Mesalamine

Lialda

Lialda is a specialized medication designed for the management of ulcerative colitis. Available as delayed-release 1.2-gram tablets, it targets the colon to reduce inflammation, which is crucial in alleviating symptoms such as diarrhea, rectal bleeding, and abdominal pain. Recommended for both inducing and maintaining remission, Lialda is typically taken once daily with food, simplifying the treatment regimen for patients. The medication is generally well-tolerated, with common side effects, including headache and nausea, which are usually temporary. However, patients should be aware of potentially severe side effects like kidney problems and acute pancreatitis, which require prompt medical attention. For those affected by ulcerative colitis, Lialda offers a practical and effective treatment option, helping to manage symptoms and improve quality of life by maintaining long-term remission. So, if you want to buy Lialda for ulcerative colitis, you need to get a valid prescription from your doctor.

Product Overview

Lialda (mesalamine) is an effective medication specifically formulated to manage ulcerative colitis. It is primarily available in the form of delayed-release 1.2-gram tablets designed to ensure the medication is released in the colon, directly targeting the site of inflammation. The typical dosing regimen involves taking two to four tablets once daily with food, making it convenient for sustained daily use. Mesalamine, the active ingredient in Lialda, functions by reducing inflammation in the colon, a hallmark of ulcerative colitis. This action helps to alleviate common symptoms such as diarrhea, rectal bleeding, and abdominal pain, thereby improving the quality of life for those affected by this chronic condition. Lialda is particularly valued for its dual role in inducing and maintaining remission and preventing the recurrence of active symptoms.

Safety is paramount with Lialda, and it is well-tolerated by most patients. Common side effects may include headache, nausea, and abdominal pain, which are generally transient. However, users must be aware of potentially serious side effects, such as kidney problems and acute pancreatitis, which necessitate immediate medical attention.

Lialda’s ease of use—one or two doses daily with meals and its coated tablet form that should not be crushed or chewed—supports adherence to treatment. Regular monitoring by a healthcare provider is advised to tailor the therapy to individual needs and ensure the effectiveness of the drug without significant risks. For those managing ulcerative colitis, Lialda offers a reliable, targeted approach to control inflammation and maintain remission, making it a cornerstone of inflammatory bowel disease management.

What Exactly Does Lialda Do?

Lialda is used primarily for the treatment of ulcerative colitis.

What Strengths & Forms Are Available for Lialda?

Lialda is available primarily in the form of delayed-release tablets. Here is the strength in which Lialda is typically available:

• 1.2 grams (1200 mg) tablets

What Is the Recommended Lialda dosage?

The Lialda dose for ulcerative colitis depends on the patient’s needs and conditions. Always adhere to the dosage instructions on the prescription label or a healthcare professional’s direction.

For Induction of Remission in Ulcerative Colitis:

• Adults: The recommended dosage is 2.4 to 4.8 grams (two to four 1.2-gram tablets) taken daily with food.

For Maintenance of Remission in Ulcerative Colitis:

• Adults: The recommended dosage is 2.4 grams (two 1.2-gram tablets) taken daily with food.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Lialda? 

Using Lialda (mesalamine) effectively involves following specific guidelines to ensure it works as intended. Here’s a concise guide:

• Always use Lialda precisely as your doctor has prescribed. Do not alter the dose without consulting your healthcare provider.
• Take Lialda at the exact times each day to maintain an even level of the medication in your bloodstream.
• Lialda can be taken with or without food. However, some patients find that taking it with food can help to reduce stomach upset.
• Do not chew or crush the tablets. They should be swallowed whole. Lialda tablets are coated to ensure the medication is released in the colon, where it is needed. Crushing or chewing the tablet could release the medication too early.
• Keep yourself well-hydrated while taking Lialda to help the medication work effectively and to reduce potential kidney side effects.
• Regular visits to your healthcare provider are necessary to monitor the drug’s effectiveness and check for side effects. You may also need blood tests to check your kidney function and blood cell counts.
• Do not stop taking Lialda suddenly, as this may worsen your symptoms. If you need to stop taking it, your doctor will likely decrease your dose gradually.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Lialda Work?

