
Sertraline



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Upload your prescription.
Complete your purchase by processing the payment.
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Zoloft (sertraline hydrochloride) is a prescription medication classified as a selective serotonin reuptake inhibitor (SSRI). It works by increasing levels of serotonin, a neurotransmitter in the human brain that helps regulate mood, emotions, and behavior. Zoloft is taken orally, usually once daily, with or without food. Zoloft is not a controlled substance and is not typically associated with drug-seeking behavior.
Zoloft (sertraline) is available in tablet and oral solution forms. Currently, our pharmacy provides Zoloft in tablet form only. Many patients purchase this medication from licensed Canadian pharmacies with a valid prescription to save on costs.
| Category | Details |
|---|---|
| Brand Name | Zoloft |
| Generic Name | Sertraline Hydrochloride |
| Drug Class | Selective Serotonin Reuptake Inhibitor (SSRI) |
| Manufacturer | Pfizer Inc. |
| Prescription Required | Yes |
| FDA‑Approved Indications | Major Depressive Disorder (MDD); Premenstrual Dysphoric Disorder (PMDD); Post‑Traumatic Stress Disorder (PTSD); Obsessive‑Compulsive Disorder (OCD); Panic Disorder (PD); Social Anxiety Disorder (SAD) |
| Dosage Forms | Tablets (25 mg, 50 mg, 100 mg); Oral solution (20 mg/mL) |
| Half‑Life | ~26 hours (steady state reached in about 1 week) |
| Common Side Effects | Nausea, diarrhea, insomnia, dry mouth, dizziness, fatigue, and sexual dysfunction |
| Serious Side Effects | Suicidal thoughts/behavior (boxed warning), serotonin syndrome, severe allergic reactions, abnormal bleeding, seizures |
| Monitoring | Watch for mood changes, suicidal ideation, serotonin syndrome, and bleeding risk; dose adjustments may be needed in hepatic impairment |
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According to the FDA prescribing information, Zoloft (sertraline HCl) is indicated for the treatment of:
Zoloft Boxed Warning: Increased Risk of Suicidal Thoughts and Behaviors
Antidepressants, including Zoloft (sertraline hydrochloride), increase the risk of suicidal behaviors & thoughts in adolescents, children, and young adults (ages 18–24) during the initial stages of treatment and during dose changes. Short-term studies did not show an increased risk in adults over age 24, and there was a reduction in risk in adults aged 65 and older.
Patients taking Zoloft should be closely monitored for unusual changes in behavior, suicidal thoughts, or worsening depression, especially during the first few months of treatment. Caregivers and families should be advised to observe patients closely and report concerning symptoms to a healthcare provider immediately.
Zoloft should not be used in the following situations:
| Common Side Effects of Zoloft | Rare or Serious Side Effects of Zoloft |
|---|---|
| Nausea | Suicidal thoughts or behaviors (boxed warning) |
| Diarrhea | Serotonin syndrome (confusion, agitation, rapid heart rate, sweating, muscle rigidity) |
| Insomnia | Severe allergic reactions (rash, itching, swelling of face/tongue/throat) |
| Dry mouth | Seizures |
| Fatigue or somnolence | Abnormal bleeding (especially with NSAIDs, aspirin, anticoagulants) |
| Dizziness | Hyponatremia (low sodium, more common in the elderly) |
| Tremor | Mania or hypomania activation in bipolar disorder |
| Sexual dysfunction (decreased libido, delayed ejaculation) | Angle‑closure glaucoma |
| Sweating | Elevations in liver enzymes (rare) |
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Zoloft (sertraline HCl) works by increasing the levels of serotonin, a neurotransmitter in the human brain that helps regulate emotions, mood, and behavior.
Zoloft belongs to a class of medications called SSRIs. It works by blocking the reuptake (reabsorption) of serotonin into nerve cells, thereby increasing its availability in the brain. By improving serotonin activity, Zoloft helps:
Zoloft tablets do not provide immediate relief. It may take several weeks of consistent use to experience the full therapeutic benefits.
