Synvisc

Synvisc Hylan GF20 Injection is an FDA-approved viscosupplementation treatment containing Hylan G-F 20, a natural glycosaminoglycan prescribed to alleviate knee pain associated with osteoarthritis. They are administered as a single intra-articular injection spaced one week apart, totaling three injections, each containing 2 ml (16 mg) of Hylan G-F 20. It works by supplementing the natural synovial fluid in the knee joint, enhancing joint lubrication, and reducing friction during movement. Patients with knee infections, allergies to bird feathers or egg products, or blood clotting issues should not take Synvisc. Follow your doctor’s advice for missed doses and consult for medical advice about side effects and storage.

Product Overview

Synvisc One Injection is a viscosupplementation treatment containing Hylan G-F 20, a natural glycosaminoglycan used to alleviate knee pain caused by osteoarthritis. It is administered as a single intra-articular injection spaced one week apart, totaling three injections, to provide relief for up to 6 months. Each injection contains 2 ml (16 mg) of Hylan G-F 20 and should only be injected into one knee.

Synvisc works by supplementing the natural synovial fluid in the knee joint, enhancing joint lubrication and reducing friction during movement, thereby alleviating pain and protecting the knee’s cartilage from further deterioration. It replaces damaged synovial fluid with a substance similar to that found in healthy joints, promoting joint function restoration.

Common side effects of Synvisc One Injection include injection site reactions, muscle pain, trouble walking, fever, chills, nausea, vomiting, headache, dizziness, itching, or skin irritation around the knee. Serious side effects may include joint stiffness, arthralgia, joint swelling, joint effusion, injection site pain, joint warmth, arthropathy, arthritis, and gait disturbance.

Patients should not take Synvisc if they are allergic to bird feathers or egg products, have infections in or around the knee, or have circulation problems or blood clots in the legs. It should not be injected into a vein or artery. The Synvisc syringe is for single use only and should be used immediately after opening. Store Synvisc at room temperature, away from direct sunlight and excessive heat. Follow your doctor’s advice regarding missed doses and overdoses, and consult with your healthcare provider for medical advice about side effects and proper storage.

Synvisc is used to:

• Treat knee pain caused by osteoarthritis

Synvisc is supplied in a 2.25 mL glass syringe containing:

• 2 ml (16 mg) dose of Hylan G-F 20.

Recommended Dosage for Synvisc-One

Usual Dosage for Osteoarthritis Knee Pain

Synvisc-One is given as a solitary injection into the joint space spaced one week apart, totaling three injections, to provide relief for up to 6 months. The total dose of 6 mL is to be injected in one knee only.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

• Synvisc Hylan GF20 knee injection should only be done by a qualified doctor.
• It is administered as a single intra-articular injection spaced one week apart, totaling three injections, to provide relief for up to 6 months.
• Synvisc one injection is usually given using an 18- to 22-gauge needle.
• After properly cleaning and numbing the injection site, the medical professional will inject the Synvisc using the standard technique.
• It is important to note that most patients experienced pain relief starting around four weeks after receiving treatment for knee osteoarthritis with Synvisc-One or even as early as one week with Synvisc injection.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Synvisc operates through a process known as viscosupplementation, acting as a supplement to the natural synovial fluid within the knee joint. This supplementation is vital in enhancing joint lubrication by increasing the viscosity of the joint fluid. By doing so, Synvisc Hylan GF 20 effectively reduces friction during movement, consequently alleviating pain associated with joint mobility. Furthermore, the gel-like consistency of Synvisc Hylan GF 20 plays a crucial role in safeguarding the knee’s cartilage from further deterioration.

This protective cushioning effect helps prevent additional wear and tear on the cartilage. Notably, this treatment method involves replacing damaged synovial fluid with a substance found in the healthy joints of individuals aged 18 to 27. This approach addresses existing discomfort and promotes the restoration of joint function, offering patients a comprehensive solution for managing knee pain.

Common side effects of Synvisc include:

• Injection site reactions
• Muscle pain
• Trouble walking
• Fever
• Chills
• Nausea and vomiting
• Headache
• Dizziness
• Itching or skin irritation around the knee

Serious side effects of Synvisc include:

• Arthralgia
• Joint stiffness
• Joint effusion
• Joint swelling
• Joint warmth
• Injection site pain
• Arthritis
• Arthropathy
• Gait disturbance

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

• You should not take Synvisc if you have an infection in your knee or the area around your knees.
• Tell your doctor if you are allergic to bird, feathers, or egg products.
• Let your doctor know if you have blood clots or circulation problems in your legs.
• You should not stand for more than 1 hour and indulge in strenuous activity, jogging, or high-impact sports for at least 48 hours after using Synvisc Hylan GF20 injection. Ask your doctor how long you should wait before resuming these activities.
• Disinfectants that contain quaternary ammonium salts should not be used to clean the injection spot on the skin.
• Synvisc should not be injected into a vein or artery because it may increase the risk of unwanted side effects.

• The syringe containing Synvisc Hylan gf 20 is intended for single use. The medication should be used immediately after it has been opened.
• Do not use Synvisc one injection if it has been opened or damaged.

Other Important Precautions

Before taking the medication, let your doctor know if:

• You are pregnant or planning to get pregnant.
• You are breastfeeding a baby
• You are less than 21 years of age

Synvisc one 1x6ml is contraindicated in patients with:

• Known hypersensitivity to hyaluronan products.
• Infections in or around the knees.

• If you have missed your appointment of Synvisc Hylan GF20 Injection, contact your healthcare provider or doctor to know what should be done next.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

Since this medication is to be given by a medical professional, an overdose of the medication is unlikely to occur. But if you notice any signs of an overdose, tell your doctor immediately.

[Note: If someone you know has accidentally overdosed on the medication, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

• Store it in original packaging away from direct sunlight or excessive heat at room temperature.
• Do not freeze the medication.
• Keep it away from the reach of children.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Medications that interact with Synvisc-one include:

• benzalkonium chloride topical
• cetylpyridinium topical

[Note: This isn’t a complete list, and there could be other drugs that interact with Synvisc-one. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

• Diclofenac (diclofenac potassium)
• Mobic (mobicox)
• Celecoxib (apo celecoxib)
• Ibuprofen
• Voltaren (diclofenac sodium)
• Naproxen

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.