Sacubitril / Valsartan

Entresto Tablets

Entresto, a combination of sacubitril and valsartan, is FDA-approved for treating heart failure in adults and symptomatic children over the age of one. This medication works by improving heart function and reducing hospitalizations related to heart failure. Available in tablet form, Entresto tablets for heart failure treatment are prescribed with dosages adjusted according to individual health conditions and responses. Before starting Entresto, it’s important to consider potential interactions with other medications, including ACE inhibitors, ARBs, certain diuretics, and lithium, as these may require dosage adjustments. Patients should consult with their healthcare providers about all medications and supplements to avoid any harmful interactions and ensure safe, effective treatment. If you’re looking to buy Entresto tablets online, remember that a prescription from your doctor is required to ensure appropriate use for chronic heart failure treatment. Always follow medical advice to get the best outcomes with this therapy.

Product Overview

Entresto, containing sacubitril and valsartan, is primarily prescribed for heart failure treatment in adults and symptomatic children aged one year and older. This medication helps enhance heart efficiency, reduce the risk of cardiovascular death, and prevent hospitalizations. Available in tablet form, Entresto tablets for heart failure treatment come in various strengths and may be converted into an oral suspension for patients who have difficulty swallowing. For those looking to buy Entresto tablets online, it’s essential to understand that the dosage of Entresto is tailored to the individual, starting at a lower dose and potentially increasing based on the patient’s response and tolerance. 

Regular medical supervision is necessary to adjust dosages and monitor heart function, ensuring the medication works effectively. In addition to heart failure, Entresto for managing hypertension offers a valuable option for controlling high blood pressure. However, there are key drug interactions to be aware of. For instance, Entresto should not be taken within 36 hours of ACE inhibitors due to the risk of severe allergic reactions, such as angioedema. Caution is also required when combining Entresto with ARBs or certain diuretics, particularly potassium-sparing diuretics, as this can increase the risk of high blood potassium levels.

Patients who take lithium should also be aware that combining it with Entresto could lead to dangerously high lithium levels, necessitating dosage adjustments. While there are no specific food interactions noted, it is essential to consult healthcare providers before using herbs or supplements to prevent any potential negative interactions. Entresto’s efficacy in managing heart failure and hypertension, combined with its comprehensive safety profile, makes it a significant therapeutic option. However, close monitoring and careful consideration of possible drug interactions are crucial for optimizing treatment and minimizing risks.

What Are the Uses of Entresto?

Entresto, a combination of sacubitril and valsartan, is approved for use in the following groups:

• Adults with Chronic Heart Failure: It is used to reduce the risk of cardiovascular death and hospitalization due to heart failure.
• Children Ages 1 Year and Older: It is indicated for children who have symptomatic heart failure accompanied by systemic left ventricular systolic dysfunction.

What Are the Forms & Strengths of Entresto?

Entresto is available in three tablet strengths:

• 24/26 mg: Contains 24 milligrams (mg) of sacubitril and 26 mg of valsartan, which may also be referred to as the 50 mg strength (24 mg + 26 mg).
• 49/51 mg: Contains 49 mg of sacubitril and 51 mg of valsartan, which may also be referred to as the 100 mg strength (49 mg + 51 mg).
• 97/103 mg: Contains 97 mg of sacubitril and 103 mg of valsartan, which may also be referred to as the 200 mg strength (97 mg + 103 mg).

What Are the Recommended Dosage for Entresto?

The recommended dosage of Entresto depends on the patient’s condition, age and weight. Below are the dosage guidelines for adult patients with heart failure, as well as dosage recommendations for children based on age and weight:

Dosage for Heart Failure

• Starting Dosage: Initially, you will be prescribed Entresto at a dosage of 49/51 mg, to be taken twice daily.
• Adjustment Period: After 2 to 4 weeks, based on your response to the medication, your doctor may increase the dosage to 97/103 mg, also to be taken twice daily.

This approach allows your doctor to carefully monitor your response to the medication and adjust the dosage to an effective level for managing your heart failure.

Dosage for Children

• General Administration: Children aged 1 year and older typically take Entresto twice daily, similar to adults.
• Dosage Form for Young Children: For children who weigh less than 88 pounds (approximately 40 kilograms), Entresto is recommended as an oral suspension. This form allows accurate dosing using an oral syringe.
• Dosage Adjustments Based on Age and Weight: The dosage of Entresto for children is tailored based on their specific weight and age. The doctor will gradually increase the dose every 2 weeks until the optimal dosage is established for ongoing treatment.

