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Irbesartan is an FDA-approved angiotensin II receptor blocker used to treat hypertension and protect kidneys in people with type 2 diabetes mellitus nephropathy. It is available as a tablet in strengths of 75, 150, and 300 mg, typically once daily, with or without a meal. It works by blocking a substance that tightens blood vessels and helps relax it. You should consult a licensed medical professional before starting to take the medication for safe and effective use. If you have any queries or concerns regarding usage, dosage, storage, and more, feel free to ask them. To ensure the medication you are using is authentic, you can buy Irbesartan online from trusted and reliable sources. 

Irbesartan Overview

Irbesartan is an ARB, or angiotensin II receptor blocker, used to treat hypertension and protect the kidneys in patients with diabetes and nephropathy. By blocking a substance that tightens blood vessels, Irbesartan helps relax blood vessels, lower blood pressure, and increase the blood and oxygen supply to the heart. It is available in tablet form with 75, 150, and 300 mg strengths. It is typically taken once daily, with or without food. 

For adults, the initial recommended dose for hypertension is usually 150 mg daily, which may be increased to 300 mg. For diabetic nephropathy, the standard dose is 300 mg daily. This medication is not recommended for children under 18 years old. Geriatric patients may require a lower dose due to slower drug processing.

Common side effects include diarrhea, dizziness, heartburn, and tiredness. Severe side effects can include allergic reactions, kidney problems, high potassium levels, liver issues, and low blood pressure. 

Patients should avoid taking Irbesartan if pregnant or planning to become pregnant. Missed doses should be taken as soon as remembered, but double dosing should be avoided. In case of a medication overdose, seek immediate medical help. Store Irbesartan at room temperature, away from light, moisture, and heat. Do not freeze or store in the bathroom. Keep out of reach of children and pets. Proper disposal of unused medication is essential, and a medicine take-back program is recommended. See your doctor or healthcare provider if you have any concerns or questions regarding using Irbesartan.

Uses of Irbesartan

It is used to:

  • Treat hypertension (high blood pressure)
  • Sometimes treat heart failure. 
  • Protect the kidneys of people with diabetes and nephropathy, a type of kidney disease. 

Irbesartan Dosage

Irbesartan is available in the form of a tablet that is to be taken orally by mouth. It comes in the following strengths:

  • 75 mg
  • 150 mg 
  • 300 mg 

Recommended Dosage for Different Patients

For hypertension 

  • Adults: The typical initial dosage is 125 mg once daily. Your doctor may gradually increase your dosage to 300 mg daily.
  • Pediatric patients: The safety and efficacy of this medication have not been established in children under six years old, so it is not recommended for use in anyone under 18 without consulting your doctor. 
  • Geriatric patients: The bodies of elderly patients over 65 may process the drug more slowly, requiring a lower dosage or a different treatment schedule. 

For Diabetic Nephropathy in Individuals With Diabetes Mellitus Type 2

  • Adults: The typical initial dose is 300 mg once daily. 
  • Pediatric patients: The medication’s safety and efficacy have not been established in children under six years of age, so it is not recommended for use in individuals under 18 without consulting a licensed healthcare professional.
  • Geriatric patients: The bodies of elderly patients aged more than 65 may process the drug more slowly, so they require a lower dose or a different treatment schedule.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take Irbesartan?

  • Irbesartan comes in the form of a tablet that is taken orally by mouth once daily, with or without a meal. 
  • You should maintain consistency in dosage, and to help you remember to take the medication regularly, you should try to take it around the same time every day. 
  • Before starting to take the medication, you should carefully read and follow the instructions for use that came with it. 
  • If you do not understand any part of the patient information leaflet, ask your physician or pharmacist to explain it to you. 
  • You should take Irbesartan exactly as your doctor directs. 
  • You should not take this medication more or less than prescribed, in large quantities, or more frequently. 
  • Your doctor may ask you to start taking the medication at a low dose initially, which will be gradually increased when your doctor determines that it is working well for you. 
  • Irbesartan controls hypertension but does not cure it. It may take around fourteen days to start noticing the full benefits of the medication. 
  • Do not stop taking Irbesartan without consulting your doctor. Continue taking this medication even if you feel well. People with hypertension don’t usually feel any symptoms. 
  • You may need to use medications for hypertension for the rest of your life. Treatment for managing high blood pressure may also include exercise, diet, controlling diabetes, and not smoking. 
  • While you are receiving treatment with this medication, you may need to check your blood pressure regularly and report to your doctor. Your kidney function may also need to be checked frequently to look for any unwanted side effects.
  • If you are sick with diarrhea or vomiting or if you are sweating more than usual, call your doctor immediately. 
  • Keep Irbesartan at room temperature and away from light, moisture, and heat. 
  • You should not take salt substitutes containing potassium without consulting your doctor. If your doctor has recommended a low-salt or low-sodium diet, you should follow their instructions carefully. 
  • Let your doctor know if your condition does not improve or if it worsens even after taking Irbesartan for more than two weeks. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Irbesartan Work?

