Lisinopril / Hydrochlorothiazide

Zestoretic

Zestoretic, a combination of lisinopril (an ACE inhibitor) and hydrochlorothiazide (a diuretic), is prescribed to treat high blood pressure. Lisinopril relaxes blood vessels while hydrochlorothiazide reduces fluid retention, effectively lowering blood pressure and reducing risks of heart attacks, strokes, and kidney problems. Available in various strengths, Zestoretic is generally taken once daily. It’s crucial for patients to adhere to their prescribed dosage and maintain consistent medication levels for effectiveness. Lifestyle adjustments and regular monitoring are recommended to enhance treatment outcomes and manage side effects. Always consult with a healthcare provider before you buy Zestoretic tablet or start or adjust your treatment.

Product Overview

Zestoretic is a prescription medication specifically designed to treat hypertension, a prevalent condition that can lead to severe cardiovascular issues if unmanaged. This medication synergistically combines lisinopril and hydrochlorothiazide. Lisinopril works by inhibiting the angiotensin-converting enzyme (ACE), which leads to relaxed blood vessels and improved blood flow. On the other hand, hydrochlorothiazide acts as a diuretic that prompts the kidneys to remove unnecessary salt and water from the body through urine, effectively reducing blood volume and pressure.

Zestoretic is generally prescribed when monotherapy does not sufficiently control blood pressure. The formulation is available in oral tablet forms with varying dosages, such as 10 mg/12.5 mg, 20 mg/12.5 mg, and 20 mg/25 mg, to cater to different therapeutic needs. The typical starting dose can range based on previous treatments, with options to adjust based on efficacy and patient response, up to a maximum of hydrochlorothiazide 50 mg and lisinopril 80 mg daily.

Patients are advised to take Zestoretic once a day, ideally in the morning, to avoid nocturnal urination due to its diuretic effect. It can be taken with or without food. Consistency in the timing of the dose helps maintain steady medication levels in the body, enhancing overall effectiveness. For optimal results, Zestoretic should be part of a broader treatment plan that includes dietary changes, regular exercise, and possibly other medications. You may buy Zestoretic tablet online to treat high blood pressure with a prescription that you may receive from your doctor.

What Is Zestoretic Used For?

• Zestoretic tablet is used in the treatment of High blood pressure in adults

What Strengths Does Zestoretic Come In?

It comes in the form of oral tablets and has the following strengths and quantity:

• 10mg/12.5mg (Quantity 90 tablets)
• 20mg/12.5mg Quantity 30 tablets)
• 20mg/25mg Quantity 30 tablets)

What Is the Typical Dosage of Zestoretic?

The recommended dosage of Zestoretic can vary depending on several factors such as the type and severity of the condition being treated, as well as the specific strength of the medication prescribed by your doctor. Typically, doctors will start with an initial dose and may adjust this dose over time based on how effective the medication is and your response to it. It’s important to note that the dosage information provided here is a general guideline. If your doctor has prescribed a different dosage, you should follow that prescription and always consult with your doctor before making any changes to how you take your medication.

Dosage of Zestoretic for Hypertension

• Usual Adult Dosage for High Blood Pressure:

• • • Initial Dosage: Start with a combination of 12.5 mg of hydrochlorothiazide and 10 to 20 mg of lisinopril, taken orally once daily. The exact starting dose depends on the dose of any previous blood pressure medication you were taking.
    • Maximum Dosage: The highest recommended dosage is 50 mg of hydrochlorothiazide and 80 mg of lisinopril per day.

• Additional Guidance:

• • Your doctor may choose to increase the dosage every 2 to 3 weeks based on how your blood pressure responds.
  • If your blood pressure is well-managed with 25 mg of hydrochlorothiazide alone but you are experiencing significant potassium loss, your doctor might adjust your treatment to 12.5 mg of hydrochlorothiazide with 10 mg of lisinopril daily. This adjustment helps maintain blood pressure control while potentially reducing the risk of electrolyte imbalances.

[Note: Always follow your doctor’s instructions carefully, and have regular check-ups to monitor your blood pressure and potassium levels. Adjustments to your medication should only be made under medical supervision.]

How to Use Zestoretic?

Zestoretic should not be the first medication you use to begin treating high blood pressure. Initially, each component of Zestoretic, which includes lisinopril and hydrochlorothiazide, should be taken separately as individual tablets. This allows your doctor to determine the appropriate dose of each medication that effectively controls your blood pressure. Once the right doses of both medications are established, you can then start taking them combined into a single Zestoretic tablet.