Lialda works by reducing inflammation in the colon, which is a critical factor in the symptoms and progression of ulcerative colitis. It is part of a class of medications known as aminosalicylates. Mesalamine acts directly on the colon’s lining to inhibit certain substances that cause inflammation, thereby reducing swelling, bleeding, and discomfort associated with inflammatory bowel disease (IBD). The exact mechanism of how mesalamine reduces inflammation is not fully understood, but it is thought to involve blocking the production and activity of inflammatory chemicals in the colon. This targeted action helps to maintain remission and prevent flare-ups of ulcerative colitis symptoms.

What Are the Important Safety Information for Using Lialda?

What Are the Lialda Side Effects?

Common Side Effects of Lialda: Lialda can lead to some side effects. These are usually temporary, lasting from a few days to weeks. If these side effects continue beyond this period, bother you, or become intense, it’s essential to consult your doctor or pharmacist. Common side effects of Lialda may include:

• • Dizziness: A sensation of lightheadedness or feeling off-balance can occur. This may lead to challenges with coordination or difficulty maintaining focus during daily activities.
  • Visual Disturbances: Users may experience blurred vision or difficulty focusing, potentially affecting tasks like reading or driving. This issue can vary in intensity and may interfere with overall visual clarity.
  • Headache: Frequent or recurring headaches, ranging from mild discomfort to more intense pain, are reported. These headaches can potentially disrupt daily routines or concentration.
  • Nausea: Some users experience nausea, which can often be managed by taking Lialda with food or adjusting the timing of the dose. 
  • Fatigue or Weakness: This medication can cause a general feeling of tiredness or decreased energy levels, making physical and mental tasks more demanding or challenging.
  • Tremor: This medication may cause tremors that involve involuntary, rhythmic muscle movements, often affecting the hands or arms. These can interfere with daily tasks like writing or holding objects and may cause frustration or embarrassment in social settings.
  • Shortness of Breath: When you use this Lialda medication, you may feel like you cannot breathe enough air, even at rest or with minimal exertion. This can lead to discomfort, fatigue, and difficulty performing physical activities.
  • Chest Pain: Chest pain can occur, which ranges from mild discomfort to sharp or pressure-like sensations. It may cause anxiety and limit physical activity due to fear of worsening symptoms or potential underlying issues.
  • Palpitations or Irregular Heartbeat: Due to the use of this medication, palpitations may occur as a fluttering or pounding sensation in the chest. Irregular heartbeats can create a sense of unease, dizziness, or lightheadedness, potentially affecting concentration or normal routines.
  • Nervousness or Anxiety: When you use this medication, this condition can occur as persistent worry, restlessness, or difficulty focusing. These feelings may disrupt sleep patterns, decision-making, and overall emotional well-being.

• Constipation: Constipation while taking Lialda may occur as a result of changes in gastrointestinal function or slowed bowel movement, leading to infrequent or hard stools. Patients might experience bloating, discomfort, or a feeling of incomplete evacuation due to the medication.

• Loss of appetite: This is a potential side effect of Lialda, where patients may experience a reduced desire to eat or feel uninterested in food. This could be due to the medication’s impact on the gastrointestinal system or overall body response.

• Dry mouth: Lialda may cause dry mouth, or xerostomia, by reducing saliva production. This side effect can result in a parched sensation, difficulty speaking, swallowing, or chewing, and, if persistent, may increase the risk of oral infections.

• Skin rash: A skin rash associated with Lialda may present as red, itchy, or inflamed patches on the skin. This could indicate a mild irritation or, in some cases, an allergic reaction to the medication.

• Swelling of the hands, feet, or ankles: This condition, also known as peripheral edema, may occur with Lialda use. Fluid retention causes this side effect, which can lead to noticeable puffiness, tightness, or discomfort in the affected areas.

