Tadalafil PAH

Tadalafil PAH is an FDA-approved medication with the active ingredient Tadalafil and is usually marketed as Adcirca. It treats pulmonary arterial hypertension (PAH) by relaxing the blood vessels of the lungs and relieving stress in the heart. It is available in tablet form in strength: Tadalafil 20mg. The standard daily dose is 40 mg, with or without food, and your healthcare provider may adjust the dosage. Common side effects may occur, such as headaches, flushing, and back pain. Rarely, severe effects like sudden vision or hearing loss may occur. Avoid missing doses and take it immediately if you’re not close to the next planned dose. Do not overdose; it may worsen side effects. Store at room temperature, away from heat, moisture, and children. Discuss any concerns about safe use with your healthcare provider.

Tadalafil PAH is an FDA-approved medication containing the active ingredient Tadalafil. It is a phosphodiesterase type 5 inhibitor commonly marketed under the brand name Adcirca. It is used for the treatment of pulmonary arterial hypertension (PAH), which is a kind of high blood pressure in the arteries of the lungs. It works by settling the blood vessels in the lungs to improve blood flow, thereby decreasing the stress on the heart and improving exercise capacity in those with PAH.

Tadalafil PAH is typically available in tablet form with strength: Tadalafil 20mg. The recommended dose is usually 40 mg once daily, with or without food. It’s crucial to follow the dosage prescribed by a healthcare professional, as dosage may vary based on individual factors such as age, weight, and severity of the condition.

Common side effects of Tadalafil PAH may include headache, flushing, stomach upset, back pain, and muscle pain. In some cases, more severe side effects, like sudden vision or hearing loss, may occur. You should seek medical attention if you experience any severe side effects.

You should not miss doses, as it may reduce the effectiveness of the medication. If so, take the missed dose unless it is almost time for the next one. It should not be taken more than once daily to prevent the risk of overdose. It should be stored at room temperature, away from moisture, heat, children, and pets. You should discuss the usage guidelines with a healthcare professional to ensure safe use.

• It is used for the treatment of pulmonary arterial hypertension (PAH)

Dosage

Strengths and Forms

It is available in tablet form with strength: Tadalafil 20mg.

Recommended Dosage for Tadalafil PAH

For Adults with PAH:

• The recommended dose is 40 mg (two Tadalafil 20mg tablets) once daily, with or without food.

For Patients with Renal Impairment:

• The Initial dose is 20 mg daily and increases to 40 mg based on tolerability.
• People with serious renal impairment and hemodialysis should not use it.

For Patients with Hepatic Impairment:

• The initial dose is 20 mg for mild to moderate cases
• It is not recommended for severe cases.

For Geriatric Patients (>65 Years):

• No dosage adjustment is needed without renal or hepatic impairment.

For Pediatric Patients:

• Not recommended.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your Tadalafil 20mg dosage accordingly.]

• Take Tadalafil PAH as directed by your healthcare provider.
• The recommended dose is 40 mg (two Tadalafil 20mg tablets) once daily.
• Take the medication with or without food.
• Swallow the tablets whole with a glass of water; do not crush, break, or chew them.
• Do not divide the 40 mg dose over the day.

[Note: Your doctor will decide the right amount of Tadalafil PAH for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Tadalafil PAH works by relaxing the blood vessels in the lungs, decreasing stress on your heart. Tadalafil is a kind of phosphodiesterase type 5 (PDE5) inhibitor. By inhibiting PDE5, Tadalafil increases levels of cyclic guanosine monophosphate (cGMP), which is a type of chemical that helps to dilate blood vessels. This dilation improves blood flow in the lungs, alleviating symptoms of pulmonary arterial hypertension (PAH) and reducing the workload on the heart.

Common side effects of Tadalafil PAH may include:

• Headaches
• Flushing (reddening and warming of the face)
• Back pain
• Muscle pain
• Runny nose or sore throat
• Cough, fever, or other respiratory infection
• Pain in hands and feet
• Stuffy or congested nose
• Upset stomach

Mild side effects of Tadalafil PAH may include:

• Nasal congestion
• Muscle aches
• Dizziness
• Diarrhea
• Upset stomach

Serious side effects of Tadalafil PAH may include:

• Sudden vision or hearing loss
• Chest pain
• Fainting
• Migraine
• Seizures
• Memory problems
• Low blood pressure
• Irregular heartbeat (arrhythmia)
• Difficulty breathing or shortness of breath
• Allergic reactions such as rash, itching, or inflammation (swelling of the face, lips, or throat)
• Priapism
• Fluid builds up in the lungs

[Note: Remember, this list may not cover all possible side effects of Tadalafil 20mg. Always consult with your healthcare giver for medical advice about side effects.]

