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Tadalafil

Adcirca

Adcirca is an FDA-approved medication designed to effectively manage pulmonary arterial hypertension (PAH) by improving exercise capacity and reducing symptoms such as shortness of breath and fatigue. It contains tadalafil, a PDE5 inhibitor that works by relaxing the blood vessels in the lungs, allowing for better blood flow and reducing pressure on the heart. Individuals looking for a trusted treatment option can conveniently buy Adcirca online from Canada, ensuring access to high-quality medication at competitive prices. When you buy Adcirca to treat pulmonary arterial hypertension, you opt for a clinically tested solution shown to enhance daily functioning and overall well-being. It is available in tablet form and is typically taken once daily, with or without food, making it easy to incorporate into your routine. For those seeking a reliable source, buy Adcirca online from Canada through licensed pharmacies that offer genuine medication, discreet shipping, and customer support. Take control of your PAH symptoms with Adcirca, a proven treatment backed by regulatory approval and trusted by healthcare professionals worldwide.

Product Overview

Adcirca is a trusted and effective medication used to treat pulmonary arterial hypertension (PAH), helping to improve exercise capacity in both men and women. It works by relaxing the blood vessels in the lungs, reducing the strain on the heart, and allowing for better blood flow. Adcirca contains tadalafil, a well-researched phosphodiesterase type 5 (PDE5) inhibitor, which increases cyclic guanosine monophosphate (cGMP) levels to promote smooth muscle relaxation and vasodilation. If you’re looking for a reliable solution to manage PAH, you can buy Adcirca online from Canada, ensuring access to high-quality medication at affordable prices with the convenience of doorstep delivery.

When you buy Adcirca to treat pulmonary arterial hypertension, you’re investing in a clinically approved treatment that offers consistent benefits when used as prescribed by your healthcare provider. Adcirca is available in tablet form, typically taken once daily, and can be consumed with or without food based on individual preferences. It is essential to follow dosage recommendations, especially for individuals with renal or hepatic impairment, to ensure safe and effective use. Regular intake of Adcirca helps reduce symptoms such as shortness of breath and fatigue, allowing patients to engage in daily activities with greater ease and comfort.

Choosing to buy Adcirca online from Canada provides an excellent option for those seeking convenience and competitive pricing without compromising on quality. Canadian pharmacies are known for their stringent regulatory standards, ensuring you receive authentic medication. Additionally, online purchasing allows patients to access helpful resources, professional support, and discreet shipping options. Whether you’re starting treatment or continuing your PAH management journey, Adcirca remains a trusted choice for improving overall pulmonary health and enhancing quality of life.

What Are the Uses of Adcirca? 

  • Adcirca is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.

[Important Warning: It’s important to note that while tadalafil is also marketed under the brand name Cialis for conditions like erectile dysfunction and benign prostatic hyperplasia, Adcirca specifically addresses PAH. Patients should not take Adcirca while also taking Cialis unless directed by a healthcare provider.]

What Are the Forms & Strengths of Adcirca?

Adcirca is available in the following form and strength:

  • Tablets: 20 mg, orange, film-coated, almond-shaped tablets (not scored) debossed with “4467”. 

What Is the Recommended Dosage of Adcirca?

The appropriate dosage of this medication depends on individual health conditions, including kidney and liver function and other medications. Adjustments may be necessary to ensure safety and effectiveness. Patients should follow prescribed guidelines and consult their healthcare provider for personalized recommendations.

Renal Impairment:
  • Mild to Moderate (creatinine clearance 31 to 80 mL/min): Initiate treatment with 20 mg once daily. The dose may be increased to 40 mg once daily based on individual tolerability.
  • Severe (creatinine clearance <30 mL/min and on hemodialysis): Adcirca is not recommended due to increased tadalafil exposure and limited clinical experience.
Hepatic Impairment:
  • Mild to Moderate (Child-Pugh Class A or B): Consider a starting dose of 20 mg once daily, given the limited clinical experience in this population.
  • Severe (Child-Pugh Class C): Adcirca is not recommended, as it has not been studied in this group.
Concomitant Use with Ritonavir:
  • For patients on Ritonavir for at least one week, Start Adcirca at 20 mg once daily. Depending on individual tolerability, the dose may be increased to 40 mg once daily.
  • Initiating Ritonavir in Patients Already on Adcirca: Avoid using Adcirca during the initiation of ritonavir. Discontinue Adcirca at least 24 hours before starting ritonavir. After at least one week on ritonavir, Adcirca can be resumed at 20 mg once daily, with the possibility of increasing to 40 mg once daily based on tolerability.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Adcirca?

