Invokamet

Invokamet is a potent combination medication prescribed for adults with Type 2 Diabetes Mellitus. It blends canagliflozin and metformin to control blood sugar effectively. Canagliflozin reduces glucose reabsorption in the kidneys, while metformin decreases liver glucose production levels and increases insulin sensitivity. Available in multiple strengths and formulations, Invokamet also helps lower the possibility of major cardiovascular events, hospitalization for heart failure & progression of kidney disease in certain patients. Always follow healthcare guidance to optimize treatment outcomes. You will need a prescription to buy Invokamet online from Canada that you can get from your doctor.

Invokamet is an advanced medication designed for enhancing glycemic control in people with Type 2 Diabetes. It combines canagliflozin and metformin, targeting multiple mechanisms to lower blood sugar levels effectively. Canagliflozin, an SGLT2 inhibitor, reduces glucose reabsorption in the kidneys, promoting its excretion, while metformin decreases glucose production in the liver and boosts insulin sensitivity in muscles. This dual approach helps optimize glucose uptake.

Available in both regular and extended-release forms, Invokamet allows for flexible dosing options, ranging from 50 mg/500 mg to 150 mg/1000 mg combinations, accommodating the diverse needs of patients, whether they are new to treatment or already on canagliflozin or metformin. Apart from managing blood sugar, Invokamet also reduces the risk of significant diabetes-related complications such as cardiovascular events, hospitalization for heart failure & progression of kidney disease, especially in those with existing heart disease and diabetic nephropathy.

Patients should take Invokamet for diabetes management as prescribed, ideally with meals, to reduce gastrointestinal side effects and maintain regular blood sugar monitoring. Potential side effects, including urinary and genital infections, should be aware of. Patients experiencing severe symptoms like lactic acidosis or ketoacidosis should seek immediate medical attention. Discuss with your doctor about the proper usage and dosage to prevent future complications and side effects before you buy Invokamet online or start your treatment with it.

Invokamet is used to treat or manage the following medical conditions:

• Type 2 Diabetes
• Reduces the chances of severe cardiovascular events (such as heart attacks & strokes) in adults with Type 2 diabetes and existing heart disease.
• Lowers the probability of hospitalization for heart failure, cardiovascular mortality & progression of kidney disease in certain adults with Type 2 diabetes & diabetic kidney disease.

What Strengths Does Invokamet Come In?

Invokamet is available in various dosage forms and strengths, combining canagliflozin with metformin. Here are the specific options:

• Regular Tablets:
  • 50 mg canagliflozin / 500 mg metformin
  • 50 mg canagliflozin / 1000 mg metformin
  • 150 mg canagliflozin / 500 mg metformin
  • 150 mg canagliflozin / 1000 mg metformin
• Extended-Release Tablets:
  • 50 mg canagliflozin / 500 mg metformin XR (extended-release)
  • 50 mg canagliflozin / 1000 mg metformin XR
  • 150 mg canagliflozin / 500 mg metformin XR
  • 150 mg canagliflozin / 1000 mg metformin XR

What Is the Typical Dosage of Invokamet?

The dosage of Invokamet for diabetes management can vary depending on your specific condition, how severe it is, and the form of the medication prescribed. Typically, your doctor will start you on a lower dose and may adjust it over time based on how you respond to the medication.

It’s important to remember that the following dosage guidelines are just general recommendations. If your doctor has prescribed a different dose for you, it’s essential not to change it on your own.

