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Product Details

What Is Zoloft?

What Is Zoloft?

Zoloft (sertraline hydrochloride) is a prescription medication classified as a selective serotonin reuptake inhibitor (SSRI). It works by increasing levels of serotonin, a neurotransmitter in the human brain that helps regulate mood, emotions, and behavior. Zoloft is taken orally, usually once daily, with or without food. Zoloft is not a controlled substance and is not typically associated with drug-seeking behavior.

Zoloft (sertraline) is available in tablet and oral solution forms. Currently, our pharmacy provides Zoloft in tablet form only. Many patients purchase this medication from licensed Canadian pharmacies with a valid prescription to save on costs.

Quick Facts About Zoloft

Quick Facts About Zoloft

CategoryDetails
Brand NameZoloft
Generic NameSertraline Hydrochloride
Drug ClassSelective Serotonin Reuptake Inhibitor (SSRI)
ManufacturerPfizer Inc.
Prescription RequiredYes
FDA‑Approved IndicationsMajor Depressive Disorder (MDD); Premenstrual Dysphoric Disorder (PMDD); Post‑Traumatic Stress Disorder (PTSD); Obsessive‑Compulsive Disorder (OCD); Panic Disorder (PD); Social Anxiety Disorder (SAD)
Dosage FormsTablets (25 mg, 50 mg, 100 mg); Oral solution (20 mg/mL)
Half‑Life~26 hours (steady state reached in about 1 week)
Common Side EffectsNausea, diarrhea, insomnia, dry mouth, dizziness, fatigue, and sexual dysfunction
Serious Side EffectsSuicidal thoughts/behavior (boxed warning), serotonin syndrome, severe allergic reactions, abnormal bleeding, seizures
MonitoringWatch for mood changes, suicidal ideation, serotonin syndrome, and bleeding risk; dose adjustments may be needed in hepatic impairment

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What Is Zoloft Used For?

What Is Zoloft Used For?

According to the FDA prescribing information, Zoloft (sertraline HCl) is indicated for the treatment of:

  • Major Depressive Disorder (MDD) in adults
  • Panic Disorder (PD)
  • Obsessive-Compulsive Disorder (OCD) in children (ages 6–17) and adults
  • Post-Traumatic Stress Disorder (PTSD)
  • Social Anxiety Disorder (Social Phobia)
  • Premenstrual Dysphoric Disorder (PMDD)
Zoloft FDA Black Box Warning

Zoloft FDA Black Box Warning

Zoloft Boxed Warning: Increased Risk of Suicidal Thoughts and Behaviors

Antidepressants, including Zoloft (sertraline hydrochloride), increase the risk of suicidal behaviors & thoughts in adolescents, children, and young adults (ages 18–24) during the initial stages of treatment and during dose changes. Short-term studies did not show an increased risk in adults over age 24, and there was a reduction in risk in adults aged 65 and older.

Patients taking Zoloft should be closely monitored for unusual changes in behavior, suicidal thoughts, or worsening depression, especially during the first few months of treatment. Caregivers and families should be advised to observe patients closely and report concerning symptoms to a healthcare provider immediately.

Who Cannot Take Zoloft?

Who Cannot Take Zoloft?

Zoloft should not be used in the following situations:

  • Do not use Zoloft with MAOIs (such as phenelzine, tranylcypromine, linezolid, or methylene blue) or within 14 days of stopping an MAOI, as this may cause serotonin syndrome.
  • Concomitant use with pimozide is contraindicated due to the risk of QT prolongation.
  • Do not take Zoloft if you have had an allergic reaction to sertraline or any of its inactive ingredients.
Zoloft (sertraline) Precautions and Warnings

Zoloft (sertraline) Precautions and Warnings

  • Suicidal thoughts and behaviors: Antidepressants, including Zoloft, increase the risk of suicidal behaviors & thoughts in adolescents, children, and young adults, especially during the initial treatment period.
  • Serotonin syndrome: This risk increases when combined with other serotonergic drugs (e.g., other antidepressants, triptans, certain pain medications).
  • Bleeding risk: Increased risk when taken with NSAIDs, aspirin, or blood thinners.
  • Mania or hypomania activation: Use caution in patients with bipolar disorder.
  • Seizures: Use cautiously in people with a history of seizures.
  • Hyponatremia (low sodium levels): More common in elderly patients or those taking diuretics.
  • Angle-closure glaucoma: Zoloft may trigger angle-closure in patients with anatomically narrow angles.
What Are the Side Effects of Zoloft?

