Vortioxetine

Brintellix

Brintellix, known generically as vortioxetine, is an FDA-approved medication to treat major depressive disorder (MDD). It functions by modulating serotonin levels in the brain, which can improve mood, sleep, appetite, and energy levels, thereby addressing various symptoms associated with depression. Available in tablet form, Brintellix comes in strengths of 5mg, 10mg, 15mg, and 20mg. This medication stands out from traditional antidepressants as it also aids in enhancing cognitive functions, such as concentration and memory, which are often impaired by depression. Brintellix is generally prescribed when other treatments have not yielded effective results, providing new hope for individuals dealing with persistent depressive symptoms. So, if you want to buy Brintellix online from Canada, getting a valid prescription is essential.

Product Overview

Brintellix, with its active ingredient vortioxetine, is a revolutionary antidepressant approved by the FDA to tackle major depressive disorder (MDD). Its mechanism of action sets it apart from traditional antidepressants by not only balancing serotonin levels in the brain but also enhancing cognitive functions such as memory and focus. These improvements are particularly valuable in depressive states where cognitive impairment is prevalent. Brintellix is available in tablet form and comes in dosages of 5mg, 10mg, 15mg, and 20mg. Designed for patients who have found little relief from other treatments, it offers a beacon of hope, enhancing both emotional and cognitive health.

The drug is tailored for adults experiencing a spectrum of depressive symptoms—from persistent sadness and anxiety to sleep disturbances and loss of interest in activities once enjoyed. Its administration involves an initial dose of 10mg daily, which may be adjusted based on the individual’s response and under a healthcare provider’s guidance. The treatment maintains a steady state of the medication in the body, which is crucial for its effectiveness, and requires adherence to a prescribed regimen even after symptoms improve to avoid discontinuation syndrome.

Brintellix’s side effects range from mild to severe, including gastrointestinal disturbances, increased sweating, and potential weight gain. It also carries a risk of serious conditions like serotonin syndrome and angle-closure glaucoma. Moreover, its boxed warning from the FDA underscores an increased chance of suicidal thoughts in young adults and children, emphasizing the need for careful monitoring. Despite these considerations, Brintellix remains a vital tool for managing depression with a detailed approach to both mental and cognitive health restoration.

What Is the Drug Brintellix Used For?

Brintellix is used to treat a wide range of major depressive disorder depressive symptoms, including:

• Reduced appetite,
• Difficulty in concentrating,
• Inner tension (feeling anxious),
• Sadness,
• Sleep disturbances (reduced sleep),
• Feelings of worthlessness,
• A feeling of being slowed down,
• Loss of interest in favorite activities.

What Strengths and Forms Does Brintellix Come In?

Brintellix is available in tablet form and has the following strengths: 

Tablets:

• 5mg
• 10mg
• 15mg
• 20mg

What Is the Recommended Dosage of Brintellix?

Brintellix to Treat Depression

• The standard initial Brintellix dosage for this medication is 10 milligrams (mg), which should be taken orally once every day. Depending on the patient’s response to this starting dose and under the instructions of a healthcare professional, the dosage may then be adjusted. Generally, the Brintellix dose may be increased to 20mg per day if deemed necessary by your doctor.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How Do You Take Brintellix?

To ensure proper use of Brintellix (vortioxetine), it’s crucial to adhere to the instructions prescribed by your healthcare professional. Before starting treatment, thoroughly read all the information provided with the medication and make sure to understand each directive. Consider the following guidelines:

• When you buy Brintellix (vortioxetine) online or from any pharmacy, remember you can take the medication with or without food according to your preference. However, it’s important to take it simultaneously each day to maintain an even level of medication in your body.
• Continue taking Brintellix (vortioxetine) consistently as your doctor has instructed, even if you start to feel better. Abrupt discontinuation or irregular intake can affect the efficacy of the treatment & may lead to adverse health implications. 
• Always consult your doctor before making any changes to how you take your medication.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Brintellix Work?

