Caverject

Caverject is a prescription injectable medication that contains alprostadil, a prostaglandin E1 (PGE1). It is used in adult men for the treatment of erectile dysfunction (ED). Caverject is administered as an intracavernosal injection, meaning it is injected directly into the penis, where it works locally to produce an erection. It is available only by prescription and should be used exactly as instructed by a trained healthcare provider.

What Is Caverject Injection Used For?

According to FDA prescribing information, Caverject (alprostadil) is indicated for:

• Treatment of erectile dysfunction (ED)

Key benefits of Caverject 20 mcg (20 µg) include:

• Produces an erection independent of sexual stimulation
• Acts locally, though systemic effects such as hypotension may occur
• Effective in men who do not respond to oral erectile dysfunction medications
• FDA‑approved with well‑established clinical use in erectile dysfunction management

Caverject (alprostadil) works by relaxing smooth muscle and dilating blood vessels in the penis, which increases blood flow and produces an erection. Alprostadil is a synthetic form of prostaglandin E1 (PGE1) and acts locally at the injection site.

When administered as an intracavernosal injection, Caverject:

• Relaxes trabecular smooth muscle in the corpora cavernosa
• Dilates cavernosal arteries
• Increases penile blood flow
• Produces an erection sufficient for sexual intercourse

Caverject (alprostadil) is administered as an intracavernosal injection and must be used only after proper training by a healthcare provider. You should follow the instructions provided by your prescriber. Here are general administration guidelines for Caverject:

• Caverject is injected into the corpora cavernosa of the penis.
• It is intended for self-administration only after physician instruction.
• The medication is prepared according to the product formulation (vial kit or Caverject Impulse dual‑chamber system).
• Do not use more than one dose in 24 hours or more than 3 times per week.
• Injection sites should be alternated to reduce the risk of penile injury or fibrosis.
• The first dose of this injection must be administered under medical supervision to monitor response and safety.

Caverject and Muse are both FDA-approved prescription medications that contain alprostadil and are used to treat erectile dysfunction (ED). While Caverject and Muse share the same active ingredient, they differ in route of administration, dosage form, and dosing method, which may affect patient preference and response.

According to clinical studies, Caverject (alprostadil) injection has shown a high success rate in men with erectile dysfunction when used as directed under medical supervision.

Key findings from a 6-month NIH-indexed clinical study include:

• In a 6-month self-injection study, approximately 94% of injections produced an erection sufficient for sexual activity
• About 87% of patients and 86% of partners rated the sexual activity as satisfactory
• Effective in men with erectile dysfunction caused by diabetes, vascular disease, or nerve damage
• Demonstrated benefit in patients who did not respond to oral ED medications
• An erection typically developed within 5 to 20 minutes after intracavernosal injection

These results indicate that Caverject has demonstrated effectiveness in clinical studies when used as prescribed and monitored by a healthcare professional.

This is not a complete list of Caverject side effects. If you notice other adverse reactions, tell your doctor right away.

Common Side Effects of Caverject Injection

• Penile pain (most frequent)
• Injection site pain or mild bruising
• Prolonged erection (sometimes lasting more than desired)
• Minor bleeding at the injection site

Caverject Serious Side Effects (require medical attention)

• Priapism (erection lasting more than 4 hours; can cause permanent damage if untreated)
• Penile fibrosis (scarring or curvature of the penis with repeated use)
• Hypotension (low blood pressure, dizziness, fainting)
• Hematoma or significant bleeding at the injection site

Caverject (alprostadil) dosing is individualized and must be initiated under a healthcare provider's supervision.

Caverject (alprostadil) is contraindicated in patients with certain medical conditions where its use may increase the risk of serious adverse effects. Caverject should not be used in patients who have:

• Hypersensitivity to alprostadil or any component of the formulation
• Conditions that predispose to priapism, such as:
  • Sickle cell anemia or sickle cell trait
  • Multiple myeloma
  • Leukemia
• Anatomical deformation of the penis, including:
  • Penile angulation
  • Cavernosal fibrosis
  • Peyronie’s disease
• Penile implants
• Men for whom sexual activity is inadvisable due to underlying cardiovascular conditions

Use of Caverject 20 mcg (20 µg) in these situations may result in prolonged erection, priapism, or penile injury.

What Should I Tell My Doctor Before Using Caverject?

Before starting Caverject, inform your healthcare provider if you have:

• A history of prolonged erections or priapism
• Bleeding disorders or are taking anticoagulants (risk of injection-site bleeding)
• Heart disease, stroke, or blood pressure problems
• Any penile abnormalities or prior penile surgery
• Known allergies to medications, especially prostaglandins

Before using Caverject, consider the following precautions during Caverject therapy:

• Initial dosing must be performed under physician supervision
• Use the lowest effective dose of Caverject to reduce the risk of priapism
• Do not inject more than once in 24 hours and no more than 3 times per week
• Injection sites should be rotated to help lower the risk of fibrosis and hematoma
• Use caution in patients taking anticoagulants or antiplatelet medications

The safety and effectiveness of Caverject have not been established in women or children.

Caverject (alprostadil) is administered as an intracavernosal injection and acts primarily at the site of injection. Because of the local mechanism of action, systemic drug interactions are generally limited compared to oral ED medications. Here are certain Caverject drug interactions you should be aware of:

If Caverject is not suitable or causes side effects, your healthcare provider may consider other FDA-approved alprostadil-based treatments for erectile dysfunction.

• Edex (alprostadil)
• Muse (alprostadil)

Many patients choose to buy Caverject from Canada because it is often more affordable than U.S. retail pricing while maintaining high quality and safety standards. At Polar Bear Meds, we partner with a network of licensed Canadian and international pharmacies that operate under regulated dispensing practices to help ensure medication authenticity and proper handling.

By ordering Caverject online through our pharmacy, patients may benefit from significant cost savings compared to typical U.S. pharmacy prices, along with reliable delivery and customer support.

A valid prescription from a licensed healthcare provider is required to buy Caverject from Canada. Polar Bear Meds also offers additional savings options, including:

• 10% off your first order with a Caverject coupon
• Competitive, transparent pricing
• Referral programs

• https://www.accessdata.fda.gov/drugsatfda_docs
• https://www.pfizermedical.com/caverject-impulse-alprostadil/warnings
• https://www.webmd.com/drugs/alprostadil-muse
• https://my.clevelandclinic.org/health/treatments/10051-alprostadil
• https://www.mayoclinic.org/drugs-supplements/alprostadil-intracavernosal-route/description/drg-20067404
• https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a295fc1e-d82c-4f44-bc2d-a552bf594c98&audience=consumer