Afinitor Disperz

Afinitor Disperz is a cancer medicine approved by the FDA that contains everolimus. This prescription medicine is used to treat subependymal giant cell astrocytoma related to tuberous sclerosis complex. Everolimus works by inhibiting the growth and developing the growth of tumor cells. This medication may be used alongside other medicines to treat certain types of seizures. It comes in the form of a dispersible tablet with 2mg, 3mg & 5mg strengths. It is suitable for use in adults and children after medical advice. You can take this medicine with or without food orally by mouth once daily. For a safe and effective use of the drug, seek medical advice and guidance. If you want to buy Afinitor Disperz TB online from Canada, look for reputable platforms to ensure the authenticity of the product.

Afinitor Disperz is an FDA-approved medication that is used for treating subependymal giant cell astrocytoma associated with tuberous sclerosis complex. It contains everolimus as its active ingredient that works by blocking the mTOR pathway, which regulates the growth of the cells, survival, and division, thereby slowing the progression of tumors. This medication is available in the form of dispersible tablets, which come in the strengths of 2mg, 3mg, and 5mg.

It is meant for once-daily administration on an empty stomach or consistently with food. The tablet should be dispersed in water and consumed immediately. You should not keep it for later use. It is prescribed to pediatric and adult patients with SEGA requiring therapeutic intervention but not amenable to surgery. Everolimus regulates abnormal cell proliferation and helps decrease tumor size over time. Similar to other medicines, it can cause certain temporary side effects in some users, which mainly include fatigue, rash, hyperglycemia, and diarrhea.

Rare but serious reactions such as non-infectious pneumonia, renal failure, or increased risk of infections may occur. Routine blood tests are necessary to monitor liver enzymes, kidney function, and blood glucose levels. Pregnant or breastfeeding women should avoid the use of this medicine. Missed doses should be taken within six hours; otherwise, skip and resume the next dose as scheduled. Overdose of Afinitor Disperz may require immediate medical attention. Keep it at room temperature, away from moisture, heat, and excess heat.

It is used to treat:

• Subependymal giant cell astrocytoma
• Tuberous sclerosis complex
• Advanced breast cancer
• Neuroendocrine tumors
• Renal cell carcinoma

What Are the Forms & Strengths of Afinitor Disperz?

It comes in the form of a tablet that you dissolve in water with the following strengths:

• 2mg
• 3mg
• 5mg

What Is the Recommended Dosage of Afinitor Disperz?

The dosage of Afinitor Disperz varies from patient to patient and is typically based on the condition being treated, its severity, the patient’s age, needs, and other factors. It also depends on the medication’s form, strength, and duration. The recommended dose given here is applicable to everyone. If your doctor has prescribed you a dose that is different from the one given here, you should use this medication exactly as directed by your doctor and not make changes in your dosage without talking to your doctor first.

Dosage for Breast Cancer

• The recommended initial dose is 10mg per day.

Dosage for Kidney Cancer

• The recommended initial dose is 10 mg each day.

Dosage for Neuroendocrine Tumors

• The recommended starting dose is 10 mg every day.

Dosage for Brain Tumors

• The recommended daily initial dose of Afinitor Disperz is 4.5mg per square meter of your body surface area (BSA)
• Your doctor will help you calculate your BSA

Dosage for Seizures

• For partial seizures, the recommended daily initial dosage is 6mg per square meter of your BSA.

Dosage for Children

• For SEGA, the recommended dosage is 4.5mg per square meter of BSA.
• For partial seizures in pediatric patients, the recommended dosage is 5mg per square meter of BSA.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