Dosage for Children Under 88 lbs (40 kg)

• Starting Dose: The initial dosage is 1.6 mg/kg, administered twice daily.
• Adjustments: After 2 weeks, the dose may be increased to 2.3 mg/kg. Following another 2 weeks, it may be further increased to 3.1 mg/kg.
• Preparation: A pharmacist will prepare the oral suspension and provide instructions on the correct amount for your child to take.

Dosage for Children Weighing 88 lbs to 110 lbs (40 kg to 50 kg)

• Starting Dose: The usual starting dose is 24/26 mg, taken twice daily.
• Adjustments: After 2 weeks, the dose may be increased to 49/51 mg. After 4 weeks, the dose may be increased further to 72/78 mg.
• Dosing Method: The 72/78 mg dose can be achieved by taking three 24/26 mg tablets.

Dosage for Children Weighing Over 110 lbs (50 kg)

• Starting Dose: The usual starting dose is 49/51 mg, taken twice daily.
• Adjustments: After 2 weeks, the dose may be increased to 72/78 mg. After another 2 weeks, it may be increased to 97/103 mg.

These dosage adjustments are based on the child’s response to the medication under the guidance of their doctor. Always follow the specific instructions provided by your child’s healthcare provider.

Long-Term Use

Entresto is intended for long-term treatment. If both you and your doctor find that Entresto is safe and effective for your condition, you will likely be prescribed this medication for ongoing use. This approach helps ensure sustained management of your symptoms and overall health improvement under medical supervision.

[Note: Entresto’s recommendations can vary from person to person. You can discuss them with your doctor or healthcare giver, and they’ll customize your Entresto tablet dosage accordingly.]

How to Take Entresto?

Taking Entresto is crucial for treating heart failure and other cardiovascular conditions. Whether you’re just beginning your treatment, or managing a long-term condition, following these steps will help you ensure safe and effective consumption of this medication. Below is a detailed overview of how to take this medication: 

• Always take Entresto exactly as prescribed by your healthcare provider. Do not take more or less than directed.
• Entresto can be taken with or without food, depending on your preference. The absorption of the medication is not significantly affected by food.
• The typical starting dose for most patients is 49/51 mg (sacubitril/valsartan) twice daily, though this can vary based on your condition and response to treatment. Your doctor may adjust the dose based on your health status and tolerance.
• Take the tablets whole with a full glass of water. Do not crush, chew, or break the tablets, as this may alter the effectiveness or cause side effects.
• Take Entresto at the same time each day to help you remember. If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up to make up for a missed dose.
• Drink plenty of fluids while taking Entresto, unless your doctor advises otherwise. Staying hydrated helps prevent some side effects, such as dizziness or low blood pressure.
• Do not stop taking Entresto suddenly unless directed by your doctor, as this may worsen your condition.
• Regular follow-up appointments are essential to monitor your response to the medication, kidney function, and electrolyte levels (especially potassium).
• Limit alcohol intake while on Entresto, as it may increase the risk of low blood pressure and dizziness.
• Your doctor may conduct routine tests to monitor your kidney function and blood pressure while you are on this medication.

How Does Entresto Work?

Entresto combines two active ingredients to support heart function: sacubitril and valsartan. Sacubitril is part of the neprilysin inhibitor class, which targets the enzyme neprilysin, known for breaking down beneficial peptides that help your body eliminate sodium and fluid. By inhibiting neprilysin, sacubitril increases these peptides, enhancing fluid and sodium removal and easing the workload on the heart. Valsartan belongs to the class of drugs known as angiotensin II receptor blockers (ARBs). It operates by blocking the effects of the hormone angiotensin II, leading to relaxed blood vessels and improved elimination of water and salt by the kidneys. This action results in lowered blood pressure and reduced stress on the heart. Together, sacubitril and valsartan work synergistically to help the heart pump blood more efficiently throughout the body.

Important Safety Information of Entresto

What Are the Side Effects of Entresto?

