.
• The maximum recommended dosage is 4 mg in divided doses.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

Zaditen is FDA-approved for the temporary prevention of eye itching due to allergic conjunctivitis. While it can be an effective treatment for many people, it’s essential to use Zaditen correctly and under the guidance of a healthcare professional to maximize its benefits & minimize potential side effects.

• Before using Zaditen, you should carefully read and follow the instructions for use in the patient information leaflet and medication guide provided by your pharmacist or healthcare provider. If you have any questions or concerns or if you do not understand any part of the leaflet, you should ask your doctor.
• You should use ketotifen exactly as prescribed by your doctor. Do not use more or less of it, in large doses, or more frequently than prescribed, as it can cause unwelcome side effects. Ask your doctor if you are uncertain how and when to take it.
• You should take the oral form of this medication with food.
• Do not change the medication dose or discontinue using Zaditen without consulting your doctor, no matter how well you feel, as it can cause undesirable symptoms.
• If you plan to discontinue using the medication, you should tell your doctor. They will help you gradually taper off the medication over a two to four-week period.
• For children aged 5 and older, your doctor may recommend a dose of 1 mg (in tablet form) twice daily, in the morning and evening after a meal.
• Your doctor may suggest starting at a low dose and increasing to 1 mg twice daily after five days to decrease the risk of unwelcome side effects.
• The medication dosage is based on the age, condition being treated, patient’s response to treatment, and other medications you may be taking. In pediatric patients, it is also based on body weight. If your doctor has recommended you a different dose than the one mentioned above, do not change it without consulting your doctor.
• If you are using an oral liquid form of Zaditen, you should use a measuring spoon, syringe, or device that comes with your prescription. These devices give a more accurate measurement of the medication dosage than household spoons. Consult your pharmacist or medical provider if you do not have a measuring device.
• You should swallow the tablets and liquid with or without food. However, if you experience a stomach upset, you can take it with food or milk.
• If you are taking Zaditen as a tablet or slow-release tablet, you should swallow it whole. Do not break, crush, or chew it.
• This medication does not relieve symptoms of an allergic attack or asthma. To get the most benefit from your medication, you should maintain consistency in dosage and try to take it around the same time every day.
• If you are using a Zaditen eye dropper, use it exactly as your doctor has told you. If you use it less than prescribed, it may not work as it should, whereas using it more than prescribed will not improve your condition any faster but will cause unwanted side effects.
• To prevent the dropper tip from becoming dirty or contaminated, do not allow it to contact any surface, including your eye, fingers, or skin.
• If you use soft contact lenses, you should remove them 15 minutes before using this medication and wait for at least 15 minutes after using them before reinserting them back into your eyes.
• This medication contains benzalkonium, a preservative which can discolor the soft contact lenses.
• Do not share your medications with others, even if they have the same condition as you.
• Tell your doctor if your condition does not get better or if they worsen.

Follow the steps given below to use Zaditen in a multi-dose bottle:

• Before using the eye dropper, properly wash your hands using soap and water.
• Open the multi-dose dropper and ensure the dropper tip does not touch any surface, as this can cause contamination of the ophthalmic solution.
• Hold the bottle in your hand between the thumb and forefinger to put the eye drops.
• Tilt your head backward, use the forefinger of your other hand, and pull down the lower lid of the infected eye to make a pouch.
• Place the dropper above your eye at 90 degrees, squeeze the dropper bottle gently so that a drop can fall into the pouch, and then release the lower lid.
• After putting one drop in, close your eye gently and press the inner corner of your eye near the nose with your forefinger for 45 seconds to one minute.
• Repeat the procedure if your doctor has prescribed that you use the ophthalmic solution for your other eye.
• After use, close the cap tightly and store the bottle at room temperature, away from sunlight, excess heat, and moisture.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Zaditen’s mechanism of action is not quite clear. The medication contains ketotifen, a histamine H-1 receptor agonist that obstructs histamine and other agents in the body that cause allergic reactions. Ketotifen has anti-inflammatory properties that help reduce the overall inflammatory response in the airways, making it easier to breathe and reducing asthma symptoms. By addressing both the immediate allergic response and the underlying inflammation, Zaditen provides comprehensive relief from allergic symptoms and helps manage conditions like mild allergic asthma. It may take several weeks of consistent use of Zaditen before you start to see benefits from this medication.