• Before using Afinitor Disperz for the first time, and each time you get a refill, you should refer to the patient information leaflet and medication guide given by your pharmacist or healthcare provider. If you have any queries regarding medication use or if you have any difficulty understanding any part of this leaflet, you should ask your doctor or healthcare provider.
• You should take Afinitor Disperz tablets exactly as your doctor has instructed. Do not take them more or less than prescribed, more often, or in large quantities, as they can cause harm.
• You should not change the form or brand of this medicine without first discussing it with your doctor.
• You can take this medication with or without food orally by mouth, usually once daily. It is essential that you choose one way of taking it and take the medicine the same way with every dose.
• You should not swallow this tablet as a whole. Disperse in water and then swallow it immediately. Do not keep it for later use. If someone else is preparing this medicine solution, they should wear gloves while preparing this medicine to avoid possible contact with the drug.
• Do not crush or break the dispersible tablet. You should not disperse more than 10 grams in total at a time.
• You can use an oral syringe or a drinking glass to take the medicine. If you are using an oral syringe, place Afinitor Disperz into the syringe. Put one teaspoon of water into it and place the syringe in a container for approximately three minutes to allow the tablets to disperse.
• Before taking the medication, gently swirl the syringe five times.
• Add another teaspoon of water to the syringe and swirl it gently to ensure you get the full medicine dose. Then, take the remaining mixture.
• If you are using a drinking glass, you should place the medicine in a glass with approximately five teaspoons of water. Do not use any other kind of liquid to mix the medicine. Avoid crushing or breaking the dispersible tablets. After three minutes, gently mix the mixture with a spoon, then drink all of the mixture immediately. To ensure you have taken the whole dose, add another five teaspoons of water to the glass to rinse it & drink all the rinse water.
• You should take Afinitor Disperz within one hour of mixing in water.
• The dosage of this medicine is based on the age, medical condition being treated, and the needs of the patient. It is also based on body size, lab tests, and other medicines you may be taking. Make sure to tell your doctor or healthcare provider about all the products you are using, including herbs, supplements, prescriptions, and over-the-counter drugs.
• To get the most out of the drug you are being treated with, you should use it regularly. Take it at the same time every day to help you remember to take it.
• Do not increase your dose without talking to your doctor first. Doing so will not improve your medical condition any faster; it will just increase your risk of getting serious infections.
• Avoid intake of grapefruit/grapefruit juice while being treated with Afinitor Disperz unless your doctor or pharmacist tells you to do so safely. Grapefruit can increase the chances of experiencing side effects associated with the use of Afinitor Disperz. Ask your physician or medical provider for more information.
• Since Afinitor Disperz can be absorbed through the skin & lungs, it can cause harm to an unborn baby. Women who are pregnant or suspect a pregnancy should not handle this medicine or breathe the dust from the tablets.
• If you have had a liver or kidney transplant, you may have to take this medication for the rest of your life to prevent rejection of the organ by the body. Do not change your medication dosage or stop using Afinitor Disperz without talking to your doctor first.
• Your doctor may prescribe mouthwash to prevent mouth sores or ulcers. After using the mouthwash, avoid drinking or eating for at least one hour.
• If you have a kidney transplant, your doctor will recommend you take Afinitor Disperz with another medicine known as cyclosporine. Take both medicines at the same time each day.
• If you have a liver transplant, your doctor will give you Afinitor Disperz with another medicine known as tacrolimus. Use both drugs simultaneously.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Afinitor Disperz functions by inhibiting the action of a protein called mTOR, which plays a crucial role in the growth & development of cells, proliferation, and survival. By blocking this protein, Afinitor Disperz helps slow down the growth & spread of cancer cells and reduce the size of tumors associated with certain conditions, such as neuroendocrine tumors, breast cancer, and renal cell carcinoma. It is also effective in reducing the number of seizures you have.

Common side effects of Afinitor Disperz: Similar to other medicines, Afinitor Disperz can cause certain temporary side effects in some people using it. These side effects usually resolve independently within a couple of days or weeks without medical intervention as your body starts to adjust to the medication. However, if they persist or become bothersome, tell your doctor or healthcare provider. To ensure safety from the drug you are using, report any new or bothersome side effects you experience while being treated with Afinitor Disperz. Its common side effects include: 