Common side effects of Entresto

While it is effective in managing these conditions, it may cause certain side effects, some of which are more common than others. Below is a list of common side effects that may occur while taking Entresto, based on information from medically verified sources:

• Dizziness: This is a frequent side effect, especially during the initial stages of treatment. It may occur due to the medication’s effect on blood pressure, causing it to drop too low, particularly when standing up quickly. It’s important to rise slowly from sitting or lying positions.
• Cough: A dry, persistent cough is commonly reported by people taking Entresto. This is due to the medication’s effect on the body’s chemical balance, which can irritate the airways. If the cough is bothersome, speak with your doctor to discuss alternatives or symptom management.
• Fatigue: Feeling unusually tired or weak is a common side effect. This is often a result of the medication’s impact on the heart and circulatory system, especially when adjusting to the treatment. Maintaining good hydration and a balanced diet may help manage this symptom.
• Elevated Potassium Levels (Hyperkalemia): Entresto can increase potassium levels in the blood, leading to hyperkalemia. Symptoms include muscle weakness, fatigue, and irregular heartbeats. Regular blood tests are essential to monitor potassium levels.
• Low Blood Pressure (Hypotension): Entresto can lower blood pressure, particularly when you first start taking it or after an increase in dosage. Symptoms of hypotension include dizziness, lightheadedness, or fainting. It’s important to monitor blood pressure regularly.
• Nausea: Some people experience nausea as a side effect of Entresto, particularly when first starting treatment. This may be due to the medication’s effect on blood pressure and the body’s adjustment. Taking medication with food may reduce nausea.
• Headache: Headaches can occur as a result of changes in blood pressure, which may be a common response when beginning treatment with Entresto. If the headache persists, speak to your healthcare provider to rule out other causes or adjust your treatment plan.
• Elevated Creatinine Levels: Entresto can affect kidney function, causing an increase in creatinine levels, which is a marker for kidney health. Elevated levels might indicate that the kidneys are not functioning optimally, requiring regular monitoring.
• Diarrhea: Gastrointestinal issues such as diarrhea have been noted in some people taking Entresto. This can occur as a response to the medication affecting the gut or as a result of changes in fluid balance.
• Rash: Skin reactions, including rashes, may occur. These are typically mild, but in some cases, they may signal an allergic reaction. If you develop a rash, especially if it is severe or accompanied by other symptoms, consult your doctor.

Serious side effects of Entresto

Although serious side effects from Entresto are rare, they can occur. If you experience any of these serious side effects, contact your doctor immediately. If you believe your symptoms are life-threatening or you’re having a medical emergency, call 911 right away. Serious side effects and their symptoms may include the following:

• Hyperkalemia (High Potassium Levels): Entresto can increase potassium levels in the blood, leading to hyperkalemia. This condition can cause serious symptoms, such as muscle weakness, irregular heartbeats, nausea, and even life-threatening heart arrhythmias. Regular blood tests to monitor potassium levels are important while taking Entresto.
• Kidney Problems (Renal Impairment or Failure): Entresto may cause kidney issues, especially in people with pre-existing kidney conditions. Signs of kidney problems include dark-colored urine, swelling in the legs or feet, confusion, and reduced urine output. Kidney function should be monitored through blood tests to detect any early signs of impairment.
• Angioedema (Severe Allergic Reaction): Angioedema is a serious allergic reaction that involves swelling of the face, lips, tongue, or throat, and can impair breathing. This condition is potentially life-threatening and requires immediate medical attention if it occurs. If you notice any swelling or difficulty breathing, seek emergency care.
• Fetal Toxicity (Harm to an Unborn Baby): Entresto can cause severe harm to a developing fetus, leading to birth defects or fetal death. As a result, it is not recommended for use during pregnancy. Women who are pregnant or planning to conceive should avoid taking Entresto and consult their healthcare provider for alternative treatments.
• Severe Hypotension (Low Blood Pressure): In some cases, Entresto can cause a significant drop in blood pressure (hypotension), leading to symptoms such as dizziness, fainting, and fatigue. Severe hypotension can be dangerous, particularly in people with already low blood pressure or those who are taking other medications that lower blood pressure.
• Liver Problems: Although rare, Entresto may cause liver problems in some people, including elevated liver enzymes. Symptoms might include yellowing of the skin or eyes (jaundice), dark urine, or pain in the upper right side of the abdomen. If any of these signs occur, immediate medical evaluation is necessary.
• Severe Dehydration and Electrolyte Imbalance: Entresto can cause dehydration, especially in combination with diuretics or other medications that affect fluid balance. Dehydration may lead to symptoms like dry mouth, dizziness, and low blood pressure. Severe electrolyte imbalances can also occur, affecting heart and muscle function.
• Respiratory Problems (Breathing Difficulties): In some cases, Entresto may cause severe respiratory issues, such as shortness of breath, wheezing, or even pulmonary edema (fluid buildup in the lungs). Anyone experiencing these symptoms should seek immediate medical help.

