
Insulin deglude…


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Tresiba FlexTouch is a long-acting insulin used to help control blood sugar levels in people with diabetes. Its active ingredient, insulin degludec, is prescribed for adults and children (≥1 year) with Type 1 or Type 2 diabetes.
Tresiba FlexTouch is a prefilled injection pen that delivers insulin under the skin. One key benefit of Tresiba FlexTouch is its ultra-long duration of action, lasting up to 42 hours, which helps reduce fluctuations in blood sugar.
Tresiba FlexTouch Pen is FDA-approved for once-daily use as part of a broader diabetes management plan. This plan may include mealtime insulin, regular physical activity, healthy eating, and regular blood sugar monitoring.
| Generic name | Insulin degludec |
|---|---|
| Brand | Tresiba |
| Drug Class | Ultra-long-acting basal insulin (human insulin analog) |
| FDA indications | Improves glycemic control in patients with diabetes mellitus (Type 1 and Type 2) |
| FDA age range | Pediatric patients 1 year and older and adults |
| Onset of action | 30-90 minutes (may vary depending on individual factors) |
| Duration of action | Up to 42 hours |
| Form | Prefilled injection pen (FlexTouch) |
| Strengths | 100 u/mL, 200 u/mL |
| Dosing frequency | Once daily, at the same time each day |
| Initial U.S. approval | FDA approved in 2015 |
| Manufacturer | Novo Nordisk |
| Not Approved for | Treatment of diabetic ketoacidosis (DKA) |
| Key warnings | Do not share pens; adjust carefully when changing insulin regimens; monitor for hypoglycemia/hyperglycemia |
| Storage (unopened) | Refrigerate at 2-8°C (36-46°F) |
| Storage (in‑use) | Room temperature (below 30°C); discard after up to 8 weeks (follow label) |
| Legal Status | Prescription/Professional Use Only |
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| Patient Group | Starting Dose | Adjustment | Maximum Units per Injection | Notes |
|---|---|---|---|---|
| Adults (Type 1 or Type 2 diabetes) | Initial dosing should be individualized per provider. | Adjust based on blood glucose and the doctor’s advice | U‑100 pen: 80 units U‑200 pen: 160 units | Can be combined with mealtime insulin if needed |
| Children (≥1 year) | U-100 vial may be used for doses <5 units. | Adjust based on blood glucose and the doctor’s advice | Same as adults | Not recommended if the child requires <5 units/day |
| Switching from once‑daily basal insulin | Use the same total daily dose | Adjust as needed | Same as adults | Monitor closely during transition |
| Switching from twice‑daily basal insulin | Start with 80-90% of the total daily dose | Adjust as needed | Same as adults | Helps reduce the risk of hypoglycemia |
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Always follow your healthcare provider’s instructions for proper insulin injection technique. Below is a general step-by-step guide for using the Tresiba FlexTouch pen:
Tresiba FlexTouch contains insulin degludec, a long-acting insulin. After injection under the skin, it forms stable multihexamers that create a slow-release depot, allowing insulin to be absorbed gradually over 24 hours or longer. Insulin degludec helps move glucose from the bloodstream into cells for energy. This steady, long-lasting action supports more consistent blood sugar control throughout the day and night, helping reduce fluctuations such as highs and lows.
Using Tresiba FlexTouch (insulin degludec) correctly can help you achieve more stable blood sugar control and reduce the risk of side effects. The following patient tips may help improve safety and effectiveness:
Tresiba FlexTouch (insulin degludec) can interact with several medications that affect blood sugar control. Always inform your doctor about all medicines you are taking, including over‑the‑counter drugs and supplements.
| Drug Category | Drug Examples |
|---|---|
| Oral anti‑diabetic medicines | Metformin, Glimepiride |
| GLP‑1 receptor agonists | Liraglutide, Semaglutide |
| Beta‑blockers | Propranolol, Metoprolol |
| ACE inhibitors | Lisinopril, Enalapril |
| Salicylates | Aspirin |
| Thiazide diuretics | Hydrochlorothiazide |
| Glucocorticoids | Prednisone, Dexamethasone |
| Thyroid hormones | Levothyroxine |
| Sympathomimetics | Albuterol, Epinephrine |
| Octreotide / Lanreotide | N/A |
| Alcohol | Ethanol |
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If Tresiba (insulin degludec) is not suitable, you may consider the following alternatives for Type 1 and Type 2 diabetes under medical supervision:
Both are FDA‑approved long‑acting basal insulins for Type 1 and Type 2 diabetes. The “better” choice depends on your blood sugar needs, lifestyle, and cost considerations. Below is a comparison to help you understand the key differences between Tresiba and Lantus:
| Attribute | Tresiba (Insulin degludec) | Lantus (Insulin glargine) |
|---|---|---|
| Drug Class | Long‑acting basal insulin (analog) | Long‑acting basal insulin (analog) |
| Form | Prefilled FlexTouch pen | Prefilled SoloStar pen or vial |
| Strengths | U‑100 (100 units/mL), U‑200 (200 units/mL) | U‑100 (100 units/mL) |
| Onset of Action | ~30–90 minutes (varies) | ~1–2 hours |
| Peak Effect | Minimal peak; steady release | Relatively peakless, but may show a slight activity curve |
| Duration of Action | Up to 42 hours (ultra‑long) | ~24 hours |
| Dosing Frequency | Once daily, flexible timing | Once daily, same time each day |
| FDA Indications | Type 1 & Type 2 diabetes (≥1 year old) | Type 1 & Type 2 diabetes (≥6 years old) |
| Initial FDA Approval | 2015 | 2000 |
| Manufacturer | Novo Nordisk | Sanofi |
| Pros | Ultra‑long duration, flexible dosing, fewer hypoglycemia episodes overnight | Well‑established, widely available, cost‑effective |
| Cons | More expensive, newer, with less long‑term data | Shorter duration, stricter timing, may require dose adjustments |
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Choosing Polar Bear Meds allows U.S. patients to access Tresiba FlexTouch through a trusted network of licensed Canadian pharmacies.
Polar Bear Meds provides general medication information to support patient awareness and understanding. The information on this page is for educational purposes only & is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare provider or pharmacist before stopping, starting, or changing any medication, including Tresiba FlexTouch.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/203314s018s020lbl.pdf
https://www.webmd.com/drugs/2/drug-170029/tresiba-flextouch-u-100-subcutaneous/details
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=456c5e87-3dfd-46fa-8ac0-c6128d4c97c6 https://www.mayoclinic.org/drugs-supplements/insulin-degludec-subcutaneous-route/description/drg-20155729
https://www.ema.europa.eu/en/documents/product-information/tresiba-epar-product-information_en.pdf

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.
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