Irbesartan is an ARB or angiotensin II receptor blocker used to treat high blood pressure & protect the kidneys from damage due to diabetes. It blocks a substance in the body that causes blood vessels to tighten. As a result, it relaxes blood vessels, reducing blood pressure and increasing the oxygen and blood supply to the heart. By allowing the kidneys to eliminate extra water and salt, Irbesartan helps improve kidney function.

Irbesartan Side Effects

Common side effects of Irbesartan may include:

  • Diarrhea 
  • Dizziness
  • Heartburn 
  • Excessive tiredness

Mild side effects of Irbesartan may include:

  • Bladder Pain
  • Chest Pain
  • Difficulty, Burning, or Painful Urination
  • Fast, Pounding, or Irregular Heartbeat
  • Lower Back or Side Pain

Serious side effects of Irbesartan may include:

  • Allergic reactions: Swelling of face, lips, tongue, or throat; difficulty breathing; hives
  • Kidney problems: Changes in urination, swelling in feet/ankles
  • High potassium levels: Irregular heartbeat, muscle weakness
  • Liver problems: Yellowing of skin/eyes, dark urine, abdominal pain
  • Low blood pressure: Dizziness, fainting

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Irbesartan Warnings

  • Do not take Irbesartan if you are pregnant or planning to become pregnant. If you become pregnant, you should discontinue the use of this medication and tell your doctor right away. 
  • If you have diabetes type 1 or type 2, you should not take Irbesartan with any medication that contains Aliskiren, which is a blood pressure medication. 
  • Do not share your medications with others, even if they have the same symptoms as you. 

Irbesartan Boxed Warning

Irbesartan has a black box warning stating the risk of fetal harm from this medication. You should not take this medication if you are pregnant, suspect a pregnancy, or if you plan to become pregnant. Irbesartan may harm the unborn baby or terminate your pregnancy. If you get pregnant while taking Irbesartan, tell your doctor immediately.

Irbesartan Precautions

  • Before taking this medication, tell your doctor if you have an allergy to Irbesartan, any other medication, or any of the inactive ingredients present in the medication. Consult your doctor or pharmacist for the complete list of ingredients. 
  • Before taking Irbesartan, you should share your complete medical and personal history with your doctor, especially if you have diabetes and are taking Aliskiren. It is most likely that your doctor will not tell you to take Irbesartan if you have diabetes and are also taking Aliskiren. 
  • To prevent any unwanted drug interaction, you should tell your physician, pharmacist, or healthcare provider about all the medications you are using, including all prescription, non-prescription, and over-the-counter drugs and herbal supplements you may be taking or planning to take.
  • Before taking this medication, tell your doctor or pharmacist if you have or ever had kidney disease or heart failure. 
  • It is not known whether this medication passes into your breast milk. If it does, it may cause harm to the nursing infant. Tell your doctor before breastfeeding while taking this medicine. 
  • You should know that this medication may cause lightheadedness, dizziness, and fainting when you try to get up too quickly after lying down. This is more common during the initial days of starting treatment with Irbesartan. To prevent this, you should slowly get out of your bed, resting your feet on the ground for a while before standing up. 
  • Your doctor may ask you to undergo certain tests to check your body’s urea, potassium, and creatinine levels. 
  • You should avoid taking anti-inflammatory medications along with Irbesartan without consulting your doctor. 
  • Do not abruptly stop taking Irbesartan without consulting your doctor, as it may cause your condition to worsen. 