[Note: This list may not cover all possible side effects of Entresto tablets. Always consult with your healthcare provider for medical advice about side effects.]

What Are the Warnings for Entresto Tablets?

Before starting Entresto, it’s important to discuss your medical history with your doctor. Entresto may not be suitable for you if you have certain health conditions. These include:

• Angioedema: If you have experienced angioedema with angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors previously, you are at increased risk of it recurring with Entresto. Angioedema is a serious allergic reaction that can be life-threatening. Discuss with your doctor alternative treatments for heart failure that might be safer for you.
• Allergic Reaction: If you have previously experienced an allergic reaction to Entresto or any of its ingredients, it is crucial that you avoid this medication. Allergic reactions can range from mild to severe and pose significant health risks. It’s important to consult with your doctor to discuss alternative treatments for heart failure that are safer for your specific health profile. Your doctor can recommend different medications or therapies that effectively manage your condition without the risk of an allergic response.
• Diabetes and Aliskiren: If you have diabetes and are taking the medication aliskiren (Tekturna), you should avoid using Entresto. Combining Entresto with aliskiren increases the risk of serious kidney issues, including kidney failure. It can also lead to hyperkalemia (an elevated potassium level in your blood) and hypotension (low blood pressure). These conditions can have severe health implications, so it’s crucial to discuss alternative medications with your doctor that might be safer and more effective for managing your condition.
• Severe Liver Disease: Entresto is generally not recommended for individuals with severe liver disease due to the potential for exacerbated health problems. The drug’s effects on a compromised liver can lead to worsening of the liver condition or additional complications. If you have liver disease, it is essential to consult with your doctor to evaluate whether Entresto is a suitable option for your heart failure treatment or if other therapies might pose less risk and provide better management of your condition.
• Changes in Weight: Weight gain was not observed in clinical studies of Entresto, but it is common to experience rapid weight changes when you have heart failure. An increase in weight could indicate that your heart failure is worsening, possibly because your heart is not pumping effectively and fluid is accumulating in your body. It’s important to monitor your weight daily and discuss these measurements with your doctor during each visit. If you notice sudden weight changes or if you’re concerned about your weight, consult your doctor. They can determine if your heart failure is the cause and recommend appropriate treatments.

What is the Boxed Warning for Entresto Tablets? 

FDA Warning About Risk of Fetal Harm: You should not take Entresto if you are pregnant. This medication can harm the fetus and carries a serious warning, known as a boxed warning, from the Food and Drug Administration (FDA). This type of warning is used to highlight potentially dangerous effects of a medication. Using Entresto during pregnancy can cause serious kidney problems in the child, which can be fatal. If you find out you are pregnant while taking Entresto, stop using the medication immediately and consult your doctor. Your doctor might suggest a different medication for treating your heart condition. They may also conduct ultrasound exams to monitor your and your baby’s health. If you took Entresto during pregnancy, it’s important to watch your newborn for certain conditions, which include:

• Hypotension (low blood pressure)
• Hyperkalemia (high potassium levels in the blood)
• Oliguria (producing very little urine)

What Are the Precautions of Entresto Tablets?

When taking Entresto tablets, it’s essential to be aware of certain precautions to ensure the medication is both safe and effective for you. Below is a list of important precautions to consider before starting or while taking Entresto.

