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Plendil, or felodipine, is a prescription medication used to treat hypertension (high blood pressure). It is a calcium channel blocker that relaxes the heart and blood vessels, allowing for more effortless blood flow. The typical starting dosage is 2.5 to 5 mg once daily, with a maximum recommended dosage of 20 mg daily. Plendil should be taken consistently and swallowed whole. Patients with liver disease, low blood pressure, or heart failure should use caution. It’s essential to inform healthcare providers of all medications being taken due to potential drug interactions.

Product Overview

Plendil, also known as felodipine, is a prescription medication used primarily in managing hypertension (high blood pressure). This FDA-approved medication works by relaxing the muscles of the heart and blood vessels, enabling smooth blood flow and reducing the pressure on the heart. It is available in extended-release tablets with strengths of 2.5 mg, 5 mg, and 10 mg. Adults typically start with a dose of 2.5 to 5 mg once daily, which may be adjusted based on response and tolerance. The maximum recommended dosage is 20 mg per day. 

Plendil should be taken consistently, with or without food, and the tablets should be swallowed whole without crushing or breaking. It is generally well-tolerated, but common side effects can include swelling of the hands, ankles, or feet (edema), headache, flushing, dizziness, and increased heart rate. More severe side effects, such as overgrowth of gums, rash, and fainting, may occur and should be reported to a healthcare provider.

Patients with liver disease, low blood pressure, or heart failure should use caution when taking Plendil. It is also essential to inform healthcare providers of all medications being taken, as Plendil can interact with other drugs, including beta-blockers, CYP3A4 inhibitors, and grapefruit products. Plendil should be stored in a cool, dry place below 25°C, away from heat and moisture. 

Uses of Plendil

  • Treats hypertension (high blood pressure)

How to Use Plendil?


Strengths and Forms

Tablets, Extended-release

  • 2.5mg
  • 5mg
  • 10mg

Recommended Dosage for Different Patients

For Adults

Hypertension (high Blood Pressure):

  • Start with 2.5 to 5 milligrams (mg) taken orally once a day.
  • Maintenance dose: 2.5 to 10 mg taken orally once daily; some experts suggest that up to 20 mg per day can be used if needed.

Hepatic Impairment (Liver Problems):

  • Start with 2.5 mg taken by mouth once a day.

For Children

Hypertension (Off-label use):

  • Start with 2.5 milligrams (mg) taken by mouth once a day.
  • Do not exceed 10 mg taken by mouth once a day.

For Older Adults

Starting dose: 2.5 milligrams (mg) taken orally once a day. The dosage should be adjusted based on how the patient responds to the treatment. Any increase in the dosage should be made at intervals of at least 2 weeks. The highest dose allowed is 10 mg taken by mouth once a day.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • Take Plendil exactly as your doctor prescribes. Follow the instructions on your prescription label and any medication guides or instruction sheets. Your doctor may adjust your dose from time to time.
  • Plendil is typically taken once a day.
  • You can take Plendil with or without food, but be consistent in how you take it each time.
  • Swallow the tablet whole; do not crush, break, or dissolve it.
  • Regularly check your blood pressure.
  • Continue using Plendil even if you feel well, as high blood pressure often shows no symptoms.
  • Do not alter your dose or stop taking Plendil without consulting your doctor.
  • Your treatment plan may include a healthy diet, regular exercise, weight management, and periodic blood tests.
  • Maintain good dental hygiene by brushing and flossing your teeth regularly while taking Plendil.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Plendil Work?

Plendil is a brand name for the medication felodipine, a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Specifically, it blocks calcium entry into the heart cells and bloodstream. This action widens blood vessels, reducing the pressure and making it easier for the heart to pump blood. As a result, Plendil is an effective option in treating hypertension (high blood pressure) and preventing chest pain (angina). By lowering blood pressure, it helps prevent strokes, heart attacks, and kidney problems.

Important Safety Information

Side Effects

Common Side Effects

  • Swelling of the hands, ankles, or feet (edema)
  • Headache
  • Flushing (feeling of warmth)
  • Dizziness
  • Increased heart rate
  • Low blood pressure
  • Cough
  • Nausea
  • Constipation
  • Diarrhea
  • Stomach pain
  • Sleep problems (insomnia)
  • Joint pain or muscle cramps
  • Urinating more than usual
  • Cold symptoms such as a stuffy nose, sneezing, and sore throat

Adverse/Serious Side Effects

Overgrowth of Gums: Swelling and enlargement of the gums.

Rash: Skin rashes or allergic reactions.

Frequent Urination: Needing to urinate more often than usual.

Palpitations: Feeling your heartbeat strongly or irregularly.

Upper Respiratory Tract Reactions: Symptoms may include coughing, a stuffy nose, or a sore throat.

Fainting: Suddenly losing consciousness.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


  • Inform your doctor if you have liver disease or congestive heart failure before taking Plendil.
  • Discuss all other medications you are taking with your doctor, as many drugs can interact with Plendil.
  • Regularly check your blood pressure and undergo any additional blood tests recommended by your doctor.
  • Continue taking Plendil as prescribed, even if you feel well since high blood pressure often shows no symptoms.
  • Maintain good dental hygiene by brushing and flossing your teeth regularly to prevent mild swelling of the gums caused by Plendil.


