Logo
Envarsus XR - Image 1

Envarsus XR

No packages found
price-match-guarantee

Price Match Guarantee

We offer competitive pricing on all our medications. Find a lower price? We'll match it from any verified Canadian online pharmacy! Know More

Similar Medications

How to Order

Ordering your medication online is simple and convenient.

STEP 01

Select the prescribed dosage and quantity, then proceed to checkout.

STEP 02

Sign in or create a new account.

STEP 03

Upload your prescription.

STEP 04

Complete your purchase by processing the payment.

Shipping takes approximately 3-5 business days.

Our Pharmacy Reviews

Read what our customers have to say about their shopping experience.

Product Details

Description

Buy Envarsus XR Online from Licensed Canadian Pharmacies

Envarsus XR (tacrolimus) extended-release tablets are a prescription immunosuppressant designed to prevent kidney transplant rejection. Its advanced once-daily formulation provides consistent drug levels, supporting long-term kidney health while simplifying medication routines. It lowers the risk of rejection and improves transplant outcomes by suppressing T-lymphocyte activity.

Patients benefit from steady bioavailability, fewer fluctuations in drug levels, and a more predictable dosing experience compared to immediate-release tacrolimus. Taken in the morning on an empty stomach, Envarsus XR is generally well-tolerated and plays a vital role in maintaining transplant success and overall quality of life. Order Envarsus XR medication online from certified Canadian sources to ensure safety and affordability.

Generic NameTacrolimus (extended-release)
Brand NameEnvarsus XR
FormsExtended-release tablets
Strengths Available0.75mg &1mg & 4mg
Packaging100 tablets per pack
Requires PrescriptionPrescription only (Rx)
Ships to the USAYes
Uses and Benefits
  • Prevents organ rejection in kidney transplant patients.

Benefits of Envarsus XR

  • The extended-release formulation enables once-daily dosing, thereby enhancing medication adherence.
  • Provides consistent and steady levels of tacrolimus in the blood throughout the day.
  • May offer better bioavailability compared to immediate-release tacrolimus formulations.
  • Helps maintain stable immunosuppression to protect the transplanted kidney.
  • Convenient dosing schedule reduces the burden of multiple daily medications.
  • May provide more predictable drug levels, potentially reducing the need for frequent blood level monitoring.
  • Can be taken with or without food, offering flexibility in administration.
  • Helps improve long-term transplant outcomes when used as part of a comprehensive immunosuppressive regimen.
  • May reduce the risk of acute rejection episodes in kidney transplant patients.
  • Allows for a better quality of life by simplifying the medication routine for transplant recipients.
Dosage

Recommended Dosage of Envarsus XR for Kidney Transplant

  • For Adults:
    • The initial dose is individualized based on previous tacrolimus therapy or as directed by a transplant specialist.
    • Typically administered once daily in the morning, on an empty stomach for best absorption.
  • Pediatric Use: Not generally recommended; safety and efficacy not fully established in children.
  • Elderly Patients: Same adult dosing; may require closer monitoring due to slower metabolism or comorbidities.

Note: Always follow your transplant physician’s dosing instructions and monitor blood levels regularly.

Usage Guide

Envarsus XR should be taken exactly as prescribed.

  • Take once daily, preferably in the morning.
  • Swallow the tablets whole; do not crush or chew them.
  • Take on an empty stomach (at least 1 hour before or 2 hours after meals).
  • Maintain consistency in timing and relation to meals.
  • Avoid grapefruit or grapefruit juice.
  • Regular blood tests are needed to adjust dosage.
  • Do not stop suddenly without consulting a doctor.
How It Works

Envarsus XR contains tacrolimus, a calcineurin inhibitor that works by suppressing the immune system. It decreases the activity of T-lymphocytes, the immune cells responsible for attacking foreign tissues. By lowering immune activity, it reduces the likelihood of the body rejecting a transplanted kidney, while its extended-release formulation ensures stable drug levels throughout the day with a single dose.

Side Effects

Common Envarsus XR side effects may include:

  • Headache
  • Nausea
  • Diarrhea
  • Constipation
  • High blood pressure
  • Tremors
  • Insomnia
  • Increased blood sugar
  • Swelling of hands or feet

Serious side effects (rare):

  • Kidney dysfunction
  • Serious infections
  • Seizures or confusion
  • Severe hypertension
  • Increased risk of cancer (lymphoma, skin cancer)

Note: Contact your healthcare provider if you experience any serious symptoms or unusual changes.