Dosage for Type 2 Diabetes Mellitus

• Initial Dosage:
• • Patients not previously treated with canagliflozin or metformin:
    • Invokamet: 50mg/500mg orally twice daily (BID)
    • Invokamet XR: Two tablets (50mg/500mg each) once daily (quay)
  • Patients currently on metformin:
    • Invokamet: One tablet orally BID, matching the total daily dose (TDD) of canagliflozin 100 mg with the current or closest suitable metformin dose
    • Invokamet XR: Two tablets once daily, matching TDD of canagliflozin 100 mg with current or closest suitable metformin dose
  • Patients currently on canagliflozin:
    • Invokamet: One tablet BID, matching the same daily dose of canagliflozin and metformin 1000 mg
    • Invokamet XR: Two tablets qDay, matching the same daily dose of canagliflozin and metformin 1000 mg
  • Patients on both canagliflozin and metformin:
    • Invokamet: One tablet BID, matching the same daily doses of canagliflozin and metformin
    • Invokamet XR: Two tablets qDay, matching the same daily doses of canagliflozin and metformin
• Maintenance Dosage: For additional glycemic control (patients with eGFR ≥60 mL/min/1.73 m^2):
  • Invokamet: For those tolerating canagliflozin 50 mg BID, increase to 150 mg BID with a gradual escalation of metformin dose based on tolerability
  • Invokamet XR: For those tolerating canagliflozin 100 mg per day, increase to 300 mg per day with a gradual escalation of metformin dose based on tolerability
• Maximum Dosage: Not to exceed a total daily dose of 300 mg canagliflozin and 2000 mg metformin

[Note: Remember, these recommendations may vary from person to person. Discuss it with your medical professional, and they’ll customize your dosage accordingly.]

Before you buy Invokamet online or start your treatment with this medication, make sure to carefully read the instructions in the patient information leaflet and the medication guide. Here are some important steps to follow when using Invokamet for diabetes management:

• Start Invokamet only on the advice of your healthcare provider. Your provider will prescribe the correct dosage based on your health condition & response to treatment.
• Take Invokamet precisely as prescribed, typically once or twice a day with meals to lower the risk of an upset stomach.
• Do not crush, chew, or break the Invokamet tablets. Swallow the tablet whole to ensure the medication is released correctly in the body.
• You should take Invokamet during meals to help lessen any gastrointestinal side effects, such as nausea or an upset stomach.
• Consistently check your blood sugar levels according to your doctor’s instructions. Invokamet doses may be adjusted based on your blood sugar test results.
• Ensure you stay hydrated while taking Invokamet, as it can cause you to urinate more often.
• Be aware of possible side effects such as genital infections, urinary tract infections, and increased urination. Report any severe or persistent symptoms to your healthcare provider.
• Maintain all scheduled appointments with your healthcare provider to evaluate the effectiveness of your treatment and make necessary adjustments.

[Note: Your doctor will determine the appropriate dosage for you based on your medical condition, following established guidelines and research on the medication. Adjustments may be made over time as necessary.]

Invokamet is a combination medication used in the treatment of type 2 diabetes, containing two active ingredients: canagliflozin and metformin. Canagliflozin works by inhibiting sodium-glucose co-transporter 2 (SGLT2) in the kidneys. This inhibition prevents glucose reabsorption back into the blood, promoting the excretion of glucose through urine and thus lowering blood sugar levels. Metformin reduces glucose production levels by the liver and heightens the sensitivity of muscle cells to insulin, enhancing glucose uptake. Together, these actions help improve glycemic control, lower blood sugar levels & lower the possibilities of diabetes-related complications when diet and exercise alone are insufficient.

Common Invokamet Side Effects: When taking Invokamet for glycemic control, you may experience some common side effects. These are usually temporary and can last anywhere from a few days to a couple of weeks. If these side effects continue for a longer period, become bothersome, or get worse, it’s important to reach out to your doctor or pharmacist to ensure everything is safe. Common side effects of Invokamet may include:

• Urinary Tract Infections (UTIs): You may experience symptoms like pain or burning while urinating, frequent urges to urinate, or cloudy, foul-smelling urine. UTIs are common with medications like Invokamet.
• Genital Yeast Infections: This could lead to itching, soreness, or a rash in the genital area, and it’s more common for people who take medications that affect blood sugar levels.
• Nausea and Vomiting: Feeling sick to your stomach (nausea) and throwing up (vomiting) can sometimes happen, especially when starting the medication. If this continues, talk to your doctor.
• Diarrhea: Some people may experience loose or watery stools, which can happen while your body is adjusting to Invokamet. Staying hydrated is important during this time.
• Increased Urination: You may find yourself urinating more often than usual, which can be a normal side effect of the medication. However, if this becomes excessive or bothersome, let your doctor know.
• Thirst: Feeling unusually thirsty or dry mouth is another common side effect. This is related to the way the medication works on your blood sugar levels and fluid balance.
• Headache: Some people may experience mild headaches. If this is frequent or severe, it’s a good idea to discuss it with your healthcare provider.
• Abdominal Discomfort: This can include mild stomach cramps, bloating, or a general feeling of discomfort in your abdomen.

