Question 1

Can Janumet (sitagliptin/metformin) affect kidney function?

Accepted Answer

There have been instances where Janumet (sitagliptin/metformin) has led to worsening kidney function, including acute kidney issues that sometimes needed dialysis. Due to this risk, your healthcare provider will conduct blood tests to monitor your kidney function before and during treatment to ensure the medication is safe for you. Janumet (sitagliptin/metformin) may not be suitable for individuals with kidney problems.

Question 2

Why is it recommended that Janumet XR be taken in the evening?

Accepted Answer

The reason for the manufacturer’s recommendation to take Janumet XR (sitagliptin/metformin) in the evening is not entirely clear. However, research indicates that DPP-4 inhibitors like sitagliptin, which is one of the components of Janumet XR, may be effective in managing morning hyperglycemia (high blood sugar levels in the morning).

Question 3

Does Janumet (sitagliptin/metformin) lead to weight loss?

Accepted Answer

While Janumet (sitagliptin/metformin) is not officially approved for weight loss, some people in clinical trials experienced weight loss while taking it. This effect is likely due to metformin, one of the components of Janumet, which is known to have a positive impact on weight. However, the number of participants who lost weight with Janumet was similar to those who took metformin alone or a placebo. Therefore, any weight loss effect might be attributed to the recommended balanced diet and exercise plan that accompanies this medication.

Question 4

What should you avoid when taking Janumet?

Accepted Answer

If a patient is prescribed Januvia or Janumet alongside medications that can lead to hypoglycemia or deficient blood sugar levels, like sulfonylureas or insulin. Patients using it must take caution to avoid excessive lowering of blood sugar. It is crucial to be mindful of potential drug interactions, such as with Digoxin in the case of Januvia. Additionally, the consumption of alcohol can significantly heighten the risk of lactic acidosis when taking Janumet.

Janumet XR

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