Spironolactone / Hydrochlorothiazide

Spironolactone and Hydrochlorothiazide is an FDA-approved combination medication used to treat hypertension and edema in individuals with congestive heart failure, liver cirrhosis, or a kidney condition known as nephrotic syndrome. The prescription medication is available in the form of tablets with two different strengths taken orally with or without food. Users may experience some side effects that are common and may go away with time. Consult a licensed healthcare provider for prescription to buy Spironolactone Hydrochlorothiazide online, for personalized advice and guidance for the safe and efficient use of the medication.

Spironolactone/Hydrochlorothiazide is an FDA-approved medication containing two active ingredients: Spironolactone, a potassium-sparing diuretic, and Hydrochlorothiazide, a thiazide diuretic. This combination primarily treats hypertension (high blood pressure). It also treats edema by helping the body eliminate excess salt and water while retaining potassium, which reduces blood pressure & fluid buildup.

The prescription medication is available in tablet form with two strengths: 25-25mg, 50-50mg (contains spironolactone/hydrochlorothiazide equally). It should be taken orally or by mouth, either as a single dose or in divided doses, with or without food. The medication dosage is based on the patient’s condition and response to treatment. Children and adults can take this medication under a doctor’s supervision.

Patients may experience some common side effects that may include dizziness, leg cramps, and electrolyte imbalances. Patients should avoid driving a vehicle or using heavy machinery if they have dizziness or drowsiness. You will need to monitor severe side effects, such as allergic reactions or high potassium levels, and seek medical attention if required. Store the medication in a cool, dark & dry place. Always consult an expert medical provider for personalized advice.

It is used to treat:

• High blood pressure (hypertension)
• Edema

What Strengths Do Spironolactone/Hydrochlorothiazide Come In?

It is available in the form of a tablet, which comes with the following strengths:

• 25 mg- 25 mg (Spironolactone- Hydrochlorothiazide)
• 50 mg- 50 mg (Spironolactone- Hydrochlorothiazide)

What Is the Typical Dosage of Spironolactone and Hydrochlorothiazide?

The medication dosage for each patient varies based on age, medical condition & response to treatment. For safe and efficient use of the medication, you should follow the instructions given by your doctor and the directions for use given in the patient information leaflet & medication guide provided by your pharmacist or healthcare provider.

The amount of medication you take depends on its strength and form. It also depends on the number of doses you take each day, the gap between each dose, and the duration of the medication course.

Dosage for High Blood Pressure

• Adults: Initially, you should take 50-100 mg each of Spironolactone and Hydrochlorothiazide daily, given as a single dose or divided doses. Your doctor may make dosage adjustments as required. 
• Children: Your doctor will determine your usage and dosage. 

Dosage for Edema

• Adults: The initial daily recommended dose is 100 mg of each Spironolactone and Hydrochlorothiazide, given as either a single dose or divided into various doses. Your doctor may make dosage adjustments as needed. 
• Children: Your doctor will determine your usage and dosage. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

When you are on a treatment on Spironolactone and Hydrochlorothiazide for blood pressure management, you should carefully read and follow the instructions for use given in the patient information leaflet & medication guide provided by your pharmacist or healthcare provider.

• You should take this medication orally by mouth, exactly as your doctor prescribes, or follow the directions mentioned on the prescription label. Do not take it more or less than prescribed, in large quantities, or more frequently than recommended.
• The medication dosage is based on the amount of medicine you take and the strength of the tablet. It may also be influenced by the number of prescribed doses in a day, the gap between each dose, and the duration of the treatment.
• If your doctor has prescribed you a different dose than the one mentioned above, you should follow your doctor’s instructions and do not change it unless instructed otherwise.
• Swallow the Spironolactone HCTZ tablet as a whole with a glass of water. Do not crush, break, or chew it.
• Spironolactone / Hydrochlorothiazide can be taken with or without food. However, if you experience an upset stomach, it can be taken with food or milk.
• This medication is to be used in combination with a treatment plan consisting of weight control and dietary changes. Before making any major dietary adjustments, you can consult your dietician and ask your doctor which of the abovementioned changes is most important for you.
• You should continue taking your medication even if you feel well. Do not discontinue taking this medication without consulting a licensed healthcare professional, as it can cause unwelcome side effects.
• This medication will not help you cure your condition but manage it. You should continue to use it as recommended if you want to lower your blood pressure.
• Usually, most patients with hypertension do not experience any symptoms and may feel normal, so you should take it daily. If you and your doctor determine that this medication is safe for you to use long-term, you may have to take it for the rest of your life.
• To get the most benefit from your medication, you should maintain consistency in dosage and try to take it around the same time every day.
• Do not share this medication with other people, even if they have the same symptoms as you, as it can cause unwanted side effects.
• If your condition does not get better or if it worsens, tell your doctor.

