What is Trulicity?
Trulicity is an FDA-approved and brand- name pharmaceutical drug. In combination with exercise and diet, it’s used by people with type 2 diabetes to enhance blood sugar situations. It’s also used to reduce the threat of cardiovascular issues ( problems with blood vessels or heart) similar as heart attack or stroke in people who have multiple cardiovascular threat factors or heart complaint.
USAGE & STORAGE
Trulicity isn’t approved to be used by anyone under 18 years of age.
Each prefilled Trulicity injection pen have just one use. Pen should be disposed of after use indeed if there’s still medicine inside.
When disposing of Trulicity, people should use a perforation- proof “ sharps” bucket. Follow US state or domestic laws when disposing of drug.
Keep medication out of reach from children and family animals.
Before using Trulicity, review people guides and instruction booklets included with the drug. Follow instructions as handed by your medical professional and apothecary and ask questions if you don’t completely understand the instructions.
Trulicity is to be administered by injection which is taken subcutaneously (under the skin). The frequency of each dosage should be taken at the same time of day onetime per week.
Trulicity can be taken with or without ingesting food.
It’s fitted under the skin of the tummy ( stomach), thigh or upper arm. A healthcare professional similar as your medical professional or nurse will show you how to duly inject.
Rotate injection spots and avoid fitting into the same area more than once as this can lead to complications.
Blood sugar (glucose) situations can be affected by a variety of factors including :
- skipping meals
Still, you may feel the following if you witness low blood sugar (hypoglycemia):
- increased thirst
- increased urination
Still, you should consume a glucose tablet, sugarcoated food (i.e. If you have any of the symptoms mentioned above hard dessert, raisins, crackers) or sugarcoated drink ( i.e. fruit juice, non-diet pop).
I you have severe hypoglycemia, your medical professional may specify a glucagon emergency container. Close family or friends should be instructed on how to administer the glucagon injection in the event you lose consciousness and can not consume anything orally.
How to store Trulicity
The effectiveness of this drug can depend on how and where it’s stored.
Trulicity should be stored in a refrigerator in its original packaging or at room temperature (no higher than 86 °F/ 30 °C).
Throw away if drug becomes frozen and don’t use if already frozen.
Don’t keep drug past the expiration date that should be found on the tag.
Trulicity may be stored at room temperature for over to 2 weeks (14 days).
Store out from direct light.
Generally your medical professional will probably start you on a low dose and make changes to it over time while they watch how your body responds and find the dose that’s right for you.
The following information describes common doses for Trulicity even so it’s important to follow the dose specified by your medical professional.
Trulicity contains an active medicine named dulaglutide. It come in a single- dosage prefilled pen that contains a liquid solution.
Trulicity pens come in two strengths:
- 0.75 mg of dulaglutide in 0.5 mL of solution
- 1.5 mg of dulaglutide in 0.5 mL of solution
Trulicity pens contains a single dosage and designed to deliver the entire dosage in a single injection.
Dose for lowering blood glucose situations in type 2 diabetes
Generally the starting dosage for lowering blood sugar situations is0.75 mg taken onetime per week. If your blood glucose situations need to be lowered more yet the dose my be increased to1.5 mg once per week.
If blood sugar situations are still too high after at least 4 weeks while taking1.5 mg daily also your medical professional may increase the dose to 3 mg once per week.
Still, your medical professional may increase your dose further to 4, If your blood sugar situations are still too high.5 mg but only after you ’ve been taking 3 mg per week for at least 4 weeks.
Dose for reducing cardiovascular troubles in type 2 diabetes
The recommended dosage for reducing cardiovascular troubles is the same as it’s for lowering blood glucose situations for those with type 2 diabetes
Trulicity and metformin
Trulicity is generally taken with metformin (Riomet, Glumetza) which is a drug frequently used to lower blood sugar situations for type 2 diabetics. Metformin is generally taken onetime or two times per day. Your medical professional may specify both Trulicity and Metformin together to lower blood sugar situations.
Suchlike to taking any insulin drug, Trulicity may have side effects that range from mild to severe. The information below doesn’t cover all side effects suffered by those who have taken this drug.
To familiarize yourself with all side effects, read the patient information and speak to your medical professional or apothecaries about the possible troubles. Your medical professional may tailor your dose and supply tips on how to deal with side effects.
Common Side Effects
The more common side effects suffered when taking Trulicity include:
- abdominal pain
- decreased appetite
Generally these side effects go down within a number days or weeks. Consult your medical professional if these side effects worsen or don’t go down
Serious Side Effects
Any serious side effects associated with taking Trulicity don’t happen frequently. Inform your medical professional right away if you witness any severe side effects. Call 911 if you feel the symptoms are life- threatening.
