Trazodone 

Trazodone Hydrochloride 

Trazodone is an FDA-approved antidepressant that belongs to a drug class called serotonin modulators. The prescription medication is used to treat depression and related disorders. It mainly contains trazodone as its main ingredient, which functions by modulating the brain’s serotonin levels. It is available in the form of a tablet that comes in strengths of 50mg, 100mg, 150mg, and 300mg, to be taken orally once or twice daily, with or without food. You should take Trazodone exactly as prescribed by your doctor. You can seek guidance from a licensed medical provider if you have any queries regarding the medication usage or dosage. If you want to buy Trazodone for sleep or depression, obtain it from reputable sources to ensure the medicine you are using is authentic.

Product Overview

Trazodone Hydrochloride is a serotonin modulator approved by the FDA used to treat major depressive disorder. It contains trazodone which functions by modulating the brain’s serotonin levels, though the exact mechanism of action is not fully known. This adjustment helps to improve mood, appetite, and energy levels, aiding in the recovery from depression.

Trazodone Hydrochloride is available in multiple strengths, with dosages depending on the severity of the medical condition. It is generally taken once or twice daily, preferably with food, to minimize stomach upset. It is suitable for adults and should be taken regularly to achieve the maximum benefit. The drug’s action involves restoring the balance of serotonin in the brain, which helps to enhance mood and alleviate the symptoms of depression.

Possible side effects include drowsiness, dizziness, and dry mouth. Patients should consult their doctor if these persist or worsen. Precautions include avoiding alcohol and informing the prescriber of any history of bipolar disorder or glaucoma. Missed doses should be taken promptly unless it’s near the time for the next dose; do not double up. In case of Trazodone overdose, seek immediate medical attention. Trazodone Hydrochloride should be stored at room temperature, away from light and moisture. Always follow the recommendation of your healthcare provider regarding use & potential interactions.

What Are the Uses of Trazodone Hydrochloride?

It is used to treat:

• Depression 

What Are the Forms & Strengths of Trazodone Hydrochloride?

It is available in the form of a tablet that comes in the following strengths:

• 50 mg 
• 100 mg
• 150 mg 
• 300 mg  

What Are the Recommended Dosage of Trazodone Hydrochloride?

The dosage of Trazodone Hydrochloride varies based on the individual patient factors, including the age, needs, and the medical condition being treated. The recommended medication dosage is generalized. If your doctor has recommended a dose different from the one mentioned, you should use the medication exactly as your physician has prescribed and do not make changes to your medication dose without consulting them. The dose of Trazodone Hydrochloride to treat depression in patients belonging to different age groups usually includes:

For Depression 

For Adults

• Initial dose: 150 mg taken orally every day with or without food, in divided doses. 
• Maintenance dose: Your doctor may increase your dose up to 300 mg daily. 
• Maximum dose: 400 mg daily

For Elderly Patients

• Initial dose: 75-100 mg daily to minimize the risk of side effects.
• Dosage adjustments are made more cautiously in this population. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Trazodone Hydrochloride? 

Before taking this medication, you should carefully read and follow the instructions for use given in the medication guide or patient information leaflet shared by your healthcare provider or pharmacist. If you have any queries or concerns or if you do not understand any part of this leaflet, you should ask your doctor. 

• Take Trazodone Hydrochloride exactly as prescribed by your doctor. Your doctor may occasionally change your medication dose. Do not take more or less of it, in large quantities, or more frequently than prescribed, as it may lead to unwanted side effects. 
• If your medication dose is 300 mg or less daily, your doctor will most likely tell you to take it as a single dose at night. Since Trazodone may make you feel sleepy, using it at night time may help if you are having difficulty sleeping. 
• You may take it after a meal or snack to decrease the chance of an upset stomach. 
• It may take up to two weeks before your symptoms get better.
• You should continue to take this medication even if you feel well. You should not stop taking it abruptly, as it may cause unwanted side effects such as vomiting, sweating, confusion, dizziness, tingling, or numbness. If you plan to discontinue taking this medication, you should tell your doctor. They will help you gradually taper off the medication to lessen the chances of withdrawal symptoms.  
• Tell your doctor if your condition does not get better or if it worsens. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Trazodone Hydrochloride Work?