Hypotension: Tadalafil PAH can cause a significant drop in blood pressure, particularly if you are already taking antihypertensive medications. Caution should be exercised, especially during initiation of therapy or dosage adjustments.

Cardiovascular Risks: Patients with preexisting cardiovascular conditions may be at increased chance of cardiovascular events, including myocardial infarction, sudden cardiac death, or stroke. Tadalafil should be used with caution in such patients.

Priapism: Prolonged erections or priapism lasting more than 4 hours have been reported in those who used Tadalafil. You should seek immediate medical attention if you encounter an erection that lasts more than 4 hours.

Vision Loss: Cases of sudden vision loss, including non-arteritic anterior ischemic optic neuropathy (NAION), are reported in patients taking Tadalafil. Patients experiencing sudden vision loss should discontinue the medication and seek prompt medical attention.

Hearing Loss: Sudden hearing loss or decrease in hearing has been reported with the use of Tadalafil. Patients experiencing sudden hearing loss should discontinue the medication and seek medical evaluation.

Pulmonary Vasodilators: Tadalafil is not recommended for patients with other forms of pulmonary hypertension or the treatment of erectile dysfunction.

• Take Tadalafil strictly as recommended by your doctor.
• Let your doctor know about all medications you’re taking, including over-the-counter drugs and supplements.
• Inform your doctor about any history of cardiovascular problems, low blood pressure, hepatic or renal disease, or vision or hearing issues before starting Tadalafil.
• Avoid alcohol consumption while taking Tadalafil.
• Avoid using Tadalafil if you are taking a nitrate drug for angina (chest pain) or cardiovascular problems.
• Seek medical help if you experience sudden vision loss or hearing loss while taking Tadalafil.
• Contact your doctor immediately if you have a painful or prolonged erection for 4 hours or longer.

• Hypersensitive to Tadalafil or any other component.
• Using any form of organic nitrate ((e.g., nitrates, nitrites, or nitric oxide donors).
• Taking guanylate cyclase stimulators, such as riociguat.

In case of a missed dose of Tadalafil PAH:

Take it when you remember. If it’s near to your next planned dose, skip the missed one and take the next dose at your usual time.

Avoid taking two doses simultaneously to compensate for the missed one.

Stick to your regular dosing plan.

[Note: If you have missed a dose of Tadalafil 20mg and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Avoid taking more than the dose prescribed by your healthcare professional. Symptoms of overdose may include severe lightheadedness, fainting, prolonged erection, or vision changes.

[Note: If you consumed more than the recommended doses of Tadalafil 20mg, get medical help right away or call the Poison Help line at 1-800-222-1222.]

• Keep it tightly closed in its original container at room temperature, away from moisture and heat.
• Store it out of reach of children and pets.
• Do not freeze Tadalafil.
• Dispose of any expired or extra medication properly, following local regulations or guidelines.

[Note: Discuss with your healthcare professional about the proper disposal of unused Tadalafil PAH tablets and any questions you may have regarding their storage.]

• Nitrates
• Erectile dysfunction medicines
• Tadalafil products (including Cialis)
• Riociguat
• High blood pressure medications
• Certain drugs used for treating HIV
• Antifungal medicines like fluconazole, itraconazole, ketoconazole, and voriconazole
• Seizure medications like carbamazepine, phenytoin, and phenobarbital.
• Grapefruit juice
• Macrolide antibiotics
• Prostate problem medications
• Rifamycins (such as rifabutin, rifampin, or rifapentine)

[Note: This isn’t a complete list, and there could be other drugs that interact with Tadalafil PAH. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

• Revatio (sildenafil)
• Flolan (epoprostenol)
• Remodulin (treprostinil)
• Ventavis (iloprost)
• Uptravi (selexipag)
• Cialis (tadalafil)
• Adcirca (tadalafil)

[Note: Your doctor will choose what’s the best alternative to Tadalafil PAH for you. Only use these alternative medications after consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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