What Are the Side Effects of Zoloft?

Common Side Effects of ZoloftRare or Serious Side Effects of Zoloft
NauseaSuicidal thoughts or behaviors (boxed warning)
DiarrheaSerotonin syndrome (confusion, agitation, rapid heart rate, sweating, muscle rigidity)
InsomniaSevere allergic reactions (rash, itching, swelling of face/tongue/throat)
Dry mouthSeizures
Fatigue or somnolenceAbnormal bleeding (especially with NSAIDs, aspirin, anticoagulants)
DizzinessHyponatremia (low sodium, more common in the elderly)
TremorMania or hypomania activation in bipolar disorder
Sexual dysfunction (decreased libido, delayed ejaculation)Angle‑closure glaucoma
SweatingElevations in liver enzymes (rare)

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How Does Zoloft Work?

How Does Zoloft Work?

Zoloft (sertraline HCl) works by increasing the levels of serotonin, a neurotransmitter in the human brain that helps regulate emotions, mood, and behavior.

Zoloft belongs to a class of medications called SSRIs. It works by blocking the reuptake (reabsorption) of serotonin into nerve cells, thereby increasing its availability in the brain. By improving serotonin activity, Zoloft helps:

  • Improve mood
  • Reduce symptoms of depression
  • Decrease anxiety, panic, and obsessive thoughts
  • Improve emotional balance over time

Zoloft tablets do not provide immediate relief. It may take several weeks of consistent use to experience the full therapeutic benefits.

How to Properly Take Zoloft Tablets?

How to Properly Take Zoloft Tablets?

Follow these Zoloft administration guidelines for the safe and effective use:

  • It can be taken with or without food.
  • Swallow Zoloft tablets with a glass of water. Do not crush, chew, or split the Zoloft tablet.
  • Take Zoloft at the same time each day to help maintain steady medication levels in your body.
  • Do not stop taking Zoloft suddenly. Stopping abruptly may cause withdrawal symptoms. Your doctor will guide you on how to taper the dose safely if needed.
  • If you have diabetes, keep track of your blood sugar levels as instructed by your provider. Zoloft may alter glycemic control in patients with diabetes.
What Are the Symptoms of Taking Too Much Zoloft?

What Are the Symptoms of Taking Too Much Zoloft?

Taking too much Zoloft (sertraline) can result in an overdose, which may be serious and require immediate medical attention. The symptoms might vary depending on the amount taken and whether other substances were involved.

Common symptoms of Zoloft overdose include:

  • Confusion, restlessness, or agitation
  • Extreme drowsiness or sudden changes in consciousness
  • Nausea
  • Dizziness
  • Rapid, slow, or irregular heartbeat
  • Difficulty breathing or shortness of breath
  • Seizures or uncontrolled shaking

If you suspect that someone has taken too many Zoloft tablets, treat it as an emergency. Contact your nearest emergency services or the poison control center immediately. Do not wait for symptoms to worsen and do not attempt to manage the overdose on your own, as early medical treatment can prevent serious complications.

Zoloft Tablets Dosage Guide

Zoloft Tablets Dosage Guide

The Zoloft dosage schedule can vary based on the individual response and tolerability. Zoloft doses are typically started low and adjusted gradually to improve tolerability and effectiveness, under the guidance of a healthcare provider.

Zoloft Dosage for Adults

IndicationInitial DoseRecommended Dose RangeMaximum Dose
Major Depressive Disorder (MDD)50 mg once daily50–200 mg once daily200 mg/day
Obsessive‑Compulsive Disorder (OCD)50 mg once daily (adults)50–200 mg once daily200 mg/day
Panic Disorder (PD)25 mg once daily50–200 mg once daily200 mg/day
Post‑Traumatic Stress Disorder (PTSD)25 mg once daily50–200 mg once daily200 mg/day
Social Anxiety Disorder (SAD)25 mg once daily50–200 mg once daily200 mg/day
Premenstrual Dysphoric Disorder (PMDD)50 mg once daily (continuous or luteal phase dosing)50–150 mg once daily150 mg/day

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Zoloft Dosage for Children & Adolescents

IndicationAge GroupInitial DoseRecommended Dose RangeMaximum Dose
Obsessive‑Compulsive Disorder (OCD)Children (6–12 years)25 mg once daily25–200 mg once daily200 mg/day
Obsessive‑Compulsive Disorder (OCD)Adolescents (13–17 years)50 mg once daily50–200 mg once daily200 mg/day

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How Should Zoloft Be Stored?