Brintellix, which contains the active ingredient vortioxetine, functions as an antidepressant by interacting uniquely with various serotonin receptors within the brain. Vortioxetine has a dual-action mechanism on these receptors: it blocks some while stimulating others, altering the serotonin dynamics. Additionally, vortioxetine inhibits the serotonin transporter, a protein responsible for serotonin reuptake from the neural synapse. This inhibition leads to an enhanced concentration of serotonin in the brain. Serotonin plays an essential role in mood regulation and the modulation of other neurotransmitters that are directly linked to depression and anxiety. By enhancing serotonin activity, vortioxetine can significantly improve symptoms associated with depression, leveraging the neurotransmitter’s regulatory effects on both mood and overall emotional balance.

Important Safety Information for Using Brintellix

What Are the Brintellix Side Effects?

Common Side Effects of Brintellix: When you buy Brintellix online for depression treatment, you can consider the common side effects associated with this:

• Gastrointestinal Effects: Brintellix may cause various gastrointestinal disturbances, including constipation, nausea, and vomiting. These effects arise as the medication interacts with serotonin receptors in the gut, which play a crucial role in regulating motility and secretion. While these symptoms are typically mild to moderate, persistent gastrointestinal issues may lead to complications such as dehydration or electrolyte imbalances if fluids are not adequately replaced.
• Increased Sweating: This side effect is due to Brintellix’s impact on the body’s thermoregulatory processes, which are partly modulated by serotonin levels. Increased sweating can be uncomfortable and may necessitate changes in clothing or bedding, especially at night.
• Fever: A fever associated with Brintellix is relatively uncommon but can occur. It might indicate an immune response or an adverse reaction to the medication. Continuous monitoring is essential, and if the fever is high or accompanied by other symptoms like a rash or difficulty breathing, quick medical attention should be sought.
• Rash: Skin rashes from Brintellix are potential indicators of an allergic reaction. The rash may appear as small red spots, hives, or a widespread rash covering large body areas. If a rash develops, it’s important to consult a healthcare provider to determine whether it’s related to the medication or another cause.
• Weight Gain: Weight gain can occur with Brintellix, though it’s less common than other antidepressants. The mechanism may involve changes in appetite or metabolism induced by serotonin modulation. Monitoring dietary intake and physical activity can help manage this side effect.
• Headache: Headaches are a common side effect when taking Brintellix, likely due to changes in serotonin levels, which could affect blood vessels in the brain. Most headaches are mild, but if they become severe, consulting a healthcare provider is advisable for further evaluation and potential adjustment of the treatment plan.

Serious Side Effects of Brintellix: Brintellix may cause several serious side effects, each with distinct symptoms and potential consequences:

• Serotonin Syndrome: This is a possibly life-threatening condition that can occur when Brintellix is taken in conjunction with other medications that affect serotonin levels. Symptoms of serotonin syndrome may vary from mild to severe and include agitation, hallucinations, confusion, coma, rapid heartbeat, fluctuating blood pressure, dizziness, excessive sweating, flushing, elevated body temperature, tremors, rigid muscles, muscle twitching, loss of coordination, seizures, and gastrointestinal symptoms like nausea, vomiting, and diarrhea. Immediate medical attention is crucial upon noticing any of these symptoms.
• Increased Risk of Bleeding: Brintellix, especially when taken with medications such as aspirin, NSAIDs, warfarin, or other blood thinners, can enhance the risk of bleeding. It is important to monitor for signs of unusual bleeding or bruising and report these to your healthcare provider immediately.
• Manic Episodes: People with bipolar disorder are at risk of experiencing manic episodes when taking Brintellix. These episodes can be as unusually high energy, racing thoughts, disproportionate self-esteem, increased talkativeness, reduced need for sleep, reckless behavior, and excessive happiness or irritability.
• Discontinuation Syndrome: Abruptly stopping Brintellix can lead to discontinuation syndrome, which is characterized by signs such as nausea, sweating, mood changes, irritability, agitation, dizziness, sensations resembling an electric shock, tremors, anxiety, confusion, headache, fatigue, sleep disturbances, hypomania, ringing in the ears, and seizures. It is important to consult a doctor before discontinuing the medication to manage these symptoms effectively.
• Eye Problems: Brintellix can cause angle-closure glaucoma, a serious eye condition, particularly in individuals with specific pre-existing eye issues. Symptoms might include eye pain, vision changes, or swelling or redness around the eyes. An eye examination may be necessary to assess risk and initiate preventative measures if required.
• Low Levels of Salt (Sodium) in Your Blood: Hyponatremia, a critical drop in blood sodium levels, can occur during treatment with Brintellix, particularly in the elderly and those taking certain other medications. Symptoms include headache, memory changes, difficulty concentrating, confusion, weakness, and unsteadiness, potentially leading to falls. In severe cases, hallucinations, fainting, seizures, coma, and respiratory arrest may occur.
• Sexual Problems: Brintellix may cause sexual dysfunction in both men and women. Men may experience delayed ejaculation, decreased libido, or erectile difficulties. Women might have a reduced sex drive or difficulty achieving orgasm. If sexual side effects occur, it is highly advisable to discuss them with your doctor for appropriate management.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Brintellix?

