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What Is a Combivent Respimat Inhaler?

The Combivent Respimat inhaler is a prescription medication used for the treatment of chronic obstructive pulmonary disease (COPD). It combines two active ingredients, ipratropium bromide and albuterol sulfate, which work together to relax and open the airways, making it easier to breathe. It is administered via inhalation and comes in the form of a convenient, easy-to-use inhaler device. 

The Respimat technology delivers a fine mist of medication for effective inhalation and optimal respiratory relief. Combivent Respimat inhaler and Trelegy Ellipta are highly recommended for individuals dealing with COPD alongside Spiriva Inhaler.

COPD (Chronic Obstructive Pulmonary Disease): It is a progressive respiratory condition characterized by persistent airflow limitation in the lungs. 

Dosage, Usage, and Storage of Combivent Inhaler

Here’s essential information on the dosage, correct usage, and appropriate storage of Combivent Respimat Inhaler to help you get the most out of your COPD management. Following these guidelines ensures optimal results in your respiratory health regimen.


The recommended dosage for Combivent Respimat Inhaler is one inhalation four times daily. This standard dose is typically effective in managing COPD symptoms. Following inhalation, effects are typically noticeable within 15 minutes. However, it’s crucial not to surpass six inhalations within 24 hours. The efficacy of inhaled medication hinges on factors like proper inhaler usage and individual patient characteristics, including breathing capability. Ensure that the duration of your inhalation is at least as long as the spray (approximately 1.5 seconds).


Here are the steps for using the inhaler:

  • Ensure the cartridge is clean.
  • Place the Combivent inhaler into the provided unit.
  • If using it for the first time, or if not used for more than 3 days or 21 days, prime it.
  • Breathe in through your mouth. Before this, spray away from you to confirm it’s working and to avoid medication in your eyes.
  • Wipe the mouthpiece with a damp cloth at least once a week.
  • After inserting a new cartridge, dispose of the old one after 3 months, even if it still contains unused medicine. The inhaler has a locking system after 120 sprays.

How to Store?

  • Store Combivent inhaler at room temperature (68°F to 77°F or 20°C to 25°C).
  • Keep away from direct sunlight and heat.
  • Avoid storing in areas with excessive moisture.
  • Do not freeze the inhaler.
  • Ensure the cap is closed when not in use.
  • Keep out of reach of children and pets.

Always follow the specific instructions provided by your healthcare provider or on the medication label. If you have any questions or concerns about the usage or storage of Combivent Respimat, consult your healthcare professional.

How Does Combivent Respimat Work?

Combivent inhaler combines two active ingredients: ipratropium bromide and albuterol sulfate.

  • Ipratropium bromide: This is an anticholinergic bronchodilator. It works by blocking the action of acetylcholine, a neurotransmitter, on the smooth muscle cells in the airways. This leads to relaxation and dilation of the airways, making it easier to breathe.
  • Albuterol sulfate (Salbutamol): This is a beta-agonist bronchodilator. It stimulates beta receptors in the lungs, causing the smooth muscles to relax. This action opens up the airways, allowing for improved airflow.

By combining these two medications, Combivent Respimat provides a dual bronchodilator effect, offering more comprehensive relief for individuals with chronic obstructive pulmonary disease (COPD). 

Combivent Respimat vs. Duolin HFA CFC-Free Inhaler

Combivent Respimat and Duolin HFA CFC-Free Inhaler are both medications used in the treatment of respiratory conditions:

  • Combivent Respimat Inhaler: It is a combination inhaler containing ipratropium bromide (an anticholinergic bronchodilator) and albuterol sulfate (a beta-agonist bronchodilator). It helps relax and open the airways, making it easier to breathe. It is commonly used for conditions like chronic obstructive pulmonary disease (COPD).
  • Duolin HFA CFC-Free Inhaler: Duolin inhaler contains a combination of two active ingredients, ipratropium bromide and salbutamol (also known as albuterol). Duolin HFA inhaler is similar to Combivent Respimat; Duolin inhaler helps in relaxing the airways, making it easier to breathe. Duolin HFA inhalers are used for conditions like asthma and COPD.

