


We offer competitive pricing on all our medications. Find a lower price? We'll match it from any verified Canadian online pharmacy! Know More

We offer competitive pricing on all our medications. Find a lower price? We'll match it from any verified Canadian online pharmacy! Know More
Ordering your medication online is simple and convenient.
Select the prescribed dosage and quantity, then proceed to checkout.
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Upload your prescription.
Complete your purchase by processing the payment.
Select the prescribed dosage and quantity, then proceed to checkout.
Sign in or create a new account.
Upload your prescription.
Complete your purchase by processing the payment.
Shipping takes approximately 3-5 business days.
Aklief (trifarotene) 50 mcg is a prescription topical retinoid specifically designed to treat acne on both the face and body. It works by targeting clogged pores, reducing inflammation, and promoting smoother skin over time. As the first retinoid developed to treat facial and truncal acne, Aklief offers an effective once-daily option for improving breakouts and overall skin texture. When you buy Aklief online, speak with your dermatologist to confirm it is the right option for your acne treatment plan.
| Generic Name | Trifarotene |
|---|---|
| Brand Name | Aklief |
| Forms | Topical Cream |
| Strengths Available | 50 mcg |
| Packaging | 75 g per pack |
| Requires Prescription | Prescription only (Rx) |
| Ships to the U.S. | Yes |
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Aklief 50 mcg (trifarotene) cream is prescribed for the treatment of:
If you plan to buy Aklief online, it’s important to know the correct dosage and application method to ensure effective treatment.
Here are some important steps on how to use Aklief 50 mcg cream correctly:
Aklief 50 mcg supports your skin’s natural renewal process, helping pores clear more efficiently.
It helps unclog pores, reduce inflammation, and prevent new acne from forming. As the skin turns over more smoothly, breakouts lessen, and the overall texture of the skin gradually improves.
Common Aklief side effects include:
Serious side effects can include:
Note: Contact your dermatologist or healthcare provider if you experience any other symptoms that are not mentioned above.
These warnings will help ensure you use Aklief safely. Before you buy Aklief online, talk to your doctor and understand the potential risks.
Follow these precautions to use Aklief cream effectively:
If you miss a dose of Aklief cream, simply apply it when you remember. If it is almost time for your next scheduled application, skip the missed dose. Do not apply extra cream.
Since Aklief is a topical cream with minimal systemic absorption, overdose is unlikely. However, using too much cream or applying it too frequently may cause severe skin irritation, redness, dryness, or peeling. If accidental ingestion or significant overuse occurs, seek medical help immediately or call the Poison Control helpline at 1-800-222-1222.
Follow these Aklief storage instructions to help keep your medication effective for its full shelf life:
Aklief cream is topical with minimal systemic absorption, so serious drug interactions are not expected. However, combining it with other acne treatments or irritants may increase local side effects. Always tell your doctor or pharmacist about all medications and skincare products you are using. Some of these include:
| Drug Category | Examples | Effect or Precaution |
|---|---|---|
| Topical Retinoids / Other Acne Treatments | Tretinoin, Adapalene, Benzoyl Peroxide | May increase local skin irritation (redness, dryness, peeling). Use together only under medical guidance. |
| Photosensitizing Agents | Tetracycline antibiotics, Sulfonamides, Thiazides | Can increase the risk of sunburn when combined with Aklief. Always use sunscreen and limit sun exposure. |
| Cosmetic Products (Irritants) | Alcohol‑based cleansers, Astringents, and Harsh scrubs | May worsen dryness or irritation. Avoid or use gentle skincare products. |
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Note: This list is not complete; you can talk to your doctor for a detailed Aklief interactions list.
Here are some alternatives to Aklief (trifarotene) cream that you can consider under a doctor's supervision:
| Alternative Medication | Active Ingredient | Potency Level | Best For | Form | Key Advantage |
|---|---|---|---|---|---|
| Retin‑A | Tretinoin | Medium | Acne vulgaris, photoaging | Topical cream/gel | Well‑established retinoid with decades of clinical use |
| Differin | Adapalene | Low–Medium | Mild to moderate acne | Topical gel/cream/lotion | OTC availability in some markets; gentle retinoid with lower irritation risk |
| Tazorac | Tazarotene | High | Moderate to severe acne, psoriasis | Topical cream/gel | Strong retinoid with additional benefit for psoriasis |
| Epiduo | Adapalene \+ Benzoyl Peroxide | Medium | Acne vulgaris | Topical gel | Combination therapy targets both clogged pores and bacterial growth |
| Altreno | Tretinoin (lotion) | Medium | Acne vulgaris | Topical lotion | Newer tretinoin formulation designed for better tolerability and hydration |
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At Polar Bear Meds, we’re committed to making prescription medications like Aklief more accessible and affordable for patients in the U.S. Our prices are significantly lower than typical U.S. pharmacy retail rates without compromising on safety or quality. Every order is sourced exclusively from licensed and trusted pharmacies and undergoes complete prescription verification to ensure compliance and authenticity. We offer discreet, trackable shipping to all U.S. states, along with refill support for ongoing treatment. Our friendly customer service team is here to help you.
Buy Aklief from Canada and get it delivered to your doorstep in the U.S. You can also save more by using the Aklief coupon code “WELCOMEPB10” for 10% off on your first order. There are no hidden handling or processing fees, as we believe in complete transparency. If Aklief prices are a concern for you, we make it easy to manage your overall medical expenses. Join our referral program & earn a $20 credit every time you refer a friend or a family member. Your referral will also receive a $20 credit, so everyone wins. Additionally, after every 10 verified customers' referrals, you'll receive a $100 credit in your account as a thank-you for spreading the word.
At Polar Bear Meds, your safety is our priority. Every order is dispensed from a fully licensed Canadian pharmacy following strict standards for quality, security, and patient care. To conveniently buy Aklief from Canada at a substantial discount, call us at 1-888-779-2193 toll-free.

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.
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We offer competitive pricing on all our medications. We'll match if you find a lower price on an identical product at a verified Canadian online pharmacy!
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