Valsartan and Hydrochlorothiazide

Valsartan HCT

Valsartan HCT is an FDA-approved combination medication that contains two active ingredients: valsartan & hydrochlorothiazide. It is used to treat high blood pressure and heart failure. It comes in the form of tablets, which come in different strengths and are to be taken orally with or without food. The medication dosage is based on the condition being treated and the patient’s response to treatment. For safe and efficient use of the medication, you should consult a healthcare provider and seek their guidance regarding usage, dosage, storage, and more. You can buy Valsartan HCT for blood pressure control and heart failure from the convenience of your home at low prices.  

Product Overview

Valsartan HCT is a combination medication approved by the FDA containing two active ingredients: valsartan, an angiotensin II receptor blocker, and hydrochlorothiazide, a thiazide diuretic. Valsartan works by relaxing blood vessels to improve blood flow, while hydrochlorothiazide helps reduce fluid retention by increasing urine production. This combination is used to manage high blood pressure (hypertension) and may also help reduce the risk of heart complications.

Valsartan HCT is available in strengths of 80/12.5 mg, 160/12.5 mg, and 160/25 mg. It is typically taken once daily, with or without food, as directed by your healthcare provider. The dosage is based on the individual’s condition and response to treatment. The medication is generally prescribed for adults, with pediatric use determined by a doctor. The combined effect of valsartan and hydrochlorothiazide works to control blood pressure effectively.

Common side effects include dizziness, lightheadedness, and dehydration. It is important to stay hydrated and avoid excessive salt intake. If you miss a dose, take it as soon as possible unless it’s close to your next dose; do not take two doses at once. In case of overdose, seek immediate medical attention. Store Valsartan HCT at room temperature, away from light and moisture. Always follow your healthcare provider’s instructions for safe and effective use.

What Are the Uses of Valsartan HCT?

It is used to treat:

• High blood pressure
• Heart failure 

What Are the Forms & Strengths of Valsartan HCT?

It is available in the form of tablets, which come in different strengths:

• 80 mg valsartan / 12.5 mg HCT
• 160 mg valsartan / 12.5 mg HCT
• 160 mg valsartan / 25 mg HCT
• 320 mg valsartan / 12.5 mg HCT
• 320 mg valsartan / 25 mg HCT

What Are the Recommended Dosage of Valsartan HCT?

The appropriate dosage varies significantly from person to person and is based on various factors such as medical history, blood pressure levels, age, and other medications being taken. This medication should only be taken under the supervision of a healthcare provider, who will determine the correct dosage based on individual patient needs and monitor its effectiveness while watching for potential side effects.

For Heart Failure

Adults: Start with 40 mg twice daily. The doctor may adjust the dose as needed, but it typically should not exceed 320 mg per day.

Children: The use and dosage should be determined by a doctor.

For High Blood Pressure

Adults: Begin with 80 or 160 mg once daily. The doctor may adjust the dose to a maximum of 320 mg daily.

Children aged 1 to 16 years: Dosage is based on body weight and determined by a doctor. The usual initial dose is one mg per kg of body weight once daily. The doctor may adjust the medication dose, but it should be at most 4 mg per kg or 160 mg per day.

Children under one year: It is not recommended for use. 

For Heart Attack-Related Left Ventricular Failure

Adults: Start with 20 mg twice daily. The doctor may adjust the dose as needed, but the maximum is 320 mg daily.

Children: The use and dosage should be determined by a doctor.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Valsartan HCT? 

Before using Valsartan HCT, carefully read and follow the instructions for use given in the patient information leaflet and medication guide provided by your healthcare provider or pharmacist. If you have any questions or concerns or do not understand any part of the leaflet, ask a medical practitioner. 

• Take this tablet orally by mouth, with or without food, usually once daily. If you experience an urge to urinate more often while using this medication, it is best to take it at least four hours before sleeping to prevent having to get up to urinate.
• If you are also taking certain drugs to reduce your cholesterol, you should take this medication at least four hours before or at least four to six hours after medications such as cholestyramine or colestipol. 
• The medication dosage is based on the condition being treated and the patient’s response to the treatment. 
• To get the most benefit from your medication, you should maintain consistency in dosage. To help you remember taking it, you should try to take it around the same time every day. 
• You should continue taking this medication even if you feel well. Patients suffering from hypertension don’t usually feel sick. 
• Do not share your medication with others, even if they have the same symptoms as you. 
• Tell your doctor if your condition does not get better or if it worsens. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Valsartan HCT Work?