[Note: If you have any queries or concerns or if you do not understand any part of the information leaflet, you should consult an expert medical practitioner.]

This product contains two ingredients: Spironolactone and Hydrochlorothiazide. Both medications are diuretics (water pills), which help your body get rid of extra salt and water, which further relaxes the blood vessels helping blood flow easily. This may also increase the urine amount when you initially start using the medication. This medication is also effective in the treatment of low blood potassium levels and blocks the activity of aldosterone, a natural substance present in the body that can cause edema. Your doctor may first prescribe that you start taking Spironolactone and Hydrochlorothiazide separately, and if it is suitable for you, then switch over to this combination medication, including both medications as ingredients.

Common Side Effects of Spironolactone & Hydrochlorothiazide: When you start taking a combination of Spironolactone and Hydrochlorothiazide, you might experience some side effects. These are usually not serious and tend to go away as your body adjusts to the medication. While these side effects are typically mild and temporary, it’s important to talk to your doctor if they persist or become bothersome. Remember, not everyone experiences these effects. Here’s what you might notice:

• Leg Cramps: You may feel sudden, sharp pains or a tightening sensation in your legs.
• Drowsiness: You might feel unusually sleepy or tired during the day.
• Weakness: A general feeling of reduced strength or energy might occur.
• Dizziness: You could feel lightheaded or as if the room is spinning, especially when you stand up or move quickly.
• Lack of Energy: Feeling less energetic or sluggish can happen while your body is adjusting to the medicine.
• Feeling like you may pass out: This is a feeling of extreme lightheadedness that might lead to fainting, often related to the drop in blood pressure or dehydration.
• Electrolyte Imbalance: This medication can alter the levels of minerals in your blood, like potassium or sodium, which might make you feel weak, tired, or lead to muscle cramps.
• Nausea: You may feel an upset stomach or like you need to vomit.
• Vomiting: This involves forcefully expelling the contents of the stomach through the mouth.
• Severe Pain in the Upper Side of the Abdomen Spreading to Your Back: If you experience this, it could be a sign of a more serious condition, such as pancreatitis, and you should seek medical attention.

Mild Side Effects of Spironolactone / Hydrochlorothiazide: While taking Spironolactone combined with Hydrochlorothiazide (HCTZ), you might experience some mild side effects. These are usually not serious and often don’t require medical attention. However, it’s important to communicate with your doctor if any of these effects are new, worsen, or become a concern. Here’s a breakdown of possible mild side effects:

• Cramp: You may feel sudden, involuntary muscle contractions that are often painful.
• Dizziness: This includes feeling unsteady, lightheaded, or as if the room is spinning.
• Allergy: Symptoms can include itching, rash, or more severe reactions like difficulty breathing.
• Diarrhea: Frequent loose or watery stools.
• Arthralgia: Pain in the joints.
• Indigestion: Discomfort or pain in the stomach associated with difficulty in digesting food.
• Breast Pain or Swelling: Discomfort and enlargement of breast tissue.
• Anorexia: Lack of appetite or decreased interest in food.
• Easy Bruising: Bruising more easily than usual.
• Vomiting: Throwing up the contents of the stomach.
• Blurred Vision: Not being able to see clearly, which may make objects appear out of focus.
• Confusion: Difficulty in thinking clearly or feeling disoriented.
• Heart Arrhythmia: Irregular heartbeat that can feel like a fluttering or racing heart.
• Headache: Pain or discomfort in the head, scalp, or neck.
• Dehydration: A significant loss of body fluids that can make you feel very thirsty, dry, or lightheaded.
• Difficulty Maintaining or Achieving an Erection: Problems with sexual function in men.
• Drowsiness: Feeling unusually sleepy or lethargic.
• Irregular Menstrual Periods: Changes in the timing or flow of menstrual bleeding.
• Tiredness: Feeling unusually fatigued or lacking energy.
• Yellowing Eyes or Skin: Also known as jaundice, indicating potential liver issues.
• Blood in Stools: Seeing red or black in your stools, which can indicate bleeding in the digestive tract.
• Dark Urine: Urine that is darker than usual can be a sign of dehydration or liver problems.

Serious Side Effects of Spironolactone / Hydrochlorothiazide: Spironolactone combined with Hydrochlorothiazide (HCTZ) can sometimes lead to severe side effects that require immediate medical attention. Although these are rare, it’s crucial to recognize them early as they can be life-threatening. Below is a description of serious side effects that you should be aware of:

• Allergic Reaction: Signs of a severe allergic reaction include hives, skin rashes, fever, difficulty breathing, and swelling around the mouth, lips, tongue, or throat. This is an emergency situation.
• Fluid and Electrolyte Imbalance: This condition can manifest as intense thirst, extreme weakness or fatigue, a fast heart rate, feeling dizzy, or experiencing dryness in the mouth. These symptoms arise from an imbalance of minerals and fluids in your body.
• Extremely High Potassium Levels: High levels of potassium in your blood can lead to severe muscle weakness, inability to move your arms or legs, extreme tiredness, a slower than normal heart rate, and feelings of tingling or numbness in your arms and hands.
• Gynecomastia: This is an enlargement of breast tissue in men, which can be uncomfortable or distressing.
• Severe Skin Reactions: Symptoms include skin that blisters or peels easily, changes in skin color, or skin that loosens, especially inside the mouth.
• Cardiovascular Issues: If you experience chest pain or tightness, severe dizziness or fainting, or a rapid or irregular heartbeat, these might be signs of serious heart-related problems.
• Kidney or Urinary Issues: Look out for changes in how often or how much you urinate, the presence of blood in your urine, or if it becomes painful or difficult to urinate. These can be signs of kidney problems or other urinary tract issues.
• Liver Issues: Symptoms indicating liver problems include yellowing of the skin or eyes (jaundice), dark-colored urine, or severe pain in the abdomen. 

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

There are certain warnings that you should take into consideration while using this medication:

• The safety & efficacy of this medication have not been established in the pediatric population, so you should consult an expert medical practitioner before using Spironolactone / Hydrochlorothiazide for children.
• You should not use Spironolactone / Hydrochlorothiazide if you have an allergy to any of the excipients of the product. Also, inform your medical team about all other allergies you may have.
• Spironolactone / Hydrochlorothiazide may interact with other medications. Before using this medication, you should tell your doctor about all the medications you are using or plan to use, including all prescription, non-prescription, and over-the-counter drugs and herbal or vitamin supplements.
• If you experience signs and symptoms of an allergy, including rash, hives, or swelling in your face, mouth, hand, or feet, you should discontinue using this medication and call your doctor at once.
• You should monitor your blood pressure on a regular basis, especially during the initial period of treatment with this medication, and share the reports with your doctor.
• This combination medication is not recommended during pregnancy due to the greater risk of fetal abnormalities with thiazide diuretics. If you are pregnant, suspect a pregnancy, or plan to become pregnant while using this medication, immediately call your doctor.
• If your doctor has recommended you to take a low-sodium diet or daily exercise program, you should continue to follow it and avoid potassium-containing salt substitutes while receiving treatment with Spironolactone and Hydrochlorothiazide. You may also be required to limit your consumption of foods containing high levels of potassium. For more information, you should consult an expert medical practitioner.