Serious Side Effects of Lialda: Lialda is generally well-tolerated, but like all medications, it can cause serious side effects in some people. It’s essential to be aware of these potential risks and seek immediate medical attention if they occur. Here are the serious side effects of Lialda:

• Kidney Problems: Symptoms may include changes in the amount of urine produced, swelling of the ankles or feet, or fatigue. Regular kidney function tests may be required.
• Acute Pancreatitis: Sudden and severe abdominal pain, nausea, vomiting, and a rapid pulse can indicate pancreatitis.
• Liver Damage: Symptoms like yellowing of the skin or eyes (jaundice), dark urine, severe nausea or vomiting, and abdominal pain could signal liver issues.
• Severe Allergic Reactions: Symptoms such as difficulty breathing, hives, and swelling of the face, lips, tongue, or throat indicate a severe allergic reaction.
• Blood Disorders: Unexplained bleeding or bruising, sore throat, fever, and extreme fatigue could be signs of blood disorders such as agranulocytosis or aplastic anemia.
• Heart Conditions: Although rare, mesalamine can affect the heart, causing symptoms like chest pain, shortness of breath, or irregular heartbeats.
• Severe Skin Reactions: Lialda can rarely cause serious skin conditions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, which are characterized by widespread rash, blistering, and peeling skin.
• Intestinal Blockage: Symptoms like severe abdominal pain, bloating, constipation, or vomiting might indicate a blockage in the intestine.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Lialda? 

Yes, there are several warnings associated with the use of Lialda (mesalamine), which are important to consider to ensure safe and effective treatment:

• Kidney Impairment:

• • • Lialda can cause kidney problems, including interstitial nephritis and renal failure. Patients are advised to have their kidney function monitored before starting treatment and periodically after that.

• Hypersensitivity Reactions:

• • • Some patients may experience hypersensitivity reactions, including anaphylaxis, angioedema, and severe skin reactions. If symptoms of an allergic reaction occur, the drug should be discontinued immediately.

• Hepatic Impairment:

• • • Patients with liver disease need to be monitored closely as they have an increased risk of developing hepatic toxicity while using mesalamine.

• Mesalamine-Induced Acute Intolerance Syndrome:

• • • This syndrome may resemble an exacerbation of ulcerative colitis. Symptoms include cramping, acute abdominal pain, bloody diarrhea, and sometimes fever, headache, and rash. If suspected, prompt withdrawal of the medication is required.

• Blood Disorders:

• • • Lialda may cause blood disorders such as agranulocytosis, aplastic anemia, and other blood dyscrasias. Regular blood tests may be recommended to monitor for these conditions.

• Interaction with Laboratory Tests:

• • • Mesalamine can interfere with specific laboratory tests, including urinary normetanephrine and certain urine testing for ketones.

• Photosensitivity:

• • Lialda can increase sensitivity to sunlight, leading to an increased risk of sunburn. Patients are advised to use sunscreen and wear protective clothing when spending time outdoors.

What Precautions Should Be Taken When Taking Lialda?

When taking Lialda (mesalamine), several precautions must be taken to ensure the medication’s safe and effective use. This includes:

