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Revatio
Revatio is a medication containing sildenafil citrate, primarily used to treat pulmonary arterial hypertension (PAH) and erectile dysfunction. It works by relaxing blood vessels, improving blood flow to the lungs and penis. For PAH, the typical dosage is 20 mg orally three times a day. At the same time, for erectile dysfunction, Viagra (a brand of sildenafil) is used, with a starting dose of 50 mg taken about an hour before sexual activity. Patients should adhere to prescribed dosages and not exceed recommended limits. It’s essential to inform healthcare providers about any other medications being taken to avoid interactions. Side effects can include headaches, indigestion, and flushing, with more severe reactions requiring immediate medical attention.
Product Overview
Revatio, containing the active ingredient sildenafil citrate, is primarily used for treating pulmonary arterial hypertension (PAH) and erectile dysfunction. Sildenafil relaxes blood vessel muscles, increasing blood flow to specific body areas. In PAH, it helps improve exercise capacity and delays disease progression by reducing pulmonary artery pressure. For erectile dysfunction, it enhances blood flow to the penis, aiding in achieving and maintaining an erection.
Available in tablet form (20mg), injectable solution (10mg/12.5mL), and oral suspension (10mg/mL), Revatio is taken orally or administered intravenously. It’s suitable for adults and children aged 1-17 years for PAH, while Viagra, a brand of sildenafil, is used for erectile dysfunction in adults. Common side effects include headaches, indigestion, and flushing. More severe reactions, such as chest pain or vision changes, require immediate medical attention.
Patients should be cautious about interactions with other medications and inform their healthcare provider of all drugs they take. Take the medication as soon as possible for missed doses, but skip it if it’s close to the next scheduled dose. In case of an overdose, seek emergency medical help. Store Revatio oral suspension in a refrigerator and discard after 60 days. Keep all forms of the medication out of reach of children.
Uses of Revatio
- Pulmonary arterial hypertension (PAH)
- Erectile Dysfunction
How to Use Revatio?
Dosage
Strengths and Forms
Revatio Tablets: 20mg
Viagra Tablets:
- 25mg
- 50mg
- 100mg
Revatio Injectable Solution: 10mg/12.5mL
Revatio Powder for Oral Suspension: 10mg/mL (when reconstituted)
Liqrev Oral Suspension: 10mg/mL
Recommended Dosage for Revatio
For Adults
Erectile Dysfunction:
- Viagra (only for Erectile Dysfunction)
- Indicated for erectile dysfunction.
- Take 50 mg orally approximately 1 hour before sexual activity; however, it can be taken anywhere from 30 minutes to 4 hours before sexual activity.
- Maximum dosing frequency is once per day.
- The dose may be increased to a maximum of 100 mg or decreased to 25 mg based on effectiveness and tolerance.
Pulmonary Arterial Hypertension:
- Revatio and Liqrev (only for Pulmonary Arterial Hypertension)
- Used in treating pulmonary arterial hypertension (PAH) to improve exercise ability and delay clinical worsening.
- Revatio and Liqrev: 20 mg orally three times a day (TID); may titrate up to 80 mg TID, if required, based on symptoms and tolerability.
- Revatio: 10 mg intravenous bolus TID.
- A 10-mg intravenous dose is predicted to provide a pharmacologic effect equivalent to a 10-mg oral dose.
Dosage Adjustments (in adults):
For Liver Problems (Hepatic Impairment)
- Viagra:
- If you have severe liver problems (like cirrhosis), you might start with a lower dose of 25 mg.
- Do not change the dose if you have mild or moderate liver problems.
- If you have severe liver problems (Child-Pugh C), it’s not clear how the drug works, as it hasn’t been studied.
For Kidney Problems (Renal Impairment)
- Viagra:
- If you have mild or moderate kidney problems, you don’t require a change in dosage.
- If you have severe kidney problems (CrCl <30 mL/min), you might start with a lower dose of 25 mg.
- No matter how severe your kidney problems are, you don’t need to change the dose.
For Children
Pulmonary Arterial Hypertension (PAH):
- Revatio is used to improve exercise ability and, in children too young for standard exercise tests, to improve lung blood flow, which is thought to help with exercise ability.
- Dosage for children:
- If the child weighs less than 20 kg (about 44 lbs), take 10 mg by mouth thrice daily.
- If the child weighs between 20 kg and 45 kg (about 44-99 lbs), take 20 mg by mouth thrice daily.
- If the child weighs 45 kg (about 99 lbs) or more, take 20 mg by mouth thrice daily.
- There is no maximum dose identified for children. Based on adult experience, the dose may be increased to 40 mg thrice daily, depending on symptoms and how well it is tolerated.