Serious Invokamet Side Effects: While Invokamet for managing blood sugar levels is generally well-tolerated, it can cause some serious side effects in rare cases. If you experience any of the following, it’s important to contact your doctor immediately. If any of these symptoms seem life-threatening or if you believe you are having a medical emergency, call your local emergency number or 911 right away. Serious side effects of Invokamet may include:

• Lactic Acidosis: This is a rare but serious condition where there is too much lactic acid in the blood. It can cause symptoms like muscle pain, difficulty breathing, stomach discomfort, and extreme fatigue. If you notice these signs, it’s essential to get medical help right away.
• Ketoacidosis: A severe condition where your body makes too many ketones, which are acids in the blood. This can cause symptoms such as nausea, vomiting, abdominal pain, and trouble breathing. Ketoacidosis requires immediate medical attention.
• Kidney Problems: Invokamet can affect your kidneys, leading to sudden kidney injury or making existing kidney issues worse. Signs to watch for include swelling, changes in urination, or fatigue. Your doctor will monitor your kidney function while you are on this medication.
• Serious Urinary Tract Infections (UTIs): In some cases, a UTI can become severe and lead to a blood infection (urosepsis), which can be life-threatening. If you experience painful urination, fever, or blood in the urine, seek medical attention immediately.
• Low Blood Sugar (Hypoglycemia): This can happen, especially if you are using Invokamet with other diabetes medications. Symptoms of low blood sugar include shaking, sweating, dizziness, confusion, or fainting. It’s important to monitor your blood sugar regularly and report any unusual symptoms.
• Vitamin B12 Deficiency: Long-term use of Invokamet can sometimes lead to a drop in vitamin B12 levels, which can cause symptoms like fatigue, weakness, and nerve problems (like tingling or numbness). Your doctor may recommend regular monitoring of your vitamin B12 levels.
• Severe Joint Pain: Some people may experience severe pain in their joints, which can affect their mobility. If this occurs, consult your doctor for proper treatment.
• Increased Risk of Bone Fractures: Invokamet can increase the risk of bone fractures, particularly with long-term use. If you notice bone pain, or if you are more prone to breaking bones than usual, talk to your doctor.
• Allergic Reactions: Some people may have serious allergic reactions, including symptoms like swelling of the face, lips, tongue, or throat, which could make breathing difficult. Anaphylaxis is a severe allergic reaction that requires immediate medical attention.
• Increased Risk of Lower Limb Amputation: This is especially a concern for people who have cardiovascular disease. If you notice unusual pain, sores, or infections in your legs or feet, seek medical help as soon as possible.

[Note: This enumeration may not encompass all potential side effects. Always seek guidance from your healthcare professional for advice on side effects.]

Invokamet is used alongside diet and exercise to improve blood sugar control levels in adults with type 2 diabetes. However, it’s associated with several serious health risks, which may be heightened in certain groups. If you have concerns, discuss alternative treatments with your healthcare provider.