• Use Lialda cautiously if you have narrowing or blockage in your stomach or upper intestine, as it may worsen symptoms like pain or nausea.
• Older adults, especially those 65 or older, are at a higher risk of side effects like kidney issues and may require regular monitoring and dose adjustments.
• Avoid Lialda if you have a history of allergic reactions to salicylate medications like aspirin or mesalamine to prevent severe hypersensitivity reactions.
• Your doctor should monitor your progress during regular visits. This helps determine if the medication is effective and if you should continue using it. Blood and urine tests may be necessary to detect any unwanted effects.
• Asacol®  Lialda delayed-release tablets can cause severe kidney problems, including kidney stones. Contact your doctor immediately if you experience lower back or side pain, reduced frequency or amount of urine, bloody urine, increased thirst, loss of appetite, nausea, vomiting, unusual tiredness or weakness, swelling of the face, fingers, or lower legs, weight gain, or difficulty breathing.
• Seek medical attention right away if you have stomach pain, bloody diarrhea, cramps, fever, headache, or a rash while using this medication, as these may be symptoms of mesalamine-induced acute intolerance syndrome.
• If you experience difficulty breathing or swallowing, a rapid heartbeat, itching, rash, skin redness, or swelling of the face, throat, or tongue, contact your doctor immediately. These could be signs of an allergic reaction.
• Notify your doctor immediately if you experience upper stomach pain or tenderness, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellowing of the eyes or skin. These symptoms could indicate a serious liver problem.
• This medication may increase your sensitivity to sunlight and cause severe skin reactions, particularly if you have existing skin conditions such as atopic dermatitis or eczema. Contact your doctor if you experience increased skin sensitivity to sunlight, itching, redness or discoloration, severe sunburn, or a skin rash. Use sunscreen when outdoors, and avoid sunlamps and tanning beds.
• Do not take antacids (such as Amphojel®, Maalox®, Mylanta®, or Tums®) while taking Apriso® capsules, as they can alter the medication’s release in your body.
• Ensure any doctor or dentist who treats you knows you are using mesalamine, as it may affect specific medical test results.
• Avoid taking other medications, including prescription, nonprescription (OTC), herbal, or vitamin supplements, unless discussed with your doctor.

What Are the Contraindications of Lialda? 

The contraindications for Lialda include:

• Hypersensitivity to Mesalamine or Any Component of the Formulation:

• • • Patients with a known hypersensitivity to mesalamine, salicylates (e.g., aspirin), or any other components of Lialda should not use the medication.

• Severe Renal Impairment:

• • • Lialda is contraindicated in patients with severe renal impairment (kidney function).

• Severe Hepatic Impairment:

• • • Patients with severe hepatic (liver) impairment should not use Lialda.

• Intestinal Obstruction:

• • Lialda is contraindicated in patients with intestinal obstruction.

What If You Missed a Dose of Lialda?

If you miss a dose of Lialda (mesalamine), take it as soon as you remember. However, if it’s nearly time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses simultaneously to make up for the missed one. Consistency in taking Lialda is important for maintaining its effectiveness in managing your condition. If you frequently miss doses, it may be helpful to set reminders or alarms to ensure you take the medication as prescribed. Always follow your healthcare provider’s instructions regarding missed doses.

[Note: If you have missed a medication dose and are unsure of the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Lialda?

Taking too much Lialda (mesalamine) can lead to several potential side effects and complications. Overdose symptoms may include severe abdominal pain, vomiting, nausea, and diarrhea. In some cases, it can cause kidney problems, such as interstitial nephritis, leading to symptoms like reduced urine output and swelling in the legs or ankles. Additionally, taking too much Lialda can exacerbate common side effects such as headache, dizziness, and allergic reactions, including rash, itching, and difficulty breathing. Overdose may also increase the risk of blood disorders, such as a decrease in the number of platelets, which can result in easy bruising or bleeding. If an overdose is suspected, it is crucial to seek immediate medical attention to manage and mitigate these risks effectively. Healthcare providers may perform supportive treatments and monitor for complications to ensure patient safety.

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How Do You Store Lialda?

When you want to use Lialda for UC (ulcerative colitis), you should consider the following general storage guidelines:

• Keep Lialda at room temperature, typically between 68°F to 77°F (20°C to 25°C).
• Store the medication in a dry place. Avoid areas that are prone to moisture, such as bathrooms.
• Keep Lialda away from direct sunlight. Storing it in its original packaging can help protect it from light exposure.
• Ensure that Lialda is kept out of reach of children and pets to prevent accidental ingestion.
• Do not use Lialda if the packaging is torn or shows signs of tampering.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Lialda?

Several medications can interact with Lialda (mesalamine), potentially affecting its efficacy or increasing the risk of side effects. These include:

• Non-steroidal anti-inflammatory Drugs (NSAIDs):

• • • Examples: ibuprofen, naproxen, aspirin
    • Potential interaction: Increased risk of kidney damage.