Warnings

Envarsus XR should be used with caution under medical supervision. Key warnings include:

  • Risk of serious infections due to immune suppression.
  • May increase the risk of developing lymphoma or skin cancer.
  • Kidney toxicity possible; monitor function regularly.
  • Can raise blood pressure and blood sugar levels.
  • Avoid live vaccines during therapy.
  • Grapefruit and alcohol may interfere with drug levels.
  • Use caution in patients with liver impairment.
  • Must not be interchanged with other tacrolimus formulations without medical advice.
Safety Guide

To ensure safe use of Envarsus XR:

  • Always take under the supervision of a transplant specialist.
  • Do not skip blood level monitoring.
  • Report any signs of infection (fever, chills, sore throat).
  • Monitor blood pressure and blood sugar regularly.
  • Protect skin from the sun (risk of skin cancer).
  • Avoid self-medicating with herbal supplements like St. John’s Wort.
  • Inform all healthcare providers about your use of Envarsus XR.
  • Pregnant or breastfeeding patients should consult their doctor before use.
Missed Dose

If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.

Overdose

Taking more than the prescribed dose of Envarsus XR can cause kidney damage, confusion, tremors, or severe infection risk. Seek immediate medical attention or call your poison control center if an overdose is suspected.

Storage Guide

Store Envarsus XR tablets properly to maintain effectiveness:

  • Keep at room temperature (20°C to 25°C / 68°F to 77°F).
  • Store in original packaging.
  • Protect from moisture and heat.
  • Do not refrigerate or freeze.
  • Keep out of reach of children.
  • Do not use after the expiration date.
  • Dispose of unused tablets safely through a pharmacy take-back program.
  • Do not store in bathrooms or humid areas.
Interactions

Envarsus XR interacts with several drugs that affect metabolism or immune suppression. Common interacting drugs include:

  • Prograf (tacrolimus immediate-release)
  • Neoral / Sandimmune (cyclosporine)
  • Cellcept (mycophenolate mofetil)
  • Rapamune (sirolimus)
  • Zortress (everolimus)
  • Diflucan (fluconazole)
  • Nizoral (ketoconazole)
  • Erythrocin (erythromycin)
  • Norvir (ritonavir)
  • Rifadin (rifampin)
Alternatives

Other medications used for transplant rejection prevention include:

  • Prograf (tacrolimus immediate-release)
  • Astagraf XL (tacrolimus extended-release)
  • Neoral (cyclosporine modified)
  • Sandimmune (cyclosporine non-modified)
  • Cellcept (mycophenolate mofetil)
  • Myfortic (mycophenolic acid)
  • Rapamune (sirolimus)
  • Zortress (everolimus)
Cost & Coupons

Why Buy Envarsus XR from Polar Bear Meds?

At Polar Bear Meds, we’re committed to making prescription medications like Envarsus XR more accessible and affordable for patients in the USA. Our prices are significantly lower than typical USA pharmacy retail rates without compromising on safety or quality. Every order is sourced exclusively from licensed and trusted pharmacies and undergoes complete prescription verification to ensure compliance and authenticity. We offer discreet, trackable shipping to all states in the USA, along with refill support for ongoing treatment. Our friendly customer service team is here to help you.

Cost & Coupons

Get Envarsus XR delivered straight from Canada to your doorstep in the USA. You can also save more by using the coupon code “WELCOMEPB10” for 10% off on your first order. There are no hidden handling or processing fees, as we believe in complete transparency. Looking to save even more? Join our referral program and earn a $20 credit every time you refer a friend or a family member. Your referral will also receive a $20 credit, so everyone wins. Additionally, after every 10 verified customer referrals, you'll receive a $100 credit in your account as a thank-you for spreading the word.

FAQ

Guarantee

AtPolar Bear Meds, your safety is our priority. Every order is dispensed from a fully licensed Canadian pharmacy following strict standards for quality, security, and patient care. To conveniently buy Envarsus XR from Canada at a substantial cost, call us at 1-888-779-2193 toll-free.

Important Notice

The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.

Dr. Jackson Miller

Medically Reviewed by "Dr. Jackson Miller (M.D)"

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.

Find Dr. Jackson Miller on:LinkedIn
Price matching guarantee certificate

We offer competitive pricing on all our medications. We'll match if you find a lower price on an identical product at a verified Canadian online pharmacy!

Eligibility Criteria:

  • The competitor's price must be active (no past/future sales).
  • It is only valid for Canadian online pharmacies with a verifiable address.
  • The product must match the strength, pack size, quantity, manufacturer & origin.
  • There are no price matches on used/expired medications.
  • You must submit your requests before placing an order.
  • We cannot adjust prices after purchase.
  • Request via live chat or phone before placing your order.

Need help? Call our friendly support team at 1-888-779-2193 or fill out the Contact Form