• Allergy to Sacubitril or Valsartan: If you are allergic to any of the components of Entresto, such as sacubitril or valsartan, do not take the medication. Symptoms of an allergic reaction may include rash, itching, or swelling, especially around the face and throat.
• Pregnancy: Entresto should not be used during pregnancy due to the risk of fetal harm or birth defects. If you become pregnant while taking Entresto, inform your healthcare provider immediately. Alternative treatments should be considered.
• Breastfeeding: It is not recommended to breastfeed while taking Entresto, as it can pass into breast milk and may harm the baby. Consult with your healthcare provider to discuss alternatives.
• Kidney Impairment: Entresto may affect kidney function, especially in patients with pre-existing kidney disease. Kidney function should be monitored regularly through blood tests, and dosage adjustments may be necessary.
• Liver Problems: If you have liver problems, especially liver impairment, Entresto may not be suitable for you. Your healthcare provider may need to adjust your dose or recommend an alternative medication.
• Low Blood Pressure (Hypotension): Entresto can cause low blood pressure, particularly during the initial stages of treatment. If you have low blood pressure or are taking other medications that lower blood pressure, discuss this with your doctor before starting Entresto.
• Dehydration or Electrolyte Imbalance: Dehydration or imbalances in electrolytes (such as potassium and sodium) can increase the risk of side effects, including kidney problems and low blood pressure. Ensure you are adequately hydrated, and have regular blood tests to monitor your electrolyte levels.
• Angioedema (Swelling of the Face or Throat): A rare but serious side effect of Entresto is angioedema, which involves swelling of the face, lips, tongue, or throat, leading to difficulty breathing. If this occurs, seek immediate medical attention as it can be life-threatening.
• Combination with ACE Inhibitors or ARBs: Entresto should not be taken in combination with ACE inhibitors (such as enalapril or lisinopril) or other angiotensin receptor blockers (ARBs) due to an increased risk of serious side effects, including kidney failure, low blood pressure, and high potassium levels.
• Hypersensitivity to Medicines: If you have experienced hypersensitivity reactions to medications in the past, inform your healthcare provider. Entresto may cause similar reactions in some individuals.
• Monitor Potassium Levels: Entresto can increase potassium levels in the blood (hyperkalemia). Regular blood tests are required to ensure potassium levels stay within a safe range.
• Surgery or Medical Procedures: If you are scheduled for surgery, including dental procedures, inform the surgeon or dentist that you are taking Entresto, as it may interact with anesthesia or other medications used during the procedure.
• Children and Adolescents: Entresto is not approved for use in children under 18 years of age, as safety and effectiveness have not been established in this age group.

What Are the Contraindications of Entresto Tablets?

Entresto should not be used in patients who:

• Have a history of hypersensitivity to sacubitril, valsartan, or any other components of the product.
• Have experienced angioedema related to previous therapy with ACE inhibitors or ARBs.
• Are currently taking ACE inhibitors. There should be a gap of at least 36 hours between stopping the ACE inhibitor and starting Entresto.
• Have diabetes and are taking aliskiren, a renin inhibitor.

What If You Missed a Dose of Entresto Tablets?

• If you forget to take a dose of Entresto, take it as soon as you remember.
• If it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take more than one dose at a time to avoid an increased risk of side effects.
• If you are concerned about any missed doses, talk to your doctor for advice.
• To help ensure you don’t miss a dose, consider setting a reminder on your phone or using a medication timer.

[Note: If you have missed a medication dose of Entresto tablets and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

What If You Take Too Much of Entresto? 

Taking more Entresto than your doctor recommends can result in severe side effects, including hypotension (low blood pressure), which is a common symptom of an overdose. If you suspect that you have taken an excessive amount of this medication, immediate action is necessary:

Contact your doctor as soon as possible for advice. Call America’s Poison Centers or use their online tool for guidance. Seek emergency help if your symptoms are severe. Call 911 or visit the nearest emergency room immediately. Prompt response is crucial to managing the effects of an overdose effectively.

[Note: If you consumed more than the recommended Entresto dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How to Store Entresto Tablets?

Proper storage of Entresto tablets is essential to maintain their effectiveness and ensure safe usage. Whether you’re using the tablet form or the oral suspension, following the recommended storage guidelines will help preserve the quality of the medication. Below are key tips on how to store Entresto tablets and the oral suspension safely:

• Store Entresto tablets at room temperature, between 68°F to 77°F (20°C to 25°C).
• Keep tablets in a tightly sealed container to protect them from light.
• Avoid storing the medication in damp or wet areas, such as bathrooms, to prevent damage.
• If you are using Entresto as an oral suspension, store it at room temperature, between 68°F to 77°F (20°C to 25°C), for up to 15 days.
• The oral suspension should not be refrigerated. It is prepared by a pharmacist who crushes Entresto tablets and mixes them with a liquid.
• Safely dispose of any unused Entresto to prevent accidental ingestion by children, pets, and others.
• Proper disposal also prevents environmental damage. Follow local guidelines or ask your pharmacist for the best ways to dispose of medications.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Are the Interactions of Entresto Tablets?