Common Side Effects of Zaditen: Similar to other medications, Zaditen may cause certain side effects in some people using it. It is noteworthy to mention that not everyone using this drug will experience side effects caused by it. These side effects are not severe and usually disappear on their own within a few days or weeks as your body adjusts to this medication. If you are concerned about the side effects caused by this medication, you should consult your healthcare provider, and they will help you prevent and manage them. Some common side effects caused by Zaditen are as follows: 

• Drowsiness
• Dry mouth
• Increased appetite
• Weight gain
• Mild headache
• Dizziness
• Nausea
• Constipation

Mild Side Effects of Zaditen: Zaditen can cause mild side effects in some people. These side effects do not typically require immediate medical assistance, but you should talk to your medical team if they are bothersome or persist. Report any new or worsening symptoms to your doctor. Mild side effects caused by this medication are as follows: 

• Irritability or nervousness
• Insomnia
• Mild skin rash or itching
• Increased urination frequency
• Mild abdominal discomfort
• Fatigue
• Slight changes in heart rate
• Mild nasal congestion

Serious Side Effects of Zaditen: In rare cases, Zaditen may cause severe side effects in patients belonging to certain groups. These side effects require prompt medical assistance and may be life-threatening if not treated promptly. If you experience any of the symptoms given below, you should immediately discontinue using the medication and call your doctor. It is important to mention that you have been prescribed Zaditen because your doctor has determined that its benefits outweigh the risks associated with its use. Serious side effects caused by Zaditen are as follows:

• Severe allergic reactions, including anaphylaxis. Its symptoms may include rapid onset of swelling of the face/lips/tongue/throat, difficulty breathing or wheezing, hives or severe itching, dizziness or fainting, and rapid or weak pulse.
• Severe skin reactions, including Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
• Seizures. Its symptoms may include temporary confusion, staring spells, uncontrollable jerking movements, and loss of consciousness.
• Severe mood changes or behavioral issues, which may include sudden onset of depression or suicidal thoughts, extreme agitation, anxiety, or panic attacks, aggressive behavior, or violent outbursts
• Difficulty breathing or swallowing may be related to anaphylaxis or other respiratory issues. Its symptoms may include shortness of breath, chest tightness, and an inability to swallow normally.
• Severe dizziness or fainting may be related to cardiovascular issues. Its symptoms include vertigo, loss of balance, and a brief loss of consciousness.
• Unusual bleeding or bruising which may indicate blood disorders or liver problems. Its symptoms may include easy bruising, nosebleeds, bleeding gums, and blood in urine or stool.
• Arrhythmias or abnormal heart rhythms. Its symptoms may include palpitations, chest pain, shortness of breath, and dizziness.
• Severe abdominal pain, which could indicate liver or pancreatic issues. Its symptoms may include intense pain in the upper abdomen, nausea, or vomiting.
• Yellowing of the skin or eyes. Its symptoms may include dark urine, pale stools, fatigue, and abdominal pain.
• Severe hepatotoxicity. Its symptoms may include jaundice, abdominal pain, nausea, vomiting, fatigue, and confusion.
• Blood disorders like agranulocytosis or thrombocytopenia may cause symptoms such as unusual infections, fever, sore throat, mouth ulcers, and easy bruising or bleeding.
• Bladder inflammation. Its symptoms may include increased urge to urinate, pain in the lower back or pelvis, frequent urination at night, red or cloudy urine, and burning sensation during urination.
• Respiratory infections. Its symptoms may include trouble breathing, body aches, headache, fever, or fatigue.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Certain warnings should be considered while using this medication. Follow your doctor’s instructions to ensure the safe and efficient use of the medication.

• You should not discontinue using other asthma medications, such as b2-agonists or corticosteroids, immediately when you start receiving treatment with Zaditen. Follow your doctor’s instructions very closely.
• Zaditen can increase the risk of seizures in children, especially if your child has had seizures in the past. If you or your child have or ever had seizures, you should discuss with your doctor how this medication may affect your condition and, how your condition may affect the dosing & effectiveness of this medication, and whether any special monitoring is required.
• You should not use Zaditen during pregnancy unless discussed with a doctor. Your doctor will help you determine if this medication is safe for you to use during pregnancy by weighing the potential risks with the benefits of this medication. If you are pregnant, plan to become pregnant, or suspect a pregnancy, you should consult with your doctor.
• Zaditen may pass into your breastmilk and affect the nursing infant. You should talk to your doctor before breastfeeding a baby while using this medication.
• The safety and efficacy of Zaditen have not been established in pediatric patients under five years of age, so you should consult an expert medical practitioner before using this medication for the aforementioned age group.
• Zaditen’s safety and efficacy have not been determined for geriatric patients, and hence, it is not indicated for use in this age group.
• Zaditen may increase the effects of alcohol, so you should avoid consuming alcohol in large amounts while receiving treatment with Zaditen tablets.
• This medication can increase the effects of certain medications, too, including antihistamines, sedatives, other medications used to treat depression/anxiety, or anticoagulant medications.
• Zaditen can cause thrombocytopenia when taken simultaneously with biguanides, certain oral antidiabetic medications. Therefore, you should avoid administration of these drugs at the same time.
• You should not discontinue taking Zaditen without consulting your doctor. If you plan to discontinue taking this medication, tell your doctor. They will help you gradually taper off the medication.
• Keep Zaditen in a secure place, out of sight and reach of children and pets.