• Diarrhea: This medication can irritate the gastrointestinal tract, causing increased bowel movements and diarrhea. This may occur because the drug affects rapidly dividing cells in the GI lining, disrupting the normal absorption process. To manage this side effect, you should maintain proper hydration throughout the day by consuming plenty of fluids and a bland diet, avoiding high-fiber foods, caffeine, and dairy products. You can use anti-diarrheal medicines after consulting with your doctor. If diarrhea persists or becomes severe, you should promptly contact your doctor. 
• Nausea/vomiting: The exact mechanism by which everolimus causes nausea and vomiting is not entirely known, but it is believed that it is related to its effects on the central nervous system and the GI tract. To prevent or reduce its effects on the CNS and the GI tract, you can take Afinitor Disperz with or without food at the same time each day, as sudden changes can trigger nausea. 
• Decreased appetite: Afinitor Disperz can alter taste perception and cause mouth sores, causing a decreased desire to eat. This side effect may be due to the drug’s impact on the cells of oral mucosa and taste buds. To manage reduced appetite, you should focus on nutrient-dense foods and consider eating smaller and more frequent meals. To help prevent mouth sores, you should maintain good oral hygiene and use alcohol-free mouthwashes. If appetite loss leads to significant weight loss or nutritional deficiencies, talk to your doctor or healthcare provider. 
• Weight loss: Weight loss may be caused by a combination of multiple factors, such as decreased appetite, nausea, and diarrhea, so it’s important to monitor your weight regularly. If you notice significant or rapid weight loss, let your doctor or healthcare provider know. They are most likely to recommend dietary or lifestyle changes, nutritional supplements, or other interventions to help you maintain a healthy weight while taking this medication. 
• Changes in taste: This medication can cause dysgeusia, a medical condition where the taste perception is altered, making foods taste metallic, unpleasant, or bland. This may occur because the drug affects the taste buds and salivary glands. To cope with taste changes, you should try experimenting with different flavors, using herbs and spices to enhance the taste of food, and maintaining good oral hygiene. To reduce the metallic taste of the medicine, you should use plastic utensils instead of metal ones. If taste changes significantly impact your nutrition, discuss it with your doctor or healthcare provider. 
• Nosebleeds: Afinitor Disperz can increase the risk of bleeding in some people, including nosebleeds. It affects platelet function. To prevent nosebleeds, keep the nasal passages moist using saline sprays or humidifiers and avoid picking or blowing the nose forcefully. If a nosebleed does occur, sit in an upright position, slightly lean forward, and pinch the part of your nose for several minutes until the bleeding stops. If nosebleeds are frequent or severe, seek medical attention. 
• Dry skin: This medication can decrease oil production and affect skin cell turnover, causing dryness. To manage this symptom, you should regularly use gentle, fragrance-free moisturizers, avoid long, hot showers, and use mild soaps. To further help prevent skin irritation, you should wear protective clothing & use sunscreen when you are under the skin. If dryness persists or leads to infections or cracking, talk to your doctor or healthcare provider. 
• Dizziness: This may be due to Afinitor Disperz’s effects on blood pressure or its effects on the central nervous system. To decrease dizziness, you should stay adequately hydrated throughout the day, avoid jerky movements, and rise slowly after sitting or lying down for extended periods of time. If dizziness occurs, you should stay still and sit or lie down until it passes. Tell your doctor if you have persistent or severe dizziness, as this may require further evaluation or adjustment for your treatment plan. 
• Headache: This may occur due to various reasons, such as changes in blood pressure, dehydration, or the body’s response to the medicine. This symptom can range from mild to moderate in severity. To manage this side effect, you should ensure adequate hydration, practice relaxation techniques, and consider using over-the-counter pain relief medicines after consulting with your doctor or healthcare provider. If headaches are persistent, severe, or are accompanied by other symptoms, you should talk to your physician for further evaluation. 