How Should Zoloft Be Stored?

Follow these Zoloft tablets storage guidelines for effective use of this medication:

  • Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F to 86°F).
  • Keep Zoloft in a dry place and protect it from excessive moisture.
  • Do not store the tablets in the bathroom or other damp areas, as humidity can affect the medication.
  • Keep it out of reach of children and pets.
  • Dispose of expired or unused Zoloft safely, following local guidelines or your pharmacy’s instructions.
Success Rate of Zoloft (Sertraline) Compared to Fluoxetine

Success Rate of Zoloft (Sertraline) Compared to Fluoxetine

In a randomized clinical study (2000) involving 44 patients with unipolar major depressive disorder, published on PubMed, the effectiveness of sertraline (Zoloft) was evaluated. Results show that a significant proportion of people respond positively to sertraline:

  • 6-week response: About 43% of patients taking sertraline 100 mg/day showed a positive treatment response.
  • 10-week response: Increasing the dose as needed resulted in 40–43% response rates.
  • These results indicate that sertraline (Zoloft) is effective in helping many patients manage symptoms of major depression, though individual outcomes may vary.

The study compared sertraline with fluoxetine, but these figures highlight the response specifically for sertraline (Zoloft). Treatment should always be tailored by a clinician to the patient's needs.

Zoloft Interactions

Zoloft Interactions

Zoloft may interact with other medicines. You should always tell your doctor about all drugs or supplements you are taking. Common Zoloft interactions include:

Drug / CategoryExamplesFDA Notes / Risks
Monoamine Oxidase Inhibitors (MAOIs)Phenelzine, Tranylcypromine, Linezolid, Methylene BlueContraindicated. Risk of serotonin syndrome. Do not use Zoloft within 14 days of stopping an MAOI, or use an MAOI within 14 days of stopping Zoloft.
PimozideContraindicated. Risk of serious heart rhythm abnormalities (QT prolongation).
Other Serotonergic DrugsSSRIs, SNRIs, Triptans, Tramadol, Fentanyl, Lithium, St. John’s WortIncreased risk of serotonin syndrome. Monitor for symptoms.
NSAIDs / Aspirin / AnticoagulantsIbuprofen, Naproxen, Warfarin, DOACsIncreased risk of bleeding. Monitor for signs of bleeding.

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Zoloft Alternatives

Zoloft Alternatives

If Zoloft is unavailable, alternative medications may be used under medical supervision. The alternatives to Zoloft tablets include:

  • Prozac (fluoxetine)
  • Paxil (paroxetine)
  • Celexa (citalopram)
  • Lexapro (escitalopram)
  • Luvox (fluvoxamine)
  • Effexor XR (venlafaxine)
  • Cymbalta (duloxetine)
Why Buy Zoloft Online from Polar Bear Meds?

Why Buy Zoloft Online from Polar Bear Meds?

  • Lower Costs: Zoloft tablets are priced significantly lower than those in typical U.S. retail pharmacies, helping patients save, especially on long-term use.
  • Licensed Canadian Pharmacies: All medications are dispensed through licensed and regulated Canadian pharmacies and shipped to the U.S., ensuring quality, safety, and authenticity.
  • Fast & Discreet Shipping: Receive your order quickly in the U.S. with discreet packaging and tracking for peace of mind.
  • Simple Online Ordering: Upload prescriptions easily, select quantities, and complete checkout with transparency.
  • Exclusive Discounts: Use the coupon code WELCOMEPB10 for 10% off your first order.
  • Referral Savings: Additional savings may be available when ordering larger quantities. Earn rewards through our referral program.
  • Customer Support: Our dedicated support team is available to assist with prescriptions, orders, and questions, providing confidence with every purchase.

Purchasing from Polar Bear Meds ensures you receive authentic, prescription-only Zoloft tablets safely and conveniently, without the high U.S. prices.

Important Disclaimer

Important Disclaimer

The information provided above about Zoloft (sertraline) is for general educational purposes only. The content on this page is not intended to replace any kind of professional advice, diagnosis, or treatment. Zoloft is a prescription-only medicine and should be used strictly under the guidance of a licensed healthcare provider. Do not start, stop, or change the dosage of this medication without consulting your doctor. Reliance on this information is solely at your own risk.

Zoloft FAQs

Zoloft FAQs

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