Clonidine

Clonidine is a prescription medicine commonly classified as a centrally acting alpha-2 adrenergic agonist used for the treatment of hypertension (high blood pressure). It is also used to manage attention-deficit/hyperactivity disorder (ADHD) in children when using extended-release formulations.

Clonidine lowers blood pressure by activating alpha-2 receptors in the brain, which reduces sympathetic nervous system activity. It can also help manage certain neurological symptoms associated with these conditions.

Clonidine is available in various forms and strengths approved by the FDA. Currently, our pharmacy provides 0.1 mg and 0.2 mg immediate‑release tablet strengths. It should only be used with a valid prescription from a licensed healthcare provider.

Clonidine is an FDA-approved prescription medication used to treat:

• Hypertension (immediate‑release tablets and transdermal patch)
• ADHD (Attention‑Deficit/Hyperactivity Disorder) in adolescents and children ≥6 years (extended‑release tablets)

Other off-label uses, such as opioid or nicotine withdrawal, or certain pain conditions, are not FDA‑approved indications. These uses should only occur when specifically recommended and closely supervised by a licensed physician or healthcare provider.

Clonidine tablets work as a centrally acting alpha-2 adrenergic agonist. Clonidine stimulates alpha‑2 receptors in the brain, reducing sympathetic nervous system activity. This slows heart rate, relaxes blood vessels, lowers blood pressure, and reduces cardiac stress. In ADHD, Clonidine’s calming effect on the central nervous system helps improve attention, impulse control, and hyperactivity.

Clonidine dosage depends on the indication, patient age, and formulation. Always follow your doctor’s instructions exactly.

Clonidine offers several therapeutic benefits when used under medical supervision, including:

• Lowers high blood pressure by reducing nerve signals that tighten blood vessels
• Helps control symptoms of ADHD in children and adolescents (extended-release form)
• Reduces heart rate and decreases cardiovascular strain
• It may help manage withdrawal symptoms (such as from opioids or nicotine) as an off-label use
• Can aid in reducing hot flashes and certain pain conditions (off-label, provider-directed)

The best way to take Clonidine tablets is exactly as prescribed by your healthcare provider. Follow these administration guidelines to take Clonidine tablets properly while ensuring effectiveness:

• Take Clonidine by mouth with a full glass of water.
• It may be taken with or without food. If stomach upset occurs, taking it with food may help.
• Take the medication at the same time each day to maintain consistent blood levels.
• Swallow the tablet whole unless your doctor instructs otherwise.
• Do not stop Clonidine abruptly. Dose changes should be made gradually under medical supervision.
• If you miss a dose, take it as soon as you remember unless it is close to your next dose. Do not double doses.

The following information outlines important precautions, warnings, and situations in which Clonidine use may require caution or be inappropriate:

• Always follow your doctor’s instructions and consult your provider before making any changes to your dosage regimen.
• Do not stop Clonidine suddenly, as abrupt discontinuation may cause rebound hypertension, nervousness, agitation, or headache.
• Inform your doctor if you have:
  • Heart disease or a history of slow heart rate (bradycardia)
  • Low blood pressure
  • Kidney disease
  • History of stroke or fainting
• Use caution if taking other medications that lower blood pressure or cause sedation (beta-blockers, sedatives, alcohol).
• Clonidine may cause dizziness/drowsiness; avoid driving or operating any machinery until you know how Clonidine affects you.
• Use caution in elderly patients, as they might be more sensitive to blood pressure-lowering effects.
• If you are using a transdermal patch, rotate application sites weekly to avoid skin irritation.
• Monitor for mood changes; Clonidine has been linked to depression in some patients.
• Use only if the benefits outweigh the risks during pregnancy and breastfeeding, as Clonidine crosses the placenta and appears in breast milk.
• Extended‑release Clonidine is FDA‑approved for ADHD in children ≥6 years; monitor closely for sedation and cardiovascular effects.

Who Cannot Take Clonidine?

Clonidine tablets should not be taken by individuals who:

• Have a known hypersensitivity or allergy to Clonidine or any component of the formulation

Clonidine should be used only under close medical supervision in patients with:

• Severe conduction disturbances (e.g., AV block)
• Severe kidney impairment
• History of syncope (fainting)
• Concurrent use of other medications affecting heart rate or blood pressure

Taking more Clonidine than prescribed can increase the risk of serious side effects and requires immediate medical attention.