When you buy Brintellix online to treat depression, consider the following warnings: 

• Brintellix is not approved for use in individuals under the age of 18 without explicit recommendation and supervision by a doctor. The safety and efficacy of Brintellix for pediatric use have not been established. Therefore, it should be administered to children and adolescents only if a healthcare provider determines it is necessary and after considering the potential risks carefully.
• Patients with bipolar disorder could have an increased risk of experiencing episodes of mania or hypomania when starting treatment with this medication. Because of this potential risk, it is essential for healthcare providers to thoroughly screen patients for any history of bipolar disorder, mania, or hypomania prior to initiating therapy. Identifying these conditions beforehand allows clinicians to make informed decisions regarding the suitability of this treatment and to consider alternative therapeutic options or necessary precautions to mitigate the risk of triggering manic or hypomanic episodes.
• The occurrence of angle closure glaucoma has been reported in patients who have untreated anatomically narrow angles and who are treated with antidepressants, including this specific medication. This condition is a serious ocular emergency that can lead to significant visual complications if not treated promptly. Patients who are known to have narrow ocular angles should undergo a detailed ophthalmic evaluation to assess the risk of angle closure glaucoma before initiating treatment with antidepressants. This proactive approach is crucial for preventing the development of this acute glaucoma type, which can rapidly lead to vision loss if not properly managed.

What Are the FDA Boxed Warning for Brintellix? 

Brintellix carries a significant warning, designated as a “boxed warning,” which is the most stringent type of warning issued by the U.S. Food and Drug Administration (FDA). This warning highlights the increased risk of suicidal thoughts and behaviors among children and young adults up to the age of 24 years. The boxed warning serves as a critical alert to both healthcare providers and patients about the potential severe risks associated with the drug.

Antidepressants, including Brintellix, have been observed to elevate the risk of suicidal ideation and behaviors, particularly in younger populations. This risk is notably heightened during the initial stages of treatment, following the commencement of medication, or when adjustments are made to the dosage.

Despite being relatively rare, the possibility of developing these severe side effects necessitates vigilance. Patients and their families should be educated on the symptoms to monitor. Prompt recognition and communication of these symptoms to a healthcare provider are crucial for safety. These symptoms may include:

• Thoughts of suicide or actual attempts at taking one’s own life
• Increased agitation, anger, or irritability
• Engagement in dangerous impulses or thoughts
• Emerging or intensifying episodes of depression or panic attacks
• Noticeable shifts in mood or behavior

It is essential to underline that Brintellix is approved by the FDA exclusively for the treatment of adults. Awareness and understanding of these risks and symptoms can ensure timely intervention and adjustments to the treatment plan, enhancing both the efficacy and safety of using Brintellix.

What Are the Brintellix Precautions?