Adcirca should be taken as prescribed by your healthcare provider. The general guidelines for its use are as follows:

    • The standard dose is 40 mg, which equates to two 20 mg tablets taken once daily. It’s important to take both tablets together simultaneously each day. This medication can be taken with or without food.
  • Adcirca can be taken with or without food, allowing flexibility based on personal preference or daily routine. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Adcirca Work?

Adcirca works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5). This enzyme breaks down a molecule known as cyclic guanosine monophosphate (cGMP). By blocking PDE5, Adcirca increases the levels of cGMP. Elevated cGMP causes the smooth muscles in blood vessels to relax, leading to vasodilation, which is the widening of blood vessels. This process improves blood flow and reduces blood pressure in specific body areas. 

Important Safety Information for Using Adcirca

What Are the Side Effects of Adcirca?

Adcirca is associated with several common side effects. Understanding these can help in managing them effectively. Here are some of the most frequently reported side effects:

  • Headache: Many individuals experience headaches, which can range from mild to moderate in intensity. This is due to the vasodilatory effects of the medication, leading to increased blood flow in the brain. 
  • Flushing: Users might notice a warm sensation or redness, particularly on the face, neck, or chest. This occurs due to blood vessel dilation near the skin’s surface. 
  • Nausea and Upset Stomach: Gastrointestinal disturbances, including nausea and stomach discomfort, are reported. These symptoms are typically mild and tend to resolve as the body adjusts to the medication. 
  • Nasal Congestion: A stuffy or runny nose can occur due to the drug’s effect on the nasal blood vessels, leading to congestion. 
  • Muscle and Back Pain: Some individuals report muscle aches or back pain, usually 12 to 24 hours after taking the medication. These pains generally subside within 48 hours. 
  • Pain in Limbs: Discomfort or pain in the arms or legs has been noted, possibly linked to the medication’s effect on blood flow and muscle relaxation. 

Serious Side Effects of Adcirca

Certain medications may lead to serious side effects that require immediate medical attention to prevent long-term complications. Recognizing these potential adverse effects early can help ensure timely intervention and minimize risks. Below are some of the serious side effects that users should be aware of:

  • Chest Pain or Discomfort: Some individuals may experience chest pain, discomfort, tightness, or heaviness, which could indicate cardiovascular complications. If such symptoms occur, seek medical help promptly.
  • Sudden Vision Loss: Rare reports have been made of sudden vision loss in one or both eyes, potentially due to non-arteritic anterior ischemic optic neuropathy (NAION). This condition necessitates immediate discontinuation of medication and urgent medical evaluation.
  • Sudden Hearing Loss: A sudden decrease or loss of hearing, sometimes accompanied by ear ringing (tinnitus) or dizziness, has been reported. If you experience these symptoms, discontinue use and consult a healthcare professional immediately.
  • Prolonged Erection (Priapism): An erection lasting more than four hours can occur, which may cause permanent damage to the penile tissue. This condition is a medical emergency and requires prompt attention.
  • Severe Allergic Reactions: Signs such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat may indicate a serious allergic reaction. Immediate medical intervention is essential in such cases.
  • Hypotension (Low Blood Pressure): Adcirca can cause a significant drop in blood pressure, leading to symptoms like dizziness, lightheadedness, or fainting. This is especially concerning when combined with other blood pressure-lowering medications or nitrates.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Adcirca? 

Being informed about potential warnings is crucial for safe and effective medication use. Some medications may pose risks related to existing health conditions, interactions with other drugs, or lifestyle factors. Recognizing these risks in advance allows for better management and helps prevent serious complications during treatment.

  • Hypotension (Low Blood Pressure): Adcirca has vasodilatory properties that may result in transient decreases in blood pressure. Patients with underlying cardiovascular conditions should be evaluated to determine if they can tolerate such effects.
  • Concomitant Use with Nitrates: Taking Adcirca alongside nitrates, commonly prescribed for chest pain, can cause a significant and dangerous drop in blood pressure. This combination is contraindicated.
  • Concomitant Use with Guanylate Cyclase Stimulators: Adcirca is contraindicated when used with medications like riociguat, a guanylate cyclase stimulator, due to the potential for dangerously low blood pressure.
  • Vision Impairment: There have been reports of sudden vision loss attributed to non-arteritic anterior ischemic optic neuropathy (NAION) in patients using PDE5 inhibitors like Adcirca. Individuals experiencing sudden vision changes should seek immediate medical attention.
  • Hearing Impairment: Some users have reported sudden decreases or loss of hearing, sometimes accompanied by tinnitus or dizziness. The exact relationship between Adcirca and these events is not well-established, but caution is advised.
  • Prolonged Erection (Priapism): Adcirca may cause priapism, a prolonged and potentially painful erection lasting more than four hours. This condition requires immediate medical intervention to prevent lasting damage.
  • Use in Specific Populations: Due to increased exposure and limited clinical experience, Adcirca should be avoided by patients with severe renal or hepatic impairment. Dose adjustments may be necessary for those with mild to moderate impairment.
  • Alcohol Interaction: Combining Adcirca with substantial amounts of alcohol can amplify the blood pressure-lowering effects, leading to symptoms like dizziness or fainting. Patients are advised to limit alcohol consumption while on this medication. 