Trazodone hydrochloride is an antidepressant that belongs to the class of serotonin antagonists & reuptake inhibitors or SARIs. It works primarily by affecting neurotransmitters in the brain, particularly serotonin. Trazodone inhibits the reuptake of serotonin, allowing more of this neurotransmitter to remain available in the synaptic cleft. This action is believed to help regulate mood and alleviate depressive symptoms. Additionally, Trazodone acts as an antagonist at certain serotonin receptors, which contributes to its sedative effects. It also has some action on other neurotransmitters like norepinephrine and histamine, which may contribute to its overall antidepressant and sleep-promoting effects.

Important Safety Information for Using Trazodone Hydrochloride

What Are the Side Effects of Trazodone Hydrochloride?

Common Side Effects of Trazodone Hydrochloride: Like many medications, Trazodone Hydrochloride may cause a range of common side effects that are generally not severe and often disappear as your body adjusts to the medication. A significant number of patients experience these effects and usually do not require medical attention unless they persist or become bothersome. Common side effects include:

• Drowsiness: Due to the sedative properties of Trazodone, some patients can experience drowsiness while using it. This effect is usually experienced during the initial days of starting treatment or when dosages are altered. To manage this side effect, patients are best advised to take this medicine at bedtime. This helps align the sedative effects of the drug with the sleep cycle. If daytime drowsiness persists or becomes worrisome, you should consult a healthcare provider. They are most likely to adjust your dosage. 

• Dizziness: The medication’s alpha-1 adrenergic receptor blockade can lead to dizziness, especially when standing or sitting after lying down for a long period of time. To prevent this, patients should rise slowly from sitting or lying positions. Staying hydrated and avoiding sudden posture changes can also help. If dizziness continues, it’s important to discuss it with a healthcare provider.

• Dry mouth: This medicine can decrease the amount of saliva produced in the mouth, resulting in dryness. To alleviate this discomfort, you should drink plenty of water throughout the day, eat sugar-free chewing gum, or use saliva substitutes. Maintaining good oral hygiene may also help prevent dental issues associated with decreased saliva. 

• Blurred vision: Some patients may experience blurred vision due to trazodone’s effects on the central nervous system. This side effect is usually temporary and disappears within a couple of days or weeks. However, if it persists or becomes bothersome, you should let your doctor know immediately. 

• Constipation: This medication can slow down gastrointestinal motility, leading to constipation. To promote bowel regularity, you should increase your fiber intake, stay adequately hydrated, and engage in regular physical activity. If constipation becomes severe, you should consult a healthcare professional. They are most likely to suggest a suitable laxative. 

• Headache: Headaches are a common side effect of Trazodone and usually occur as your body adjusts to it. After consulting with your doctor, you can take over-the-counter drugs to provide relief. But if the headache is persistent or severe, seek prompt medical assistance. 

• Nausea & Vomiting: These are some of the most commonly occurring gastrointestinal side effects associated with the use of Trazodone. You can take the medicine with food or a milky drink to minimize nausea. If you have vomiting or severe nausea, talk to your doctor. They are most likely to alter your dosage. 

• Changes in weight or appetite: This medicine can cause reduced or increased appetite, which further causes weight loss and weight gain, respectively. To manage these changes, you should monitor your dietary habits, maintain a balanced diet, and engage in regular physical exercise. If you have significant weight changes, talk to your doctor. 

• Sweating: Due to the effect of Tradozone on the autonomic nervous system, it is possible for some people to experience increased sweating. You should wear breathable cotton clothing and use antiperspirants to help manage this side effect. If the sweating is excessive, consult a healthcare professional. 