• Before using Zaditen, you should tell your medical team if you have an allergy to the medication, Ketotifen, or any other medications. This drug also contains certain inactive ingredients that can cause allergic reactions or other problems. You can ask your doctor, pharmacist, or healthcare provider for the full list of ingredients present in the product.
• Before using this medication, share your complete medical and family medical history with your doctor, especially if you have the following conditions:
  • Pregnancy
  • Breastfeeding
  • Allergy to any excipients in the medication
  • Diabetes
• You should regularly visit your doctor to check your progress and ensure that the drug is working as it should and is not causing you unwanted side effects. This information will help your doctor determine if this medication is safe for you and if you should continue taking it. If your condition does not improve or if it worsens, get in touch with your doctor at once.
• Zaditen can cause drowsiness and dizziness in some people. It may also affect alertness and vision. You should not drive a vehicle, use heavy machinery, or engage in tasks that require mental alertness and clear vision unless you determine how this medication affects you. Doing so can be dangerous if you feel dizzy, have blurred vision, or are not alert.
• Zaditen can cause some people to be irritable, excited, nervous, or have sleep disturbances, which are symptoms of central nervous stimulation. Children are most likely to experience such symptoms.
• The syrup form of Zaditen may contain sugar and affect your blood glucose levels, especially if you have diabetes mellitus type one or two. If you notice any change in the test reports of your blood or urine sugar tests or have any other queries or concerns, contact your doctor.

Zaditen is contraindicated for use in patients:

• Who have a known hypersensitivity or allergy to ketotifen or any of the inactive ingredients in Zaditen
• With a history of epilepsy or seizure disorders
• With severe liver disease
• Who are pregnant (consult a doctor before use)
• Who are breastfeeding (caution is advised)
• Who are diabetic
• With a history of urinary retention
• Who have narrow-angle glaucoma (caution is advised)
• Concurrent use of CNS depressants (caution is advised)
• Who are under three years of age
• Who have phenylketonuria

• To get the most benefit from your medication, you should maintain consistency in dosage and try to take it around the same time every day to help you remember.
• If you have missed a dose of Zaditen, you should take it as soon as you remember.
• However, if the time to take your next dose is almost here, you should omit the missed dose and continue taking your medication according to your regular dosing schedule.
• You should not take double or extra doses of the same medication to compensate for the missed dose, as it can lead to undesirable side effects.
• Call your doctor or healthcare provider if you are still unsure when to take your missed dose.
• Set a reminder on your phone to prevent missed medication doses. Medication reminders work best for this purpose.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

You should not take Zaditen more than the recommended dose as it can cause potentially dangerous side effects. To prevent accidental consumption by children, you should keep the medicines in a tightly sealed container away from their sight and reach. Symptoms of a Zaditen overdose may include dizziness, difficulty breathing, severe drowsiness, rapid or irregular heartbeat, low blood pressure, and confusion.

In children, additional symptoms may be noticeable, such as dilated pupils, twitching muscles, hallucinations, and agitation. If you suspect an overdose of Zaditen, immediately seek medical assistance. You can call a medical professional, 911, or poison control helpline. You should not induce vomiting unless directed otherwise by a medical professional. If you are experiencing severe side effects, you can also head to the nearest emergency room.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

Following the proper storage guidelines is essential for the safe and efficient use of the medication.