What Are the Adcirca Precautions?

When considering the use of Adcirca, specific precautions must be taken to ensure its safe administration. These precautions differ from warnings and focus on conditions or factors that may influence the drug’s effects or increase the likelihood of adverse reactions.

  • Cardiovascular Considerations: Adcirca possesses vasodilatory properties, which can lead to transient decreases in blood pressure. Patients with underlying cardiovascular conditions, such as heart disease or left ventricular outflow obstruction, should be evaluated carefully to determine if they can tolerate these effects. The medication is not recommended for individuals with pulmonary veno-occlusive disease, as it may worsen their condition. 
  • Renal Impairment: For patients with mild to moderate renal impairment, initiating treatment at a lower dose is advisable, with potential adjustments based on individual tolerability. However, due to increased exposure and limited clinical experience, Adcirca should be avoided in patients with severe renal impairment, especially those undergoing hemodialysis. 
  • Hepatic Impairment: Limited clinical data exist for patients with mild to moderate hepatic cirrhosis; therefore, a reduced starting dose should be considered. Adcirca is not recommended for individuals with severe hepatic cirrhosis, as they have not been studied, and the drug’s safety profile in this group remains undetermined. 
  • Concomitant Use with Alpha-Blockers and Antihypertensives: Combining Adcirca with alpha-adrenergic blocking agents or other antihypertensive medications can result in additive blood pressure-lowering effects. This combination may lead to symptomatic hypotension, characterized by dizziness or fainting. Patients should be monitored closely when these medications are used together.
  • Alcohol Consumption: Both alcohol and Adcirca are mild vasodilators. When taken together, their combined effects can increase blood pressure reduction, resulting in dizziness or lightheadedness. Patients are advised to limit alcohol intake while using this medication.

What Are the Contraindications of Adcirca?

Adcirca has specific contraindications to ensure patient safety. These contraindications are conditions or factors that make the use of this medication inadvisable:

  • Concomitant Use with Organic Nitrates: Adcirca is contraindicated in patients using any form of organic nitrate, whether regularly or intermittently. Combining these can lead to a significant and dangerous drop in blood pressure. Patients should avoid nitrates within 48 hours of the last Adcirca dose. 
  • Concomitant Use with Guanylate Cyclase (GC) Stimulators: Adcirca’s coadministration with GC stimulators, such as riociguat, is contraindicated. This combination may potentiate hypotensive effects, leading to unsafe drops in blood pressure. 
  • Known Serious Hypersensitivity to Tadalafil: Patients with a history of serious hypersensitivity reactions to tadalafil (the active ingredient in Adcirca) should not use this medication. Reported hypersensitivity reactions include Stevens-Johnson syndrome and exfoliative dermatitis.

What If You Miss a Dose of Adcirca?

If you miss a dose of Adcirca, take it as soon as you remember. However, if it’s nearly time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses simultaneously to make up for a missed dose. Maintaining a consistent dosing routine is important for the effectiveness of Adcirca. If you frequently forget doses, consider setting daily reminders or alarms to help ensure timely administration. Always consult your healthcare provider if you have questions or concerns about your medication regimen.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Adcirca?

Taking an excessive amount of Adcirca can lead to significant health risks. Overdose symptoms may include severe dizziness, fainting, or prolonged erections lasting more than four hours (priapism). In such cases, it’s crucial to seek immediate medical attention or contact the Poison Help line at 1-800-222-1222. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store Adcirca?

Proper medication storage is essential to maintain its effectiveness and ensure safety. Here are some guidelines for storing your tablets:

  • Keep the medication at a temperature between 15°C to 30°C (59°F to 86°F). 
  • Store the tablets in their original container to protect them from moisture and other environmental factors. 
  • Do not store the medication in the bathroom or other damp places, as moisture can affect its potency. 
  • Ensure the storage location is away from direct sunlight and heat sources to prevent degradation of the medication. 
  • Store the medication securely to prevent accidental ingestion by children or pets.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Adcirca?