Entresto can interact with a variety of medications, supplements, and even certain foods. These interactions can vary in their effects. Some may reduce the effectiveness of the medication, while others can increase the likelihood and severity of side effects.

Interactions with Other Medications

Before starting Entresto, it is crucial to discuss all medications you are currently taking with your doctor and pharmacist. This includes prescription drugs, over-the-counter medicines, and any vitamins, herbs, or supplements. Being open about your medication regimen helps prevent potential interactions. If you have any specific concerns or questions about how drug interactions might affect you, do not hesitate to ask your doctor or pharmacist for more information.

Interactions with Angiotensin Converting Enzyme (ACE) Inhibitors: Combining Entresto with an angiotensin-converting enzyme (ACE) inhibitor can increase your risk of angioedema, a severe type of allergic reaction. Therefore, it is advised not to take Entresto within 36 hours of using an ACE inhibitor, as this is the time needed for the ACE inhibitor to clear from your system. Some common ACE inhibitors include:

• Enalapril (Vasotec)
• Lisinopril (Zestril, Prinivil)
• Fosinopril
• Captopril
• Perindopril
• Quinapril (Accupril)
• Ramipril (Altace)
• Trandolapril

If you are currently taking an ACE inhibitor and are considering starting Entresto, it is crucial to discuss this with your doctor. They will guide you on the appropriate timing for transitioning between these two medications to minimize health risks.

Interactions with Angiotensin II Receptor Blockers (ARBs): Entresto is formulated with valsartan, a compound classified as an angiotensin II receptor blocker (ARB). This class of medication functions by blocking angiotensin II, a substance in the body that increases blood pressure. When Entresto is taken in conjunction with another ARB, it can lead to an excessive accumulation of ARB levels within the body. This elevation can significantly increase the likelihood of experiencing adverse effects associated with these medications. Common examples of ARBs include:

• Valsartan (Diovan)
• Losartan (Cozaar)
• Candesartan (Atacand)

Due to this potential for increased side effects, doctors usually do not prescribe another ARB if you are already taking Entresto. If you are currently on an ARB and are considering starting Entresto, consult your doctor. They will likely advise you to stop taking the ARB before beginning treatment with Entresto.

Interactions with Certain Diuretics: Diuretics, commonly referred to as water pills, are medications that help reduce the amount of fluid in your body. Among these, potassium-sparing diuretics prevent your body from eliminating potassium. Entresto can cause hyperkalemia, which is an elevated level of potassium in the blood. Therefore, combining Entresto with a potassium-sparing diuretic might further increase your potassium levels. Examples of potassium-sparing diuretics include:

• Spironolactone (Aldactone)
• Amiloride (Midamor)
• Triamterene (Dyrenium)
• Eplerenone (Inspra)

If you are using a potassium-sparing diuretic, it’s important to inform your doctor before starting treatment with Entresto. Your doctor will monitor your blood potassium levels to ensure they remain within a safe range during your treatment.

Interactions with Lithium: Combining Entresto with lithium (Lithobid) may cause lithium levels to increase to potentially unsafe levels in your body, leading to serious side effects. If you are taking both medications, your doctor will closely monitor your lithium levels and watch for any adverse effects. Adjustments to your lithium dosage might be necessary.

Interactions with Herbs and Supplements

There are no specific herbs or supplements known to interact with Entresto. However, it’s still important to consult your doctor or pharmacist before using any herbal or dietary supplements while you are on Entresto.

Interactions with Foods

There are no known food interactions with Entresto, meaning you can continue your usual diet unless your doctor advises otherwise.

[Note: This isn’t a complete list, and there could be other drugs that interact with Entresto. Make sure to tell your doctor or pharmacist about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Drug Alternatives of Entresto?