• Antacids:

• • • Examples: calcium carbonate, magnesium hydroxide, aluminum hydroxide
    • Potential interaction: This may affect the release of mesalamine from the Lialda tablet.

• Azathioprine and 6-Mercaptopurine:

• • • Potential interaction: Increased risk of blood disorders such as leukopenia and thrombocytopenia.
  • Methotrexate:
    • Potential interaction: Increased risk of bone marrow suppression and other side effects.

• Heparin and Heparin-like Drugs:

• • • Potential interaction: Increased risk of bleeding.

• Proton Pump Inhibitors (PPIs):

• • • Examples: omeprazole, esomeprazole
    • Potential interaction: This may reduce the effectiveness of mesalamine.

• Warfarin and Other Anticoagulants:

• • • Potential interaction: Altered anticoagulant effects, increased risk of bleeding.

• Varicella Virus Vaccine (live):

• • Potential interaction: Increased risk of adverse effects from the vaccine.

What Are the Other Lialda Interactions?

In addition to the previously mentioned interactions, other medications and substances that may interact with Lialda (mesalamine) include:

• Immunosuppressants:

• • • Examples: cyclosporine, tacrolimus
    • Potential interaction: Increased risk of kidney dysfunction.

• Digoxin:

• • • Potential interaction: Reduced absorption of digoxin, potentially decreasing its effectiveness.

• Lactulose:

• • • Potential interaction: It may affect the colon’s pH, altering mesalamine’s release and effectiveness:
    • Examples: salsalate, choline magnesium trisalicylate
    • Potential interaction: Increased risk of salicylate toxicity.

• Sulfasalazine:

• • • Potential interaction: When used together, both medications contain similar active ingredients, which may increase the risk of mesalamine side effects.

• Varicella Virus Vaccine (live):

• • Potential interaction: Increased risk of adverse effects from the vaccine.

• Interactions with Herbs: 

• • • No specific herb interactions with Lialda have been reported yet. However, this doesn’t rule out future discoveries of herbal interactions. 

• Interactions with Vitamins: 

• • • There are no specific reports of vitamin interactions with Lialda, but future interactions could be identified. Before taking any vitamins with Lialda, talk to your healthcare provider.

• Interactions with Food: 

• • • So far, no food interactions with Lialda have been reported. If you have questions about what foods to eat while taking Lialda, consult your doctor.

• Interactions with Lab Tests: 

• • Lialda might affect the results of some lab tests. It can cause falsely high results in certain urine tests for normetanephrine.

[Note: This isn’t a complete list, and there could be other drugs that interact with Lialda. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Lialda Alternatives?

Lialda (mesalamine) is used to treat inflammatory bowel diseases like ulcerative colitis. If Lialda isn’t suitable for someone, there are several alternatives available, depending on the specific needs and condition of the patient. Here are some common alternatives:

• Asacol HD (mesalamine)
• Pentasa (mesalamine)
• Apriso (mesalamine)
• Delzicol (mesalamine)
• Canasa (mesalamine) – rectal suppository
• Rowasa (mesalamine) – rectal enema
• Colazal (balsalazide)
• Giazo (balsalazide) – approved for male patients only
• Dipentum (olsalazine)
• Azulfidine (sulfasalazine)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Lialda Cost & Coupons

Lialda (mesalamine) is a vital medication for managing ulcerative colitis, but its high retail prices in the US can be challenging for many patients. To find more budget-friendly options, US residents can consider purchasing Lialda from Canadian pharmacies. Polar Bear Meds is a trusted source known for offering competitive medication pricing. By applying the coupon code “WELCOMEPB10” at checkout, customers can enjoy up to a 10% discount on their first order. Additionally, our referral program provides extra savings, including a free coupon for future purchases. Secure your Lialda supply from Canada and benefit from significant cost reductions.

Frequently Asked Questions

Is Lialda a Biologic Medication?