Valsartan HCT works through a dual mechanism to lower blood pressure. Valsartan, an angiotensin II receptor blocker (ARB), prevents angiotensin II from attaching to its receptors in blood vessels. This eases and widens the blood vessels, reducing blood pressure. Simultaneously, hydrochlorothiazide (HCT), a thiazide diuretic, increases salt and water excretion through urine. This decreases blood volume, further lowering blood pressure. Combining these two actions provides a more effective blood pressure reduction than either component alone. By addressing multiple factors contributing to hypertension, Valsartan HCT helps manage blood pressure more efficiently, potentially with lower doses of each medication and fewer side effects.

Important Safety Information for Using Valsartan HCT

What Are the Side Effects of Valsartan HCT?

Common Side Effects of Valsartan HCT: Similar to other medications, Valsartan may also cause side effects in some people taking it. These side effects don’t usually require medical attention and disappear within a few days or weeks as your body adjusts to the medication. 

• Dizziness: Due to the blood-pressure reducing effects of valsartan and the diuretic effect of HCT, some users can experience sensations of dizziness. To decrease the risk of this side effect, you should rise up slowly after sitting or lying down for a long time. If dizziness persists or worsens, consult your healthcare provider.

• Headache: This is one of the most common side effects of Valsartan, which is most likely to occur during the initial days of starting treatment with it. To alleviate headaches, you should stay hydrated and keep consistency in the dose. If you have a severe headache, you can take over-the-counter drugs after consulting with a medical practitioner. 

• Fatigue: Tiredness can occur due to the body’s adaptation to lower blood pressure. To boost energy levels, you should take adequate rest and engage in light physical activity. If you experience extreme feelings of tiredness, discuss it with your doctor. 

• Nausea: This is most likely to be experienced by patients when they start taking Valsartan HCT. Taking this medicine with food can help reduce this effect. If this symptom is severe or persist, let your doctor or healthcare provider know. 

• Increased urination: This medication contains HCT which is a diuretic, which causes more frequent urination. This is to remove excess fluid from the body. This effect is expected and commonly occurring. It indicates the medication is working properly. To prevent dehydration, you should drink sufficient fluids throughout the day. 

• Mild dehydration: Due to increased urination, there is an increased chance of dehydration. Signs and symptoms of dehydration include increased thirst, dry mouth, and decreased urine output. To prevent this, you should maintain regular fluid intake and monitor for symptoms of dehydration. 

• Low blood pressure: The primary function of valsartan is to reduce blood pressure, which can sometimes result in hypotension. Its symptoms may include lightheadedness & fainting. To manage this, you should regularly monitor your blood pressure levels and avoid standing or sitting suddenly. If the symptoms are concerning or persistent, tell your doctor.  

• Slight increase in blood sugar levels: HCT, an active ingredient in Valsartan HCT can cause minor increases in the levels of blood sugar in the body. Patients with diabetes should closely monitor their blood sugar at regular intervals and share the report with their doctor or healthcare provider. 

Mild Side Effects of Valsartan HCT: Most mild side effects caused by this medication are temporary and usually do not require medical attention. However, if they become bothersome or persist, tell your doctor. 

• Dry cough: Although this is a less common side effect of this medication, some individuals may experience a persistent dry cough. If the cough becomes bothersome, consult your healthcare provider and discuss potential alternative treatment options.

• Muscle cramps: HCT, being a diuretic, can cause a decrease in essential electrolytes like potassium and magnesium, resulting in muscle cramps. To prevent this, you should ensure that you are consuming an adequate amount of potassium-rich foods such as bananas and oranges. In some cases, your doctor may also recommend you take potassium supplements. 

• Mild skin rash: Some users may develop a mild skin rash as an allergic reaction to the medication. If you notice a rash, consult your doctor. If it persists or worsens, seek medical advice to rule out more serious reactions.

• Constipation or diarrhea: Gastrointestinal disturbances like constipation or diarrhea can occur as the body adjusts to the medication. To manage these symptoms, you can try maintaining a well-balanced diet rich in fiber and staying adequately hydrated. If they persist, talk to your doctor. 

• Mild electrolyte imbalances: HCT can cause depletion of essential electrolytes, including potassium, which can cause hypokalemia. 

• Mild stomach discomfort: Some individuals may experience stomach discomfort or pain while receiving treatment with Valsartan HCT. To alleviate this symptom, you should take it with food. If stomach discomfort persists, talk to your doctor. 