Is There a Black Box Warning for Spironolactone and Hydrochlorothiazide?

A boxed warning has been issued by the FDA for Spironolactone / Hydrochlorothiazide due to certain risks associated with its use. The key points of the boxed warning are as follows:

• Spironolactone has been shown to be producing or tending to produce tumors in a study conducted in rats, which means that it has the potential to cause tumors when used for an extended period of time.
• Spironolactone and Hydrochlorothiazide can cause significant electrolyte imbalances, which may lead to severe health issues.
• The combination medication containing Spironolactone / Hydrochlorothiazide can lead to severely high potassium levels in the body, especially when taken with other potassium-sparing diuretics, angiotensin II receptor antagonists, ACE inhibitors, NSAIDs, or potassium supplements.
• The medication should only be used for conditions that have been specifically indicated. And it should be used under strict medical supervision to avoid unnecessary risks.

When deciding to start using a medication, you should consult a licensed healthcare professional, discuss with them in detail, and weigh the risks associated with the use of the medication and its benefits. For Spironolactone / Hydrochlorothiazide, you should consider the following.

• Before using this medication, you should tell your doctor if you have an allergy to Spironolactone or Hydrochlorothiazide or if you have any other allergies to dyes, drugs, herbs, or vitamin supplements. This medication may contain certain inactive ingredients or other issues. You should talk to your pharmacist or doctor regarding the complete list of the ingredients present in the medication.
• Before using Spironolactone / Hydrochlorothiazide, you should share your complete medical and family history with your doctor, especially if you have the following conditions:
  • Untreated salt/mineral imbalance
  • Kidney disease
  • Liver condition
  • Dehydration
  • Gout
  • Lupus
  • High levels of fat in the blood
  • Decreased adrenal gland function
  • Skin disease
• If you plan to have a surgery, including a dental procedure, you should tell your dentist, doctor, or surgeon about all the medications you are using, including Spironolactone / Hydrochlorothiazide. Also tell them about all the prescription, non-prescription, over-the-counter drugs, herbal, or vitamin supplements you may be taking.
• Spironolactone / Hydrochlorothiazide may make you feel dizzy or drowsy. Alcohol consumption or using marijuana may increase this effect. You should not drive a vehicle, use heavy machinery, or engage in tasks that require mental alertness or clear vision unless you can do it safely.
• If you experience severe sweating, vomiting, or diarrhea, it can make you feel lightheaded. Call your doctor immediately if you have severe vomiting or diarrhea. You should increase your fluid intake while receiving treatment with Spironolactone / Hydrochlorothiazide to prevent dehydration, unless instructed otherwise by your doctor. 
• Spironolactone / Hydrochlorothiazide can increase your sensitivity to the sun, which can further increase your risk of skin cancer, especially when it is taken for a long time. To prevent this, you should limit your time under the sun, avoid sunlamps and tanning booths, and wear protective clothing & sunscreen when you are under the sun. Call your doctor if you have redness, skin blisters, new moles, or skin lesions.
• If you have diabetes mellitus type 1 or 2, this medication can affect your blood glucose levels. You should check your blood glucose levels on a regular basis and share the reports with your doctor. Inform your doctor if you experience symptoms of hyperglycemia, such as increased thirst or urination. Your doctor may suggest you make certain dietary changes or make adjustments to your medication or exercise program.
• Spironolactone / Hydrochlorothiazide can affect the levels of potassium in your bloodstream. You should consult an expert medical practitioner before using potassium supplements or salt substitutes that have potassium.
• Geriatric patients are at a greater risk of certain side effects caused by this medication, such as its effects on potassium, lightheadedness, or dizziness. The feeling of lightheadedness or dizziness can increase the risk of unintentional falling.
• Spironolactone / Hydrochlorothiazide can pass into breast milk but is unlikely to cause harm to the breastfeeding infant. However, you should consult your medical team before breastfeeding a baby while receiving treatment with this medication.

