Dalteparin

Fragmin

Fragmin (Dalteparin) is an FDA-approved medication used to treat and prevent blood clots. It treats other conditions such as pulmonary embolism (PE), deep vein thrombosis (DVT), and acute coronary syndrome. It is administered as an injection under the skin or through an IV. The dosage of this drug varies based on the condition being treated and patient characteristics. Some of its common side effects include increased bleeding or bruising. Following the prescribed dosage and consulting a doctor for any concerns is important. Fragmin should not be used by individuals with certain medical conditions, including major bleeding, drug-induced low platelet count, allergies to heparin or pork, and specific heart problems. So, when you decide to buy Fragmin injection online, consult a medical professional to ensure that you are using the correct form of the medication.

Product Overview

Fragmin (dalteparin) is an anticoagulant medication primarily used to prevent blood clotting formation in your blood vessels. It’s part of a group of drugs called low molecular weight heparins. Fragmin works by slowing down the body’s natural blood clotting process, reducing the chance of forming harmful clots. Doctors often prescribe it for conditions like deep vein thrombosis (DVT), pulmonary embolism, and some heart conditions.

The medication is administered through subcutaneous injections or intravenously, depending on the patient’s condition and the healthcare provider’s recommendation. This medicine comes in 3 forms and has many strengths. The dosage of Fragmin is determined based on the patient’s body weight, the specific condition being treated, and other individual factors. It is available in various strengths, including ampules, multidose vials, and prefilled syringes. You may experience some common and mild side effects of Fragmin, including increased bruising or bleeding, swelling at the injection site, and longer bleeding times from minor injuries. 

It is crucial for patients to follow their doctor’s instructions regarding dosage and administration of Fragmin. Regular monitoring through blood tests may be required to ensure the medication’s effectiveness and to adjust the dosage as necessary. Fragmin can interact with various drugs, increasing the risk of side effects; thus, talking to a healthcare professional becomes crucial. This is an effective medication for managing and preventing blood clots, but it needs careful monitoring and adherence to prescribed guidelines to ensure safety and effectiveness. Remember, this information is just a general overview and not a replacement for advice from a healthcare provider. Always consult a healthcare professional for specific details about any medication.

What Are the Uses of Fragmin?

Fragmin (Dalteparin) is used to: 

• Prevention and Treatment of Blood Clots
• Acute Coronary Syndrome
• Pulmonary Embolism (PE)
• Deep Vein Thrombosis (DVT)
• Prevent clotting of blood after certain types of surgery
• Reduction of Recurrence of Venous Thromboembolism (VTE) in Children One Month of Age and Older
• Treatment (long-term)of Venous Thromboembolism (VTE) in people with cancer

What Are the Forms & Strengths of Fragmin?

Fragmin (dalteparin sodium injection) comes in 3 forms with the following strengths:

• Ampules

• • • The solution for injection contains 10,000 IU of dalteparin sodium per ml.

• Multidose vials

• • • Each multidose vial contains dalteparin sodium at 25,000 IU/ml.

• Prefilled syringes

• • 2,500 IU/0.2 ml
  • 3,500 IU/0.28 ml
  • 5,000 IU/0.2 ml
  • 7,500 IU/0.3 ml
  • 10,000 IU/0.4 ml
  • 12,500 IU/0.5 ml
  • 15,000 IU/0.6 ml
  • 16, 500 IU/0.66 ml
  • 18,000 IU/0.72 ml

What Is the Recommended Dosage of Fragmin?

Fragmin doses are not specific for every patient. They are prescribed by a medical professional based on your medical conditions, type, severity, and response to the treatment. Your doctor will generally prescribe you a loading dose and gradually titrate it as per the body’s needs. So, it is important to follow the instructions exactly as your doctor prescribes. Moreover, the recommendations below are only the average doses. If you have been instructed otherwise or have a different dosing schedule, do not alter it without consulting your medical practitioner.

For Blood Clots Prevention After Unstable Angina or Non–Q-Wave Myocardial Infarction:

• Dosage: Based on body weight, determined by your doctor.
• Typical Dose: 120 IU per kg of body weight every 12 hours for 5 to 8 days (maximum 10,000 IU per dose).
• Aspirin: 75 to 165 milligrams (mg) once a day unless advised otherwise by your doctor.

For Deep Venous Thrombosis Prevention After Abdominal Surgery:

• Adults: 2,500 or 5,000 IU, once a day for 5 to 10 days. Alternatively, 2,500 IU, followed by another 2,500 IU 12 hours later, then 5,000 IU once a day.
• Children: Dosage must be determined by your doctor.

