Premarin Vaginal Cream

Premarin Vaginal Cream is a female sex hormone which is used as a part of hormone replacement therapy. It helps in treating the deficiency of estrogen. In some cases, it is also used to treat prostate and breast cancer along with other anticancer drugs. Before starting to take this medication, it is essential to tell your doctor if you have recently taken or are currently taking other medicines to treat the same condition. Your doctor will help you decide the dosage, frequency, and duration of the medication. They may also suggest you undergo some tests to determine the effectiveness and potential side effects of the drug.

Premarin Vaginal Cream is a type of estrogen hormone that is used in hormone replacement therapy. It is used to treat symptoms associated with a lack of estrogen, such as hot flashes and vaginal dryness. It is sometimes prescribed to treat breast cancer and prostate cancer, in addition to other anticancer medicines. You should take it at the same time every day. Your doctor will determine the appropriate dose and duration based on your symptoms. If you miss a dose, take it as soon as you remember. Do not skip any doses and complete the entire course of treatment.

Do not stop taking this medication suddenly without consulting your doctor, as it may affect its effectiveness. The cream may cause some common side effects, such as breast pain, headaches, abdominal cramps or bloating, irregular vaginal bleeding or spotting, and vomiting. However, there are some warning signs and symptoms that should be taken seriously and require immediate medical attention, such as breast lumps, dizziness, faintness, unusual vaginal bleeding, severe headaches, shortness of breath, chest pain, and pains in your legs.

Before taking this medicine, it is essential to tell your doctor if you are taking or have recently taken any other drugs for the same disease or other diseases. Before you initiate this HRT, you must consult the doctor if you have a history of a blood clot in your legs or your lungs or if you have ever had unusual vaginal bleeding. If you are pregnant or breastfeeding, you should tell your doctor before taking this medicine. Your doctor may suggest some diagnostic or laboratory tests to know the effects and side effects of this medicine on your body.

Premarin Vaginal Cream is used for:

• Female hormone replacement therapy
• Treatment of atrophic vaginitis
• Treatment of kraurosis vulvae
• Treatment of Moderate to Severe Dyspareunia

Dosage

Premarin Vaginal Cream is a medical cream that comes inside a tube that contains 30 grams of the medication. Each gram contains:

• 0.625 mg conjugated estrogens

Recommended Dosage for Premarin Vaginal Cream

Recommended Dosage for Treatment of Kraurosis Vulvae and Atrophic Vaginitis

Premarin Vaginal Cream should be administered intravaginally daily for three weeks and then off for 7 days. The recommended initial dosage for treatment should be 0.5 g. Adjustments to dosage should be based on the body’s response to medication.

Recommended Dosage for Treatment of Moderate to Severe Dyspareunia

Premarin Vaginal Cream should be administered intravaginally twice weekly or in a cyclic regimen. Adjustments to dosage should be based on the body’s response to medication.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

• You should use estrogen for the shortest duration at the lowest effective dose to reduce the risk of unwanted side effects.
• You should regularly talk to your doctor to decide the duration of the treatment and adjust the dosage of the medication.
• Vaginal cream should be administered intravaginally as directed by your doctor.
• You are required to clean and dry the affected area and apply a blueberry-sized dose (0.5 grams) with an applicator deep into your vagina or to the affected area.
• Wash your hands properly after applying the cream.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Premarin Vaginal Cream contains a combination of estrogen hormones, which are used in hormone replacement therapy to treat symptoms of menopause. It works by maintaining the levels of estrogen in menstrual women. It prevents the walls of the vagina from becoming dry and thin and helps in rebuilding vaginal tissue, and makes painful sex after menopause more comfortable.

Common side effects of Premarin Vaginal Cream may include:

• Burning sensation and abnormal bleeding vagina
• Pelvic pain
• Irritation
• Breast pain
• Vaginal spotting and itching
• Leg cramps
• Depression
• Stomach pain

Serious side effects of Premarin Vaginal Cream may include:

• Dementia
• Heart attack
• Blood clots
• Cancer of the breast, womb, or ovary
• Stroke
• High blood pressure
• High blood sugar
• Severe allergic reaction
• Enlargement of fibroids

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

• Do not use the cream if you’ve had breast or uterine cancer, unusual vaginal bleeding, blood clots, stroke or heart failure, liver problems, or hypersensitivity to Premarin Vaginal Cream or any of its inactive ingredients.
• You should not use estrogen or Premarin to prevent dementia or cardiovascular disease.
• Estrogens may increase the risk of developing endometrial cancer. You should take progestin to decrease the chances of cancer of the uterus.
• In postmenstrual women, estrogen increases the chances of developing cancer of different organs, dementia, and serious blood clots. When taken along with progestin, it may lead to heart failure.
• If you are using Premarin for the long term, you should have regular full-body checkups as suggested by your doctor.

Boxed Warning

Premarin Vaginal Cream has a boxed warning for cardiovascular disorders, endometrial cancer, breast cancer and dementia.

• Do not use Premarin Vaginal Cream if you are pregnant, planning to get pregnant, or breastfeeding a baby.
• You should not take Premarin Vaginal Cream if you are over 35 of age, if you smoke, or have a medical history of heart disease or blood clots.
• It is not recommended to engage in sexual activity immediately after using Premarin Cream, as your partner’s skin may absorb some of the medication.

• Undiagnosed abnormal vaginal bleeding.
• History of breast cancer.
• Estrogen-dependent neoplasia.
• Active or a history of conditions like deep vein thrombosis, pulmonary embolism.
• Active arterial thromboembolic disease
• Known or suspected pregnancy

• If you happen to miss a dose of Premarin Vaginal Cream, apply it as soon as you remember.
• However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose of the same medication to compensate for the missed dose.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

If a woman takes estrogen more than required, it may cause vomiting, breast tenderness, nausea, abdominal cramps, fatigue, and abnormal bleeding. Treatment of overdose involves discontinuation of therapy with premarin, and the patient is to be kept under observation till the symptoms of overdose are under control.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

• You may store the medicine in a tightly closed container at room temperature, away from direct sunlight, excess heat, or moisture.
• Do not freeze the medication and keep it away from the sight and reach of children.
• Do not keep expired medicine or medicine you no longer need. Safely discard it.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

• Atorvastatin
• Levothyroxine
• Metformin
• Prednisone
• Synthroid (levothyroxine)
• St. John’s Wort
• Grapefruit juice

[Note: This isn’t a complete list, and there could be other drugs that interact with Premarin Vaginal Cream. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

• Estradiol (estradiol)
• Estrace (estradiol)
• Prempro (medroxyprogesterone)
• Vagifem (estradiol)
• Progynova (climara)
• Premphase (estradiol)
• Menostar (estradiol)
• Divigel (estradiol)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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