No, Lialda is not a biological medication. Biologics are made using living cells designed to target specific substances in the immune system that cause inflammation. They are often used for more severe forms of ulcerative colitis when other treatments have failed. Lialda, on the other hand, is an aminosalicylate made from chemicals rather than living cells. It helps reduce bowel inflammation, but it does so in a less targeted manner compared to biologics.

Is Lialda Considered a Blood Thinner or an NSAID?

No, Lialda is neither a blood thinner nor a nonsteroidal anti-inflammatory drug (NSAID). Instead, it is classified as an aminosalicylate, which is used to reduce inflammation in the colon and rectum. The active ingredient in Lialda, mesalamine, is structurally related to aspirin—a known NSAID and blood thinner—but it functions differently in the body. Although very rare, Lialda can cause a reduction in platelet count, potentially leading to easier bruising or bleeding, but it is not prescribed as a blood thinner.

Is Lialda an immunosuppressant?

No, Lialda (mesalamine) is not an immunosuppressant. It is an anti-inflammatory medication primarily used to reduce symptoms of ulcerative colitis, such as diarrhea, rectal bleeding, and abdominal pain. Mesalamine is often one of the initial treatments for managing ulcerative colitis.

How long is Lialda typically prescribed?

Lialda is usually prescribed as a long-term treatment if you and your healthcare provider find it safe and effective. It begins to reduce bowel inflammation soon after you start taking it, but it might take several weeks to notice an improvement in symptoms.

Does Lialda cause weight loss?

Lialda (mesalamine) is not typically associated with causing weight loss directly. Clinical studies have not identified weight loss as a side effect of this medication. However, it’s important to note that the conditions Lialda treats, such as ulcerative colitis (UC), can lead to weight fluctuations. Patients with UC often experience periods of weight loss or gain due to the nature of the disease, which can affect appetite and nutrient absorption. 

Should I take Lialda in the morning or at night?

Lialda can be taken at any time of the day, at your convenience, and according to your lifestyle. However, to maintain a consistent level of medication in your body and enhance its effectiveness, it is advisable to take your dose at the same time each day. Consistency can also help in forming a routine, reducing the likelihood of missing doses. Additionally, Lialda should be taken with food to improve absorption and minimize potential gastrointestinal side effects.  

Can you drink alcohol on Lialda?

While there are no direct interactions between Lialda (mesalamine) and alcohol reported in medical literature, it is important to consult with your healthcare provider about consuming alcohol while on this medication. The reason for caution is that alcohol can potentially exacerbate some side effects of Lialda, such as gastrointestinal irritation or liver issues. Based on your overall health condition & the seriousness of your symptoms, your doctor might recommend reducing or altogether avoiding alcohol to prevent any adverse effects.

How long should you take Lialda?

Lialda is generally prescribed as a long-term treatment option for conditions like ulcerative colitis. The duration for which you will need to take Lialda depends on the chronic nature of your condition and how well your body responds to the treatment. If Lialda is proving effective and well-tolerated, your doctor will likely recommend continuing it as part of your ongoing management plan. 

What happens if you take Lialda without food?

Taking Lialda (mesalamine) on an empty stomach might increase the risk of gastrointestinal discomfort, such as stomach upset, cramps, or irritation. This is because food could act as a buffer to reduce the medication’s direct impact on the stomach lining. While following your doctor’s advice on taking your medication is generally recommended, many healthcare providers suggest taking Lialda with food or a meal to reduce potential stomach issues.

Is Lialda hard on the liver?

Lialda, a medication commonly used for treating ulcerative colitis, can have adverse effects on the liver, although such instances are relatively rare. The active ingredient in Lialda, mesalamine, has been linked to liver complications, including liver failure, especially in patients who already have pre-existing liver conditions. The risk, while low, is significant enough that medical professionals often recommend regular liver function tests to monitor the impact of the drug on patients with known liver issues or those who are exhibiting symptoms of liver distress while on the medication.  

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