Serious side effects can include:
- shortness of breath
- urinating less frequent
- dark urine
- severe digestive problems
- severe allergic reactions
- increased risk of thyroid cancer
There’s a warning on the Trulicity box about the threat of thyroid cancer. This is the strongest warning supplied by the Food & Drug Administration. This is the most serious warning issued by the FDA to detail the troubles of a drug.
Side Effect Details
The following information details some of the side effects that may be endured by people when taking Trulicity.
Allergic responses can happen if people are allergic to insulin or any of the components in a medicine. In clinical trials,0.5 of people suffered an allergic response, some of which were severe
Mild symptoms of an allergic response may include:
- flushing (redness and warmth in the skin)
- skin rash
Serious symptoms of an allergic response may include:
- swelling under the skin (typically lips, eyelids, hands or feet)
- difficulty breathing
- increased/rapid heartbeat
- losing consciousness
Still, please communicate your medical professional right away, If you witness any of the symptoms mentioned above. However, seek medical emergency or call 911, If you feel symptoms are life- threatening.
People taking Trulicity may lose weight, indeed though Trulicity isn’t intended for weight loss.
In a clinical study, people that used Trulicity for a 26 week period lost 3-5 pounds versus those that took metformin, who lost 5 pounds.
Weight loss can also vary depending on other medicines that may be taken along with Trulicity.
Still, consult your medical professional, If you have any concerns about losing weight.
Pancreatitis is a severe inflammation of the pancreas. Still rare, this was a really serious side effect that was endured during clinical studies
During clinical studies,1.4 cases in every 1000 people taking Trulicity for 1 time endured pancreatitis.0.88 cases ouf of 1000 who took other diabetes drug endured pancreatitis.
Symptoms of pancreatitis include:
- loss of appetite
- rapid heart rate
- severe abdominal pain
Inform your medical professional if you witness any symptoms and they persist. Your medical professional may tailor your treatment depending on the inflexibility and frequency of symptoms. Your medical professional may remove Trulicity from your treatment if you witness pancreatitis.
Nausea is a common side effect endured with those taking Trulicity.
During clinical studies, nausea occurred in:
- 12.4% – 21.2% of those taking Trulicity
- 5.3% of those who took the placebo
Patients also experienced burping and vomiting during clinical trials.
Vomiting occurred in:
- 6% – 12.7% of people who were taking Trulicity
- 2.3% of those who were taking a placebo
Inform your medical professional if you experiencing puking, burping or nausea while taking Trulicity. They may tailor your treatment to reduce these symptoms. The dosage of Trulicity also impacted the odds of those who endured side effects.
Injection Site Reactions
During clinical trials,0.5 of people educated injection point responses. These point responses included redness, bruising, pain and rashes. None of of the people taking the placebo endured any injection point responses.
Inform your medical professional if you witness any injection point responses.
Constipation is another side effect endured with Trulicity users. In clinical studies, constipation was endured by:
- 3.7% – 3.9% of people who took Trulicity experienced constipation
- 0.7% of people who took the placebo
Inform your medical professional if you witness constipation. Your medical professional may tailor your dose or treatment to reduce side effects.
Some people have endured digestive problems while taking Trulicity. In clinical studies, digestive problems were found in:
- 31.6% – 41% of people who were taking Trulicity
- 21.3% of people who took the placebo
Digestive problems were more common with those taking 1.5mg of Trulicity compared to those taking 0.75mg of Trulicity.
Symptoms of digestive problems include:
- abdominal pain
- lack of appetite
- severe diarrhea lasting longer than a few days
- severe vomiting lasting longer than a few days
Speak with your medical professional if you witness severe digestive problems. Your medical professional may choose to tailor your treatment.
Hypoglycemia (low blood sugar levels)
Hypoglycemia ( low blood sugar situations) is a side effect that can be endured with majority insulin drugs. People taking Trulicity were more likely to witness hypoglycemia if they were using it in combination with other diabetes medicines similar as insulin and sulfonylureas.
Symptoms of hypoglycemia include:
- rapid or irregular heartbeat
In clinical studies, 20-21 of people suffered hypoglycemia when Trulicity was taken in combination with sulfonylurea (glipizide, glimepiride or glyburide).
69-71% of people experienced hypoglycemia when Trulicity was using with insulin. This probability may vary depending on the dose given.