Understanding potential medication interactions is crucial to ensure safe and effective treatment. Certain drugs can influence how the body processes medications, leading to enhanced effects, reduced efficacy, or increased risk of side effects. Some interactions may result in significant health risks, such as dangerously low blood pressure, while others may require dosage adjustments to maintain therapeutic benefits. 

  • Nitrates (nitroglycerin, isosorbide dinitrate, isosorbide mononitrate): Nitrates are used for chest pain (angina). Combining them with Adcirca can cause a severe and potentially life-threatening drop in blood pressure. This interaction occurs because both medications relax blood vessels, leading to a dangerous synergistic effect.
  • Alpha-Blockers (doxazosin, tamsulosin): These medications are prescribed for high blood pressure or benign prostatic hyperplasia (BPH). When used with Adcirca, they may cause excessive lowering of blood pressure, dizziness, or fainting due to the combined vasodilatory effects.
  • Antifungal Medications (ketoconazole, itraconazole): These drugs inhibit the enzyme CYP3A4, which breaks down tadalafil in the liver. This can lead to increased levels of Adcirca in the bloodstream, raising the risk of side effects such as headaches, flushing, or low blood pressure.
  • Protease Inhibitors (ritonavir, saquinavir): These medications can also inhibit the CYP3A4 enzyme, which is used in HIV treatment. This leads to an accumulation of tadalafil in the body, increasing the likelihood of adverse effects like prolonged erections (priapism) or severe drops in blood pressure.
  • Antibiotics (erythromycin, clarithromycin): Similar to antifungals, antibiotics can affect how Adcirca is metabolized. They increase tadalafil levels in the blood, which may amplify its effects and side effects, requiring dosage adjustments.
  • Blood Pressure Medications (amlodipine, atenolol): Taking Adcirca with antihypertensives can enhance blood pressure-lowering effects. While this combination can be used cautiously, it may cause dizziness or fainting, particularly when standing up quickly.
  • Seizure Medications (carbamazepine, phenytoin, phenobarbital): These drugs induce CYP3A4 activity, speeding up the metabolism of tadalafil. This reduces Adcirca’s effectiveness, possibly requiring a higher dose or alternative treatment.
  • Other PDE5 Inhibitors (sildenafil, vardenafil): Combining these medications is not recommended, as it increases the risk of side effects like low blood pressure, headaches, and vision changes. The overlapping mechanisms of action can exacerbate their effects.
  • Antidepressants (fluoxetine, sertraline): While not a direct interaction, these drugs can sometimes lead to heightened side effects when combined with Adcirca, such as dizziness or changes in blood pressure due to overlapping effects on the nervous system.
  • Antacids (magnesium hydroxide, aluminum hydroxide): Antacids can delay the absorption of Adcirca, potentially altering how quickly the medication takes effect. While this interaction is less severe, it may require timing adjustments in dosing.
  • Stimulants (amphetamine, methylphenidate): These medications may increase heart rate and blood pressure. When combined with Adcirca, there is an increased risk of cardiovascular side effects such as palpitations or fainting.
  • Anticoagulants (warfarin, rivaroxaban): While no direct interaction occurs, the potential for blood pressure changes caused by Adcirca may indirectly increase the risk of complications such as bleeding when combined with anticoagulants.
  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (ibuprofen, naproxen): These medications can occasionally mask side effects such as headaches or mild pain caused by Adcirca. They may also increase the risk of gastrointestinal side effects when used together.
  • Antiarrhythmic Medications (amiodarone, quinidine): These drugs, used to treat heart rhythm disorders, may interact with Adcirca by exacerbating the risk of irregular heartbeats or causing significant drops in blood pressure.
  • Immunosuppressants (cyclosporine, tacrolimus): These medications may alter the metabolism of tadalafil, either increasing or decreasing its levels in the body. This interaction requires careful monitoring and possible dose adjustments.
  • Pulmonary Hypertension Medications (riociguat): This medication synergizes with Adcirca, leading to excessive blood pressure reduction. The combination is contraindicated due to the high risk of severe hypotension.

What Are the Other Adcirca Interactions?

Beyond other drugs, Adcirca can interact with various substances, foods, and lifestyle factors, which may alter its effectiveness or increase the risk of side effects. Below is a detailed list of interactions to consider while using Adcirca.