• Lactic Acidosis: Metformin in Invokamet can cause lactic acidosis, a severe condition where too much lactic acid builds up in the blood. Inform your doctor about your medical history and current medications. Reach out for immediate medical attention if you experience symptoms like difficulty breathing, stomach upset, extreme weakness or tiredness, feeling cold, or unusual muscle pain.
• Amputation Risks: Invokamet may increase the risk of leg and foot amputations. Be vigilant for new pain, tenderness, sores, ulcers, or infections on your legs or feet, and consult your healthcare provider promptly.
• Ketoacidosis: Some patients have developed ketoacidosis, a severe condition that makes the blood too acidic. Monitor for symptoms like dry mouth, fruity breath odor, nausea, vomiting, abdominal pain, or difficulty breathing. Seek emergency care if these symptoms occur.
• Dehydration & Low Blood Pressure: Dehydration can lead to kidney function and blood pressure problems. Stay hydrated and report symptoms like dizziness or reduced urine output to your provider.
• Genital and Urinary Tract Infections: These can raise the risk of severe infections that might require hospitalization. Symptoms such as frequent or painful urination, lower abdominal pain, or discomfort in the genital area should prompt you to contact your healthcare professional.
• Hypoglycemia: Invokamet for managing blood sugar levels can cause low blood sugar, primarily when used with other diabetes medications. Symptoms include anxiety, shakiness, confusion, a fast heartbeat, and hunger. Monitor your blood sugar levels regularly.
• Severe Allergic Reactions: Rarely, severe allergic reactions can occur. Symptoms include rash, hives, breathing difficulties, or swelling of the face, lips, or throat. Seek immediate medical assistance if these symptoms develop.
• Bone Fractures: There is an elevated risk of bone fractures starting as early as three months after beginning treatment. Discuss bone health strategies with your healthcare provider.
• Low Vitamin B12 Levels: Monitoring is essential as low levels can lead to anemia. Symptoms to watch for include low energy, muscle weakness, reduced appetite, and tingling in extremities. Routine blood tests are recommended to monitor B12 levels.

Is There a Black Box Warning for Invokamet?

Invokamet carries an FDA Boxed Warning, the strongest warning the FDA requires. This warning highlights significant risks that may be associated with the medication. Here are the critical aspects of the boxed warning for Invokamet for managing blood sugar levels:

• Lactic Acidosis:
  • Risk: Metformin, a key ingredient in Invokamet, can cause a rare yet severe condition known as lactic acidosis. This condition involves an accumulation of lactic acid in the blood, which can be life-threatening.
  • Symptoms: Symptoms of lactic acidosis include unusual muscle pain, extreme fatigue or weakness, difficulty breathing, significant drowsiness, abdominal pain, nausea or vomiting, chills, dizziness or lightheadedness, and a slow or irregular heartbeat.
  • Action: Patients are advised to get medical attention quickly if they experience any symptoms of lactic acidosis.
• Lower Limb Amputation:
  • Risk: Canagliflozin, another component of Invokamet, has been associated with an elevated risk of lower limb amputations, primarily of the toe and midfoot; however, leg amputations above and below the knee have also occurred.
  • Recommendation: Patients should be monitored for signs and symptoms of infection, new pain or tenderness, sores or ulcers involving the lower limbs, and promptly evaluated if such symptoms develop.

When considering treatment with Invokamet for managing blood sugar levels, patients should discuss every risk and benefit with their medical practitioner. Here are some of the precautions that you can take before using Invokamet:

• Allergies: Do not use Invokamet for glycemic control if allergic to canagliflozin or metformin.
• Severe Kidney Disease: Avoid if you have severe kidney disease.
• Ketoacidosis: Do not use it if you have ketoacidosis; consult your doctor for treatment instead.
• Medical Imaging: Temporarily stop taking Invokamet if undergoing an X-ray or CT scan requiring dye injection.
• Heart Issues: Inform your doctor if you have heart problems.
• Diabetic Foot Complications: Report any history of diabetic foot ulcers or amputations.
• Circulation and Nerve Problems: Disclose any circulation or nerve issues in your legs or feet.
• Liver or Kidney Disease: Ensure your doctor knows of any liver or kidney diseases.
• Nutritional Deficiencies: Discuss low levels of vitamin B12 or calcium in your blood.
• Urinary Issues: Mention any bladder infections or urination problems.
• Pancreatic Conditions: Tell your doctor about any pancreas disorders or surgeries.
• Dietary Changes: Inform your doctor if your diet has changed or you are on a low-salt diet.
• Lactic Acidosis Risk: Understand the risk factors for lactic acidosis, especially if you have other medical conditions, chronic alcoholism, or are 65 or older.
• Pregnancy: Notify your doctor immediately if you become pregnant; canagliflozin may harm the baby if taken during the second or third trimester.
• Ovulation Stimulation: Be aware that metformin may stimulate ovulation, increasing the risk of unintended pregnancy.
• Breastfeeding: Do not breastfeed while using Invokamet.
• Age Limitation: Invokamet is not approved for use by anyone under 18.