If you are using spironolactone and hydrochlorothiazide for blood pressure management, it is important to understand that this medication is contraindicated in patients who have:

• Anuria
• Severe renal impairment
• Addison’s disease
• Hyponatremia
• Hyperkalemia
• Pregnancy
• Breastfeeding

If you think that you have missed a dose of spironolactone and hydrochlorothiazide for blood pressure management or forget to take it on time, below are some instructions of what you can do:

• If you have missed a dose, you can still take it as soon as you remember.
• However, if it is almost time to take your next dose, you may leave the missed dose and continue taking your medication according to your regular dosing schedule.
• You should not take double or extra doses of the same medication to compensate for the missed dose, as it can lead to undesirable side effects.
• To further prevent missing doses, you should set a reminder on your phone. Medication reminders work best for this purpose.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

You should not take spironolactone and hydrochlorothiazide for blood pressure management more than recommended as it can cause severe side effects. Symptoms of an overdose may include:

• Disorientation
• Drowsiness
• Mood or mental changes
• Hallucination
• Lethargy
• Lightheadedness
• Rashes

If you suspect an overdose, you should seek immediate medical assistance. You can call 911, a poison control helpline, or an expert medical professional. You can also head to the nearest emergency room.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

Following the proper storage guidelines is essential, when you buy spironolactone hydrochlorothiazide online, for the safe and efficient use. Here’s how you can store your medication:

• You should keep Spironolactone and Hydrochlorothiazide in its original container or blister pack to protect it from direct sunlight, excess heat, and moisture. Do not keep it in the bathroom, under the sink, or in places with high humidity as moisture can cause damage to certain medications. 
• You should keep all medications, including Spironolactone / Hydrochlorothiazide, in a tightly sealed container in a secure place away from the reach and sight of children & pets to avoid accidental consumption of the drug.
• Do not allow the medication to freeze or be exposed to extreme temperatures.
• Do not keep medications that are no longer needed or have passed their expiration date, which is the last day of the month mentioned on the back of the blister pack or carton. You should dispose of them safely.
• You should refrain from pouring them in the water, flushing them down the toilet, or throwing them into the household garbage bin unless instructed otherwise by your healthcare provider.
• You should discard unwanted and outdated medications in such a way that prevents children, animals, and others from consuming them.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.
• For more information on how to properly dispose of unwanted medications, you should consult your local waste disposal company, pharmacist, or healthcare provider.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

When you’re taking spironolactone and hydrochlorothiazide for blood pressure management, it’s crucial to be aware of potential drug interactions. These interactions can affect how well the medication works or increase your risk of side effects. Before starting this medication, you should inform your doctor or pharmacist about all the medicines you are taking, including prescription, over-the-counter drugs, and any supplements or herbs. This helps prevent unwanted interactions. Here’s how interactions with certain medications can impact spironolactone and hydrochlorothiazide:

• Blood Pressure and Heart Medications (like Captopril, Enalapril, Lisinopril, Ramipril): These drugs can increase the risk of high potassium levels in your blood when taken with Spironolactone / Hydrochlorothiazide, which can be dangerous.
• Diabetes Medications (like Insulin, Glipizide): Taking these with Spironolactone / Hydrochlorothiazide can affect blood sugar control. It may either lower or raise your blood sugar levels more than expected.
• Anti-inflammatory Drugs (like Ibuprofen, Naproxen, Indomethacin): These can reduce the kidney function and alter the effectiveness of Spironolactone / Hydrochlorothiazide, potentially leading to further complications.
• Blood Thinners (like Warfarin): When taken with Spironolactone / Hydrochlorothiazide, there could be an increased risk of bleeding or an effect on how well the blood thinner works.
• Drugs that affect Potassium Levels (like ARBs, ACE inhibitors, and Potassium supplements): These can increase potassium to potentially dangerous levels when taken with Spironolactone / Hydrochlorothiazide.
• Cyclosporine: This medication, used to prevent organ rejection, can increase the side effects of Spironolactone / Hydrochlorothiazide, especially affecting the kidneys.
• Opioids (like Methadone, Tramadol): These can increase the risk of electrolyte imbalances and worsen side effects like dizziness and confusion when used with Spironolactone / Hydrochlorothiazide.
• Antidepressants and Mood Stabilizers (like Lithium): Can increase the risk of toxicity from these drugs due to changes in kidney function caused by Spironolactone / Hydrochlorothiazide.