When considering the use of Brintellix (vortioxetine), it’s crucial to take certain precautions to ensure it is safe for you. Here are detailed steps and considerations:

• Discuss your health history with your doctor: Before starting Brintellix, inform your doctor if you have:

• Bipolar disorder (manic depression)
• History of drug abuse or suicidal thoughts
• Glaucoma
• Seizures or epilepsy
• Bleeding problems
• Low levels of sodium in your blood

• Allergy considerations: If you are allergic to vortioxetine or any other ingredients in Brintellix, you should avoid taking this medication. It’s crucial to check all the ingredients in the medication to ensure that you do not have an allergic reaction.
• Assess the impact on your daily activities: Brintellix may impair your ability to drive, operate heavy machinery, or perform other potentially dangerous tasks. This is because it can cause drowsiness or dizziness. Do not engage in such activities until you know how Brintellix affects you.
• Pregnancy: Always inform your doctor if you become pregnant or plan to become pregnant while on Brintellix. While the effects of Brintellix during pregnancy are not fully known, your doctor will help you weigh the benefits & risks of continuing treatment.
• Breastfeeding: Consult your doctor before starting breastfeeding while on Brintellix. It’s not fully known if vortioxetine passes into breast milk, so decisions should be made whether to discontinue breastfeeding or the medication, considering the drug’s importance to the mother.

What If You Have Missed Brintellix Dose?

If you forget to take a dose of Brintellix, assess the time until your next scheduled dose. Take the missed dose immediately if there’s ample time before the next dose. However, if your next dose is due soon, simply skip the missed Brintellix dose and continue with your regular schedule. Do not take a double Brintellix dose to compensate for the missed one, as this could increase the risk of side effects. If you’re unsure how to handle a missed dose or if you frequently forget to take your medication, consult your doctor for guidance. They can offer strategies to improve adherence, such as setting reminders and ensuring you maintain consistent therapeutic levels of the medication.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Brintellix?

Taking too much Brintellix can lead to potentially serious health risks, and it is important to seek immediate medical attention if you believe you have overdosed on this medication. Even in the absence of symptoms, it’s crucial to contact your doctor or the Poison Help line available at your nearest hospital. Having these contact numbers readily accessible can make a critical difference in emergencies. Symptoms of a Brintellix overdose may vary but commonly include dizziness, nausea, diarrhea, stomach discomfort, widespread itching, sleepiness, and flushing. More severe cases can result in seizures, which can occur when the dosage taken is several times higher than the prescribed amount.

[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

How to Store Brintellix?

When you buy Brintellix online from Canada, consider the following storage guidelines associated with this:

• Brintellix should be stored at a stable temperature of 77°F (25°C), but it is permissible for it to be exposed temporarily to temperatures ranging from 59°F-86°F (15°C-30°C). This allows for some flexibility during transportation or if storage conditions aren’t consistently maintained.
• While Brintellix does not require any specialized storage conditions, it is crucial to keep the medication in a secure location that is out of sight & reach of children to prevent accidental ingestion or misuse.
• Always check the expiration date on the Brintellix packaging before use. Do not consume the medication if the date has passed, as it may not be effective or safe.
• Store Brintellix in a dry place to avoid moisture accumulation, which could potentially damage the medication. It is advised not to store it in a bathroom, where humidity levels are typically higher.
• Avoid disposing of Brintellix by flushing it down a toilet or pouring it down a drain unless specifically directed by a healthcare professional. Such practices may be harmful to the environment. If you have any doubts about the best way to dispose of Brintellix, consult your pharmacist. They can provide information on drug take-back programs and an environmentally responsible way to dispose of unused or expired medications.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Brintellix?

Brintellix (vortioxetine) is an antidepressant that can interact with several types of medications. Here are the details of these interactions categorized by the type of drugs:

• Monoamine Oxidase Inhibitors (MAOIs): Brintellix should not be used if you have taken a monoamine oxidase inhibitor (MAO inhibitor) in the past 14 days. MAO inhibitors, such as isocarboxazid, phenelzine, methylene blue injection, and tranylcypromine, can cause serious drug interactions that may result in severe side effects or life-threatening conditions. Similarly, after discontinuing Brintellix, allowing a waiting period of at least 21 days is crucial before initiating any treatment with MAO inhibitors. This precaution helps prevent potential pharmacological conflicts that could adversely affect your health.
• Other Serotonergic Drugs: Using Brintellix in combination with other serotonergic drugs like SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St. John’s Wort can also increase the risk of serotonin syndrome. Monitoring for symptoms of serotonin syndrome is advised, and if it occurs, a reduction or discontinuation of Brintellix or other serotonergic drugs might be necessary.
• Strong Inhibitors of CYP2D6: Strong CYP2D6 inhibitors like bupropion, fluoxetine, paroxetine, and quinidine can raise the plasma concentrations of vortioxetine. When coadministered with these drugs, it may be necessary to halve the dose of Brintellix.
• Strong CYP Inducers: Conversely, strong inducers of CYP enzymes like rifampin, carbamazepine, and phenytoin can decrease the plasma levels of vortioxetine. It might be necessary to increase the dose of Brintellix when used concurrently with these medications, though not more than three times the original dose.
• Drugs that Interfere with Hemostasis: Brintellix’s use with antiplatelet agents or anticoagulants like aspirin, clopidogrel, heparin, and warfarin may increase the risk of bleeding. Patients should be informed about this risk. Monitoring the international normalized ratio (INR) in patients taking warfarin is essential.
• Drugs Highly Bound to Plasma Protein: Since Brintellix is highly bound to plasma protein, its concurrent use with other tightly bound drugs may lead to increased free concentrations of either Brintellix or the other drugs. It may be necessary to monitor for adverse reactions and adjust the dosage of Brintellix or the other tightly bound drugs accordingly. An example of such a drug is warfarin.

What Are the Other Brintellix Interactions?

Apart from medications, Brintellix may have other interactions, including:

• Herbs: Herbal supplements, particularly St. John’s Wort, can interact with Brintellix and pose significant health risks. St. John’s Wort is often believed to alleviate symptoms of depression by raising levels of serotonin in the brain. However, combining it with Brintellix, which also affects serotonin, can significantly increase the risk of serotonin syndrome—a potentially life-threatening condition characterized by symptoms such as rapid heart rate, confusion, high blood pressure, restlessness, and severe nausea. If you are considering or already using St. John’s Wort, it is crucial to inform your doctor. They can assess potential risks and provide safer alternatives to support your treatment plan without compromising your health.
• Alcohol: Consuming alcohol while taking Brintellix can heighten the likelihood of experiencing adverse side effects associated with the medication, such as drowsiness and impaired judgment. If you are already experiencing these mild side effects, alcohol consumption may exacerbate them, possibly making you feel worse. Doctors can provide guidance on whether it is safe for you to drink alcohol and, if so, advise on the amount that can be consumed without compromising the effectiveness of your treatment or increasing health risks.
• Vitamins: As of now, there are no known interactions between Brintellix and vitamins. However, the absence of current reports does not guarantee that potential interactions won’t be discovered in the future. Therefore, it’s crucial to consult your doctor or pharmacist before adding any vitamins to your regimen while undergoing treatment with Brintellix. This precaution helps ensure that all aspects of your health are considered and managed appropriately during your treatment.
• Foods: Regarding the interaction of Brintellix with food, no interactions have been documented to date. Nonetheless, if you have specific concerns about your diet or the impact of certain foods while taking Brintellix, it is advisable to discuss these with your doctor. They can provide personalized advice considering your overall health and treatment specifics.
• Vaccines: In terms of vaccines, there are also no reported interactions between Brintellix and any vaccinations. If you plan to get vaccinated, discussing this with your doctor is wise, especially if you are concerned about how your medication might interact with the vaccine. Your doctor can guide you on the best course of action based on your health status and the medications you are taking.
• Lab Tests: Brintellix has been noted to potentially affect lab tests, specifically causing false-positive results in urine tests for methadone, a medication often used for pain relief & as part of drug addiction detox programs. If you are taking Brintellix and need to undergo a urine test for methadone, it is important to inform the lab technician and your doctor about your medication use. Providing this information helps ensure that your test results are interpreted correctly, avoiding misdiagnosis or unnecessary additional testing.

[Note: This isn’t a complete list, and there could be other drugs that interact with Brintellix. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Brintellix Alternatives?