Invokamet has specific contraindications where its use should be avoided because of the potential risk for severe adverse effects or interactions. Here are the critical contraindications for Invokamet for glycemic control:

• Renal Impairment or Disease: Invokamet is contraindicated in patients with severe renal impairment (eGFR below 30 mL/min/1.73 m²), end-stage renal disease, or patients on dialysis due to the risk of lactic acidosis from metformin accumulation.
• Metabolic Acidosis, Including Diabetic Ketoacidosis: Invokamet should not be used in patients with metabolic acidosis, including diabetic ketoacidosis (a severe complication of diabetes).
• Hypersensitivity: Invokamet is contraindicated in patients with hypersensitivity to canagliflozin, metformin, or any of the formulation’s excipients. Hypersensitivity reactions may include anaphylaxis, angioedema, rash, or urticaria.
• Liver Disease: While not explicitly contraindicated, caution is advised when using Invokamet for managing blood sugar levels in patients with liver impairment due to the potential risk of lactic acidosis from metformin.

To store your medication properly especially when you buy Invokamet online, you should follow the mentioned instructions below:

• If you remember the missed dose soon after it was due, take it as soon as you remember.
• If it’s almost time for your next scheduled dose, drop the missed dose. Do not take a double dose of Invokamet to compensate for the missed one.
• Continue with your regular dosing schedule after missing a dose to maintain consistent medication levels in your body.
• Pay close attention to your blood sugar levels after missing a dose, as fluctuations may occur.
• If you frequently miss doses, discuss this with your healthcare provider. They may offer tips or tools to help you remember your medication.

[Note: If you have missed a dose of Invokamet and are unsure when to take the next one, immediately consult your healthcare professional or pharmacist.]

Taking too much Invokamet for diabetes management can lead to serious health complications. Here’s what could happen if you overdose on Invokamet:

• Hypoglycemia (Low Blood Sugar): Since Invokamet helps to lower blood sugar, an overdose may lead to dangerously low blood sugar levels, which can result in symptoms such as shakiness, sweating, confusion, blurred vision, and even loss of consciousness.
• Lactic Acidosis: One of the components of Invokamet, metformin, can result in a rare but severe condition named lactic acidosis, especially if too much is ingested. When lactic acid accumulates in the blood, it can lead to symptoms including muscle pain, weakness, trouble breathing, stomach pain, nausea, and vomiting.
• Dehydration and Electrolyte Imbalance: Canagliflozin, another component of Invokamet, increases glucose excretion in the urine, leading to dehydration and electrolyte imbalances when taken in excess.
• Kidney Problems: Overdose might exacerbate any pre-existing kidney issues or potentially trigger new renal complications due to the drug’s effects on kidney function.

[Note: If you have consumed more than the recommended dose of Invokamet, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

Properly storing Invokamet is important to make sure the medication stays safe and works well. If you decide to buy Invokamet online, follow these easy storage guidelines to keep it effective:

• Store Invokamet at room temperature, typically between 20°C to 25°C. Avoid exposing the medication to extreme temperatures.
• Keep the medication in its original packaging until use to protect it from moisture and light. Do not store Invokamet in areas like the bathroom where it can be exposed to damp conditions.
• Ensure that Invokamet is kept in a secure place that is out of the reach of children and pets.
• Do not freeze Invokamet. Keep it in a cool, dry place where the temperature is stable.
• Check the expiry date on the Invokamet packaging regularly, and do not use the medication past its expiration date. Expired medicines should be disposed of properly.
• If you need to dispose of Invokamet, do not throw it in the trash or flush it down the toilet. Contact your pharmacy or your local waste management authorities to learn about take-back programs.

[Note: Discuss with your healthcare expert the proper disposal of unused medication and any questions you may have regarding its storage.]