Mild Side Effects of Trazodone Hydrochloride: In addition to the common side effects, some patients may experience mild side effects that are less frequent but still not typically cause for significant concern. These effects may be temporary and often resolve on their own. However, if they persist or worsen, it’s best recommended to consult a healthcare provider. Mild side effects can include:

• Confusion: Due to Trazodone Hydrochloride’s sedative properties and its effect on neurotransmitter levels in the brain, some individuals may experience confusion while using it. To manage this, try not to engage in hazardous activities, drive a car, or use machinery unless you determine how Trazodone affects you. If you experience severe or persistent confusion, talk to your doctor. 

• Weakness: Some patients experience unusual weakness or fatigue while using Trazodone. This may be caused by the medication’s effect on the central nervous system, which leads to decreased energy levels. To manage this side effect, maintain a balanced diet, engage in light exercise, and ensure adequate rest. If the weakness or fatigue starts to impact your daily life, discuss it with an expert medical practitioner. 

• Muscle pain: The exact mechanism of why this happens is not completely understood, but it may involve alterations in neurotransmitter activity that affect muscle function. The muscle pain usually ranges from mild to moderate intensity; if it is severe, you should report it to your doctor. You can use over-the-counter pain relief drugs or apply warm compresses to provide relief from the pain. 

• Skin rash & itching: These reactions can be due to hypersensitivity reactions due to Trazodone. These dermatological reactions can range from mild to severe. To prevent skin irritation, keep the skin moisturized and avoid known allergens. Over-the-counter antihistamines may alleviate itching. If a rash is accompanied by swelling, trouble breathing, or other severe symptoms, seek prompt medical attention, as this could indicate a serious allergic reaction.

• Nervousness: Some patients experience nervousness or anxiety when taking Trazodone. This effect may be due to individual response to treatment. Practicing relaxation techniques, including meditation, deep breathing, or yoga, can help manage these feelings. If nervousness persists or becomes serious, you should consult a healthcare professional. They may adjust your dosage or ask you to switch to a different medicine. 

• Changes in sexual desire or ability: This medicine can affect sexual function in some patients, leading to decreased libido or difficulties in sexual performance. This is usually temporary, but if it persists, talk to a healthcare professional. 

• Ringing sensation in the ears: Tinnitus, or ringing in the ears, has been reported by some individuals on trazodone. The cause is not entirely clear but may involve changes in neurotransmitter levels affecting auditory pathways. To manage tinnitus, reduce exposure to loud noises, limit caffeine and alcohol intake, and consider using white noise machines to mask the ringing. If tinnitus is bothersome or persistent, consult an audiologist or your healthcare provider for further evaluation and management strategies.

Serious Side Effects of Trazodone Hydrochloride: Trazodone Hydrochloride may potentially cause serious side effects that require immediate medical attention. These effects are generally rare but can be significant if they occur. It’s crucial to be aware of these potentially serious side effects and seek medical help promptly if they are experienced. Serious side effects may include:

• Priapism: Trazodone can cause an unwanted erection that is painful, persistent, and that may occur without sexual arousal. If priapism is not treated quickly, permanent damage to the penis may occur. 
• Cardiac conditions. Its symptoms may include irregular or fast heartbeat, chest pain, shortness of breath, severe dizziness, and fainting. 
• Severe infections
• Hematological disorders. Its symptoms may include unusual bruising, bleeding gums, blood in stool or urine, or nosebleeds.
• Liver dysfunction. Its symptoms may include dark urine, vomiting, stomach pain, persistent nausea, yellowing of the skin or the eyes, or dark urine.
• Seizures. Its symptoms may include loss of consciousness, convulsions, and uncontrollable jerking movements. 
• Severe allergic reactions, including anaphylaxis. Stop using trazodone and get help right away if you have any of the given symptoms of a severe hypersensitivity reaction. It includes swelling of the face/throat/mouth/tongue, difficulty breathing, itching, hives, or severe rash. 
• Low sodium levels. Its symptoms may include confusion, weakness, headache, difficulty concentrating, or memory problems.
• Angle-closure glaucoma. Its symptoms may include vision changes, severe eye pain, redness in the eye, and swelling around the eye.
• QT prolongation. Its symptoms may include seizures, fainting, or irregular heartbeat.
• Suicidal ideation. Antidepressants, including Trazodone, may increase the chance of suicidal behavior or thoughts in some children, adolescents, or young adults in the initial few months of starting treatment with the medicine or when the dose is changed. Its symptoms may include thoughts of self-harm, unusual changes in mood or behavior, or worsening depression. If you or your child experience thoughts or actions regarding suicide or self-harm, seek medical help. 
• Serotonin syndrome: This happnes when there is too much serotonin in your body. It can be caused when Trazodone is used alone or when used with other medicines. Its symptoms may include hallucinations, agitation, dizziness, rapid heart rate, flushing, muscle tremor or rigidity, vomiting/nausea, or diarrhea. This condition can be life-threatening.
• Low Blood Pressure Upon Standing: Trazodone may cause a sudden drop in blood pressure (BP) when you stand up from a seated or lying position. To help prevent this, you should rise slowly after sitting or lying for a long time. If you feel dizzy, immediately sit or lie down until the dizziness stops, then slowly try getting up again. Tell your medical provider immediately if you experience dizziness, weakness, abnormal bleeding, confusion, or blurred vision. 

