Atacand

Atacand is a prescription medicine that contains candesartan cilexetil, an angiotensin II receptor blocker. It is primarily indicated for the management of high blood pressure (hypertension) & to treat heart failure in certain patients. Candesartan functions by limiting the effects of angiotensin II, a chemical that causes blood vessels to constrict. As a result, blood vessels relax, allowing blood to flow more easily & decreasing blood pressure.

Atacand is available in tablet form with four varying strengths, typically 4mg, 8mg, 16mg & 32mg. The medication dosage depends on the condition being treated and the response to treatment. It is usually taken once daily, with or without food. This medicine is suitable for use in adult patients and in some cases, pediatric patients above age 1 for hypertension treatment, as prescribed. The full effect may take several weeks, and it is essential that you take the medicine consistently to maintain your blood pressure levels.

Atacand may cause dizziness, headache, back pain, and fatigue in some people using it. Severe side effects are rare but include renal issues, high potassium levels, or allergic reactions. You should tell your doctor of any existing medical conditions, especially renal or hepatic conditions. In case of a missed dose, you should take it as soon as you think of it unless it is close to your next scheduled dose. In case of an overdose, seek medical attention. Keep Atacand at room temperature and away from moisture and heat. Always follow the prescribing physician’s guidance and schedule routine checkups to have your kidneys and blood pressure checked. If you want to use Atacand for hypertension treatment, make sure you have a valid doctor’s prescription.

It is primarily used to treat:

• High blood pressure in adults and children aged 1-17 years, and to manage certain types of heart failure in adults.

What Are the Forms & Strengths of Atacand?

Atacand is available in the form of a tablet and comes in the following strengths:

• 4mg
• 8mg
• 16mg
• 32mg

What Is the Recommended Dosage for Atacand?

The recommended dosage of Atacand can vary from person to person and may vary depending on factors such as the patient’s age, medical condition, and tolerability. The dosage mentioned here applies to all. If your doctor has instructed you to use this medicine at a different dosage, follow their instructions. Do not alter your dosage without consulting them first, as it can cause unfavorable outcomes. If you are looking to purchase Atacand from Canada, speak with your healthcare provider about the right dosage for your condition. The typical dosage may include:

For Hypertension and Heart Failure

• The recommended initial dosage is 16mg once daily, which can be taken with or without food. The total daily dose ranges from 8mg to 32mg.
• For heart failure patients, the initial dosage is 4mg once daily, which can be gradually increased to a maintenance dose of 32mg once daily, as tolerated by the patient.
• The recommended daily dose for children aged 1-6 is 0.20mg/kg, with a range of 0.04-0.05mg/kg.

For Pediatric Hypertension

• Children under 50kg: The recommended dosage is 4-8mg per day, with a range of 2-16mg daily.
• Children over 50kg: The usual initial Atacand dose is 8-16mg daily, with a range of 4-32mg daily.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they will customize your dosage accordingly.]

To ensure the safe and effective use of Atacand, carefully read and follow the directions for use in the patient information leaflet & medication guide given by your pharmacist or medical provider. Refer to the information below.

• You should take Atacand with or without food, exactly as your doctor instructed.
• If your child cannot swallow the Atacand tablet as a whole, your pharmacist can mix the medicine into a liquid.
• If you are using the oral form of Atacand, you should properly shake the liquid before using it. Carefully measure the dose with the dosing syringe provided or a medicine dose-measuring device. Do not use a kitchen spoon to measure your dose, as it cannot accurately measure it.
• The dose of Atacand is based on weight in pediatric patients. Your child’s dosage may require dosage alterations if your child loses or gains weight.
• You may require regular blood pressure checkups while using this medicine. Your doctor may also recommend that you check your kidney function regularly.
• Immediately call your doctor if you are sick with diarrhea/vomiting, or if you are sweating more than usual. You may become easily dehydrated while using this medicine.
• If your doctor determines that Atacand is safe for you to use long-term, they may suggest that you do so. The treatment also includes exercise, diet, reducing cholesterol, not smoking, and controlling diabetes.
• It may take around two to four weeks to control your blood pressure. You should continue using Atacand as directed, even if you feel well. High blood pressure often has no symptoms.
• If you plan to have surgery, including a dental procedure, tell your dentist or surgeon you are using Atacand. They may recommend that you discontinue using it for a short time.
• Keep this medicine at a controlled room temperature to make sure it is safe for use.
• Tell your doctor if your symptoms have not improved or if they worsen.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They'll adjust it as needed over time.]