Dosage Adjustments (for children):
- Liver Problems (Hepatic Impairment):
- No dose change is needed if the child has mild or moderate liver problems.
- If the child has severe liver problems, it’s not clear how the drug works, as it hasn’t been studied.
- Kidney Problems (Renal Impairment): No matter how severe the kidney problems are, no dose change is needed.
For Older Adults
Erectile Dysfunction (Viagra only):
- Viagra is used to treat erectile dysfunction.
- For people aged 65 or older: Start with 25 mg by mouth about 1 hour before sexual activity. However, you can take it anywhere from 30 minutes to 4 hours before sexual activity.
- You can take Viagra only once per day.
- Depending on how well it works and tolerates it, you can increase the dose to a maximum of 100 mg or decrease it to 25 mg.
Pulmonary Arterial Hypertension (Revatio only):
- Revatio is used to treat pulmonary arterial hypertension (PAH) to improve exercise ability and delay the worsening of the condition.
- For oral use (PO): Take 20 mg by mouth thrice daily (TID). You can increase the dose to 80 mg thrice a day, depending on symptoms and how well you tolerate it.
- For intravenous use (IV): Take a 10 mg IV bolus thrice daily.
- A 10 mg IV dose is expected to have the same effect as a 10 mg oral dose.
- Do not exceed the recommended oral or intravenous dose.
[Note: Remember, these recommendations may vary from person to person. For suitable dosage, consult with your doctor, and they’ll customize your dosage based on that.]
How to Take It?
- Take Revatio exactly as prescribed by your doctor.
- Follow all the instructions on your prescription label and read any medication guides or instruction sheets provided.
- Revatio is typically taken three times a day, with each dose spaced about 4 to 6 hours apart.
- Shake the oral suspension well before use.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
How Does Revatio Work?
Revatio (sildenafil) works by relaxing the muscles in the blood vessel walls, increasing blood flow to certain body areas. In the case of pulmonary arterial hypertension (PAH), it helps to relax and widen the blood vessels in the lungs, reducing the pressure in the pulmonary arteries and improving the ability to exercise. It achieves this by inhibiting an enzyme called phosphodiesterase-5 (PDE-5), which helps regulate lung blood flow.
Important Safety Information
Side Effects
Common Side Effects
- Headaches
- Indigestion
- Flushing
- Diarrhea
- Muscle pain
- Redness
- Fever
- Nosebleed
- Trouble breathing
- Trouble sleeping
Adverse/Serious Side Effects
- Chest pain or pressure, pain spreading to your jaw or shoulder, accompanied by nausea and sweating (indicative of a heart attack).
- Changes in vision or sudden loss of vision.
- An erection that is painful or lasts longer for more extended periods (prolonged erection can damage the penis).
- Severe shortness of breath, accompanied by coughing up foamy mucus.
- Hearing a ringing sound in your ears or sudden loss of hearing.
- Irregular heartbeat.
- Swelling in your hands, ankles, or feet.
- A seizure (convulsions).
- Feeling light-headed, as if you might faint.
[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]
Warnings
Death in Children: Not recommended for long-term use in children due to increased risk of death.
Low Blood Pressure: Can lower blood pressure too much. Monitor regularly and report any significant changes.
Serious Lung Disease: Can cause pulmonary veno-occlusive disease. Seek medical help if PAH symptoms worsen or you have trouble breathing.
Nosebleeds: More likely if you have PAH due to connective tissue disease or are taking blood thinners.
Vision Loss: Rarely causes permanent eye damage. Seek emergency help if you notice sudden vision changes.
Hearing Loss: Reports of permanent hearing loss. Seek emergency help if you notice changes in hearing.
Dangerous Interaction: Do not take with other PDE-5 inhibitors to avoid dangerous blood pressure drops.
Prolonged Erection: Seek medical help if you have an erection lasting more than 4 hours.
Sickle Cell Crisis: Higher risk for those with PAH due to sickle cell disease. Consult your doctor before taking it.
Precautions
Allergies: Notify your healthcare provider or pharmacist if you have an allergy to sildenafil or any other allergies. This medication may include inactive components that could trigger allergic reactions or other issues.
Medical History: Tell your doctor or pharmacist about your medical history, especially if you have:
- Dehydration
- Stroke in the past 6 months
- High or low blood pressure
- Lung conditions (e.g., pulmonary veno-occlusive disease)
- Heart problems (e.g., heart attack, irregular heartbeat, chest pain, heart failure)
- History of painful or prolonged erection (priapism)
- Conditions that may increase the risk of priapism (e.g., sickle cell anemia, multiple myeloma, leukemia)
- Penis conditions (e.g., angulation, Peyronie’s disease, fibrosis/scarring)
- Eye problems (e.g., sudden decreased vision, retinitis pigmentosa, NAION)
Side Effects: This drug may cause dizziness or vision problems. Alcohol or marijuana can increase dizziness. Avoid driving, using machinery, or doing anything requiring alertness or clear vision until you can do so safely. Limit alcoholic beverages and discuss marijuana use with your doctor.