Serious side effects of Afinitor Disperz: It is rare that Afinitor Disperz causes serious side effects in some users belonging to certain risk groups. These side effects require immediate medical advice and can become life-threatening. If you experience any of the following signs and symptoms of an adverse reaction to this drug, call a licensed healthcare provider or 911. You can also head to the nearest medical care center. Your doctor has recommended you use Afinitor Disperz after determining that the benefits justify the risks associated with the use of everolimus. Serious side effects include: 

• Liver failure: This medicine can cause liver dysfunction, potentially leading to liver failure. This may manifest as jaundice, easy bruising, bleeding, abnormal swelling, sleepiness, confusion, or even coma. The exact mechanism behind this involves the drug’s impact on liver cells, causing impaired liver function. To manage this risk, liver function tests should be performed before and during treatment. If significant liver impairment is detected, your doctor may recommend that you make dosage adjustments or discontinue the medication. Patients should report any symptoms indicative of liver issues to their healthcare provider. 
• Rhabdomyolysis: This medical condition involves the breakdown of muscle tissue, causing the release of muscle fibers into the bloodstream, which may lead to kidney damage. Its symptoms include muscle pain, weakness, and dark-colored urine. While rare, this medication has been associated with rhabdomyolysis. The proposed mechanism is related to the drug’s effect on muscle cell integrity. To prevent this, patients should report unexplained weakness or muscle pain, especially if accompanied by dark urine. Immediate medical evaluation is required, and discontinuation of the medication may be required if rhabdomyolysis is confirmed. 
• Sepsis and septic shock: This medicine can suppress the immune system, increasing susceptibility to infections, including severe ones like sepsis. Its symptoms may include fever, chills, dizziness, rapid breathing, rapid heartbeat, and reduced urine output. Sepsis happens when the body’s response to infection causes widespread inflammation, leading to tissue damage and organ failure. You should watch out for signs and symptoms of an infection and seek prompt medical attention if symptoms arise. To prevent this side effect, you should follow good hygiene practices and avoid coming into contact with individuals who have contagious illnesses. 
• Alterations in Menstrual Changes: This medication can cause changes in vaginal bleeding, such as increased or decreased bleeding, spotting, or missed periods. The drug’s influence on hormonal pathways and the endometrial lining is believed to contribute to these changes. Patients should monitor their menstrual pattern changes and report significant changes to their healthcare provider. Its management involves adjusting the medicine dose or exploring alternative treatments.
• Stroke: There have been reports of stroke in patients taking everolimus, presenting as sudden numbness/weakness, especially on one side of the body, difficulty speaking, confusion, vision problems, dizziness, or loss of balance. It may happen due to the drug’s effect on clotting pathways or blood vessels. To mitigate this risk, you should manage cardiovascular risk factors including high cholesterol, high blood pressure, and diabetes mellitus. If symptoms of stroke occur, you should seek immediate medical attention. 

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

• Afinitor Disperz can cause you to feel dizzy. Consuming alcohol or marijuana can increase dizziness. You should not drive a car, use heavy machinery, or engage in any such tasks that need alertness until you can do it safely. You should limit your alcohol consumption while being treated with Afinitor Disperz. You should also avoid consuming intake of alcoholic beverages and medications that contain alcohol. Discuss with your doctor if you use marijuana.
• This medication can make you feel lightheaded or dizzy, especially when you stand up after sitting or lying down for a long period of time. To prevent the risk of falling & injuring yourself, you should stand up slowly and avoid jerky movements. You should get up and down the stairs carefully.
• Afinitor Disperz increases your risk of developing infections, including severe infections, or makes current infections worse. While being treated with this drug, you should stay away from anyone who has an infection that may spread easily. Talk to your physician or healthcare professional for more details or if you have been exposed to any infection.
• Geriatric patients may have an increased risk of sensitivity to the side effects of this medication. Afinitor Disperz should be used with caution in patients belonging to this age group.
• Afinitor Disperz may affect fertility in both male and female patients. Talk to your doctor for more information.

What Are the FDA Boxed Warning for Afinitor Disperz?