Still, consume a glucose tablet, sugarcoated snack (raisins, If you witness symptoms of hypoglycemia.
Still, they should inform their medical professional right away so they can tailor their treatment, If people are constantly suffering hypoglycemia.
Trulicity has a boxed warning from the Food & Drug Administration (FDA) which is presented when medicines have serious side effects. Trulicity has a boxed warning to warn medical professionals and people for the possible side effect of thyroid cancer.
It was found in animal testing in rats, that this drug increased the threat of thyroid growths and thyroid cancer. It isn’t known whether there’s an increased threat of thyroid growths from Trulicity in humans.
You shouldn’t take Trulicity if you have a family history of medullary thyroid carcinoma (a rare type of cancer) or multiple endocrine neoplasia syndrome type 2 ( MEN 2).
Symptoms of thyroid cancer include:
- difficulty swallowing
- lump in your neck
- shortness of breath
- hoarse voice that won’t improve
Inform your medical professional right away if you witness any of these symptoms. They may choose to recommend a treatment based on your individual requirements.
Joint Pain (not a side effect)
Other diabetes drug similar as Tradjenta (linagliptin) and Januvia (sitagliptin) may lead to severe joint pain. Still, common pain wasn’t a side effect from clinical studies involving Trulicity.
Inform your medical professional if you’re feeling any common pain while taking diabetes drug. Your medical professional may tailor your drug or supply ways to help reduce the pain.
WARNINGS & PRECAUTIONS
You shouldn’t take Trulicity if you have a individual or family history of medullary thyroid carcinoma (a type of thyroid cancer) or Multiple Endocrine Neoplasia syndrome type 2 ( MEN 2)..
It isn’t known whether Trulicity causes thyroid growths or thyroid cancer in human as concluded in animal studies.
Speak to your medical professional about the possible hazards or if you have any signs of growths or thyroid cancer similar as trouble swallowing, briefness of breath, a coarse voice, swelling or a lump in your neck.
Don’t use Trulicity if you’re in a state of diabetic ketoacidosis.
Inform your doctor if you have ever had:
- a stomach or intestinal disorder;
- gastroesophageal reflux disease (GERD) or slow digestion;
- eye complications related to diabetes (retinopathy);
- kidney or liver disease
- if you have used either oral diabetes medication or insulin
- if you have been ill with diarrhea or vomiting
Before taking Trulicity you should inform you medical professional of any existing allergies. This drug may contain components that may bring an allergic response.
Previous to starting treatment using Trulicity, let your medical professional know about your medical history, especially if you have a history of heart or kidney complaint, pancreatitis, stomach/ intestinal problems or certain eye complications ( i.e. retinopathy).
Due not drive or operate heavy machinery while taking this drug as it may impact blood sugar situations that cause result in vision problems similar as blurred vision, dizziness, sleepiness. Only drive or operate heavy machinery if you’re certain you can do them safely and have clear vision and and internal alertness.
Limit alcohol use while taking Trulicity as this can affect in low blood sugar situations.
Inform your medical professional or dentist that you’re on this drug ( including other medicines, over the counter specifics and herbal supplements) previous to going into surgery.
Blood sugar situations may be affected by stress, illness, injury, surgery or infections. Inform your medical professional if you witness any of these as this may warrant an adjustment to your treatment, drugs and blood sugar monitoring.
If is unknown whether this drug will harm an future baby. Gestation may cause or worsen diabetes. Inform your medical professional if you’re pregnant or planning to be pregnant. Your medical professional may modify your diabetes treatment during gestation similar as diet and blood sugar monitoring. This drug should only be used when demanded if a person is pregnant.
It’s unknown if this drug passes through breast milk and still may not be safe to use if people are presently nursing. Speak to your medical professional about the hazards of taking Trulicity if you’re presently nursing.
The following list of specifics may interact with Trulicity. The list doesn’t contain all possible medicines that may interact with Trulicity.
Inform your medical professional or apothecary about any specifics, over-the-counter medicines or herbal supplements you’re presently taking as this can help avoid any possible interactions.
Speak to your medical professional or apothecary if you have any concerns about possible medicine interactions.
When Trulicity is taking with other diabetes specifics it may affect in hypoglycemia ( low blood sugar situations).
The following are medications that my increase the risk of hypoglycemia:
- glimepiride (Amaryl)
- glipizide (Glucotrol, Glucotrol XL)
- glyburide (DiaBeta, Glynase)
- insulin detemir (Levemir)
- insulin glargine (Basaglar, Lantus, Toujeo)
- insulin degludec (Tresiba)
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