For Deep Venous Thrombosis Prevention After Hip Replacement Surgery:

• If started the evening dose before surgery: 5,000 IU, 10 to 14 hours before the surgery. Then followed by 5,000 IU 4 to 8 hours after surgery, then 5,000 IU once a day.
• If started on the day of surgery: 2,500 IU within 2 hours before surgery, followed by 2,500 IU 4 to 8 hours after surgery, then 5,000 IU once a day.
• If started after surgery: 2,500 IU, 4 to 8 hours after surgery, then 5,000 IU once a day for 5 to 10 days.

For Prevention of Deep Venous Thrombosis in Medical Patients With Acute Illness:

• Dosage: 5,000 IU, once a day for 12 to 14 days.

For Prevention of Symptomatic Pulmonary Embolism and Deep Venous Thrombosis in Children:

• 8 to 16 years: Dosage based on body weight, determined by your doctor. Initially, 100 IU per kg of body weight, twice a day.
• 2 to 7 years: Dosage based on body weight, determined by your doctor. Initially, 125 IU per kg of body weight twice a day.
• Four weeks to 1 year: Dosage based on body weight, determined by your doctor. Initially, 100 IU per kg of body weight, twice a day.
• Younger than four weeks: Dosage must be determined by your doctor.

For Symptomatic Deep Venous Thrombosis and Pulmonary Embolism in Patients With Cancer:

• Dosage: Based on body weight, determined by your doctor.
• First 30 days: 200 IU per kg of body weight, once a day (maximum 18,000 IU).
• Months 2 to 6: 150 IU per kg of body weight, once a day.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Inject Fragmin?

When you decide to buy Fragmin injection online, you must know the proper instructions to avoid any potential side effects. Here are some of the important steps that you should follow while administering your medication:

• Dalteparin is given through an injection just under the skin, often in the lower belly area. In some cases, it can be given through an IV (intravenous) in the hospital. 
• If you’re giving yourself the shot, your doctor or healthcare professional will teach you the right way to do it. 
• If you have any questions about how to use your medication, reach out to your doctor or healthcare professional.
• Don’t use the medication if the syringe is leaking or if the medication looks cloudy or discolored.

• Wash your hands and clean the area where you’ll inject with an alcohol swab. Don’t rub the injection site.
• Take off the needle cover. Be careful not to push the syringe plunger and lose any medicine. Hold the syringe like a pen.
• Take hold of a fold of skin in the lower part of your belly (left or right side). Use a different spot for each shot to avoid always injecting in the same place.
• While holding the skin fold, put the whole needle straight into the skin fold and push the syringe plunger all the way down.
• Take out the needle and release the syringe plunger. (The syringe will move into the device until the needle is covered.)
• Press the injection site with the alcohol swab for 5 to 10 seconds. Don’t rub the injection site.
• Dispose of the used syringe safely in approved containers, and keep it away from children.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Fragmin Work?

Fragmin, also known as Dalteparin, is a blood thinner medication that prevents blood clots. It works by blocking a specific enzyme called Factor Xa, which is essential in blood clotting. By doing this, Fragmin also indirectly reduces the formation of another enzyme called thrombin, which helps turn a protein called fibrinogen into fibrin. Fibrin is critical in blood clots, forming a mesh that traps blood cells to create a stable clot. As a result, Fragmin helps prevent the growth of existing blood clots and then the formation of new ones, ensuring smooth blood flow through the vessels and reducing the risk of blockages that can lead to serious health issues. This action is crucial in preventing conditions like deep vein thrombosis (DVT) and pulmonary embolism, as well as preserving blood vessels’ health. Fragmin effectively controls events where blood clots can move through the bloodstream and cause life-threatening problems.

Important Safety Information for Using Fragmin

What Are the Side Effects of Fragmin?

Common Side Effects of Fragmin: This medication is well-tolerated, but it can cause several reactions like all medications. These side effects are generally temporary and last a few days to weeks. It usually does not require any immediate medical attention, as these effects disappear on their own. However, if you notice any worsening signs or notice that they last more than the mentioned time, you may want to consult a doctor. Following are some of the common side effects of Fragmin:

• • Increased Bleeding: Dalteparin is a blood thinner medication that prevents your blood from clotting. As a result, it increases the risk of bleeding in case of a cut or injury. If you suspect any serious cut or increased bleeding, seek immediate medical attention.
  • Injection Site Reactions: Fragmin is injected under the skin, which may sometimes irritate or injure the small blood vessels in that area. If the blood vessel is damaged, swelling at the injection site (filled with blood) can occur. 

