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Linagliptin, Metformin Hydrochloride 


Jentadueto is a combination of antidiabetic medication that is available for patients suffering from type 2 diabetes. These oral tablets help in the management of blood sugar levels in adults. One can find this medication in the form of immediate-release and extended-release oral tablets. Besides, it also prevents kidney damage, blindness, loss of limbs, and nerve problems. Its dosage can vary depending on the patient’s tolerability and condition. Usually, doctors advised to take this medication by mouth twice daily. However, it is important to note that Jentadueto is not advised for people with type 1 diabetes. You can discuss detailed information with your healthcare practitioner.

Product Overview

Jentadueto is a prescription medication designed to manage type 2 diabetes. It contains two active ingredients: linagliptin and metformin. Linagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4), and metformin, a biguanide, work together to control blood sugar levels. This FDA-approved medication is used in combination with diet and exercise for effective management of type 2 diabetes.

Jentadueto is available in two strengths, 2.5 mg linagliptin combined with 800 mg metformin and 2.5 mg linagliptin along with 1000 mg metformin. It should be taken exactly as prescribed by a healthcare provider, typically twice daily, with meals to reduce gastrointestinal side effects. It is suitable for adult patients with type 2 diabetes as the medication improves the body’s ability to use insulin effectively and reduces blood sugar levels post-meals, ultimately lowering HbA1c levels.

However, there are certain side effects of Jentadueto, including gastrointestinal symptoms like nausea, diarrhea, and stomach discomfort. It is crucial to talk to a medical practitioner if any side effects persist or worsen. People should inform their healthcare provider about any allergic reactions or pre-existing conditions before starting Jentadueto. In case of a missed dose, take it as soon as remembered unless it is near the time for the next dose. Avoid doubling doses. Overdose requires immediate medical attention. Store Jentadueto at room temperature, away from direct sunlight and moisture. Always follow the doctor’s advice and maintain regular monitoring of blood glucose levels when starting this treatment. For complete information and personalized advice, consult your healthcare provider to ensure Jentadueto is the right choice for your diabetes management.

Uses of Jentadueto

Jentadueto has the following uses:

  • Blood Sugar Control: It helps lower blood glucose levels in people with type 2 diabetes.
  • Combination Therapy: It is used in combination with other diabetes medications or insulin to improve blood sugar control.
  • Reduction of HbA1c: Helps reduce HbA1c levels, which helps in long-term blood glucose control.
  • Prevention of Complications: Aids in preventing problems associated with high blood sugar levels, like nerve and kidney damage, along with eye problems.
  • Improvement of Glycemic Control: Enhances overall glycemic control by improving the body’s ability to use insulin more effectively.
  • Post-Prandial Glucose Reduction: Reduces blood sugar spikes that occur after meals.
  • Convenient Dosing: Offers a convenient dosing regimen, as it is a combination of two medications (linagliptin and metformin) in a single tablet.

How to Use Jentadueto?


Strengths and Forms

Jentadueto comes in an oral tablet form with the following strengths:

Immediate-Release Oral Tablet

  • Linagliptin of 2.5 mg/Metformin of 500 mg
  • Linagliptin of 2.5 mg/Metformin of 850 mg
  • Linagliptin of 2.5 mg/Metformin of 1,000 mg

Extended-Release Oral Tablet

  • Linagliptin of 2.5 mg/Metformin of 1,000 mg
  • Linagliptin of 5 mg/Metformin of 1,000 mg

Recommended Dosage for Different Patients

For Extended-Release Tablets


  • Patients taking metformin alone are recommended to add 5 mg of linagliptin to the existing metformin dose. The dosage will not remain fixed as your doctor may adjust them to achieve a controlled blood sugar level. However, the daily dose will not exceed 5 mg of linagliptin & 2000 mg of metformin.
  • Patients taking just linagliptin are advised to start with one 5 mg tablet of linagliptin and 1000 mg of metformin once daily. Later, your doctor may increase the dose gradually until your blood sugar is controlled. Usually, the maximum daily dose is 5 mg of linagliptin and 2000 mg of metformin.
  • Patients taking Jentadueto are recommended to take the same dose of metformin with 5 mg of linagliptin. Your doctor may modify the dose until your blood glucose level is appropriate. The highest daily dose is 5 mg of linagliptin and 2000 mg of metformin once a day.


  • Your healthcare professional determines the usage and dose of Jentadueto.

For Immediate-Release Tablets


  • Patients taking metformin alone are advised to use the same dose as the doctors prescribed. The dosage will not remain fixed as you doctor may adjust them to achieve a controlled blood sugar level. However, the daily dose will not exceed 2.5 mg of linagliptin & 1000 mg of metformin twice a day.
  • Patients taking linagliptin alone are advised to start with one 2.5 mg tablet of linagliptin and 500 mg of metformin twice daily. Later, your doctor may increase the dose gradually until your blood sugar is controlled. Usually, the maximum daily dose is 2.5 mg of linagliptin and 1000 mg of metformin.
  • Patients taking Jentadueto are recommended to take the same dose of linagliptin and metformin as prescribed by an expert. Your doctor may alter the dose until your blood glucose level is appropriate. The maximum daily dose is 2.5 mg of linagliptin and 1000 mg of metformin two times a day.