A boxed warning has been issued for Afinitor Disperz by the FDA due to the following risks:

• Infections: Afinitor Disperz can weaken the immune system, thereby increasing the chance of developing infections or making current infections worse, including bacterial, viral, and fungal infections. Healthcare professionals should monitor their patients for signs and symptoms of an infection. 
• Lung problems: You may develop non-infectious pneumonitis, which can cause severe or fatal lung-associated complications. If you experience signs and symptoms such as shortness of breath, cough, or fever, discontinue using Afinitor Disperz and have your symptoms evaluated by a healthcare provider. 
• Tumor lysis syndrome: In patients with high tumor burden, there may be a risk of tumor lysis syndrome, a potentially fatal condition caused by the rapid breakdown of tumor cells. 
• Delayed wound healing: This medication can slow down the healing of a wound, making it critical for use in patients who have recently undergone surgery or who may require surgery. 

• Before taking Afinitor Disperz, you should tell your physician or healthcare provider if you have an allergy to it, to everolimus, sirolimus, temsirolimus, or any other active or inactive ingredient it has. Its active ingredients can cause allergic reactions or other issues. If you are not aware of all the ingredients it contains, you should ask your pharmacist.
• Before using this medication, let your doctor know about your complete medical and family history, especially if you have or have ever had a liver disease, recent or current infections, high cholesterol, diabetes, or radiation treatment.
• Before having vaccinations or immunizations, you should let your doctor or healthcare provider know if you are using Afinitor Disperz. You should avoid contact with people who have recently received live vaccines.
• To reduce the risk of getting injured, cut, or bruised, you should use sharp objects such as razors and nail cutters with caution and avoid activities such as contact sports.
• If you plan to have a surgery, including a dental procedure, let your dentist or surgeon know about all medicines you are using, including Afinitor Disperz. They will likely recommend you discontinue using this medication at least one week before surgery as this medication makes wounds heal more slowly. Follow their instructions closely on when to stop or resume taking Afinitor Disperz.
• You should let your doctor know if you are pregnant, think you may be pregnant, or plan to become pregnant while being treated with Afinitor Disperz. Do not become pregnant while using this drug, as it can cause harm to an unborn fetus. Women using this drug should consult a doctor and discuss the reliable forms of birth control while being treated with everolimus and for eight weeks after the last dose.
• Men using everolimus should also ask their doctor about reliable forms of birth control while receiving treatment with this drug and for four weeks after taking the last dose. If you or your partner becomes worse while using Afinitor, inform your doctor right away and discuss with them the risks & benefits associated with everolimus use.
• Since this medicine may be absorbed through the skin and lungs, and can potentially cause harm to an unborn child, women who are of childbearing age should not handle this medication without wearing a glove or breathe the dust from the Afinitor Disperz tablets.
• It is still not known if everolimus passes into breast-milk. Due to the potential risk to the infant, you should not breastfeed while being treated with this drug and for two weeks after the last medication dose. Get in touch with your doctor before breastfeeding an infant while using Afinitor Disperz.

Afinitor Disperz is contraindicated for use in patients who have:

• Clinically significant hypersensitivity to everolimus or other rapamycin derivatives.
• Severe hepatic impairment (consult with a doctor)

• To get the most benefit from the medication you are using, you should stay consistent with the dose and take it at the same time each day to help you remember to take it.
• If you have missed a dose of Afinitor Disperz, you may take it if it is within 6 hours of your normal dose. If you remember after six hours that you have missed a dosage, you may skip the dose and take it according to the regular dosing schedule.
• You should not take two doses of the same medicine to make up for a missed dose, as this can lead to adverse outcomes.
• If you have queries about missing a dose, you should talk to your physician or healthcare provider.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Using Afinitor Disperz can cause severe side effects such as lung problems, severe infections, kidney issues, liver problems, or low blood cell counts. If you or someone you know has taken everolimus more than the prescribed dose, you should seek immediate medical assistance by calling a healthcare professional or 911. You can also go to the nearest medical care center.

