ABOUT JANUVIA (Sitagliptin)
Januvia is the brand name for the generic medication Sitagliptin, used to treat type 2 diabetes. It belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. An oral diabetic medication called Januvia 50 mg tablet helps regulate blood sugar. It functions by managing the insulin levels produced by your body post-meals.
When combined with diet and exercise, Sitagliptin tablets aid patients with type 2 diabetes mellitus better control their blood sugar levels. Treatment with Januvia is not possible in adults with type 1 Diabetes.
Dosage
Take this medication exactly as directed by your doctor which is generally once a day. Your dosage comes in: januvia 25 mg tablet, januvia 50 mg tablet, januvia 100 mg tablet. Read all medication guidelines or instruction sheets and adhere to all instructions on your prescription when you buy Januvia from Canada.
You have the option to take this medicine with or without food. Periodic blood tests may be conducted by your doctor to assess your kidney function, and they may adjust your dose based on the test results.
Missed Dose
If you forget to take a dose, take it as soon as you recall. However, if it’s nearly time for your next scheduled dose, then skip the missed dose and resume your regular dosing schedule. Avoid taking two doses of JANUVIA simultaneously.
Overdose
If you suspect an overdose, immediately seek emergency medical assistance or contact the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe weakness, blurred vision, excessive sweating, speech difficulties, tremors, abdominal pain, confusion, and seizures (convulsions).
Storage: Keep this medication away from moisture, heat, and light at room temperature.
Advantages of Januvia
Blood Sugar Control: This diabetic medication helps manage blood sugar levels in individuals with type 2 diabetes patients by inhibiting the action of DPP-4, an enzyme that breaks down incretin hormones. Incretins are hormones that stimulate insulin release and reduce glucose production by the liver, thereby helping regulate blood sugar levels.
Improved Glycemic Control: It helps improve glycemic control when used as part of a comprehensive diabetes management plan that comprises diet, exercise, and other medications. It can lower both fasting and post-meal blood sugar levels.
Weight-Neutral: One of the advantages of this tablet is that it is typically weight-neutral, meaning it is less likely to result in weight gain compared to some other diabetes medications.
Lower Risk of Hypoglycemia: When used as a monotherapy or combined with other medications, Januvia lowers the risks of Hypoglycemia.
Cardiovascular Benefits: While not a primary indication, some studies have suggested potential cardiovascular benefits associated with Januvia use, such as a reduced risk of major cardiovascular events in certain patient populations.
Kidney Benefits: It is known to offer some benefits for kidney health, including a potential reduction in the progression of diabetic kidney disease.
Side Effects
While generally well-tolerated, this medicine may cause side effects in some individuals. It’s important to consult with your healthcare professional before you buy Januvia online. Some commonly noted side effects of this medicine may include:
Upper Respiratory Tract Infection: Signs such as a scratchy throat, blocked or runny nose, and cough are relatively common.
Headache: There is a possibility that some people will have mild to moderate headaches.
Stomach Upset: This can include symptoms like nausea, diarrhea, or stomach discomfort.
Pancreatitis: Although rare, pancreatitis has been reported as a side effect. Signs of pancreatitis can include severe abdominal pain, nausea, and vomiting.
Allergic Reactions: Rarely, Januvia may cause serious allergic reactions, including rash, itching, facial puffiness, swollen tongue or throat, severe dizziness, or difficulty breathing.
Joint Pain: Some individuals may experience joint pain or swelling.
Drug Interactions
Sitagliptin can interact with other medications, potentially affecting its potency or increasing the risk of side effects. Here are some primary drug interactions associated with Januvia:
Insulin and Sulfonylureas: When Januvia is taken in combination with insulin or sulfonylureas (e.g., glipizide, glyburide), there is an increased risk of Hypoglycemia (low blood sugar). Your healthcare provider might have to modify the dosages of these medications to avoid low blood sugar levels.
Certain Blood Pressure Medications: Certain drugs prescribed for hypertension, especially angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), could influence kidney function.
Cyclosporine: If you take cyclosporine (an immunosuppressant), Januvia levels in your bloodstream may be elevated. Close monitoring and potential dosage adjustments may be necessary.
Rifampin: Rifampin, an antibiotic, may reduce the effectiveness of Januvia. Your healthcare provider may consider alternative diabetes management strategies if you need to take rifampin.
Digoxin: This medicine may increase digoxin levels in the blood. Regular monitoring of digoxin levels is advisable when taking these medications together.
Certain Antifungal Medications: Some antifungal medications, such as ketoconazole and itraconazole, may interact with Januvia and require dose adjustments.
Warnings
If you have diabetic ketoacidosis, you shouldn’t use Sitagliptin tablets (call your doctor for treatment with insulin).
If you experience any of the following heart failure symptoms: shortness of breath, joint pain, swollen legs or feet, or abrupt weight gain, call your doctor right away.
Suppose you get severe side effects, including upper abdominal pain radiating to your back, with or without vomiting. In that case these are symptoms of pancreatitis, and you should stop taking sitagliptin phosphate and notify your doctor.
Prior to Using This Medication
If you have a sitagliptin allergic reaction or diabetic ketoacidosis, you shouldn’t buy Januvia from Canada (call your doctor for treatment with insulin).
Inform Your Physician If You’ve Ever Had:
- Renal Disease or Are Receiving Dialysis;
- Heart Issues;
- Pancreatitis;
- Elevated Blood Fat Levels Called Triglycerides;
- or Gallstones
- Alcoholism.
If you are pregnant or want to become pregnant, use Januvia 50 mg tablet according to your doctor’s advice. Blood sugar regulation is crucial throughout pregnancy, and your dosage requirements may change from trimester to trimester. High blood sugar can complicate pregnancy for both the mother and the child.
When you begin taking this medication, you might need to register your name on a Januvia pregnancy registry.
Breastfeeding a baby while using this medication might not be safe. Ask your doctor if there are any risks.
Anybody under the age of 18 is not allowed to use this medicine.
Frequently Asked Questions
Is weight gain a side effect of Januvia 50 mg tablet?
Clinical trials did not report either gaining weight or weight loss as a side effect of this tablet. However, if you experience an unusually rapid increase in weight could indicate more severe side effects associated with Januvia, such as heart failure or kidney problems. In such cases, you must contact your doctor for evaluation and guidance.
Does Januvia interact with other diabetes medications like Ozempic, Trulicity, Farxiga, or Jardiance?
Januvia is not known to interact with diabetes medications such as semaglutide (Ozempic), dulaglutide (Trulicity), dapagliflozin (Farxiga), or empagliflozin (Jardiance). However, it may interact with other diabetes drugs like sulfonylureas, meglitinides, and insulin.
Will I experience withdrawal symptoms if I discontinue Januvia?
It’s unlikely. There have been no reported withdrawal symptoms associated with this medication. However, if you are considering discontinuation, it’s essential to consult your doctor first. Your medical professional can guide you on discontinuing your treatment and offer alternative strategies for managing your diabetes effectively.
What precautions should be observed while using Januvia?
When taking Janumet, exercise caution while using medications, known to induce Hypoglycemia (low blood sugar), like sulfonylureas and insulin. Potential drug interactions may include Digoxin with Januvia and the possibility of increased risk of lactic acidosis with alcohol when using Janumet.
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