• Back pain: While not common, some patients report back pain while using Valsartan HCT. If the pain persists, consult your healthcare provider or doctor. 

• Joint pain: Some individuals may have joint pain while using this medication. Staying active and performing joint-friendly exercises can help maintain flexibility. Over-the-counter pain relievers may provide relief, but consult your doctor before taking any additional medications.

Serious Side Effects of Valsartan HCT: In rare cases, Valsartan may cause serious side effects in some patients using it. You should report any new or bothersome side effects immediately to your doctor. Serious side effects caused by this medication require prompt medical attention and may be fatal if not treated promptly. 

• A severe allergic reaction, including anaphylaxis, may occur. Its symptoms may include swelling of the face, mouth, lips, tongue, or throat; difficulty breathing; severe itching or hives.
• Severe electrolyte imbalances can cause confusion, seizures, irregular heartbeat, and muscle weakness.
• Kidney problems or failure: Valsartan can affect kidney function, especially in individuals with pre-existing kidney conditions. Signs include reduced urine output, swelling in the legs or feet, and fatigue. Regular monitoring of kidney function through blood tests is essential.
• Liver problems. Its symptoms may include dark urine, abdominal pain, nausea, and yellowing of the skin or eyes. It can further lead to liver failure if not treated promptly. 
• Severe skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis. It can cause severe blistering and peeling of the skin. 
• A notable drop in white blood cell count which can severely compromise the immune system, leaving the body vulnerable to infections.
• Severe dehydration: HCT, as a diuretic, increases urine output, which can lead to dehydration. Symptoms include extreme thirst, dry mouth, dizziness, and reduced urine output. Ensure adequate fluid intake and monitor for signs of dehydration. If severe symptoms occur, seek medical attention.
• Sudden eye problems. Its symptoms may include severe eye pain, visual disturbances, and vision loss.
• Severe dizziness or fainting: Significant drops in blood pressure can cause severe dizziness or fainting. To reduce risk, rise slowly from sitting or lying positions. If these symptoms persist, consult your healthcare provider.
• Persistent, severe gastrointestinal issues: While mild stomach discomfort is common, persistent or severe gastrointestinal symptoms like prolonged nausea, vomiting, or abdominal pain should be reported to your doctor. These could indicate a more serious underlying issue. 

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Valsartan HCT? 

• Low Blood Pressure: This medication may reduce your blood pressure, particularly when you start taking it. Contact your doctor if you experience symptoms like feeling lightheaded, dizzy, or faint. Low blood pressure risks increase if you:
  • Are not consuming sufficient fluids
  • Are sweating excessively
  • Have diarrhea or are vomiting
• Kidney Function: This medication could reduce your kidney function. Signs of kidney problems may include altered urine output, swelling in your feet and ankles, and confusion. If you notice these symptoms, call your doctor at once.
• Eye Problems: Valsartan can cause eye problems, including myopia & glaucoma. If you experience vision difficulties or eye pain, discontinue using the medication immediately and tell your doctor.
• Pregnancy: Do not take this medication if you are pregnant, plan to become pregnant, or suspect a pregnancy, as it may cause fetal harm or death. 
• Allergy: Do not use this medication if you are unable to urinate or allergic to sulfa drugs. 
• Combination: If you have diabetes or kidney disease, you should not take this medication in combination with any medication that contains aliskiren. 

What Are the FDA Boxed Warning for Valsartan HCT?

A boxed warning for Valsartan HCT has been issued by the FDA. The critical point of this warning is:

• People who are pregnant or plan to become pregnant should not take this medication as it can terminate the pregnancy. Additionally, drugs that directly affect the renin-angiotensin system, including Valsartan, may cause injury or death to the developing fetus. You should consult a healthcare provider before taking this medication, especially if you are pregnant, plan to become pregnant, or suspect a pregnancy. 

What Are the Valsartan HCT Precautions?

• Before using this medication, tell your doctor if you have an allergy to valsartan, hydrochlorothiazide, sulfonamide-derived drugs, or any of its components. This product contains certain inactive ingredients that can cause allergic reactions and other problems.  
• Before starting to use this medication, share your complete medical and family history with your doctor, especially if you have the following conditions:
  • Liver disease
  • Kidney disease
  • Decreased urination 
  • Congestive heart failure 
  • Asthma 
  • Gallstones
  • Allergy to valsartan or hydrochlorothiazide 
  • If you are on a low-sodium diet 
  • Electrolyte imbalance
  • Lupus 
  • Gout or high uric acid in your bloodstream
  • High cholesterol or triglyceride levels 
  • Glaucoma
  • Allergy to penicillin 
• This medication is not approved for use in anyone less than 18 years of age.
• You should not use this medication if you are pregnant. If you get pregnant, discontinue using this medication immediately and inform your doctor. 
• Do not use this medication while breastfeeding an infant, as it may pass into your breastmilk and cause harm to the nursing baby.