If you’re taking Entresto for heart failure or other cardiovascular conditions and are considering alternative treatments, several other medications may be suitable depending on your specific needs and health profile. Below is a list of drug alternatives to Entresto, each serving a unique role in managing heart failure and related heart conditions:

• Corlanor (ivabradine)
• Zestril (lisinopril)
• Prinivil (lisinopril)
• Vasotec (enalapril)
• Epaned (enalapril)
• Accupril (quinapril)
• Altace (ramipril)
• Cozaar (losartan)
• Diovan (valsartan)
• Atacand (candesartan)
• Aldactone (spironolactone)
• Inspra (eplerenone)
• Lanoxin (digoxin)
• Fosinopril
• Captopril
• Perindopril
• Trandolapril

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Entresto Tablets Cost & Coupons

The cost of Entresto tablets can vary depending on factors like your insurance plan, location, and the pharmacy you use. For some patients, the price of this heart failure medication can be quite high. Insurance coverage plays a crucial role in managing the cost, as some plans may cover Entresto, while others may not include it in their formulary. If you’re based in the USA and looking for a more affordable option to manage the cost of Entresto tablets, consider buying Entresto tablets online from Canada through Polar Bear Meds. By purchasing from Canada, you can take advantage of discounted rates, and first-time customers can enjoy a 10% discount with the coupon code WELCOMEPB10 on their first order. This is a more budget-friendly way to access the medication you need for heart failure treatment.

Frequently Asked Questions

Can I suddenly stop taking Entresto?

You can stop taking Entresto suddenly if your doctor advises it, as this is generally safe and doesn’t cause withdrawal symptoms. However, it’s important to remember that the symptoms of heart failure or the condition you were treating with Entresto might return if you discontinue the medication. Therefore, your doctor will likely suggest an alternative treatment to continue managing your condition effectively. Always consult your doctor before stopping Entresto or any other prescribed medication. An exception to this advice is if you become pregnant while taking Entresto, you should stop taking the medication immediately due to the risk of fetal harm and inform your doctor promptly to discuss alternative treatments.

Can I still exercise if I’m using Entresto?

Yes, you can definitely continue to exercise while taking Entresto. The American College of Cardiology suggests that people with heart failure can engage in a variety of activities, such as walking, rowing, cycling, climbing stairs, lifting weights, and bodyweight exercises. It’s crucial to consult your doctor to determine which exercises are most suitable for you. Staying active is an essential part of managing heart failure, and your doctor might recommend enrolling in a cardiac rehabilitation program. This program provides guidance from trained professionals who can help you exercise safely and effectively.

Can I use Entresto if I’m on dialysis?

Entresto has not been specifically studied in people with heart failure who are undergoing dialysis. Dialysis is a medical procedure that removes waste, excess water, and sometimes medications from your blood. Because of this, it is difficult to know how effective or safe Entresto is for patients on dialysis.

Additionally, Entresto binds strongly to proteins in the blood, which means it is not removed during the dialysis process. There is also a risk of serious kidney-related side effects, including kidney failure, when taking Entresto. If your kidney function is impaired and you are not on dialysis, your doctor may prescribe a lower dose of Entresto. Always consult your doctor for the most appropriate treatment advice for your specific health condition.

Will Entresto affect my BNP level?

Yes, Entresto can influence your B-type natriuretic peptide level. BNP is a hormone produced by your heart, and it is used along with another hormone called NT-proBNP to monitor heart failure through blood tests. Generally, when heart failure worsens, levels of BNP and NT-proBNP increase, and they decrease when heart failure is stable. These hormones don’t cause heart failure but serve as indicators to help your doctor assess the health of your heart and how well it’s responding to treatment with Entresto.

One of the active ingredients in Entresto, sacubitril, prevents the body from breaking down BNP, which can lead to increased BNP levels when you are taking the medication. However, sacubitril does not affect the breakdown of NT-proBNP, so levels of NT-proBNP may decrease during treatment. Your doctor will consider these effects when interpreting your test results to manage your heart failure effectively.

How long does it take to work?

After starting treatment with Entresto, it typically takes a few days before you might start observing any noticeable improvements in your symptoms of heart failure. The duration before these benefits become apparent can vary from person to person. Entresto functions by progressively enhancing the heart’s efficiency and function. Therefore, as the medication begins to take effect, it gradually improves the heart’s ability to pump blood more effectively, which can lead to a reduction in symptoms. However, the exact timeframe for experiencing these improvements can differ based on individual health conditions and the severity of heart failure.

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