  • Your healthcare professional determines the usage and dose of Jentadueto.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • Read your medication guide or Patient Information Leaflet carefully before taking your medications or when you get a refill. 
  • Follow the instructions given by your healthcare practitioner to avoid any complications.
  • Generally, the tablets are advised to be taken by mouth twice daily, along with meals. 
  • Consume plenty of fluids when taking your medication unless your doctors advise otherwise.
  • Take your medicines regularly to get the most benefit from them.
  • Swallow the tablets as a whole. 
  • Avoid chewing, breaking, or crushing the tablets. 
  • If you can not swallow the tablets, talk to a medical expert. They will suggest alternate options or other treatments.
  • Do not alter or discontinue your medications without consulting them first with your medical practitioner, as this will create problems in the future.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Jentadueto Work?

Jentadueto is an antidiabetic medication that contains a combination of linagliptin and metformin. These medications belong to different groups of medications, yet they work together to treat type 2 diabetes. Let’s break down the Jentadueto mechanism of action:

  • Linagliptin: This medication belongs to a dipeptidyl-peptidase-4 (DPP-4) inhibitors class of drugs. These inhibitors raise the insulin level in the body. Insulin usually helps in transferring sugar from the bloodstream to the body’s cells. When a patient takes this medication, it helps them by reducing the blood glucose level that the body produces.
  • Metformin: It belongs to a biguanides class of drugs that help by decreasing the amount of glucose your life produces. This drug also aids in lowering the glucose amount in the body, thus improving your body’s ability to use insulin effectively. 

When these actions are combined in the form of one medication, Jentadueto, your blood sugar level is effectively managed, but it is important to note that you are taking this medicine in combination with diet and exercise. 

Important Safety Information

Side Effects

Common side effects of Jentadueto may include:

  • Loss of appetite
  • Diarrhea
  • Stuffy or runny nose
  • Sore throat
  • Cough
  • Nausea
  • Vomiting
  • Itching

Serious side effects of Jentadueto may include:

  • Low blood sugar (Hypoglycemia). Its symptoms include:
    • Shaking or jittery feeling
    • Sweating
    • Increased heartbeat
    • Vision changes
    • Dizziness
  • Lactic Acidosis. Symptoms are:
    • Severe weakness
    • Muscle pain
    • Difficulty in breathing
    • Stomach pain 
    • Cold feeling in arms and legs
    • Irregular heartbeat
  • Allergic reactions. Some of its symptoms are:
    • Swelling on the face, lips, and throat
    • Difficulty while swallowing or breathing
    • Skin rash
    • Hives
  • Pancreatitis (inflammation of the pancreas). Its symptoms are:
    • Unusual stomach pain that goes to your back
    • Swelling or tenderness in the stomach area
  • Low vitamin B12 levels. Symptoms may include:
    • Tiredness
    • Memory issues
    • Balance problem
    • Severe joint pain
  • Bullous pemphigoid (blisters on skin). Its symptoms include:
    • Large blisters filled with fluid
    • Itchy skin

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


  • Inflammation of the Pancreas: It has been noted that linagliptin may cause pancreatitis. So, if you are taking this medication and notice a sudden stomach pain that travels to the back, combined with a swollen stomach area, nausea, and vomiting, make sure that you inform your doctor about all this.
  • Surgery: Undergoing surgery can increase your risk of developing lactic acidosis. To avoid such risk, your doctor may reduce the dosage or discontinue the use before surgery. You can continue the treatment after your surgery.
  • Radiocontrast Dye-Containing Tests: If you have an X-ray that utilizes radiocontrast dye, avoid taking this medication, as the dye can alter the functioning of your kidneys, increasing the risk of lactic acidosis. While not so common, it can lead to death if not treated timely.

Boxed Warning 

Black box or boxed warnings are the most serious warnings issued by the FDA. These warnings alert doctors and patients about the drug effects that may create life-threatening situations. Jentadueto is a combination medication, and one of its drugs- metformin, can cause a serious problem of lactic acidosis (lactic acid buildup in the blood). While this happens rarely, if this condition is not treated, it can also lead to death. Patients with severe kidney problems have higher chances of developing this condition. Besides, the risk increases with various factors like:

  • Dehydration
  • Surgery
  • Consuming too many alcoholic beverages
  • Liver problems
  • Heart diseases, including congestive heart failure