Atacand is an angiotensin II receptor blocker prescribed to treat hypertension and certain kinds of heart failure. It functions by inhibiting receptors that normally bind to angiotensin II, a chemical that causes blood vessels to constrict & signals the kidneys to retain sodium. By preventing this binding, Atacand helps ease the blood vessels. This further improves blood flow and reduces blood pressure. This mechanism of action reduces the risk of stroke, heart attack, and hospitalization.

Common side effects of Atacand: Similar to other drugs, Atacand can cause certain temporary side effects in some people using it. These side effects are usually temporary and may not be experienced by all users. These reactions usually resolve on their own within a couple of days or weeks as your body starts to adjust to the drug. However, if they continue or become worse, talk to your doctor or healthcare provider. Common Atacand side effects may include:

• Hyperkalemia: Atacand can cause elevated potassium levels in the body by restricting the action of angiotensin II, which decreases aldosterone secretion. This can further cause potassium retention in the body. Its symptoms may include:
  • Muscle weakness
  • Nausea
  • Tingling sensations
  • Chest pain
  • Irregular heartbeats

To manage this risk, you should regularly monitor your potassium levels. Avoid using potassium-containing salt substitutes unless your doctor recommends them.

• Headache and back pain: These are some of the most commonly reported side effects linked with using candesartan. Headache may be due to the medicine's vasodilation effects, as it lowers blood pressure, leading to changes in cerebral blood flow. Back pain could be due to muscle relaxation or changes in posture related to blood pressure reduction. Consult a healthcare professional if these worsen or persist.
• Cold symptoms: Some patients may experience upper respiratory tract symptoms like nasal congestion, runny nose, sneezing & sore throat while using Atacand. These symptoms may be due to a mild immunological reaction or the medication's impact on the blood vessels in the nasal passages. Stay hydrated and use saline sprays or over-the-counter medicines if required to manage this.
• Dizziness: This can occur with Atacand use, especially when you quickly stand up. This happens due to the drug's blood pressure-lowering effects, leading to orthostatic hypotension. It is more common in the initial stages of treatment or when the dose is increased. You should get up slowly from sitting or lying positions.
• Abnormal kidney test results: Atacand can affect kidney function in some people, causing changes in blood tests such as increased serum creatinine or blood urea nitrogen levels. This may be due to alterations in renal blood flow and filtration pressure caused by the inhibition of angiotensin II.

Severe side effects of Atacand: While Atacand is well-tolerated, some patients may experience rare but severe adverse side effects while using Atacand for hypertension treatment. These symptoms require immediate medical attention due to their impact on vital organs and overall health. Immediately call a licensed healthcare professional or 911 if you experience any of the symptoms given below. These mainly include:

• Light-headed feeling: This can occur due to the blood-pressure-lowering effects of candesartan. This is particularly common during the initial days of treatment or after your dosage increases. The vasodilation effect reduces systemic vascular resistance, leading to decreased blood pressure and cerebral perfusion, resulting in dizziness. If this persists, talk to your doctor or healthcare provider.
• Little or no urination: A significant decrease in urine output may indicate acute kidney injury. This medicine may impair renal function by decreasing glomerular filtration pressure, especially in people with pre-existing kidney conditions or those who are volume-depleted. This effect is exacerbated when combined with NSAIDs or diuretics. Report any noticeable decrease in urine output to your doctor promptly.
• Decreased blood pressure: The antihypertensive action of candesartan can cause excessive blood pressure reduction, resulting in hypotension. This is more likely in people who are sodium-depleted, dehydrated, or are on high doses of diuretics. Symptoms may include:
  • Dizziness
  • Fainting
  • Blurred vision
• Kidney damage: While candesartan is used to protect kidney function in certain conditions, it can paradoxically cause renal impairment in susceptible individuals. Risk factors include bilateral renal artery stenosis, heart failure, and concurrent use of nephrotoxic drugs. Regular monitoring of renal parameters and cautious use in high-risk patients are essential preventive measures. ​
• Severe allergic reactions: Though rare, candesartan can cause severe allergic reactions, including angioedema, characterized by facial swelling, which can obstruct airways. This reaction is believed to be due to increased bradykinin levels. Immediate discontinuation of the drug and emergency medical treatment are imperative. Patients with a history of angioedema should inform their healthcare providers before starting candesartan. ​

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Patients should be aware of potential warnings associated with its use. Key points of the warnings may include:

• Allergy: Do not take Atacand if you are allergic to candesartan or any other inactive ingredients in this product. You should be aware of all the ingredients in the product you are using. If you do not know, ask your healthcare provider or pharmacist.
• Diabetes: If you have diabetes, avoid taking Atacand with any other medicine that contains aliskiren, a blood pressure medicine.
• Renal Condition: If you have a renal condition, you should not take this medicine with aliskiren.
• Use with Supplements: Avoid using salt substitutes or potassium supplements with Atacand unless your doctor instructs you to do so.