  • Inform your doctor or pharmacist if you are suffering from any allergies, including an allergy to felodipine, before taking it.
  • Plendil may encompass inactive ingredients that can cause allergic reactions or other issues. Consult your pharmacist for more information.
  • Share your medical history with your doctor or pharmacist, particularly if you have heart disease (such as heart failure), liver disease, or swelling of the arms and legs (edema).
  • Inform your doctor or dentist about all the products you use, including prescription and nonprescription drugs and herbal products, before undergoing surgery.
  • Felodipine may cause dizziness. It’s best not to drive, use heavy machinery, or perform any activity that requires alertness. Limit alcohol consumption and discuss the use of marijuana (cannabis) with your doctor, as these can increase dizziness.
  • Older adults may be more sensitive to the side effects of this medication, especially dizziness.
  • Use this medication during pregnancy only if needed. Discuss the risks and benefits with your doctor.
  • It has not been proven yet if Prendil passes into breast milk. Thus, consulting a doctor before breastfeeding is advised.

Plendil Contraindications

  • Hypersensitivity: Do not take Plendil if you are allergic to it.
  • Low Blood Pressure: Plendil should not be used for low blood pressure.
  • Heart Failure: Avoid using Plendil if you have heart failure.

Missed Dose

If you miss a dose of Plendil, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses of Plendil at the same time.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]


Symptoms of a Plendil overdose may include a slow heart rate, low blood pressure, a feeling of warmth or tingling, and feeling light-headed as if you might faint.

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]


  • Keep Plendil tablets in their original blister pack until it’s time to use them.
  • Once removed from the blister pack, Plendil ER will not keep well.
  • Store Plendil in a cool, dry place with a temperature below 25°C (77°F).
  • Do not store Plendil or other medicine in the bathroom or near a sink.
  • Keep Plendil away from heat and moisture, as these conditions can damage some medications.
  • Do not leave Plendil in the car on hot days.
  • Keep Plendil out of reach of young children. Store it in a locked cupboard at least one-and-a-half meters (about 5 feet) above the ground.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Plendil Interactions

  • Beta-blockers: Concurrent use of beta-blockers may increase the risk of heart problems. Close monitoring is advised.
  • CYP3A4 Inhibitors: Medications that restrict the CYP3A4 enzyme (e.g., certain antifungal drugs, macrolide antibiotics) can increase felodipine levels, potentially leading to side effects.
  • Grapefruit Products: Grapefruit and grapefruit juice can alter how Plendil is metabolized, potentially leading to increased levels in the blood.
  • CYP3A4 Inducers: Drugs that inhibit the CYP3A4 enzyme (e.g., rifampin) may decrease felodipine levels, reducing its effectiveness.
  • Other Antihypertensive Medications: Concurrent use of other blood pressure-lowering medications may lead to excessive blood pressure reduction.
  • Lithium: Felodipine may increase lithium levels in the blood, potentially leading to lithium toxicity.
  • Digoxin: Concurrent use may lead to an increased risk of digoxin toxicity.
  • Simvastatin: Co-administration with Plendil may increase simvastatin levels, potentially leading to muscle-related side effects.
  • Ciclosporin: Felodipine may increase ciclosporin levels in the blood.

[Note: This isn’t a complete list, and there could be other drugs that interact with Plendil. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Plendil Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Is there an age limit for taking Plendil?

There is an age limit for taking Plendil, and those under 18 should abstain from using the medication due to potential risks and interactions with other medications. However, the specific age limit for taking Plendil should be determined by a healthcare professional based on an individual’s medical history and current health status. Always consult a doctor before starting or stopping any medication.

Does Plendil need to be taken with food?

Felodipine is typically recommended with a light, low-carbohydrate, and low-fat repast for optimal efficacy. It is important to adhere to the instructions given by your healthcare specialist since the dosage may vary. Furthermore, it is essential to remember that taking medication without food may lead to decreased absorption.

Can Plendil (felodipine) tablets be split in half?

You should not cut, split, chew, or crush Plendil (felodipine) tablets. They are designed as extended-release medications with a special coating. Cutting the tablet can damage this coating and alter the way the medication is released in your body. If you’re experiencing difficulty swallowing Plendil tablets, consult your healthcare provider to discuss alternative options.

Can Plendil (felodipine) lead to dry mouth?

Although it’s uncommon, a few individuals on Plendil (felodipine) have noted dry mouth as a side effect. If you experience dry mouth while taking Plendil, inform your healthcare provider. They may suggest methods to alleviate the discomfort, such as utilizing saliva substitutes, chewing sugar-free gum, or sipping water regularly throughout the day.

Is it safe to consume alcohol while taking Plendil (felodipine)?

It is advisable to avoid alcohol consumption when taking Plendil or other blood pressure medications. Regular alcohol intake can increase your blood pressure and reduce the effectiveness of Plendil and similar medications. Additionally, alcohol can exacerbate side effects like dizziness. If you find it challenging to eliminate alcohol entirely, consult your healthcare provider. They can offer support to help you quit or advise on a safer amount of alcohol for you to consume.

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