• Before You Start:
  • Patient Information Leaflet: Always read the Patient Information Leaflet provided by your pharmacist when you start taking Zestoretic and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
• Taking the Medication:
  • Method of Administration: Take Zestoretic orally, with or without food, as your doctor prescribes. It is generally recommended to take your dose in the morning.
  • Frequency of Urination: Since Zestoretic can increase urination, try to take it at least 4 hours before bedtime to avoid having to get up during the night.
• If Taking Other Medications:
  • Cholesterol-Lowering Drugs: If you are also on bile acid-binding resins like cholestyramine or colestipol, take Zestoretic at least 4 to 6 hours after or 4 hours before taking these medications.
• Dosage:
  • Individual Adjustment: Your dose will depend on your medical condition and how you respond to treatment.
• Consistent Use:
  • Daily Routine: To maximize the benefits, take Zestoretic at the same time every day. Continue taking it even if you feel fine, as high blood pressure often has no symptoms.
  • Regular Intake: It’s important to take this medication regularly as prescribed to maintain steady blood pressure levels.
• Monitoring:
  • Response to Treatment: Inform your doctor if your condition does not improve or if your blood pressure readings increase or remain high.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Zestoretic Work?

Zestoretic works by combining two different types of medications that help to lower blood pressure in distinct ways. The first component, lisinopril, is an ACE inhibitor. It helps relax your blood vessels by blocking a protein called ACE that usually causes blood vessels to tighten. The second component, hydrochlorothiazide, is a type of medication known as a thiazide diuretic or a “water pill.” It aids in lowering blood pressure by causing the kidneys to get rid of excess water and certain electrolytes, such as sodium and potassium. By removing this extra fluid, your blood pressure goes down, making it easier for your heart to pump blood.

What Are the Important Safety Information for Using Zestoretic?

What Are the Side Effects of Zestoretic?

Common Side Effects of Zestoretic: Zestoretic can cause some side effects that usually don’t last long—typically just a few days to a few weeks. If these side effects don’t go away or start to bother you, it’s important to talk to your doctor or pharmacist. Always keep track of how you feel after taking Zestoretic and let your healthcare provider know if any side effects continue for a long time or get worse. The common side effects you might experience with Zestoretic include:

• Headache: You may feel a persistent or occasional pain in your head.
• Cough: You might develop a dry or persistent cough.
• Tired feeling: You may feel unusually tired or have a lack of energy.
• Dizziness: You might feel lightheaded or as if the room is spinning, especially when getting up too quickly from sitting or lying down.

Serious Side Effects of Zestoretic: Zestoretic can sometimes lead to serious side effects. While the list below does not cover all possible serious side effects, it includes some of the major ones. If you experience any of these symptoms, it’s crucial to contact your doctor immediately. If the side effects seem life-threatening, or if you think you’re having a medical emergency, call 911 or your local emergency number right away. Here are some serious side effects to be aware of:

• Feeling Like You Might Faint: You may feel extremely light-headed, almost as if you are about to pass out.
• Eye Issues: You could experience pain in your eyes or have trouble with your vision.
• Urination Problems: If you notice you’re producing little to no urine, this could be a sign of kidney problems.
• Weakness and Fatigue: You may feel unusually weak, tired, or have an overwhelming sense of restlessness.
• Infection Symptoms: Watch for signs of an infection such as fever, chills, a sore throat, mouth sores, and difficulty swallowing.
• Jaundice: If your skin or the whites of your eyes turn yellow, this may indicate liver issues.
• High Potassium Levels: Symptoms can include nausea, a tingling sensation, chest pain, irregular heartbeats, and loss of muscle movement.
• Low Potassium Levels: You might experience leg cramps, constipation, irregular heartbeats, a fluttering sensation in your chest, increased thirst or urination, numbness, tingling, muscle weakness, or feel limp.
• Low Sodium Levels: Symptoms could include headaches, confusion, slurred speech, severe weakness, vomiting, loss of coordination, or feeling unsteady.

[Note: It’s essential to monitor how you feel while taking Zestoretic and report any prolonged or severe symptoms to your healthcare provider.]

Are There Any Warnings for Using Zestoretic?