• Low Platelet Count: This medication may cause your platelet counts to drop due to heparin-induced thrombocytopenia. This usually happens when your immune system mistakenly attacks platelets, thus resulting in reduced levels of platelets. 
• Bruising: Fragmin increases the risk of bleeding, causing bruising more easily. These bruises occur when small blood vessels break and leak blood into the surrounding tissues. So, when you are on your medication, your blood takes longer to clot, resulting in more visible bruising.

Serious Side Effects of Fragmin: This medication can cause some adverse side effects if not taken properly. These effects usually happen if you have certain side effects or are not taking the medication properly. So, if you notice any unusual signs, do not overlook them, as they can lead to life-threatening situations. While the following list does not include every possible serious side effect of Fragmin, some of them are:

• Bleeding: This medication can make you more likely to bleed. This side effect is more likely to happen if your platelet levels are low. So, if you notice any of the following symptoms, reach out to a medical professional:
  • Increased bruising
  • Blood-filled swelling in the spine, with symptoms of numbness in the legs, tingling, and muscle weakness
  • Coughing up blood
  • Vomiting blood
  • Increased nosebleeds
  • Blood in your urine
  • Blood in your stools (may be dark red, tarry, bright red, and black)
  • Increased gum bleeding after brushing or flossing
  • Dark red spots under your skin
• Gasping Syndrome: It is a feeling of suffocation in which you may find yourself unable to breathe properly. It happens when the medication forms blood clots in your lungs, leading to restricted blood flow. As a result, you find it difficult to breathe properly. This syndrome is a rare side effect that can appear in premature infants, but if you notice any such issues, talk to your doctor. 
• Increased Liver Enzymes: Fragmin can affect the functioning of your liver, indicating liver damage. Some of its symptoms may include:
  • Vomiting
  • Pain in the abdomen (stomach area)
  • Yellowing of your skin or the whites of your eyes
  • Nausea
• Allergic Reactions: Certain people may notice allergic reactions to dalteparin sodium injection. These reactions occur due to an affected immune system. Its symptoms may consist of:
  • Fever
  • Reaction at the injection site, including swelling, redness, or itching
  • Itching
  • Rash
  • Trouble breathing
  • Hives (itchy welts)

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Fragmin?

Fragmin helps prevent blood clots, but it has several important warnings that every patient must know before considering treatment with this medication. To avoid potential risks, be mindful of the following warnings:

• History of Spinal Surgery or Defects: If you’ve had injections into your spine’s epidural space or a procedure involving a spinal puncture, this medication increases your risk of bleeding in that area. The risk is higher if you have a spinal defect or recent spinal surgery. This bleeding can lead to serious movement issues, including paralysis, which may be permanent.
• Major Bleeding: Do not use this medication if you currently have serious bleeding.
• History of Drug-Induced Low Platelet Count: If you’ve experienced a low platelet count due to using the drug heparin, avoid this medication.
• Allergic to Heparin or Pork: Do not use this medication if you’ve had a reaction to heparin or pork.
• Current or Past Heart Problems: If you have a history of certain heart issues, your risk of bleeding increases when taking this medication. These issues include uncontrolled high blood pressure and heart infections.
• History of Stroke: Your risk of bleeding increases when taking this medication.
• Severe Kidney or Liver Problems: Your chances of bleeding increases when taking this medication. Consult with your doctor about whether this medication is safe for you.
• Eye Problems: If you have eye issues whether it is caused by high eye pressure or diabetes, your chances of bleeding increases when taking this medication. Consult with your doctor about whether this medication is safe for you.
• Bleeding Disorders: If you have these disorders, such as a low platelet count or dysfunctional platelets, your risk of bleeding increases when taking this medication. Consult with your doctor about whether this medication is safe for you.
• Recent Stomach Bleeding or Stomach Ulcers: Your risk of bleeding increases when taking this medication. Consult with your doctor about whether this medication is safe for you.

What Are the FDA Boxed Warning for Fragmin?

FDA warnings are among the most strict warnings issued by the FDA about the harmful effects of a particular drug. They alert doctors and patients beforehand to avoid any potential risks. Fragmin also has boxed warnings that indicate that the long-term use of this medication may cause spinal or epidural hematoma. This condition occurs when blood builds up and puts pressure on the spinal cord. It can occur in patients who are taking certain blood-thinning medications, such as low molecular weight heparins (LMWH) or heparinoids and are undergoing spinal puncture (a procedure to remove spinal fluid for testing) or receiving neuraxial anesthesia (injections near the spine). These blood clots can lead to long-term or permanent paralysis, which is the inability to move body parts. Doctors should carefully consider these risks when planning spinal procedures for patients, as they may have a higher risk of developing blood clots.

What Are the Fragmin Precautions?