What Are the Contraindications of Valsartan HCT?

Valsartan is contraindicated for use in patients who have:

• Anuria
• Hypersensitivity to any sulfonamide-derived drugs or any of its components.
• Concomitant use with Aliskiren
• Hypotension
• Fluid or electrolyte imbalance 
• Pregnancy 

What If You Missed a Dose of Valsartan HCT?

• If you have missed a dose of Valsartan HCT, you should take it as soon as possible. 
• However, if it is almost time to take your next dose, you may omit the missed dose and continue taking your medication according to the regular dosing schedule. 
• Do not simultaneously take double or extra doses of the same medication to compensate for the missed dose. 
• You can set a reminder on your phone to prevent further missing your doses. 

[Note: If you have missed a medication dose and are still determining when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Valsartan HCT?

If someone has taken Valsartan HCT more than recommended, immediate medication assistance should be sought. If you suspect an overdose, immediately call your doctor, 911, or poison control helpline. You may also head to the nearest emergency room.

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How to Store a Valsartan HCT?

Proper storage of Valsartan HCT is essential to maintain its safety and efficacy. 

• Store Valsartan HCT in its original container to protect it from direct sunlight, excess heat, and moisture. 
• Keep it in a cool and dry place at room temperature. 
• Do not keep the medications in the bathroom, near the sink, or places high in humidity. 
• Do not allow the medication to freeze or expose it to an open flame. 
• Keep all medications, including Valsartan HCT, in a safe place, away from the sight and reach of children and pets. 
• Do not keep medications that are outdated or no longer needed. Discard them safely. 
• Dispose of unwanted medications in such a way that prevents children, animals, and others from consuming them. 
• Do not pour them down the drain, flush them down the toilet, or throw them into the household garbage bin.    

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Valsartan HCT?

Certain medications may interact with Valsartan and affect how it may work. Before taking this medication, tell your doctor about all the medicines you are using or plan to take alongside Valsartan, including all prescription, non-prescription, over-the-counter drugs, and herbal or vitamin supplements. This information will help them identify and manage drug interactions. Some potential drug interactions of Valsartan are as follows:

• Acarbose
• Aceclofenac
• Acemetacin
• Acetyldigoxin
• Albiglutide
• Albuterol
• Aliskiren
• Alogliptin
• Amphetamine
• Amtolmetin Guacil
• Arsenic Trioxide
• Asciminib
• Aspirin
• Benazepril
• Benzphetamine
• Bromfenac
• Bromocriptine
• Bufexamac
• Buprenorphine
• Canagliflozin
• Captopril
• Cefepime
• Ceftobiprole Medocaril
• Celecoxib
• Chlorpropamide
• Choline Salicylate
• Cilazapril
• Clonixin
• Codeine
• Cyclosporine
• Dapagliflozin
• Darolutamide
• Deslanoside
• Desmopressin
• Dexibuprofen
• Dexketoprofen
• Dextroamphetamine
• Diclofenac
• Diflunisal
• Digitalis
• Digitoxin
• Digoxin
• Dihydrocodeine
• Dipyrone
• Dofetilide
• Droperidol
• Droxicam
• Dulaglutide
• Elexacaftor
• Eltrombopag
• Empagliflozin
• Enalapril
• Enalaprilat
• Etodolac
• Etofenamate
• Etoricoxib
• Exenatide
• Felbinac
• Fenoprofen
• Fentanyl
• Fepradinol
• Feprazone
• Flecainide
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Formoterol
• Fosinopril
• Furosemide
• Glimepiride
• Glipizide
• Glyburide
• Hydromorphone
• Ibuprofen
• Indomethacin
• Insulin
• Insulin Aspart, Recombinant
• Insulin Bovine
• Insulin Degludec
• Insulin Detemir
• Insulin Glulisine
• Ketanserin
• Ketoprofen
• Ketorolac
• Levomethadyl
• Linagliptin
• Liraglutide
• Lisdexamfetamine
• Lisinopril
• Lithium
• Lixisenatide
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Meperidine
• Methadone
• Methamphetamine
• Methotrexate
• Metildigoxin
• Miglitol
• Moexipril
• Morniflumate
• Morphine
• Morphine Sulfate Liposome
• Nabumetone
• Naproxen
• Nateglinide
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oliceridine
• Ouabain
• Oxaprozin
• Oxymorphone
• Oxyphenbutazone
• Parecoxib
• Perindopril
• Phenylbutazone
• Piketoprofen
• Pioglitazone
• Piroxicam
• Porfimer
• Potassium Citrate
• Potassium Phosphate
• Pramlintide
• Proglumetacin
• Propyphenazone
• Proquazone
• Proscillaridin
• Quinapril
• Ramipril
• Repaglinide
• Rofecoxib
• Rosiglitazone
• Salicylic Acid
• Salsalate
• Saxagliptin
• Simeprevir
• Sitagliptin
• Sodium Salicylate
• Sotalol
• Sparsentan
• Spirapril
• Sufentanil
• Sulindac
• Tacrolimus
• Tapentadol
• Tenoxicam
• Tiaprofenic Acid
• Tolazamide
• Tolbutamide
• Tolfenamic Acid
• Tolmetin
• Topiramate
• Tramadol
• Trandolapril
• Trimethoprim
• Valdecoxib
• Vildagliptin
• Voclosporin
• Vonoprazan
• Zofenopril  