Before starting Zestoretic, it’s very important to discuss your medical history with your doctor. Make sure to inform them about any allergies you might have, any medications you are currently taking, whether you are pregnant or breastfeeding, and any other significant health details. These factors are crucial because they can affect how you should use this medication:

• Pregnancy: Do not take Zestoretic if you are pregnant. If you find out you are pregnant while taking this medication, stop using it immediately and inform your doctor.
• Breastfeeding: It is unknown if lisinopril passes into breast milk, whereas hydrochlorothiazide does pass into breast milk but is unlikely to harm a nursing infant. Discuss with your doctor before breastfeeding.
• Angioedema and Allergies: Avoid using Zestoretic if you have a history of angioedema (severe swelling), are unable to urinate, or have allergies to sulfa drugs or ACE inhibitors.
• Interactions with Other Medications: Do not take Zestoretic within 36 hours before or after using medications containing sacubitril, such as Entresto. If you have diabetes, you should also avoid taking Zestoretic with medications containing Aliskiren, which is used to treat high blood pressure.

[Note: Always consult with your doctor before making any changes to your medication regimen, especially if you have underlying health conditions or are taking other medications.]

What Are the Safety Precautions for Zestoretic?

Before you begin using Zestoretic, it’s very important to have a discussion with your doctor about the potential risks and benefits of the medication. Here are some steps you should consider before starting this treatment:

• Do Not Share: This medication is prescribed specifically for you. Do not share it with anyone else.
• Lifestyle Adjustments: To enhance the effectiveness of Zestoretic, consider making lifestyle changes such as increasing physical activity, quitting smoking, and adopting a low-cholesterol and low-fat diet. Discuss these potential changes with your doctor.
• Regular Testing: While taking Zestoretic, it’s important to undergo routine lab and medical tests to monitor your kidney function and potassium levels and conduct skin exams. Make sure to keep all scheduled medical and lab appointments.
• Monitoring Health at Home: Regularly monitor your blood pressure and heart rate at home. Knowing how to check these vitals and reporting the readings to your doctor can help manage your condition more effectively.
• Allergies: Inform your doctor or pharmacist if you have allergies to lisinopril, hydrochlorothiazide, other ACE inhibitors (like captopril or benazepril), or any other substances. This medication may contain inactive ingredients that can cause allergic reactions or other problems.
• Medical History: Share your medical history with your healthcare provider, especially if you have had:
  • Procedures to filter your blood (such as dialysis, LDL apheresis)
  • Swelling reactions (angioedema)
  • Conditions like kidney disease, gout, liver disease,  lupus, or skin cancer
  • Treatments for wasp/bee sting allergy
• Dizziness: Zestoretic may cause dizziness. Avoid alcohol and marijuana, as these can increase dizziness. Do not drive or operate machinery until you know you can do so safely.
• Dehydration Risks: Inform your doctor if you experience severe sweating, diarrhea, or vomiting, as these can lead to dehydration and dizziness. Drink plenty of fluids unless advised otherwise by your doctor.
• Diabetes: This medication may impact your blood sugar levels. Regularly check your blood sugar as directed and discuss the results with your doctor. Your diabetes management plan may need adjustments.
• Sun Sensitivity: Zestoretic can increase your sensitivity to the sun and your risk for skin cancer over long-term use. Limit sun exposure, avoid tanning booths and sunlamps, and wear protective clothing and sunscreen when outdoors. Notify your doctor if you experience any skin changes like sunburn, blisters, or redness.
• Potassium Levels: This medication can affect potassium levels. Consult your healthcare provider before using potassium supplements or salt substitutes that contain potassium.
• Surgical Considerations: Before undergoing any surgery, inform your healthcare team about all medications you are taking, including prescription, over-the-counter, and herbal products.
• Older Adults: If you are an older adult, be aware that you may be more sensitive to the side effects of this drug, particularly dizziness and changes in urine output.

What Should Not Use Zestoretic?

Zestoretic, which contains lisinopril and hydrochlorothiazide, before you buy zestoretic tablet online from Canada or start using it, you must tell your healthcare provider if you have any of the following conditions or circumstances, as it may not be safe for you:

• Diabetes and Aliskiren Use: Do not use Zestoretic if you are taking aliskiren (Tekturna) and have diabetes. This combination can cause serious complications.
• Neprilysin Inhibitors: Avoid taking Zestoretic within 36 hours before or after using neprilysin inhibitors, such as Entresto (sacubitril/valsartan), due to potential severe interactions.
• Urinary Issues: Do not use Zestoretic if you are unable to produce urine, as it can worsen your condition.
• Sulfa Drug Allergy: If you are allergic to sulfa medications, avoid taking Zestoretic. It contains hydrochlorothiazide, a sulfa drug that could cause allergic reactions.
• ACE Inhibitor Allergy: Do not take Zestoretic if you have had allergic reactions to ACE inhibitors in the past.
• History of Angioedema: If you have a history of severe swelling (angioedema), mainly related to previous use of ACE inhibitors, Zestoretic is not recommended for you.