Both Combivent inhaler and Duolin inhaler are administered via inhalation and serve as bronchodilators, but they have slightly different combinations of active ingredients. Always use Combivent and Duolin HFA inhalers as prescribed by your healthcare provider. 

Warnings and Precautions

  • If you have a history of hypersensitivity reactions to ipratropium, albuterol, or any components in Combivent Respimat, inform your healthcare provider.
  • Paradoxical Bronchospasm can occur with any inhalation therapy, including Combivent Respimat. If this happens, discontinue use immediately and seek medical attention.
  • Combivent inhalers may have cardiovascular effects. Inform your healthcare provider if you have heart conditions or high blood pressure.
  • Use with caution in patients with urinary retention or narrow-angle glaucoma.
  • If symptoms worsen or do not improve after use, consult your healthcare provider.
  • Inform your healthcare provider of all medications you’re taking, especially other anticholinergic drugs or sympathomimetic agents.
  • Use during pregnancy or nursing should only be done if the benefits outweigh the potential risks.
  • Discontinue Combivent Respimat if hypersensitivity reactions occur.
  • Safety and effectiveness in pediatric patients have not been established.
  • Use with caution in patients with narrow-angle glaucoma or cataracts.

Always follow your healthcare provider’s instructions and inform them of any existing medical conditions or medications you’re taking. 

Side Effects

Common side effects of Combivent inhaler may include:

  • Headache
  • Cough
  • Dry mouth
  • Nausea
  • Dizziness
  • Nervousness
  • Sinusitis
  • Upper respiratory tract infection
  • Pharyngitis
  • Runny or stuffy nose

Less common but more severe side effects may include:

  • Chest pain
  • Irregular heartbeat
  • Difficulty urinating
  • Eye pain or discomfort
  • Blurred vision
  • Wheezing or breathing difficulties (paradoxical bronchospasm)

If you experience any unusual or bothersome symptoms while using Combivent Respimat, consult your healthcare provider promptly. They can provide guidance and determine if any adjustments to your treatment plan are necessary.

Combivent Respimat Interactions

Combivent Respimat may interact with several medications. It’s crucial to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, herbal supplements, and vitamins. Some potential interactions include:

  1. Other Anticholinergic Drugs
  2. Sympathomimetic Agents
  3. Beta-Blockers
  4. Monoamine Oxidase Inhibitors (MAOIs)
  5. Tricyclic Antidepressants
  6. Diuretics
  7. Xanthine Derivatives
  8. Corticosteroids

There may be other medications that can interact with Combivent Respimat. Always consult your healthcare provider or pharmacist for a comprehensive understanding of potential interactions. 

Frequently Asked Questions

How long does a Combivent Respimat inhaler last?

A Combivent Respimat inhaler, when used as directed, typically contains enough medication for approximately 120 inhalations. This duration may vary based on individual usage patterns. It’s important to keep track of the number of doses remaining and obtain a new inhaler before it runs out to ensure uninterrupted treatment for your respiratory condition.

Can Combivent Respimat be used in children?

Combivent Respimat is generally not recommended for use in children under the age of 18. It’s important to consult with a pediatrician or healthcare provider for alternative treatment options suitable for children with respiratory conditions. They can provide personalized guidance based on the child’s specific medical history and needs.

Can I clean the Combivent Respimat inhaler?

No, you should not attempt to clean the Combivent Respimat inhaler. It is designed for single-patient use and should not be cleaned or reused. Using a clean, uncontaminated inhaler for each dose ensures the medication’s effectiveness and reduces the risk of potential complications. If you have any concerns about the cleanliness of your inhaler, consult your healthcare provider or pharmacist for guidance.

Are there any dietary restrictions while using Combivent Respimat?

There are typically no specific dietary restrictions associated with using Combivent Respimat. However, it’s important to maintain a balanced and healthy diet to support overall respiratory health. If you have any concerns about potential interactions between your diet and medication, consult your healthcare provider or pharmacist for personalized advice. They can provide guidance based on your specific medical condition and needs.

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