Follow these Zoloft administration guidelines for the safe and effective use:
Taking too much Zoloft (sertraline) can result in an overdose, which may be serious and require immediate medical attention. The symptoms might vary depending on the amount taken and whether other substances were involved.
Common symptoms of Zoloft overdose include:
If you suspect that someone has taken too many Zoloft tablets, treat it as an emergency. Contact your nearest emergency services or the poison control center immediately. Do not wait for symptoms to worsen and do not attempt to manage the overdose on your own, as early medical treatment can prevent serious complications.
The Zoloft dosage schedule can vary based on the individual response and tolerability. Zoloft doses are typically started low and adjusted gradually to improve tolerability and effectiveness, under the guidance of a healthcare provider.
| Indication | Initial Dose | Recommended Dose Range | Maximum Dose |
|---|---|---|---|
| Major Depressive Disorder (MDD) | 50 mg once daily | 50–200 mg once daily | 200 mg/day |
| Obsessive‑Compulsive Disorder (OCD) | 50 mg once daily (adults) | 50–200 mg once daily | 200 mg/day |
| Panic Disorder (PD) | 25 mg once daily | 50–200 mg once daily | 200 mg/day |
| Post‑Traumatic Stress Disorder (PTSD) | 25 mg once daily | 50–200 mg once daily | 200 mg/day |
| Social Anxiety Disorder (SAD) | 25 mg once daily | 50–200 mg once daily | 200 mg/day |
| Premenstrual Dysphoric Disorder (PMDD) | 50 mg once daily (continuous or luteal phase dosing) | 50–150 mg once daily | 150 mg/day |
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| Indication | Age Group | Initial Dose | Recommended Dose Range | Maximum Dose |
|---|---|---|---|---|
| Obsessive‑Compulsive Disorder (OCD) | Children (6–12 years) | 25 mg once daily | 25–200 mg once daily | 200 mg/day |
| Obsessive‑Compulsive Disorder (OCD) | Adolescents (13–17 years) | 50 mg once daily | 50–200 mg once daily | 200 mg/day |
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Follow these Zoloft tablets storage guidelines for effective use of this medication:
In a randomized clinical study (2000) involving 44 patients with unipolar major depressive disorder, published on PubMed, the effectiveness of sertraline (Zoloft) was evaluated. Results show that a significant proportion of people respond positively to sertraline:
The study compared sertraline with fluoxetine, but these figures highlight the response specifically for sertraline (Zoloft). Treatment should always be tailored by a clinician to the patient's needs.
Zoloft may interact with other medicines. You should always tell your doctor about all drugs or supplements you are taking. Common Zoloft interactions include:
| Drug / Category | Examples | FDA Notes / Risks |
|---|---|---|
| Monoamine Oxidase Inhibitors (MAOIs) | Phenelzine, Tranylcypromine, Linezolid, Methylene Blue | Contraindicated. Risk of serotonin syndrome. Do not use Zoloft within 14 days of stopping an MAOI, or use an MAOI within 14 days of stopping Zoloft. |
| Pimozide | — | Contraindicated. Risk of serious heart rhythm abnormalities (QT prolongation). |
| Other Serotonergic Drugs | SSRIs, SNRIs, Triptans, Tramadol, Fentanyl, Lithium, St. John’s Wort | Increased risk of serotonin syndrome. Monitor for symptoms. |
| NSAIDs / Aspirin / Anticoagulants | Ibuprofen, Naproxen, Warfarin, DOACs | Increased risk of bleeding. Monitor for signs of bleeding. |
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If Zoloft is unavailable, alternative medications may be used under medical supervision. The alternatives to Zoloft tablets include:
Purchasing from Polar Bear Meds ensures you receive authentic, prescription-only Zoloft tablets safely and conveniently, without the high U.S. prices.
The information provided above about Zoloft (sertraline) is for general educational purposes only. The content on this page is not intended to replace any kind of professional advice, diagnosis, or treatment. Zoloft is a prescription-only medicine and should be used strictly under the guidance of a licensed healthcare provider. Do not start, stop, or change the dosage of this medication without consulting your doctor. Reliance on this information is solely at your own risk.
Learn more about Zoloft and related topics

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