Symptoms of Clonidine overdose may include:

• Extreme drowsiness or sedation
• Low blood pressure (hypotension)
• Slow heart rate (bradycardia)
• Dizziness or weakness
• Confusion or difficulty breathing (in severe cases)

There is no specific antidote for Clonidine tablet overdose. Treatment is supportive and focuses on monitoring vital signs and managing symptoms. If you suspect a Clonidine overdose, contact Poison Control or your healthcare provider immediately.

Clonidine tablets may cause side effects ranging from mild to rare but serious reactions. This is not a complete list. Always consult your provider if you notice any unusual or severe symptoms.

If you are prescribed Clonidine tablets, follow these storage guidelines:

• Store Clonidine at room temperature (20–25°C / 68–77°F).
• Keep these tablets in their original packaging to protect them from moisture and light.
• Avoid storing Clonidine in bathrooms or damp areas.
• Do not use tablets that are damaged or discolored.
• Keep out of reach of children and pets.
• Do not use this medication after the expiration date.

Clonidine may interact with certain medications that affect blood pressure, heart rate, or the central nervous system. Always inform your provider about all prescription, over-the-counter, and herbal products you are taking.

Major Interactions (require close monitoring or avoidance)

• Beta‑blockers
  • Propranolol
  • Metoprolol
• CNS depressants
  • Benzodiazepines
  • Opioids
  • Alcohol
• Digoxin

Moderate Interactions (dose adjustment or monitoring often needed)

• Tricyclic antidepressants
  • Amitriptyline
• Other antihypertensives
  • Diuretics
  • ACE inhibitors
  • ARBs
• Calcium channel blockers (rate-lowering)
  • Diltiazem
  • Verapamil
• Sedative‑hypnotics
  • Zolpidem
  • Barbiturates
• Antipsychotics
  • Chlorpromazine
  • Risperidone

Several prescription medications can be considered as alternatives to Clonidine, depending on the condition being treated. Always use alternatives only under medical supervision.

Clonidine Alternatives for Hypertension

• Catapres (Clonidine IR)
• Tenex (Guanfacine IR)
• Aldomet (Methyldopa)
• Apresoline (Hydralazine)
• Lopressor (Metoprolol)

Clonidine Alternatives for ADHD

• Kapvay (Clonidine ER)
• Intuniv (Guanfacine ER)
• Ritalin (Methylphenidate)
• Adderall

• Get Clonidine tablets at significantly lower prices compared to typical U.S. retail pharmacies, especially for long-term use.
• All Clonidine medications are dispensed through licensed Canadian pharmacies, ensuring quality, authenticity, and regulatory compliance.
• Fast, secure shipping to the U.S. with discreet packaging and tracking for peace of mind.
• Simple online ordering with easy prescription upload and transparent checkout.
• Greater savings may be available when ordering larger quantities or using active coupon codes.
• Our dedicated customer support team is available to assist with prescriptions, orders, and questions, so you can order with confidence.

When you order Clonidine through Polar Bear Meds, you can take advantage of the following savings:

• Competitive pricing: Clonidine tablets are offered at prices often much lower than U.S. pharmacy costs (pricing varies by strength and quantity).
• Exclusive first-order discount: Use the Clonidine coupon code WELCOMEPB10 at checkout to receive 10% off your first order from Canada.
• Transparent pricing: No hidden processing or handling fees; what you see at checkout is what you pay.
• Price-match guarantee: If you find the exact same Clonidine product at a lower price from another licensed Canadian online pharmacy, we’ll match it to ensure you get the best value.
• Referral rewards program: Earn $20 in account credit for every verified referral, and your referral also gets $20 off their first order. After 10 successful referrals, receive an additional $100 account credit as a thank-you.

Actual savings may vary based on tablet strength, quantity, and current pricing at the time of order. Always review the latest pricing and available coupons on Polar Bear Meds before checkout.

• https://www.ncbi.nlm.nih.gov/books/NBK459124/
• https://www.mayoclinic.org/drugs-supplements/clonidine-oral-route/description/drg-20063252
• https://medlineplus.gov/druginfo/meds/a682243.html
• https://www.drugs.com/clonidine.html
• https://my.clevelandclinic.org/health/drugs/20986-clonidine-tablets
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/017407s034lbl.pdf