Zortress

Buy Zortress Online from Licensed Canadian Pharmacies

Zortress (everolimus) is an immunosuppressant that is used to help prevent your body from rejecting a transplanted kidney or liver. This medication is an mTOR inhibitor that calms part of your immune system, so it is less likely to attack the new organ.

In the United States, Zortress is approved for adult patients at low-to-moderate immunologic risk who receive a kidney transplant, and for adults after a liver transplant. It is always used in combination with other anti-rejection medicines, like reduced-dose cyclosporine (for kidneys) or tacrolimus (for liver), plus corticosteroids.

Zortress tablets are taken twice a day, every day, as a long-term maintenance treatment. It is commonly available in 4 different strengths: 0.25 mg, 0.5 mg, 0.75 mg, and 1 mg. If you want to buy Zortress online from Canada, get your prescription from a qualified doctor.

It lowers the risk that your immune system will damage the transplanted organ, helping to protect its function over time. It does it by reducing the activity of certain white blood cells.

At the same time, careful dosing and monitoring aim to balance these benefits with important safety concerns, like infections, kidney problems, and changes in cholesterol and blood counts.

Drug Summary

What Is Zortress Used For?

Zortress is used to treat and prevent organ rejection in certain adult kidney and liver transplant recipients.

What Are the Benefits of Zortress?

• The medicine is always used with other drugs to provide layered protection against rejection.
• It can be part of a tailored transplant regimen for patients who need strong anti-rejection therapy but also require careful management of kidney function and cardiovascular risk factors.
• Zortress supports long-term graft survival and helps preserve kidney or liver function by limiting rejection episodes.

Zortress Dosage

Dosage of Zortress for Kidney Transplant in Adults

• Starting dose: 0.75 mg by mouth two times a day (total 1.5 mg per day), begun as soon as possible after transplantation.
• Zortress is given with reduced-dose cyclosporine and corticosteroids, plus basiliximab at transplant according to the protocol.
• Dose adjustments: These are guided by everolimus trough levels (measured just before the next dose), usually targeting about 3 to 8 ng/mL and by kidney function, side effects, and rejection risk.

Dosage of Zortress for Liver Transplant in Adults

Zortress is usually started at least 30 days after liver transplantation, once the surgical site has healed.

• Starting dose: 1 mg by mouth twice daily (total 2 mg per day), in combination with reduced-dose tacrolimus and corticosteroids.
• Dose adjustments: As with a kidney transplant, the dose is adjusted based on everolimus trough levels, liver function, and clinical response.

How to Take Zortress Tablets?

Zortress is taken twice a day, every day, as part of your long-term transplant anti-rejection regimen.

• Take Zortress consistently every 12 hours, at the same times each day (for example, morning and evening).
• Swallow the tablets whole with a glass of water.
• You shouldn’t crush or chew them.
• Take this medicine the same way in relation to meals (always with food or always without food), because food can affect how much medicine your body absorbs.
• Do not take Zortress at the same time as cyclosporine. Follow your transplant center’s timing instructions so levels of both drugs stay stable.

How Zortress Works

Zortress contains everolimus, which is an mTOR inhibitor. mTOR stands for “mammalian target of rapamycin,” a key protein inside cells that helps control cell growth, metabolism, and immune cell activity.

Everolimus binds to a protein inside immune cells and forms a complex that blocks mTORC1, one part of the mTOR pathway. This blockade slows down the growth and division of T-lymphocytes and B-lymphocytes, two types of white blood cells that play central roles in organ rejection.

Zortress makes it less likely that your immune system will see the transplanted kidney or liver as foreign and attack it by dampening down this immune response.

Unlike drugs that broadly wipe out immune function, mTOR inhibitors act on a specific signaling pathway, which is why they are often used in combination with calcineurin inhibitors (like cyclosporine or tacrolimus) and steroids to provide broader, complementary protection.

What Are the Side Effects of Zortress?

Common Zortress side effects may include:

• Mouth ulcers, sores, or irritation in the mouth
• Diarrhea, constipation, stomach pain, nausea, or decreased appetite
• Headache, fatigue, or trouble sleeping
• Acne, rash, dry skin, or hair loss
• Swelling in the hands, ankles, or legs (peripheral edema)
• Elevated cholesterol or triglycerides on blood tests (hyperlipidemia)
• Mild nosebleeds or irritation of the nose or throat

Serious side effects (rare): Call your provider if you experience any serious symptoms or unusual changes.

• Serious infections (bacterial, viral, fungal, or others)
• Lymphoma or other cancers
• Kidney problems
• Poor wound healing
• Non-infectious pneumonitis
• Angioedema
• Severe metabolic problems

Zortress Warnings

Black Box Warning: Zortress has an FDA boxed warning for an increased risk of serious infections and malignancies, including lymphoma and skin cancers, with long-term immunosuppressive use.

Zortress is a powerful immunosuppressant, so consider these other warnings before using it:

• Use in heart transplant patients is not recommended due to the observed increased mortality in clinical trials.
• It is contraindicated in patients with known hypersensitivity to everolimus, sirolimus, or any component of the product.
• Using this medicine with drugs that strongly affect CYP3A4 or P-gp (like certain antifungals, macrolide antibiotics, and anticonvulsants) can significantly change everolimus levels and requires careful review.
• Women who can get pregnant should avoid becoming pregnant during treatment and for 8 weeks after the last dose. Zortress may harm an unborn baby.

What Precautions Should You Take While Using Zortress?

• Take Zortress exactly as directed and do not start, stop, or change the dose of any transplant medicine without professional guidance.
• Keep all lab appointments for everolimus levels, kidney and liver function tests, blood counts, and cholesterol testing.
• Watch for signs of infection (fever, chills, cough, burning with urination, unusual fatigue) and report them promptly.
• Protect your skin from the sun with clothing and high-SPF sunscreen, because long-term immunosuppression increases skin cancer risk.
• Avoid live vaccines and check with your doctors before receiving any immunizations.
• Tell your dentist and other health care professionals that you take Zortress before any procedures or new prescriptions.

Zortress Missed Dose

If you miss a dose of Zortress and it has only been a short time, take the missed tablet as soon as you remember, then take your next dose at the regular scheduled time.

If the time for your next routine dose is near, skip this missed one and continue with your dosing schedule.

Zortress Overdose

Do not take more tablets of Zortress than prescribed. If you have taken an overdose accidentally, call 911 or the Poison Control Center at their toll-free number 1-800-222-1222.

How to Store Zortress

When you order Zortress online from Canada, store it following these instructions:

• Store Zortress tablets at room temperature.
• Keep it away from pets and children to prevent any ingestion.
• Do not use Zortress after the expiration date.
• Dispose of the medication carefully as per your local disposal guidelines.

Zortress Interactions

Zortress Alternatives

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The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.