There are certain factors that every patient should be mindful of while considering treatment with Fragmin. Doing so may prevent the risk of serious side effects and maintain the effectiveness of the medication. So, if you decide to buy Fragmin injection online, follow some basic preventive measures, which are as follows:

• Before using dalteparin, inform your doctor beforehand if you have any allergies to heparins or pork products. The product may contain certain components that can lead to severe allergic reactions.
• When considering treatment with Fragmin, tell your healthcare provider about your medical history, including:
  • Bleeding problems
  • Artificial heart valves
  • Eye problems
  • High blood pressure
  • Kidney diseases
  • Liver issues
  • Intestinal problems
  • Spine problems
• If you have surgery planned or are undergoing a medical procedure, inform your surgeon or dentist about the products you use. This includes all medication drugs, over-the-counter medicines, and herbal products. 
• Fragmin can increase the chances of bleeding. So, if you are using this medication, avoid getting injured, bruised, or cut. Limit contact with sharp objects such as razors, nail cutters, or activities like contact sports.
• There is no clear evidence that dalteparin negatively affects the fetus, but the possibility of harm cannot be completely ruled out. If you are pregnant or planning to become pregnant, discuss the use of this medication with your doctor. It should only be used during pregnancy if necessary. Be aware that some versions of this medication contain benzyl alcohol, which can be harmful to premature infants. If you are pregnant, ensure your doctor prescribes a version without benzyl alcohol.
• Dalteparin may pass into breast milk and may cause some side effects in a breastfed infant. Consult your doctor if you are breastfeeding. You may need to choose between stopping the medication or discontinuing breastfeeding.
• As people age, their kidneys may not function as efficiently, leading to slower drug processing in the body. This can increase the risk of side effects, such as bleeding. If you are over 65 years old, weigh 99 pounds (45 kg) or even less, or have kidney problems, you have a higher risk of bleeding with this medication.
• Dalteparin has not been tested in children and should not be used in individuals under 18 years of age.
• Dalteparin increases the risk of bleeding, and consuming alcohol while taking this medication can further elevate this risk. If you consume alcohol, discuss it with your doctor. You may need to monitor the signs of bleeding.

What Are the Contraindications of Fragmin?

Fragmin (Dalteparin) should not be used in patients with the following conditions:

• A known or suspected history of a severe allergic reaction to heparin, known as heparin-induced thrombocytopenia (type II).
• Active bleeding that is significant, such as bleeding from a stomach ulcer or a brain hemorrhage.
• Serious blood clotting disorders.
• Infection of the heart’s inner lining (septic endocarditis).
• Recent injuries or surgeries involving the eyes, brain, or ears.
• Allergy to dalteparin, pork products, other low-molecular-weight heparins, or heparins.

What If You Miss a Dose of Fragmin?

Patients are not recommended to avoid any doses of their medication, but if you have forgotten to take Fragmin’s dose on time:

• Take it as soon as you recall. But if your next dose is due in a few hours, simply continue with your regular dosing schedule. 
• Avoid taking two doses simultaneously, as it may lead to adverse reactions.
• Use medication apps to avoid skipping any doses.
• If you are still unsure, ask a medical professional. They will suggest alternatives to you.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Fragmin?

Taking too much of this medication can lead to harmful levels in your body, leading to severe bleeding. If you believe you have overdosed, contact the local poison control center or your doctor immediately. In case of severe symptoms, call emergency services (911) or go to the hospital’s emergency room that is nearest to you without delay.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store Fragmin?

To maintain the safety and effectiveness of your dalteparin sodium injections, you should keep the medication in a controlled environment. Here are some basic storage guidelines of Fragmin: 

• Store Fragmin (Dalteparin) in a closed container at room temperature.
• Do not freeze it, and keep it away from direct sunlight.
• Keep it away from moisture and heat. 
• Keep Fragmin out of the reach of children.
• Do not keep medication that is outdated or no longer needed.
• Consult your healthcare professional for guidance on properly disposing of unused medication.
• If you have been provided with a bottle of medication for use with syringes, ensure to use the medication within 14 days of the first injection. 
• Dispose of any unused medication after fourteen days.
• Dispose of used needles in a sturdy, sealed container that prevents the needles from piercing through. Keep this container out of reach of children and pets.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Fragmin?