What Happens If You Miss a Dose of Zestoretic?

If you forget to take a dose of Zestoretic, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to compensate for the missed one, as this could increase the risk of side effects.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What to Do If You Take Too Much of Zestoretic?

In case of an overdose, if someone experiences severe symptoms like fainting or difficulty breathing, call 911 immediately. For less urgent symptoms such as severe dizziness or fainting, contact a poison control center for guidance. Residents in the U.S. can reach poison control at 1-800-222-1222.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How Do You Store Zestoretic Tablets?

To keep your medication effective when you buy Zestoretic tablet online from Canada, it’s important to store it correctly. Here’s a guide on how to do this correctly:

• Store Zestoretic at room temperature, away from direct light and moisture. 
• Avoid storing it in the bathroom, where it can get damp. 
• Keep all medications out of the reach of children and pets. 
• Do not dispose of medications in the toilet or down a drain unless instructed to do so. 
• To safely discard Zestoretic when it is expired or no longer needed, consult your pharmacist or your local waste disposal company for proper disposal methods.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Zestoretic?

Medications can sometimes interact with each other, which can change how they work or increase the chance of serious side effects. It’s important to keep a list of all the medications you’re using, including prescription drugs, over-the-counter products, and herbal supplements. Share this list with your doctor and pharmacist. Always check with your doctor before you start, stop, or change the dose of any medicine. Here are some medications that can interact with Zestoretic:

• Aliskiren: Used for high blood pressure, aliskiren can interact with Zestoretic, increasing the risk of side effects like high potassium levels and low blood pressure.
• Dofetilide: This heart rhythm medication can interact with Zestoretic, possibly leading to serious heart issues.
• Immunosuppressants like everolimus and sirolimus: These drugs can be less effective or lead to worse side effects when used with Zestoretic.
• Lithium: Used for mental/mood disorders, lithium’s effectiveness can be increased to dangerous levels when taken with Zestoretic.
• Drugs that increase potassium levels: Medications like angiotensin receptor blockers (ARBs) such as losartan or valsartan, and birth control pills containing drospirenone can raise potassium too much when taken with Zestoretic.
• Sacubitril: A heart failure drug that should not be taken with Zestoretic, as it can lead to serious reactions like angioedema.
• Over-the-counter medications: Some products, like cough and cold medicines, diet aids, or NSAIDs (like ibuprofen or naproxen), might increase your blood pressure or worsen heart failure when used with Zestoretic.

Zestoretic can also change the results of certain lab tests, such as those for parathyroid function, causing them to show false results. Make sure laboratory personnel and all your doctors are aware you use this medication. This ensures that they interpret your test results correctly.

Does Zestoretic Interact with Foods or Drinks?

There are no specific foods or drinks that are known to interact with the combination of lisinopril and hydrochlorothiazide found in Zestoretic. However, because this medication can affect your body’s electrolyte balance, it’s important to talk with your healthcare provider about your intake of electrolytes, such as sodium and potassium.

While it is not clear if alcohol directly affects Zestoretic, drinking alcohol might increase your risk of getting dizzy while on this medication. It’s advisable to limit the amount of alcohol you consume while taking Zestoretic to avoid potential issues.

[Note: This isn’t a complete list, and there could be other drugs that interact with Zestoretic. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Zestoretic Alternatives?

There are many alternatives available for treating high blood pressure if Zestoretic isn’t suitable for you. These alternatives include different types of medications that can also manage high blood pressure effectively. Some of these are other ACE inhibitors, Angiotensin II receptor blockers (ARBs), calcium channel blockers, diuretics (often known as water pills). Each type of medication has its own uses, side effects, and dosage requirements. It’s important to discuss these options with your healthcare provider to determine which one might be the best fit for your specific health needs.