[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

• Afinitor Disperz tablets should be kept in their original packaging in a dark, cool & dry place at a controlled room temperature, away from direct exposure to sunlight, moisture, and excess heat.
• You should keep the medicine in its original blister pack unless you are ready to use it.
• Do not allow this medicine to freeze.
• Do not keep it in the bathroom, under the sink, or in other places with high humidity, as moisture can cause harm to certain medicines.
• After preparing the mixture of Afinitor Disperz, use it within one hour. If you do not use it within the given time, throw it away, prepare another mixture and use it right away.
• You should keep all medicines, including Afinitor Disperz, in a secure place, such as a high cupboard, away from the reach and sight of children and pets to avoid accidental consumption.
• Do not keep medicines that are no longer prescribed by your doctor or have passed their expiration date. Dispose of them safely in such a way that children, pets, and other people are not able to consume them.
• With that said, you should not throw it away in the trash, flush it down the toilet, or pour it into the wastewater.
• For more information on how to discard unused, outdated, or unwanted medicines properly, ask your pharmacist or healthcare professional.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Certain medicines may interact with Afinitor Disperz tablets and reduce their effectiveness or lead to unfavorable side effects. To prevent and manage potential drug interactions with everolimus, you should tell your doctor or healthcare professional about all the medicines you are using or plan to use alongside everolimus, including all herbs, vitamin and mineral supplements, prescriptions, and over-the-counter drugs.

• ACE inhibitors such as benazepril, enalapril, lisinopril, and quinapril can increase the risk of angioedema
• Certain antiarrhythmics, such as amiodarone, dronedarone, and propafenone, can increase the risk of certain side effects caused by this medication, and certain antiarrhythmics.
• Certain antifungals such as fluconazole, itraconazole, and ketoconazole can increase the risk of certain side effects caused by this medicine.
• Certain antibiotics, such as ciprofloxacin, clarithromycin, and erythromycin, can increase the risk of certain side effects associated with everolimus or make the drug less effective.
• Certain calcium channel blockers such as felodipine, diltiazem, isradipine, and verapamil can increase the risk of side effects associated with everolimus and certain CCBs
• Certain benzodiazepines, such as alprazolam, diazepam, and midazolam, can increase the risk of certain side effects associated with the use of benzodiazepines.
• Certain antiseizure medicines such as carbamazepine, pentobarbital, and phenytoin can make Afinitor less effective.
• Certain antidepressants such as fluoxetine, nefazodone, paroxetine, and venlafaxine can increase the risk of certain side effects from Afinitor and certain antidepressants.
• Certain beta-blockers, such as metoprolol, Toprol XL, propranolol, and hemangeol, can increase the risk of beta blockers.
• Certain statin drugs, such as atorvastatin, fluvastatin, pitavastatin, and simvastatin, can increase the risk of having muscle-related side effects due to the statin.
• Certain HIV medicines such as atazanavir, cobicistat, darunavir, and ritonavir can increase the risk of having side effects associated with the use of Afinitor.
• Octreotide can increase the risk of certain side effects in some individuals using Afinitor Disperz.

What Are the Other Afinitor Disperz Interactions?

Apart from medicines, there are certain substances that may interfere with how Afinitor Disperz works. It can interact with various substances, including specific herbs, supplements, foods, and beverages. These interactions can affect how the medication functions or increase the risk of side effects. Certain foods and drinks, such as grapefruit and alcohol, can interfere with its absorption, while some herbal supplements may alter its effectiveness. Certain health conditions can also influence how the body processes Afinitor Disperz, potentially leading to complications. These mainly include:

• Hepatic disease
• Vaccination
• Renal disease
• Hematologic abnormalities
• Blood glucose
• Cholesterol
• Wound complication
• Infections

[Note: This isn’t a complete list, and there could be other drugs that interact with Afinitor Disperz. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Afinitor Disperz is a prescription medication used primarily for treating certain types of tumors and seizures. However, alternative options may be necessary if it is unavailable, unaffordable, or unsuitable due to side effects. Alternatives can include other mTOR inhibitors, generic versions, or different therapeutic approaches, depending on the treated condition. It is important to consult a healthcare professional before switching medications, as effectiveness and safety vary based on individual health conditions and medical history. Some of the alternatives to Afinitor include:

• Epidiolex
• Cannabidiol
• Sirolimus topical
• Hyftor

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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