• You should keep Zaditen in its original container to protect it from direct sunlight, excess heat, and moisture. Do not keep it in the bathroom, near the sink, or in places with high humidity, as moisture can damage certain medications.
• You should keep all medications, including Zaditen, in a tightly sealed container in a safe place that is away from the sight and reach of children & pets to avoid accidental consumption of the drug.
• Do not allow the medication to freeze, expose it to open flame, or extreme temperatures.
• Do not keep medications that are no longer needed or have passed their expiration date, which is the last day of the month mentioned on the back of the carton or blister pack. You should dispose of them safely.
• With that said, you should not pour them into the drain, flush them into the toilet, or throw them into the household garbage bin unless instructed otherwise.
• You should discard medications that are no longer needed or outdated in such a way that prevents children, animals, and others from consuming them.
• The best way to eliminate unwanted medications is to give them in a medicine take-back program.
• For more information on how to dispose of unwanted medications, contact your local waste disposal company, healthcare provider, or pharmacist.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Certain medications may interact with Zaditen and reduce its effectiveness or cause undesirable side effects. Before using this medicine, you should tell your doctor or pharmacist about all the medications you are using or plan to use alongside Zaditen, including all prescription, and non-prescription medications, over-the-counter drugs, and herbal or vitamin supplements. This information will help you and your healthcare provider identify and prevent drug interactions. Some of the potential drug interactions of this medication are as follows:

• Amantadine
• Benztropine
• Solifenacin
• Disopyramide
• Botulinum Toxin-containing Medications
• Darifenacin
• Chloral Hydrate
• Olopatadine
• Nabilone
• Potassium Chloride
• Clonidine
• Betahistine
• Amitriptyline
• Domperidone
• Topiramate
• Tizanidine
• Mirabegron
• Rotigotine
• Lemborexant
• Seizure Medications
• Glucagon
• Nitroglycerin
• Butorphanol
• Pramipexole
• Flunarizine
• Clidinium
• Perampanel
• Buprenorphine
• Flibanserin
• Efavirenz
• Umeclidinium
• Clobazam
• Pregabalin
• Mirtazapine
• EsKetamine
• Muscle Relaxants
• Prucalopride
• CannabIs
• Narcotic Pain Relievers
• Entacapone
• Codeine
• Lorazepam
• Metoclopramide
• Thalidomide
• Galantamine
• Pitolisant
• Valproic Acid
• Scopolamine
• Baclofen
• Antihistamines
• Glycopyrrolate
• Tetrabenazine
• Ipratropium
• Cariprazine
• Hydraluronidase
• Doxylamine
• Clonazepam
• Primidone
• Thiopental
• Tapentadol
• Oxybutynin
• Moclobemide
• Methylcarbamol
• Gabapentin
• Risperidone
• Pomalidomide
• Fentanyl
• Baclofen
• Haloperidol
• Trimipramine
• Escitalopram
• Hydroxyzine
• Trazodone
• Cyclobenzaprine
• Thiopentone
• Azelastine
• Benzodiazepines
• Clozapine
• Oxycodone
• Acetylcholinesterase Inhibitors
• Tolterodine
• Quetiapine
• Guanfacine
• Methocarbamol
• Tetrabenazine
• Olanzapine
• Scopolamine
• Loratadine
• Zolpidem
• Selegiline
• Azelastine
• Kava Kava
• Ropinirole
• Succinylcholine
• Atropine
• Tranylcypromine
• L-Ornithine
• Pizotifen
• Trifluoperazine
• Levomethadyl Acetate
• Clozapine
• Oxymorphone
• Quetiapine
• Cetirizine
• Aclidinium
• Zopiclone
• Trospium
• Atropine
• Fesoterodine
• Clomipramine
• Rivastigmine
• Thiazide Diuretics

What Are the Other Zaditen Interactions?

Besides medications, Zaditen may interact with certain herbs, food items, beverages, and supplements. You should not use certain medications alongside tobacco or alcohol, as it can cause unwanted interactions to occur. While using this medication, your doctor may advise you to make certain dietary and lifestyle changes. This medication also has certain disease interactions that you should consider to prevent and manage potential interactions.

• Asthma
• Diabetes
• Cardiovascular conditions
• Glaucoma
• Liver disease
• Phenylketonuria
• Urinary retention

[Note: This isn’t a complete list, and there could be other drugs that interact with Zaditen. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Zaditen, also known by its generic name ketotifen, is a medication primarily used to prevent & treat allergic conditions, including allergic rhinitis, asthma, and certain types of hives. While it is an effective medication, it may cause unwanted side effects in some people using it, or it may fail to provide desired results. In such cases, people look for alternatives to Zaditen. While many effective substitute medications are available on the market, you should not use them without consulting your doctor. If you plan to switch your medication, you should consult your doctor. They will help you determine the medication that works best for you based on your medical condition, age, and needs. Some of the popular alternatives of Zaditen are as follows:

• Alaway
• Cromolyn ophthalmic (cromolyn sodium)
• Bepreve (bepotastine besilate)
• Prednisolone ophthalmic
• Prednisone (prednisolone)
• Elestat (epinastine hydrochloride)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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