When you buy Brintellix online for depression treatment, you can also consider the following alternatives:

• Lexapro (escitalopram)
• Wellbutrin XL (bupropion)
• Zoloft (sertraline)
• Parnate (tranylcypromine)
• Paxil (paroxetine)
• Norpramin (desipramine)
• Cymbalta (duloxetine)
• Prozac (fluoxetine)
• Viibryd (vilazodone)
• Tofranil (imipramine)
• Wellbutrin SR (bupropion)
• Elavil (amitriptyline)
• Serzone (nefazodone)
• Pristiq (desvenlafaxine)
• Celexa (citalopram)
• Desyrel (trazodone)
• Remeron (mirtazapine)
• Effexor XR (venlafaxine)
• Marplan (isocarboxazid)
• Pamelor (nortriptyline)
• Nardil (phenelzine)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Brintellix Cost & Coupons

The cost of Brintellix can be quite significant, often exceeding $1000 per month, especially for those whose health insurance does not cover it. This is particularly common with medications prescribed for purposes like weight loss that are not universally supported by insurance plans. In response to these high costs, many seek more affordable alternatives to maintain their treatment without financial strain. One popular option is to buy Brintellix online through platforms like Polar Bear Meds, which offers the medication at a lower cost by sourcing it from Canada for U.S. customers. Additionally, new customers can buy Brintellix online with a coupon code WELCOMEPB10 at checkout, granting them a 10% discount on their first purchase. This approach not only makes the medication more accessible but also significantly eases the burden of out-of-pocket expenses.

Frequently Asked Questions

Is Brintellix the same as Trintellix?

Brintellix and Trintellix refer to the same medication, known generically as vortioxetine, but they are marketed under different brand names. Originally, the drug was introduced and sold as Brintellix. It is prescribed primarily as an antidepressant. In 2016, the brand name was changed to Trintellix. This change was implemented by the FDA to minimize confusion with another medication called Brilinta, which is a blood thinner. Despite the change in name, there were no alterations to the formulation, the conditions it treats, or the recommended dosages. Thus, Brintellix and Trintellix are essentially the same product, but with a different name after 2016 to avoid prescription errors.

Is Brintellix an SSRI or SNRI?

Vortioxetine, marketed under the brand name Brintellix, is primarily classified as a selective serotonin reuptake inhibitor (SSRI). It is prescribed for the treatment of MDD (major depressive disorder). As an SSRI, its primary mechanism involves modulating serotonin levels in the brain. This neurotransmitter plays a crucial role in mood regulation. By inhibiting the reuptake of serotonin, vortioxetine increases serotonin activity, which helps alleviate the symptoms of depression.

Do you gain weight on Brintellix?

Weight changes are a common concern with antidepressants, and Brintellix (vortioxetine) is no exception. While some antidepressants are more likely to cause weight gain, the effects of Brintellix on weight are generally considered minimal. However, there have been reports of weight gain both in post-approval patient feedback and in long-term studies. It’s important to note that individual responses can differ, and not everyone will experience weight changes. If weight gain is a concern or if significant weight changes are noticed, it’s advisable to discuss this with a healthcare provider.

Is Brintellix good for ADHD?

Brintellix, now known as Trintellix (vortioxetine), is not typically recommended for treating Attention Deficit Hyperactivity Disorder (ADHD). Its primary use is for the treatment of Major Depressive Disorder (MDD). As of current medical guidelines and FDA approvals, Trintellix has not been approved for use in managing symptoms associated with ADHD, nor is it indicated for other conditions such as anxiety, Obsessive-Compulsive Disorder (OCD), or Bipolar Disorder. Its therapeutic effects are specifically targeted towards alleviating depressive symptoms by influencing certain chemicals in the brain that contribute to mood regulation. Therefore, it would not be considered an appropriate medication for ADHD or related disorders.

Is Brintellix addictive?

No, Brintellix (vortioxetine) is not considered addictive, as it does not generally cause the compulsive drug-seeking behaviors seen with substances classified as addictive. However, it is crucial to use Brintellix strictly as prescribed by a healthcare provider. Misuse of Brintellix, such as taking higher doses or using the drug more frequently than recommended, can increase the risk of dependency. Recognizing signs of misuse early is important to prevent any potential risk of dependency.

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