• Exforge (amlodipine/valsartan)
• Zestoretic (combination lisinopril/hydrochlorothiazide)
• Avalide (HCTZ/irbesartan)
• Atacand (candesartan)
• Aldactone (spironolactone)
• Cardura (doxazosin)
• Coreg (carvedilol)
• Felodipine XR
• Coreg CR (extended-release carvedilol)
• Lopressor (metoprolol)
• Benicar (olmesartan)
• Micardis (telmisartan)
• Lotrel (combination amlodipine/benazepril)
• Inderal LA (extended-release propranolol)
• Lasix (furosemide)
• Lotensin (benazepril)
• Accupril (quinapril)
• Ziac (bisoprolol/HCTZ)
• Twynsta (amlodipine/telmisartan)
• Benicar HCT (HCTZ/olmesartan)
• Capozide (HCTZ/captopril)
• Vaseretic (HCTZ/enalapril)
• Hydrochlorothiazide (HCTZ)
• Atacand HCT (HCTZ/candesartan)
• Altace (ramipril)
• Tribenor (amlodipine/HCTZ/olmesartan)
• Isradipine
• Catapres (clonidine)
• Diovan (valsartan)
• Toprol XL (metoprolol extended release)
• Exforge HCT (amlodipine/HCTZ/valsartan)
• Zestril (lisinopril)
• Captopril
• Tenormin (atenolol)
• Diovan HCT (HCTZ/valsartan)
• Tekturna HCT (HCTZ/aliskiren)
• Tekturna (aliskiren)
• Accuretic (HCTZ/quinapril)
• Methyldopa
• Trandate (labetalol)
• Vasotec (enalapril)
• Bystolic (nebivolol)
• Perindopril
• Azor (amlodipine/olmesartan)
• Micardis HCT (HCTZ/telmisartan)
• Nifedical XL (extended-release nifedipine)
• Cardizem CD (diltiazem extended release)
• Hydralazine
• Cozaar (losartan)
• Fosinopril
• Benicar HCT (HCTZ/olmesartan)
• Catapres TTS (clonidine patch)
• Lotensin HCT (HCTZ/benazepril)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Zestoretic Coupons & Cost

Zestoretic can be expensive, especially without insurance coverage, often costing more than expected per month out-of-pocket. To help manage these costs, consider purchasing Zestoretic from Canadian pharmacies, which usually offer the medication at significantly lower prices. For those looking to buy Zestoretic online from Canada, Polar Bear Meds is a reputable option that offers these drugs in the USA at reduced rates. Additionally, first-time customers can benefit from a Zestoretic coupon code, “WELCOMEPB10”, which provides a 10% discount on their initial purchase. This approach ensures affordable access to Zestoretic for those managing hypertension in America.

Frequently Asked Questions

What is the best time to take Zestoretic?

Zestoretic is usually taken as directed by your healthcare provider, often recommended for the morning or early afternoon. This is because it contains hydrochlorothiazide, a diuretic, which increases urination. Taking it earlier helps prevent nighttime bathroom visits that can interrupt sleep. The exact timing can vary based on how the medication affects your urination patterns.

Can you cut Zestoretic in half?

It’s important not to cut Zestoretic tablets in half unless your healthcare provider specifically tells you to do so. The tablet contains two different medications, lisinopril and hydrochlorothiazide, and is not designed to be split. Splitting the tablet can result in uneven doses of the medications, potentially affecting how well the medicine works or increasing side effects.

How long does it take for Zestoretic to work?

Zestoretic starts working quickly, with the lisinopril component lowering blood pressure within an hour and the diuretic effect of hydrochlorothiazide kicking in a few hours after that. However, it might take 2 to 3 weeks to see the full effect on blood pressure. Your doctor may adjust the dose based on your blood pressure response, so keeping track of your blood pressure is helpful.

How long does Zestoretic stay in your system?

Zestoretic takes about three days to mostly clear from your system, based on the half-lives of lisinopril and hydrochlorothiazide. If you have kidney issues, it might take longer since the drug is eliminated through the kidneys. Regular daily dosing is crucial for maintaining steady blood pressure control.

Can I take aspirin with Zestoretic?

Before combining aspirin with Zestoretic, consult your healthcare provider. While low doses of aspirin are often used to prevent heart issues and generally do not interact with Zestoretic, aspirin can increase bleeding risks. It’s important to make sure it’s safe for your specific health situation.

What is the difference between lisinopril and Zestoretic?

Lisinopril is an ACE inhibitor used alone to treat high blood pressure. Zestoretic combines lisinopril with hydrochlorothiazide, a diuretic, enhancing its effectiveness. This combination addresses blood pressure in multiple ways. If lisinopril alone does not control your blood pressure well, your doctor might recommend Zestoretic to benefit from both medications.

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