  • Alcohol: Consuming alcohol while taking Adcirca can enhance the blood-pressure-lowering effect, leading to dizziness, fainting, or an increased heart rate. It’s advised to limit alcohol intake to avoid these risks.
  • Grapefruit and Grapefruit Juice: Grapefruit products inhibit the enzyme CYP3A4, which slows the breakdown of tadalafil in the body. This can result in higher levels of the medication, increasing the risk of side effects like headaches, flushing, or dangerously low blood pressure.
  • Food Interactions: While food doesn’t significantly affect the absorption of Adcirca, high-fat meals may slightly delay its onset of action. Taking it on an empty stomach might lead to faster results.
  • Herbal Supplements (St. John’s Wort): St. John’s Wort can reduce the effectiveness of Adcirca by increasing the metabolism of tadalafil through the CYP3A4 pathway, potentially requiring dose adjustments.
  • Tobacco: Smoking can aggravate the underlying conditions treated by Adcirca, such as pulmonary hypertension. It may also interact indirectly by altering cardiovascular response.
  • Recreational Drugs (Poppers or Amyl Nitrate): These substances are contraindicated as they can cause a severe and life-threatening drop in blood pressure when combined with Adcirca.
  • Caffeine: When combined with Adcirca, high caffeine intake may amplify side effects like palpitations, dizziness, or increased heart rate, particularly in sensitive individuals.

[Note: This isn’t a complete list, and there could be other drugs that interact with Adcirca. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Adcirca Alternatives?

When exploring alternatives, it’s essential to consider options that align with individual needs and preferences. Below is a curated list of alternatives, highlighting brand names and their generic counterparts for easy reference. Always consult a healthcare professional to determine the best choice for your requirements.

  • Cialis (tadalafil)
  • Revatio (sildenafil)
  • Viagra (sildenafil)
  • Letairis (ambrisentan)
  • Tracleer (bosentan)
  • Opsumit (macitentan)
  • Uptravi (selexipag)
  • Tyvaso (treprostinil)
  • Veletri (epoprostenol)
  • Adempas (riociguat)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Adcirca Cost & Coupons

Adcirca is a reliable medication for managing pulmonary arterial hypertension (PAH), but its high cost in the USA can be a financial burden for many. At Polar Bear Meds, we strive to make quality medications more accessible and affordable. We offer competitive prices along with additional savings opportunities, such as discount coupons, to help ease your healthcare expenses. If you’re seeking a cost-effective solution, buy Adcirca online and use the code “WELCOMEPB10” at checkout to receive 10% off your first order. Take advantage of this special offer today and start saving on your essential medication without compromising on quality.

Frequently Asked Questions

Can Adcirca affect blood pressure?

Adcirca can cause a slight and temporary decrease in blood pressure, which typically does not result in noticeable symptoms. However, if taken alongside other medications that lower blood pressure, such as metoprolol (Lopressor), doxazosin (Cardura), or tamsulosin (Flomax), the drop may be more significant. Your healthcare provider may recommend frequent blood pressure monitoring when starting Adcirca. If you experience symptoms like dizziness, blurry vision, or weakness, it’s important to inform your healthcare team, as adjustments to your medication may be necessary.

Is Adcirca used for erectile dysfunction (ED)?

No, Adcirca should not be used to treat erectile dysfunction (ED). It is FDA-approved specifically for pulmonary arterial hypertension (PAH) and is not intended for ED treatment. Although tadalafil is the active ingredient in both Adcirca and Cialis, they are prescribed for different conditions and at different dosages. Healthcare providers typically avoid prescribing multiple forms of tadalafil simultaneously, as doing so can increase the risk of serious side effects, such as dangerously low blood pressure and vision problems. If you are experiencing ED, consult your healthcare provider to explore suitable treatment options.

How does tadalafil (Adcirca) differ from tadalafil (Cialis)?

Although both medications contain tadalafil as the active ingredient, they are FDA-approved for different medical conditions. Cialis is prescribed for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH), while Adcirca is approved for treating pulmonary arterial hypertension (PAH). The dosage of tadalafil varies depending on the condition being treated, so it is essential to follow your healthcare provider’s instructions. Using tadalafil inappropriately or at incorrect doses can increase the risk of serious side effects.

How effective is Adcirca for PAH?

Adcirca helps manage pulmonary arterial hypertension (PAH) by enhancing exercise capacity. In a 4-month clinical study, individuals taking tadalafil (Adcirca) were able to walk longer distances in a 6-minute test compared to those on a placebo. If you have questions about how tadalafil can support your PAH treatment, consult your pulmonologist or healthcare provider.

Our Guarantee

At PolarBearMeds.com, we assure you the most affordable price to buy Adcirca online from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently buy Adcirca online to treat pulmonary arterial hypertension at a substantial cost, call us at 1-888-779-2193 toll-free.

IMPORTANT NOTICE : The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.

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