  • Before taking this medication, make sure to tell your doctor if you are allergic to any of Jentadueto’s ingredients, as the product may contain certain inactive ingredients that can cause severe allergies.
  • Inform your doctor about any medical history you may have, especially of:
    • Breathing problems
    • Kidney issues
    • Pancreatitis
    • Gallstones
    • Blood problems, like anemia, vitamin B12
    • Liver diseases
  • If you are undergoing any surgery or medical procedure using iodinated contrast, inform your healthcare provider about the products you use. This includes prescription drugs, nonprescription drugs, and herbal products.
  • Avoid driving or using machinery that requires alertness, as the medication can cause dizziness and blurred vision due to low or high blood sugar levels. 
  • Avoid consuming alcohol when taking Jentadueto, as it can raise the risk of lactic acidosis, pancreatitis, and low blood glucose levels.
  • Older adults are hypersensitive to the after effects of this medication, especially if they have low blood sugar levels or lactic acidosis. 
  • Metformin can cause changes in women’s menstrual cycle and increase the risk of pregnancy. So, consult your medical professional; they will suggest some reliable birth control pills while taking this medication.

Other Important Precautions 

  • If you are pregnant or planning on having a baby, talk to your doctor before starting your treatment with Jentadueto, as the medication may cause or exacerbate diabetes. Discuss every risk and benefit with your doctor and ask for suitable treatment options.
  • It is still unknown whether linagliptin, one of the medications in Jentadueto, passes into the breast milk or not. So, consult with a medical professional if you are a lactating woman.


Jentadueto is contraindicated in patients who have:

  • Severe renal problems (eGFR below 30 mL/min/1.73 m²)
  • Acute or chronic metabolic acidosis, which may include diabetic ketoacidosis
  • Hypersensitivity

Missed Dose

  • Try to not skip any doses of your medication. However, if you have forgotten a dose:
  • Take it as soon as possible or whenever you remember.
  • If it is almost time for your next dose, avoid taking the missed dose and continue your usual dosing schedule.
  • Do not try to take double doses to catch up for the missed doses.
  • Use medication apps or reminders if you tend to forget things.
  • You can consult with professionals if you have any queries or concerns.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]


If someone has mistakenly overdosed on Jentadueto, they can experience severely low blood sugar. Its symptoms may include:

  • Nausea
  • Tremors
  • Weakness
  • Sweating
  • Confusion
  • Irregular heartbeats
  • Seizures
  • Trouble speaking

If you notice such symptoms, it is advised to get medical help, or you can also call the helpline number at 911.

[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]


  • Keep the drug in a sealed container at a temperature of 20° to 25°C. You can also store them at 15° to 30°C for a brief period of time.
  • Keep the medications safe from high humidity.
  • Do not store the medicines in a place where there is direct sunlight.
  • Avoid keeping them in damp areas like the bathroom or near the sink.
  • Keep it out of reach and sight of children.
  • Do not flush the container down the toilet.
  • Discard the product when not in use.
  • Stick to the shelf life of the product.
  • Ask your pharmacist or doctor to know how you can dispose of the product properly when it is of no use.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Jentadueto Interactions

Here are some of the examples of drugs that may interact with linagliptin-metformin and cause adverse reactions:

  • Rifampin
  • Terbutaline
  • Glipizide
  • Glyburide
  • Nateglinide
  • Repaglinide
  • Insulin
  • Niacin
  • Amiloride
  • Digoxin
  • Triamterene
  • Quinidine
  • Procainamide
  • Hydrochlorothiazide
  • Amlodipine
  • Verapamil
  • Cimetidine
  • Pseudoephedrine
  • Naphazoline
  • Conjugated estrogens
  • Ethinyl estradiol
  • Zonisamide 
  • Phenytoin
  • Topiramate
  • Levothyroxine
  • Liotrix
  • Liothyronine
  • Desiccated thyroid
  • Isoniazid
  • Acetazolamide
  • Epinephrine
  • Dopamine
  • Methylprednisolone
  • Prednisone

[Note: This isn’t a complete list, and there could be other drugs that interact with Jentadueto. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Jentadueto Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Is it safe to take Jentadueto with over-the-counter medications?

Jentadueto is a prescription medication that contains linagliptin and metformin. It is highly likely that both of these drugs may interact with certain medications or supplements. So, avoid taking any over-the-counter medications with Jentadueto. Always consult with your healthcare provider before taking any such decisions.

Does Jentadueto cause constipation as a side effect?

Like every medication, Jentadueto has several side effects, including decreased thyroid function. Its symptoms can range from dry skin to tiredness, constipation, and weight gain. Therefore, it is essential to follow your doctor’s advice when starting treatment with this medication.

Do I need to follow a specific diet while taking Jentadueto?

While taking Jentadueto, follow a balanced diet, including fruits, vegetables, whole grains, and healthy fats. Manage your carbohydrate intake by choosing low glycemic index options and controlling portion sizes. Avoid sugary and highly processed foods. It is always a good idea to consult a healthcare professional for personalized dietary recommendations.

Can I stop using Jentadueto suddenly?

Do not modify or discontinue any medication without talking to your healthcare provider, as this action can cause adverse effects, which can turn into a life-threatening situation. If you want to adjust your dosage or change your treatment, seek medical guidance.

Our Guarantee

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