Like other medicines, Atacand has certain precautions that users should keep in mind. For this medicine, consider the following.

• Medical History: To make sure this medicine is safe for you to use, you should tell your doctor if you have any medical conditions, especially if you have or have ever had any of the following:
  • Heart condition other than the one being treated with Atacand.
  • Renal disease, or if you are on dialysis
  • Hepatic disease
  • If you are on a low-sodium salt
• Discontinuation: You should not discontinue this medicine without talking with your doctor first, as it can cause unfavorable outcomes.
• Pregnancy: You should not use Atacand if you are pregnant. Discontinue use and tell your doctor immediately if you get pregnant. This medicine can cause injury or death to the unborn fetus if you take Atacand during your second or third trimester. If you plan to get pregnant, ask your doctor beforehand for a safer medicine to use before and while you are pregnant. Having hypertension while being pregnant may cause complications in the baby and the mother.
• Breastfeeding: Do not breastfeed an infant while being treated with Atacand.

Dizziness: Avoid getting up immediately after being in a sitting or lying position for extended periods of time, as this can cause dizziness.

To get the most benefit from Atacand, it is important to keep consistency in dosage and take it around the same time each day to help you remember to take it on time. If you have missed a dose, ask your doctor or follow the instructions given below.

• If you miss an Atacand dose, you should take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, it is best to omit the missed dose and resume with the scheduled dose.
• Missing multiple Atacand doses may affect your blood pressure control, so it is best recommended to take it exactly as prescribed.
• Avoid taking extra doses to make up for your missed dose.
• If you frequently forget to take your medicine as per the regular dosing schedule, you should set a medicine reminder on your mobile phone.
• If you are still uncertain when to take your missed dose, consult your healthcare provider.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

An overdose of Atacand (candesartan) can lead to symptoms like severe dizziness, fainting, a rapid or slow heartbeat, or extremely low blood pressure. If you or someone has overdosed on Atacand, seek emergency medical attention by calling a healthcare professional or 911. You may also head to the nearest medical care center.

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

Following proper storage and disposal guidelines for Atacand is essential to maintaining its effectiveness & ensuring safety. These include:

• Keep Atacand at room temperature (between 15-30°C).
• Store it in a dry place, away from moisture, heat, and direct sunlight. Do not keep it in the bathroom or in other areas with high humidity, as moisture can cause harm to certain medicines.
• Keep the Atacand tablets in their original packaging to protect them from environmental damage.
• Ensure childproof storage to prevent accidental ingestion.
• Do not flush unused or outdated tablets down the toilet or sink.
• Keep expired medication away from children and pets before disposal.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Certain medicines may interact with Atacand and affect how it functions or cause unwanted side effects. To manage and prevent potential drug interactions, you should tell your doctor or healthcare provider about all the medicines you currently use or plan to use alongside Atacand. This includes all prescriptions, over-the-counter drugs, herbs, vitamins, or mineral supplements. If your doctor identifies any significant drug interaction, they may alter your dosage of one or both medicines or recommend that you switch to a different treatment option. Some of the drugs that may interact with Atacand may include:

• Aliskiren
• Amiloride
• Apomorphine
• Aspirin
• Aspirin Low Strength
• Benazepril
• Captopril
• Enalapril
• Finerenone
• Fosinopril
• Lisinopril
• Lithium
• Moexipril
• Perindopril
• Prednisone
• Quinapril
• Ramipril
• Sparsentan
• Spironolactone
• Trandolapril
• Trimethoprim
• Ziprasidone
• Zolpidem

What Are the Other Atacand Interactions?

You should avoid using certain medicines at or around the same time as consuming certain food items, as it can cause interactions. Using tobacco or alcohol with certain drugs can also cause interactions. You should discuss the use of your medicine with your doctor or healthcare professional regarding certain food items, beverages, herbs, or supplements. Apart from this, certain medical problems may affect the use of this drug. Make sure to tell your doctor about your medical history, especially about:

• Diabetes
• Kidney disease
• Electrolyte imbalances
• Fluid imbalances
• Patients with renal conditions who are also taking aliskiren
• Hepatic conditions

[Note: This isn't a complete list, and there could be other drugs that interact with Atacand. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Sometimes, Atacand may not provide the desired outcome or cause unwanted side effects. In these situations, healthcare providers may recommend other medications that align better with your health profile and treatment goals. These mainly include:

• Zestril (lisinopril)
• Topamax
• Propranolol
• Aimovig
• Amitriptyline
• Qulipta

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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