Combining two or more medications without knowing their effects can cause drug interactions. While some drugs may be required to be taken in combination with other medicines, doing so without any medical assistance may lead to various side effects. This lack of knowledge may alter the functioning of your medication or increase the risk of developing adverse side effects. Either way, you will end up with life-threatening situations. Therefore, it is best to consult a medical professional to avoid such complications. The below list contains some of the drugs that may interact with Fragmin:

• Eptifibatide
• Rivaroxaban
• Eltrombopag
• Prasugrel
• Urokinase
• Dipyridamole
• Dabigatran
• Ticlopidine
• Romiplostim
• Clopidogrel
• NSAIDs (nonsteroidal anti-inflammatory drugs)
• Heparin
• Tenecteplase
• Alteplase
• Ticagrelor
• Tinzaparin
• Ticagrelor
• Anagrelide
• Lepirudin
• Oprelvekin
• Reteplase
• Cilostazol
• Abciximab
• Fondaparinux
• Tirofiban
• Nonsteroidal anti-inflammatory drugs
• Argatroban
• Salicylates such as aspirin and others
• Warfarin
• Enoxaparin
• Dextran

What Are the Other Fragmin Interactions?

Besides the drug interactions, the functioning of this medication can be affected due to many other reasons. This includes food, diseases, herbs, and lifestyle changes. To know these interactions, refer to the following list:

• Hemophilia
• Liver disease
• Peptic ulcer disease
• Retinopathy
• Subacute bacterial endocarditis
• Active bleeding
• Hypertension
• Renal dysfunction
• Thrombocytopenia
• Prematurity
• Alcohol

[Note: This isn’t a complete list, and there could be other drugs that interact with Fragmin. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Fragmin Alternatives?

There are many reasons why people shift from one treatment option to another. One among them is medical conditions. Different patients have different body needs, so their treatment options may vary. The ideal medication for one person may show a different effect on the other individual. That’s why people opt for alternative solutions to achieve their desired results. Here are some of the drug substitutes that you can use in place of Fragmin:  

• Bevyxxa (betrixaban)
• Unfractionated heparin (heparin Sodium)
• Effient (prasugrel)
• Angiomax (bivalirudin)
• Arixtra (fondaparinux)
• Lovenox (enoxaparin)
• Eliquis (apixaban)
• Pradaxa (dabigatran)
• Aspirin
• Jantoven (warfarin)
• Xarelto (rivaroxaban)
• Argatroban
• Iprivask (desirudin)
• Brilinta (ticagrelor)
• Plavix (clopidogrel)
• Savaysa (edoxaban)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Fragmin Cost & Coupons

The cost of Fragmin may not be the same everywhere, and the options for obtaining these injections at a low price are affected by various factors, such as health insurance coverage. Many Americans find that their insurance plans do not cover blood thinner medications like Fragmin, leaving them with nothing but to purchase them at high prices. To manage these costs, many patients turn to pharmacies like Polar Bear Meds, where they can buy Fragmin online directly from Canada in the USA at reasonable costs. Moreover, customers can use the Fragmin coupon code “WELCOMEPB10” for additional savings to receive a 10% discount on their first order.

Frequently Asked Questions

When is the best time to take Dalteparin sodium injections?

There are no specific timings for taking these injections. Your doctor may advise you to take the medication once daily, but ensure that you administer the dose at the same time to maintain consistent blood-thinning effects. It is important to note that you are using this medication under medical supervision, as any inconvenienve may result in adverse reactions that can be life-threatening.

Is Dalteparin safe for children?

Dalteparin can be used in pediatric patients, but it’s essential to follow specific dosing guidelines tailored to the child’s age and weight. The starting doses are based on age groups, and adjustments may be necessary for certain conditions like thrombocytopenia or renal insufficiency. As with any medication, it should only be administered under the guidance and supervision of a healthcare provider experienced in pediatric care.

Can Fragmin be used for long-term treatment?

Yes, Fragmin (Dalteparin) can be used for long-term treatment. It is often prescribed for extended periods to manage conditions like deep vein thrombosis (DVT) and as an extended treatment for symptomatic venous thromboembolism (VTE) in adult patients with cancer. However, the specific duration and dosage will be determined by a healthcare provider based on the individual’s medical condition and response to treatment. Regular monitoring is crucial for safety and effectiveness. Always follow your healthcare provider’s instructions.

How long can you use Fragmin?

The duration of Fragmin depends on the patient’s condition and response to the treatment. However, patients with DVT are usually advised to take the medication each day until their condition improves. For those using dalteparin to prevent blood clots after surgery are advised to use the tablets for 5 to 10 days. To get detailed guidance on the dosage recommendations, consult a medical professional.

Can I take ibuprofen and Fragmin together?

If you are thinking of combining these two medications or any other drugs, you should always talk to a medical expert. You never know which medications may interact with each other. However, if you have co-administered ibuprofen and Fragmin together, you are highly likely to experience serious side effects, especially increased bleeding in the gastrointestinal tract. 

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