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Trazodone Hydrochloride? 

There are certain warnings associated with Trazodone Hydrochloride. The key points of the warnings include: 

• You should not take this medication if you have an allergy to Trazodone or any of its ingredients. Your pharmacist or healthcare provider can provide a complete list of the medication’s ingredients. 
• You should not take this medication while you are using certain other medications. To know about potential drug interactions of this medication, tell your doctor about all the medicines you are taking or plan to take, including all prescription, non-prescription, over-the-counter drugs, and herbal or vitamin supplements. 
• Do not take this medication if you have used an MAO inhibitor in the last 14 days, as it may cause a severe drug interaction. MAO inhibitors include linezolid, isocarboxazid, phenelzine, tranylcypromine, and more.
• Some young people may experience suicidal thoughts when starting an antidepressant. Your doctor will monitor your progress through check-ups on a regular basis while you are on Trazodone. Family members or caregivers should also be attentive to any changes in your mood or symptoms.
• Notify your doctor immediately if you experience any new or exacerbating symptoms, such as changes in mood or behavior, anxiety, panic attacks, difficulty sleeping, or if you feel irritable, impulsive, agitated, hostile, aggressive, restless, overly energetic (mentally or physically), more depressed, or have thoughts of suicide or self-harm.
• Do not give this medication to anyone under 18 years old without a doctor’s advice, as Trazodone is not approved for use in children.

What Are the FDA Boxed Warning for Trazodone Hydrochloride?

FDA has issued a boxed warning for Trazodone Hydrochloride due to the risk of suicidal thoughts or actions, particularly in adolescents and young adults. While this side effect is rare, it is crucial to be aware of signs & symptoms such as changes in mood or thoughts, suicidal behavior or ideation, or worsening depression. 

What Are the Trazodone Hydrochloride Precautions?

There are certain precautions that you should consider before you start using Trazodone Hydrochloride. It includes: 

• Before using Trazodone, tell your healthcare provider about all your health conditions and any medications, vitamins, minerals, herbal products, or other supplements you are taking. This information helps determine whether Trazodone is suitable for you. 
• Before using Trazodone Hydrochloride, share your complete medical and family history with your doctor, especially if you have the following conditions:
  • Bipolar disorder or mania
  • Bleeding disorders
  • Heart issues, including any family history of QT prolongation (a rare, serious heart rhythm problem)
  • Liver or kidney problems
  • Low sodium levels
  • Glaucoma
  • History of heart attack
  • Peyronie’s disease
  • Sickle cell anemia, leukemia, multiple myeloma, or other serious medical conditions
• You should not take Trazodone Hydrochloride unless it has been prescribed to you by a licensed healthcare professional. Take it exactly as your doctor prescribed.
• Do not share this medication with others, even if they have the same condition as you, as it can cause harm to them.
• Keep this medication in a safe place, away from the sight and reach of children and pets.
• To prevent the chance of an upset stomach, you should take this medication shortly after a meal or light snack. 
• You should not crush or chew the Trazodone tablet. If necessary, your doctor may suggest breaking it in half along the score line. 
• Trazodone may impact your alertness and coordination. Avoid driving, operating heavy machinery, or indulging in tasks that require these abilities until you understand how the medication affects you. If you feel drowsy or fatigued after taking Trazodone, inform your healthcare provider. They might adjust your dose or recommend taking it at a different time.
• Do not discontinue Trazodone without consulting your healthcare provider. Stopping it abruptly can lead to serious side effects, including anxiety, agitation, and sleep disturbances.
• It is unknown how Trazodone affects pregnancy or an unborn baby. Let your healthcare provider know if you are pregnant, suspect a pregnancy, or planning to become pregnant. They will advise you on whether you should take Trazodone during this time. 
• Trazodone may pass into breast milk. Tell your healthcare provider if you are breastfeeding or planning to breastfeed, and they will guide you on whether it’s safe to use Trazodone while nursing.