What Are the Other Valsartan HCT Interactions?

Apart from medications, certain herbs, supplements, foods, and beverages may interact with Valsartan. Before using this medication, ask your doctor about other interactions you should consider. Your doctor may recommend making certain dietary changes while using this medication. 

• St. John’s Wort
• Ginseng 
• Hawthorn 
• Grapefruit and grapefruit juice 
• Salt 
• Alcohol 

[Note: This isn’t a complete list, and there could be other drugs that interact with Valsartabout an HCT. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Valsartan HCT Alternatives?

People look for alternative medicines to Valsartan when it does not suit them, or they do not get the desired results. There are many effective alternative medicines available for Valsartan on the market. You should consult your medical provider before beginning to take a new medication or switching from your current prescription. Some of the popular alternative medicines to Valsartan HCT are given below: 

• Toprol-XL (metoprolol succinate)
• Carvedilol (carvedilol)
• Corlanor (ivabradine)
• Cardizem (diltiazem)
• Zestril (lisinopril)
• Norvasc (amlodipine)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Valsartan HCT Cost & Coupons

The cost of Valsartan HCT can vary significantly based on insurance coverage, often leaving patients facing substantial out-of-pocket expenses. Many seek alternatives to reduce these costs effectively. One reliable option is to order Valsartan and hydrochlorothiazide tablets from Canadian pharmacies, which may offer this medication at more affordable rates. Services like Polar Bear Meds cater to U.S. customers, providing a convenient way to access medications internationally. Additionally, new customers can benefit from promotional offers, such as using the coupon code WELCOMEPB10, which grants a 10% discount on their initial purchase, making treatment more accessible and easing the financial burden for those requiring Valsartan HCT.

Frequently Asked Questions

Can Valsartan HCT be used in patients with diabetes?

Valsartan HCT can be prescribed to patients with diabetes, but careful monitoring is required due to the risk of increased blood glucose levels. The combination of valsartan, an ARB, and hydrochlorothiazide, a diuretic, may have varying effects on blood sugar. Patients should discuss their medical condition with their healthcare provider to adjust treatment as necessary.

What are the long-term effects of using Valsartan HCT?

Long-term use of Valsartan HCT has been associated with improved blood pressure control and reduced risk of cardiovascular events. However, potential risks include electrolyte imbalances, kidney function decline, and increased blood glucose levels. Regular monitoring of the patient’s progress by a medical provider is essential to manage these risks and ensure the medication’s continued effectiveness.

How does Valsartan HCT interact with other antihypertensive medications?

Valsartan HCT can be used in combination with other antihypertensive medications, but interactions may occur, potentially leading to enhanced or reduced effects. For example, combining it with ACE inhibitors or other ARBs may increase the risk of hyperkalemia. Patients should consult their healthcare provider to manage drug interactions effectively and optimize blood pressure control.

What should be monitored during Valsartan HCT therapy?

During Valsartan HCT therapy, regular monitoring of blood pressure, kidney function, and electrolyte levels (such as potassium and sodium) is crucial. This ensures the medication is working effectively while minimizing potential side effects. Additionally, blood glucose levels should be monitored in diabetic patients, as hydrochlorothiazide may cause changes in glucose control.

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