Irbesartan Contraindications

Irbesartan is contraindicated for use in patients who have:

  • Pregnancy
  • Hypersensitivity
  • Concomitant use with aliskiren
  • Bilateral renal artery stenosis
  • Severe hepatic impairment
  • Hypovolemia or sodium depletion
  • Primary hyperaldosteronism

Irbesartan Missed Dose

  • To get the best results from your medication, you should maintain consistency in dosage and try to take it around the same time every day. 
  • If you forget to take a dose of Irbesartan, you should take it as soon as you remember. 
  • If it is almost time to take your next dose, you may omit the missed dose and continue taking your medication as per your regular dosing schedule. 
  • You should only take one dose at a time. Do not simultaneously take double or extra doses of the same medication to compensate for the missed dose, as it can cause unwanted side effects. 

[Note: If you have missed a medication dose and are still determining when to take the next one, immediately consult your doctor or pharmacist.]

Irbesartan Overdose 

If you take Irbesartan more than prescribed, in large quantities, or more frequently than recommended, it can cause harm. If you take too much of this medication, you may have the following symptoms:

  • Weakness
  • Pounding heartbeat
  • Dizziness 

If you suspect an overdose, you should call your doctor or seek immediate medical assistance by calling 911. You can also seek guidance from the poison control helpline. If you are experiencing severe symptoms such as passing out, difficulty breathing, and seizures, you can also head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

Irbesartan Storage

  • Store Irbesartan at a controlled room temperature away from direct sunlight, excess heat, or moisture. 
  • Do not keep the medication in the bathroom or inside the car, as excess temperatures can cause harm to the medication, making it less effective. 
  • Do not allow the medication to freeze. 
  • Keep all medication, including Irbesartan, in a safe place, away from the sight and reach of children and pets. 
  • Do not keep medications that are outdated or no longer needed. Discard them safely. 
  • Do not pour it down the drain, throw it in wastewater or household garbage bin, or flush it down the toilet. 
  • Dispose of unwanted medications in such a way that children, animals, and others cannot consume them. 
  • The best way to eliminate unwanted medications is to give them away in the medicine take-back program. 
  • For more information on how to properly dispose of unwanted medications, consult your healthcare provider, pharmacist, or local waste disposal company. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Irbesartan Interactions

  • Aliskiren 
  • Other ARBs, such as:
    • Valsartan 
    • Candesartan 
    • Losartan 
  • Angiotensin-converting enzyme (ACE) inhibitors, such as: 
    • Lisinopril 
    • Enalapril 
    • Captopril 
  • Lithium
  • Nonsteroidal anti-inflammatory drugs such as ibuprofen, naproxen
  • Potassium supplements
  • potassium-sparing diuretics, such as:
  • Amiloride 
  • Triamterene 

[Note: This isn’t a complete list, and there could be other drugs that interact with Irbesartan. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Irbesartan Alternatives

  • Avapro (Irbesartan)
  • Katerzia (amlodipine)
  • Norliqva (amlodipine)
  • Norvasc (amlodipine besylate)
  • Prinivil (lisinopril)
  • Qbrelis (lisinopril)
  • Zestril (lisinopril)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Can Irbesartan be used in patients with renal impairment?

Irbesartan can be used in patients with renal impairment, but dosage adjustments may be necessary depending on the severity of the impairment. Monitoring kidney function regularly is crucial, as Irbesartan can affect renal function, particularly in patients with existing kidney issues.

How does Irbesartan interact with potassium supplements or potassium-sparing diuretics?

Irbesartan can increase potassium levels in the blood. When taken with potassium supplements or potassium-sparing diuretics, there is a risk of hyperkalemia or high potassium levels. Patients should regularly monitor their potassium levels and consult their physician or healthcare provider before taking these supplements or medications concurrently.

What are the long-term effects of taking Irbesartan?

Long-term use of Irbesartan has been shown to effectively manage hypertension and protect kidney function in patients with diabetes mellitus type 2 & nephropathy. However, long-term usage requires regular monitoring of kidney function, potassium levels, and blood pressure to avoid potential adverse effects such as hyperkalemia and renal impairment.

Is Irbesartan effective for heart failure treatment?

Irbesartan is sometimes used off-label to treat heart failure, particularly in patients who cannot tolerate angiotensin-converting enzyme (ACE) inhibitors. However, it is primarily indicated for hypertension and diabetic nephropathy. A healthcare professional should evaluate the effectiveness and safety of Irbesartan for heart failure on a case-by-case basis.

Can Irbesartan cause weight gain or loss?

Weight changes are not commonly associated with Irbesartan. However, any unusual weight changes should be reported to a healthcare provider, as they could indicate other underlying health conditions or side effects. Regular monitoring and a healthy lifestyle can help manage weight effectively while on Irbesartan.

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