What Are the Other Interactions to Spironolactone and Hydrochlorothiazide?

When taking Spironolactone and Hydrochlorothiazide, it’s important to be aware of interactions not only with other medications but also with certain foods, beverages, herbal remedies, and even lifestyle choices like alcohol and tobacco use. Here’s how these can affect your treatment:

• Food and Beverages:
• • • Potassium-rich foods like bananas, oranges, and spinach can increase potassium levels in your blood, which is a concern since Spironolactone / Hydrochlorothiazide can also raise potassium. High potassium levels can be harmful to your heart health.
    • Salt substitutes often contain potassium instead of sodium and should be avoided for the same reason as high-potassium foods.
    • Alcohol can increase the blood pressure-lowering effects of Hydrochlorothiazide, potentially leading to dizziness or fainting.
• Herbal Remedies and Supplements:
• • • Licorice can interfere with Spironolactone’s effectiveness and may increase the risk of side effects from Hydrochlorothiazide.
    • Vitamin supplements, especially those containing potassium, should be used cautiously to prevent potassium levels from becoming too high.
• Tobacco and Alcohol Use:
• • • Smoking can decrease the effectiveness of Hydrochlorothiazide in lowering blood pressure.
    • Drinking alcohol can enhance the blood pressure-lowering effects of Hydrochlorothiazide, leading to increased dizziness, light-headedness, or even fainting.
• Disease Interactions:
• • Kidney problems: Spironolactone / Hydrochlorothiazide can affect kidney function, which is particularly important if you already have kidney issues. Your doctor may need to adjust your dosage or monitor your kidney function closely.
  • Liver disease: If you have liver problems, using Spironolactone / Hydrochlorothiazide can lead to further complications, including affecting how drugs are processed in your body.
  • Diabetes: The medication can affect blood sugar levels. If you have diabetes, you might need closer monitoring of your blood sugar and adjustments to your diabetes medications.
  • Gout: Hydrochlorothiazide can potentially trigger gout attacks by increasing uric acid levels in your blood.

[Note: This isn’t a complete list, and there could be other drugs that interact with Spironolactone / Hydrochlorothiazide. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

If you use spironolactone and hydrochlorothiazide for blood pressure management, it may not be suitable for everyone or may fail to provide desired results to the patient. For this reason, people are looking for alternatives to Spironolactone and Hydrochlorothiazide. There are many popular substitutes for Spironolactone HCTZ available on the market. If you plan to switch from your existing medication, you should get in touch with your doctor and according to your age, needs, and medical condition, they will help you determine the medication that will work the best for you. Some of the popular Spironolactone HCTZ alternatives are as follows: 

• Zestril
• Diovan (valsartan)
• Norvasc (amlodipine)
• Lasix (furosemide)
• Aldactone
• Altace
• Vasotec

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

The cost of spironolactone and hydrochlorothiazide for blood pressure management can vary based on factors including health insurance coverage & the purpose for which it is prescribed. Unfortunately, many health insurance plans in the U.S. do not cover this medication when used for weight loss, leading to significant out-of-pocket expenses for patients. To help manage these costs, some individuals opt to buy Spironolactone hydrochlorothiazide online from Canadian pharmacies, where prices are often lower than American counterparts. Services like Polar Bear Meds offer this medication at reduced rates, and new customers can get a 10% discount on their first order using the spironolactone and hydrochlorothiazide coupon code “WELCOMEPB10”.

AtPolarBearMeds.com, we assure you the most affordable price to buy Spironolactone Hydrochlorothiazide online from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently buy spironolactone and hydrochlorothiazide for blood pressure management and to treat hypertension at a substantial cost, call us at 1-888-779-2193 toll-free.