Surgery: Inform your doctor or dentist about all the products you use (like prescribed drugs, non-prescribed medication, and herbal products) prior to having surgery.
Pregnancy: Use sildenafil during pregnancy only when needed. Discuss the benefits and risks with your doctor, especially if you have high lung blood pressure.
Breastfeeding: Sildenafil passes into breast milk in small amounts. Consult your doctor before breastfeeding.
Revatio Contraindications
Avoid using organic nitrates: Do not use organic nitrates regularly or intermittently while taking sildenafil. This combination can significantly increase the risk of low blood pressure (hypotension).
Avoid using riociguat: Do not use riociguat, a guanylate cyclase stimulator, with sildenafil. The combination can enhance the blood pressure-lowering effects of riociguat.
Allergy to sildenafil: Do not use sildenafil if you have a known hypersensitivity to it or any of its components. Allergic reactions, including severe reactions like anaphylactic shock, have been reported with sildenafil use.
Missed Dose
Viagra is taken as needed, so it’s unlikely you’ll miss a dose. If you do skip a dose, take it as soon as you remember. However, if it is close to the timing for your next dose, drop the missed dose. Do not try to compensate for two doses at the same time.
[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]
Overdose
Symptoms of an overdose may include dizziness, fainting, and a painful or prolonged erection.
[Note: If you consumed more than the recommended dose, get medical help immediately, or call the Poison Help line at 1-800-222-1222.]
Storage
- Store Revatio oral suspension at temperatures below 30°C (86°F) or in a refrigerator between 2°C and 8°C (36°F to 46°F).
- Do not freeze Revatio oral suspension.
- Discard Revatio oral suspension after 60 days.
- Keep Revatio and all medicines out of reach of children.
[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]
Drug Interactions of Revatio
- Avanafil
- Cimetidine
- Hepatitis C Medications (Boceprevir or Telaprevir)
- Vardenafil
- Medicines for High Blood Pressure or Prostate Disorders
- Bosentan
- Conivaptan
- Imatinib
- Isoniazid
- Antidepressants
- Antibiotics
- HIV/AIDS medicines
- Antifungal Drugs
- Tadalafil
- Heart or Blood Pressure Medications
[Note: This isn’t a complete list, and there could be other drugs that interact with Revatio. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
Revatio Alternatives
- Sildenafil citrate
- Viagra (sildenafil)
- Cialis (tadalafil)
- Vardenafil
- Stendra (avanafil)
- Caverject (alprostadil)
- Caverject Impulse (alprostadil)
- Edex (alprostadil)
- Muse (alprostadil)
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
Frequently Asked Questions
Is it possible to buy Revatio online from Canada without a prescription?
Revatio tablet is exclusively obtainable through a prescription in Canada, specifically in the form of oral tablets. However, individuals with a valid prescription can conveniently buy it at low Revatio tablet price online from reputable Canadian pharmacies like Polar Bear Meds. We offer genuine medications at a remarkably low price. For inquiries and purchases, call toll-free at 1-888-779-2193 to buy Revatio online and other prescribed medications, ensuring both convenience and authenticity.
How quickly does sildenafil (Revatio) start working?
Sildenafil (Revatio) typically reaches its highest concentration in the bloodstream within 1 to 2 hours after taking a dose. However, it might take a few months to experience the full benefits of the medication. In clinical trials, individuals taking sildenafil (Revatio) began to observe significant improvements in their ability to exercise after approximately 4 weeks.
How do sildenafil (Revatio) and sildenafil (Liqrev) differ?
Both the medications, sildenafil (Revatio) and sildenafil (Liqrev), are labeled as oral suspensions of the same medication and used in the treatment of pulmonary arterial hypertension (PAH). The key difference is that sildenafil (Revatio) is approved by the FDA for use in both children and adults, whereas sildenafil (Liqrev) is specifically marketed for use in adults only. It’s essential to consult your healthcare provider to determine which option suits your needs.
How frequently can you take sildenafil (Revatio)?
You should take sildenafil (Revatio) thrice daily, spacing the doses 4 to 6 hours apart. Taking it more often can increase your risk of side effects. Typically, there’s no advantage to taking more than 20 mg three times a day. However, some healthcare providers may prescribe higher doses, which should still be taken thrice daily.
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