Invokamet interacts with various medications, which can affect how well Invokamet works or increase your risk of severe side effects. Here are some fundamental medication interactions to be aware of:

• Diuretics (Water Pills): Loop diuretics, mainly when used with Invokamet, can increase the risk of dehydration and low blood pressure.
• Insulin and Insulin Secretagogues (such as sulfonylureas): These can elevate the chances of hypoglycemia (low blood sugar). Dose adjustments may be necessary when used with Invokamet.
• Blood Pressure Medications: Invokamet can enhance the effects of drugs that lower blood pressure, potentially increasing the risk of hypotension (low blood pressure).
• NSAIDs (Nonsteroidal Anti-Inflammatory Drugs): These can affect kidney function & increase the risk of kidney problems when taken with Invokamet.
• Rifampin: This antibiotic can decrease the blood levels of canagliflozin, reducing its effectiveness.
• Digoxin: Invokamet can increase the digoxin levels in your body, necessitating monitoring and possible dose adjustment.
• Anticonvulsants (such as phenytoin and phenobarbital): These drugs can decrease the blood levels of canagliflozin, reducing its effectiveness.
• HIV Medications (ritonavir, efavirenz): Some HIV medications can affect the levels of canagliflozin, impacting its efficacy and safety.
• Steroids: These can increase blood sugar levels and potentially decrease the effectiveness of Invokamet.
• Beta-Blockers: While beta-blockers can mask some of the symptoms of hypoglycemia, they can still be used cautiously.

Are There Any Other Interactions of Invokamet?

In addition to other medications, certain foods, drinks, herbal remedies, and lifestyle choices can affect how Invokamet for managing blood sugar levels works. It’s important to be aware of these factors, as they can either increase the risk of side effects or reduce the effectiveness of the medication. Here’s how they can impact your treatment:

• Food and Drink:
• • High-Carb or High-Sugar Foods: Invokamet works by helping your body use sugar more effectively. If you eat a lot of high-carb or sugary foods, it may make it harder for Invokamet to control your blood sugar levels. This can interfere with the effectiveness of the medication.
  • Alcohol: Drinking alcohol while on Invokamet can increase your risk of serious side effects like low blood sugar (hypoglycemia). Alcohol can also affect your kidneys, which may be a concern since Invokamet is processed through the kidneys. It’s best to limit alcohol consumption and consult your doctor about safe drinking habits while on this medication.
• Herbal Remedies and Supplements: Some herbal supplements and vitamins can interact with Invokamet and either make it less effective or increase the risk of side effects. For example:
  • St. John’s Wort: This herbal remedy, often used for depression, can lower the levels of Invokamet in your body, making it less effective in managing blood sugar.
  • Ginseng: Some forms of ginseng can affect blood sugar levels, potentially interfering with how Invokamet works.

[Note: This is not a complete list, and there could be other drugs that interact with Invokamet. Make sure to tell your medical professional about any prescription, over-the-counter medicines & herbal products you’re taking.]

Invokamet combines two active ingredients, canagliflozin (an SGLT2 inhibitor) and metformin. If you’re looking for alternatives to Invokamet for diabetes management, several other medications or combinations can be considered, depending on individual patient needs, tolerability, and the specific recommendation of a healthcare provider. Here are some common and affordable Invokamet for type 2 diabetes alternatives:

• Jardiance (empagliflozin)
• Farxiga (dapagliflozin)
• Januvia (sitagliptin)
• Tradjenta (linagliptin)
• Onglyza (saxagliptin)
• Victoza (liraglutide)
• Ozempic (semaglutide)
• Trulicity (dulaglutide)
• Actos (pioglitazone)
• Avandia (rosiglitazone)
• Glucotrol (glipizide)
• DiaBeta (glyburide)
• Glynase (glyburide)
• Amaryl (glimepiride)
• Janumet (sitagliptin/metformin)
• Kombiglyze XR (saxagliptin/metformin XR)
• Jentadueto (linagliptin/metformin)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

The cost of Invokamet for diabetes management can vary widely depending on your prescription drug insurance coverage. If your insurance plan covers prescription medications, it’s important to check whether Invokamet is included and understand your cost responsibilities, which could be a fixed copay or a percentage of the medication’s price. However, not all insurance plans cover Invokamet. Many people seek alternative purchasing options to manage costs. One effective option is to buy Invokamet online from Canada, which often offers more affordable pricing. Purchasing affordable Invokamet for type 2 diabetes from Canadian pharmacies can be cost-effective for those in the USA. At Polar Bear Meds, a trusted Canadian medication provider, you can use the Invokamet coupon code “WELCOMEPB10” to receive a 10% discount on your first purchase of Invokamet.

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