What Are the Contraindications of Trazodone Hydrochloride?

Trazodone Hydrochloride is contraindicated for use in patients who:

• Have an allergy to Trazodone or any of the ingredients listed in the medication. 
• Are being treated with methylene blue injection
• Are less than 18 years of age
• Are concurrently using MAOIs or within 14 days of stopping MAOIs. 

What If You Missed a Dose of Trazodone Hydrochloride?

To get the most benefit from the medicine you use, you should keep consistency in dosage & to help you remember to take it, use it around the same time every day. If you have missed a dose of Trazodone Hydrochloride, follow the instructions given below or consult your doctor. 

• If you have missed a dose of Trazodone Hydrochloride, you should take it as soon as you remember. 
• However, if it is almost time for your next dose, you may omit the missed dose and continue taking your medication according to the regular dosing schedule. 
• Do not simultaneously take double or extra doses of the same medication to compensate for the missed dose, as it can cause undesirable side effects.  

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Trazodone Hydrochloride?

You should not use Trazodone more than prescribed, in large doses, or more often than prescribed, as it can lead to an overdose. If you suspect an overdose of Trazodone Hydrochloride, you should seek immediate medical attention. You can call your doctor, 911, or poison control helpline. You may also head to the nearest emergency room.  

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How to Store a Trazodone Hydrochloride?

To ensure the medication you are using is safe and potent, you should follow proper storage guidelines. 

• Keep Trazodone Hydrochloride in its original container to protect it from direct sunlight, excess heat, and moisture. Store at room temperature in a dark and dry place. 
• Keep all medications, including Trazodone Hydrochloride, in a safe place, away from the sight and reach of children and pets. 
• Do not keep medications that are outdated or no longer needed. Discard them safely. 
• Do not pour unwanted medication down the drain, flush it down the toilet, or throw it into the household garbage bin. 
• You should dispose of unwanted medications in such a way that prevents children, animals, and others from consuming them. 
• The best way to eliminate unwanted medications is to give them in the medicine-take-back program. 
• To learn more about the proper ways to dispose of unwanted medications, you should consult your healthcare provider, pharmacist, or local waste disposal company. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Trazodone Hydrochloride?

Certain medications may interact with Trazodone and affect how it may work, potentially leading to severe side effects or reduced therapeutic benefits. Before using this medication, it is crucial to tell your healthcare provider, pharmacist, or doctor about all the medications you are using or plan to use. This includes all prescription, non-prescription, over-the-counter drugs, and herbal or vitamin supplements. This information helps in identifying and managing potential drug interactions of Trazodone. Here are some important drug interactions to consider while taking Trazodone Hydrochloride:

• Bepridil
• Bromopride
• Cisapride
• Dronedarone
• Fluconazole
• Isocarboxazid
• Ketoconazole
• Ketazolam
• Ketobemidone
• Ketoprofen
• Ketorolac
• Levoketoconazole
• Linezolid
• Mesoridazine
• Methylene Blue
• Moclobemide
• Nelfinavir
• Nialamide
• Octreotide
• Ofloxacin
• Olanzapine
• Oliceridine
• Omaveloxolone
• Ondansetron
• Opipramol
• Phenelzine
• Pimozide
• Piperaquine
• Posaconazole
• Procarbazine
• Rasagiline
• Safinamide
• Saquinavir
• Selegiline
• Sparfloxacin
• Terfenadine
• Thioridazine
• Tranylcypromine
• Valdecoxib
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vilazodone
• Vinflunine
• Voclosporin
• Vorapaxar
• Voriconazole
• Vorinostat
• Vortioxetine
• Ziprasidone 

What Are the Other Trazodone Hydrochloride Interactions?

Other than medications, certain herbs, supplements, food items, and beverages may interact with Trazodone Hydrochloride and reduce its effectiveness or cause undesirable side effects. Your doctor may advise you to make certain dietary changes to prevent such interactions. It is important to note that this list is not exhaustive, and other interactions may exist. Inform your doctor about all supplements and significant dietary habits to prevent drug interactions with Trazodone. 

• Grapefruit juice
• St. John’s Wort

Apart from this, Trazodone Hydrochloride also has certain disease interactions, which you should be aware of before starting treatment with this medicine. It includes: 

• Angle-closure glaucoma 
• Mania 
• Suicidal thoughts or behavior 
• Hypotension 
• Seizures
• Hyponatremia 
• Renal disease 
• Liver impairment 
• Cardiovascular disease 

[Note: This isn’t a complete list, and there could be other drugs that interact with Trazodone Hydrochloride. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Trazodone Hydrochloride Alternatives?

Trazodone Hydrochloride is an effective medication used to treat depression and related disorders. While it is suitable for most patients, it may cause unwanted side effects or does not provide desirable results for some individuals who use it. Taking into account factors such as the patient’s symptoms, medical history, potential side effects, and personal preferences, your doctor can prescribe you a substitute for Trazodone. Here are some alternatives to Trazodone Hydrochloride. 

• Mirtazapine (mirtazapine)
• Doxepin hydrochloride
• Amitriptyline
• Paroxetine
• Bupropion (bupropion hydrochloride XL) 

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Trazodone Hydrochloride Cost & Coupons

Many people may find Trazodone for sleep or depression essential. Yet many Americans find out that their health insurance plan does not cover it, leading to significant out-of-pocket expenses. Due to this reason, many people turn to order Trazodone tablets from online pharmacies, such as Polar Bear Meds, which enables them to buy Trazodone Hydrochloride online from Canada at more affordable rates than typical U.S. prices. Additionally, customers looking to further reduce their financial expenses can utilize the discount coupon code WELCOMEPB10 while checkout, granting a 10% discount on their first purchase. This approach can make a critical difference for those needing regular access to Trazodone Hydrochloride without the burden of high costs.

Frequently Asked Questions

What is the biggest side effect of Trazodone?

The most significant side effect of Trazodone can be priapism, a rare but serious condition involving a painful, prolonged erection. This needs prompt medical attention to prevent permanent damage to the penis. Other common side effects include drowsiness and dizziness, which vary in intensity among individuals.

Is Trazodone safe to take daily?

Trazodone is generally safe for daily use when prescribed by a healthcare provider and taken according to the prescribed dosage. Regular monitoring by a medic is crucial to adjust dosages & manage any potential side effects or interactions with other medications.

Is Trazodone an SSRI or SNRI?

Trazodone is neither an SSRI nor an SNRI. It is categorized as a serotonin antagonist & reuptake inhibitor. Trazodone works by preventing the reuptake of serotonin in the brain and by blocking certain serotonin receptors, which helps to balance the levels of serotonin and alleviate depressive symptoms.

What is the FDA guidance for Trazodone?

The FDA advises that Trazodone should only be used as prescribed by a healthcare professional. It includes warnings about potential severe side effects such as priapism, QT interval prolongation, and the risk of suicidal thoughts & behaviors in young adults, especially when starting the medicine or adjusting the dose. Regular follow-ups and caution when used in combination with other central nervous system depressants are recommended.

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